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Conserved domains on  [gi|2079606035|gb|QYU71665|]
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adenylosuccinate synthetase, partial [Drosophila puberula]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt super family cl46237
Adenylosuccinate synthetase;
1-93 1.06e-37

Adenylosuccinate synthetase;


The actual alignment was detected with superfamily member pfam00709:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 130.16  E-value: 1.06e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSIN---VDVDAELARYKDYVEMVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLYgepLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606035  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
1-93 1.06e-37

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 130.16  E-value: 1.06e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSIN---VDVDAELARYKDYVEMVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLYgepLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606035  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-93 1.82e-31

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 113.58  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSINVDVDAELARYKDYVEMVRPYVKDTICFLHTALRNG 80
Cdd:PTZ00350  146 IGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEG 224

                          90
                  ....*....|...
gi 2079606035  81 KTILVEGANAAML 93
Cdd:PTZ00350  225 KRVLVEGANATML 237
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 1-93 2.88e-26

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 99.32  E-value: 2.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSIN----VDVDAELARYKDYVEMVRPYVKDTICFLHTA 76
Cdd:COG0104   131 IGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLYgaepLDFEELLEEYLEYAERLKPYVADTSELLNEA 209

                          90
                  ....*....|....*..
gi 2079606035  77 LRNGKTILVEGANAAML 93
Cdd:COG0104   210 LKAGKKVLFEGAQGTLL 226
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-93 1.84e-14

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 66.37  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGEllgdfnlfsekfksivnthlrlfpsinvdvdaelarykdyvemvrPYVKDTICFLHTALRNG 80
Cdd:cd03108   132 IGPAYADKAARTGIRVGD---------------------------------------------PYVVDTVELLNEALKAG 166

                          90
                  ....*....|...
gi 2079606035  81 KTILVEGANAAML 93
Cdd:cd03108   167 KKVLFEGAQGTLL 179
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
1-93 1.06e-37

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 130.16  E-value: 1.06e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSIN---VDVDAELARYKDYVEMVRPYVKDTICFLHTAL 77
Cdd:pfam00709 129 IGPAYSDKAARRGIRVGDLL-DPEVFREKLEALLELKNKLLEKLYgepLDVEEELEELLEYAERLKPYVVDTSYFLNKAL 207

                          90
                  ....*....|....*.
gi 2079606035  78 RNGKTILVEGANAAML 93
Cdd:pfam00709 208 KEGKKILFEGAQGTLL 223
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-93 1.82e-31

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 113.58  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSINVDVDAELARYKDYVEMVRPYVKDTICFLHTALRNG 80
Cdd:PTZ00350  146 IGPCYSTKASRTGLRVGDLL-NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEG 224

                          90
                  ....*....|...
gi 2079606035  81 KTILVEGANAAML 93
Cdd:PTZ00350  225 KRVLVEGANATML 237
PLN02513 PLN02513
adenylosuccinate synthase
 1-93 1.13e-30

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 111.66  E-value: 1.13e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSINVD---VDAELARYKDYVEMVRPYVKDTICFLHTAL 77
Cdd:PLN02513  135 IGPAYSSKATRNGLRVGDLR-HMDTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEAI 213

                          90
                  ....*....|....*.
gi 2079606035  78 RNGKTILVEGANAAML 93
Cdd:PLN02513  214 QAGKKILVEGAQATML 229
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 1-93 2.88e-26

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 99.32  E-value: 2.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSIN----VDVDAELARYKDYVEMVRPYVKDTICFLHTA 76
Cdd:COG0104   131 IGPAYEDKVARRGIRVGDLL-DPEVLREKLEELLEYKNFLLEKLYgaepLDFEELLEEYLEYAERLKPYVADTSELLNEA 209

                          90
                  ....*....|....*..
gi 2079606035  77 LRNGKTILVEGANAAML 93
Cdd:COG0104   210 LKAGKKVLFEGAQGTLL 226
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-93 1.76e-23

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 92.03  E-value: 1.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTH----LRLFPSINVDVDAELARYKDYVEMVRPYVKDTICFLHTA 76
Cdd:PRK01117  133 IGPAYEDKVARRGIRVGDLL-DPETFAEKLEENLEYKnfllTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDA 211

                          90
                  ....*....|....*..
gi 2079606035  77 LRNGKTILVEGANAAML 93
Cdd:PRK01117  212 LKAGKRVLFEGAQGTLL 228
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-93 1.84e-14

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 66.37  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGEllgdfnlfsekfksivnthlrlfpsinvdvdaelarykdyvemvrPYVKDTICFLHTALRNG 80
Cdd:cd03108   132 IGPAYADKAARTGIRVGD---------------------------------------------PYVVDTVELLNEALKAG 166

                          90
                  ....*....|...
gi 2079606035  81 KTILVEGANAAML 93
Cdd:cd03108   167 KKVLFEGAQGTLL 179
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-93 9.16e-12

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 59.05  E-value: 9.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKfksiVNTHLRLFPSINVD-----VDAELARYKDYVEMVRPYVKDTICFLHT 75
Cdd:PRK13788  125 IGPAYSDRARRVGIRFGDLL-DEAVLRER----VERLLEAKPNSTREagwdtVEKALADLAPMREILLPFIADTGSLLRE 199

                          90
                  ....*....|....*...
gi 2079606035  76 ALRNGKTILVEGANAAML 93
Cdd:PRK13788  200 AIREGKRVLFEGAQATLL 217
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-93 3.03e-07

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 46.48  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLGdfNLFSEKFKSIV---NTHL-RLFPSINVDVDAELARYKDYVEMVRPYVKDTICFLHTA 76
Cdd:PRK13787  134 IGICYADKMMRTGLRVGDLLD--KSYKRRLKHLVdekNRELdKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTE 211

                          90
                  ....*....|....*..
gi 2079606035  77 LRNGKTILVEGANAAML 93
Cdd:PRK13787  212 LKKGKRVLLEGAQGTGL 228
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 1-88 1.07e-06

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 44.75  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIVNTHLRLFPSI----------NVDVDAELARYKDYVEMVRPYVKDTI 70
Cdd:PRK13785  131 IGPTYEDKAGRRGVRVGDLL-DPDVLRDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEEDMTVN 209

                          90       100
                  ....*....|....*....|
gi 2079606035  71 C--FLHTALRNGKTILVEGA 88
Cdd:PRK13785  210 AgdFLAERIDDGDNVMLEGA 229
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 1-93 4.54e-05

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 40.09  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGElLGDFNLFSEKFKSIVNTHLRLFpSINVDVDAELARYKDYVEMVRPYVKDTIcFLHTALRNg 80
Cdd:PRK13783  131 IGPAYADKVMRVGVRLAD-LFDEEKLREFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPV-EIKRILEE- 206

                          90
                  ....*....|...
gi 2079606035  81 KTILVEGANAAML 93
Cdd:PRK13783  207 KSVLFEGTQGVLL 219
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 1-93 9.59e-05

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 39.01  E-value: 9.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2079606035   1 IGPAYSSKATRNGIRVGELLgDFNLFSEKFKSIV---NTHLRLF---PSINVDvDAELARYKDYVEMVRPYVKDTICFLH 74
Cdd:PRK13786  131 IGFAYIDKIARDEVRMSDLV-DKERLMRRLEELApqkEKEIKELggdPSIVRD-EALIDKYLELGRQLAPYITDVSYEIN 208

                          90
                  ....*....|....*....
gi 2079606035  75 TALRNGKTILVEGANAAML 93
Cdd:PRK13786  209 KALDEGKSVLAEGAQGTHL 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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