NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2077622628|ref|XP_042751067|]
View 

LOW QUALITY PROTEIN: centrosomal protein CCDC61-like [Lagopus leucura]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HD_CCDC61_N cd22284
N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; ...
 6-138 3.68e-66

N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; Coiled-coil domain-containing protein 61 (CCDC61), also known as variable flagellar number 3 (VFL3), is a centrosomal protein required for spindle assembly and precise chromosome alignments in mitosis. It is the human ortholog of proteins required for anchoring distinct sets of cytoskeletal fibers to centrioles in unicellular eukaryotes. CCDC61 monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two homodimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. These CCDC61 homodimers assembles into linear filaments. This model corresponds to the N-terminal head domain of CCDC61, which is structurally related to other XRCC4-superfamily members, XRCC4, XLF, SAS6, and PAXX.


:

Pssm-ID: 409001  Cd Length: 135  Bit Score: 207.46  E-value: 3.68e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077622628   6 CLQANCFFRGKEHSIQLSVSQA-VLEVEVQERCSTKRWRGRFDAASVEDLTRKTGNFKQFGIFCSMLEAALMKSSEAVSL 84
Cdd:cd22284     1 MISAELTFRGVEYLVTLKVDEGeSLSVEVEDKDTGERWRGSFTASYIEELTRKTGNFKKFSVFVKMLKSALLKTSESVSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2077622628  85 ELLTYGDLEALRCCKAGVATHVPPSASPLSSKRYLILVYCVEFDRIHYPLPLPY 138
Cdd:cd22284    81 DLLTYQDLEELRNRKSGGSSRNSASSSDLNNKRYLILTYTVEFDRVHYPLPLPY 134
 
Name Accession Description Interval E-value
HD_CCDC61_N cd22284
N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; ...
 6-138 3.68e-66

N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; Coiled-coil domain-containing protein 61 (CCDC61), also known as variable flagellar number 3 (VFL3), is a centrosomal protein required for spindle assembly and precise chromosome alignments in mitosis. It is the human ortholog of proteins required for anchoring distinct sets of cytoskeletal fibers to centrioles in unicellular eukaryotes. CCDC61 monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two homodimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. These CCDC61 homodimers assembles into linear filaments. This model corresponds to the N-terminal head domain of CCDC61, which is structurally related to other XRCC4-superfamily members, XRCC4, XLF, SAS6, and PAXX.


Pssm-ID: 409001  Cd Length: 135  Bit Score: 207.46  E-value: 3.68e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077622628   6 CLQANCFFRGKEHSIQLSVSQA-VLEVEVQERCSTKRWRGRFDAASVEDLTRKTGNFKQFGIFCSMLEAALMKSSEAVSL 84
Cdd:cd22284     1 MISAELTFRGVEYLVTLKVDEGeSLSVEVEDKDTGERWRGSFTASYIEELTRKTGNFKKFSVFVKMLKSALLKTSESVSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2077622628  85 ELLTYGDLEALRCCKAGVATHVPPSASPLSSKRYLILVYCVEFDRIHYPLPLPY 138
Cdd:cd22284    81 DLLTYQDLEELRNRKSGGSSRNSASSSDLNNKRYLILTYTVEFDRVHYPLPLPY 134
 
Name Accession Description Interval E-value
HD_CCDC61_N cd22284
N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; ...
 6-138 3.68e-66

N-terminal head domain found in coiled-coil domain-containing protein 61 and similar proteins; Coiled-coil domain-containing protein 61 (CCDC61), also known as variable flagellar number 3 (VFL3), is a centrosomal protein required for spindle assembly and precise chromosome alignments in mitosis. It is the human ortholog of proteins required for anchoring distinct sets of cytoskeletal fibers to centrioles in unicellular eukaryotes. CCDC61 monomers are comprised of an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal region. These monomers homodimerize through two homodimerization domains, the N-terminal globular head domains and long extended alpha-helical coiled-coil regions. These CCDC61 homodimers assembles into linear filaments. This model corresponds to the N-terminal head domain of CCDC61, which is structurally related to other XRCC4-superfamily members, XRCC4, XLF, SAS6, and PAXX.


Pssm-ID: 409001  Cd Length: 135  Bit Score: 207.46  E-value: 3.68e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077622628   6 CLQANCFFRGKEHSIQLSVSQA-VLEVEVQERCSTKRWRGRFDAASVEDLTRKTGNFKQFGIFCSMLEAALMKSSEAVSL 84
Cdd:cd22284     1 MISAELTFRGVEYLVTLKVDEGeSLSVEVEDKDTGERWRGSFTASYIEELTRKTGNFKKFSVFVKMLKSALLKTSESVSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2077622628  85 ELLTYGDLEALRCCKAGVATHVPPSASPLSSKRYLILVYCVEFDRIHYPLPLPY 138
Cdd:cd22284    81 DLLTYQDLEELRNRKSGGSSRNSASSSDLNNKRYLILTYTVEFDRVHYPLPLPY 134
HD_XRCC4-like_N cd22210
N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily ...
 42-138 1.80e-12

N-terminal head domain found in the XRCC4 superfamily of proteins; The XRCC4 superfamily includes five families: XRCC4, XLF, PAXX, SAS6 and CCDC61. XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor) and PAXX (paralog of XRCC4 and XLF) play crucial roles in the non-homologous end-joining (NHEJ) DNA repair pathway. SAS6 (spindle assembly abnormal protein 6) and CCDC61 (coiled-coil domain-containing protein 61) have a centrosomal/centriolar function. Members of this superfamily have an N-terminal globular head domain, a centrally located coiled-coil, and a C-terminal low-complexity region. They form homodimers through two homodimerization domains: an N-terminal globular head domain and a parallel coiled-coil domain. In addition, some members such as XRCC4 and XLF form symmetric heterodimers that interact through their globular head domains at the opposite end of the homodimer interface, and may form XLF-XRCC4 filaments. This model corresponds to the N-terminal head domain of XRCC4 superfamily proteins.


Pssm-ID: 408999  Cd Length: 115  Bit Score: 63.71  E-value: 1.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077622628  42 WRGRFDAASVEDLTRKTGNFKQFGIFCSMLEAALMKSSEA---VSLELLTYGDlealrcckagvathvppsasplssKRY 118
Cdd:cd22210    39 WTGEVSESDISQLKNDQGILVDFASFPGKLRSALEKCILAsdrFTFVLTIRGD------------------------EAY 94

                          90       100
                  ....*....|....*....|
gi 2077622628 119 LILVYCVEFDRIHYPLPLPY 138
Cdd:cd22210    95 LKLVEILDEQLPHITFALRK 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH