NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2076599778|gb|KAG8525184|]
View 

Olfactory receptor 4A15 [Galemys pyrenaicus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.28e-172

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 478.63  E-value: 1.28e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.28e-172

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 478.63  E-value: 1.28e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-301 4.43e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 146.49  E-value: 4.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 D---TYFVGIIVVadggaICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV----- 257
Cdd:pfam13853 161 DikvNNIYGLFVV-----TSTFGIDSLLIvlSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfg 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 258 RPVSTFpIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKLWC 301
Cdd:pfam13853 236 HNVPPL-LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 25-251 3.54e-06

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 47.85  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLlIVVTVFASSSLRSPMYFFLAYLSLMDAVYsTAVSPKMITDLLRDKKTISFPAC--MGQLFIE 102
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACkiVSGLYYI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGaeVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSvVQLLFVYNLpfcgPNVIDHFICDMYpl 182
Cdd:PHA03087  121 GFYNS--MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIET-TPILFVYTT----KKDHETLICCMF-- 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 183 lelACTDTYFVGIIVVADGGAICMVI-FTLLLISYGVILNSLKSHSQEGR-RKALSTCGSHITVVVLFFVP 251
Cdd:PHA03087  192 ---YNNKTMNWKLFINFEINIIGMLIpLTILLYCYSKILITLKGINKSKKnKKAIKLVLIIVILFVIFWLP 259
 
Name Accession Description Interval E-value
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 23-289 1.28e-172

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 478.63  E-value: 1.28e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15939     1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15939    81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15939   161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                         250       260
                  ....*....|....*....|....*..
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15939   241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 24-289 2.62e-143

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 404.28  E-value: 2.62e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15226     2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15226    82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15226   162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                         250       260
                  ....*....|....*....|....*.
gi 2076599778 264 PIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15226   242 PVDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-289 1.71e-123

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 354.10  E-value: 1.71e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd13954     3 LFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd13954    83 LGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd13954   163 LSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSY 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 P--IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd13954   243 SsdLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 25-289 3.12e-122

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 350.87  E-value: 3.12e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15936     3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15936    83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFP 264
Cdd:cd15936   163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFP 242

                         250       260
                  ....*....|....*....|....*
gi 2076599778 265 IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15936   243 MDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-296 5.75e-121

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 347.91  E-value: 5.75e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15225     3 LFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15225    83 LGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15225   163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 --PIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15225   243 spETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 24-289 2.35e-119

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 343.72  E-value: 2.35e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15230     2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15230    82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15230   162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 263 FP--IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15230   242 YSldQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 24-289 8.59e-115

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 332.10  E-value: 8.59e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15940     2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15940    82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15940   162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                         250       260
                  ....*....|....*....|....*.
gi 2076599778 264 PIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15940   242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 9-299 1.64e-108

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 317.00  E-value: 1.64e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778   9 EFILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK 88
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  89 TISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCG 168
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 169 PNVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVL 247
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 248 FFVPCIFMYVRPVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 10-293 2.10e-107

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 313.87  E-value: 2.10e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  10 FILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKT 89
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGP 169
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLF 248
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 249 FVPCIFMYVRPVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMK 293
Cdd:cd15408   241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 25-289 3.65e-107

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 312.88  E-value: 3.65e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15912     3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15912    83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVAdgGAICMVIFTLLL--ISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPV- 260
Cdd:cd15912   163 LSCSDTRLIELLDFI--LASVVLLGSLLLtiVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSq 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 2076599778 261 -STFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15912   241 sSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 25-289 9.32e-107

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 311.73  E-value: 9.32e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15911     3 LFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15911    83 LAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15911   163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PID--KSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15911   243 SRDlnKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 25-289 1.78e-106

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 310.93  E-value: 1.78e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLR-SPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15935     3 LFVLVLACYAAILLGNLLIVVTVHADPHLLqSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15935    83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15935   163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSS 242

                         250       260
                  ....*....|....*....|....*.
gi 2076599778 264 PIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15935   243 SVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 24-289 3.56e-106

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 310.27  E-value: 3.56e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15938     2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15938    82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILnsLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15938   162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL--VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                         250       260
                  ....*....|....*....|....*.
gi 2076599778 264 PIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15938   240 PVDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 25-296 1.83e-105

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 308.76  E-value: 1.83e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15229     3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15229    83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRP--VS 261
Cdd:cd15229   163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPnsAS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 262 TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15229   243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 24-298 5.70e-105

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 307.65  E-value: 5.70e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15417     2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15417    82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15417   162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 263 F--PIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15417   242 HsqDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 25-296 8.03e-105

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 307.27  E-value: 8.03e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15231     3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15231    83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15231   163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 PIDKS--ITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15231   243 SLDKDtlISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 22-296 2.23e-103

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 303.37  E-value: 2.23e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  22 QKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFI 101
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYP 181
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPV 260
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 261 STFPIDKS--ITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15235   241 SSYSADKDrvATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 25-289 4.34e-103

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 302.27  E-value: 4.34e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15237     3 LFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15237    83 LGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15237   163 LACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15237   243 SPdqDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 10-299 1.37e-101

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 299.57  E-value: 1.37e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  10 FILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKT 89
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGP 169
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLF 248
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTiLRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 249 FVPCIFMYVRPVSTFP--IDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15410   241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 25-298 1.79e-100

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 296.20  E-value: 1.79e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15416     3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15416    83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15416   163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 264 PID--KSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15416   243 SMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 25-289 1.55e-99

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 293.18  E-value: 1.55e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15937     3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15937    83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFP 264
Cdd:cd15937   163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFP 242

                         250       260
                  ....*....|....*....|....*
gi 2076599778 265 IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15937   243 MDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 25-289 1.95e-99

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 292.98  E-value: 1.95e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15918     3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15918    83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15918   163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PIDKSI--TVVFTVITPMLNPLIYTLRN 289
Cdd:cd15918   243 SASKDSvaAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 24-289 5.51e-99

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 291.82  E-value: 5.51e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15431     2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVyNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15431    82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQALL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRP--V 260
Cdd:cd15431   161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAvLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqsK 240

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 261 STFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15431   241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 24-298 6.33e-99

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 292.30  E-value: 6.33e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15411     2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15411    82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15411   162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 263 FPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15411   242 YSLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 25-289 7.72e-99

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 291.52  E-value: 7.72e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15915     3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15915    83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSL--KSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS- 261
Cdd:cd15915   163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSg 242

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 262 -TFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15915   243 dSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 25-296 9.64e-99

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 291.76  E-value: 9.64e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15421     3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15421    83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS-- 261
Cdd:cd15421   163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSyh 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 262 TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15421   243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 25-298 1.26e-98

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 291.62  E-value: 1.26e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15409     3 LFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15409    83 SATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15409   163 ISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLY 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 264 PIDKSI--TVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15409   243 ALDQDMmdSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 25-296 1.89e-98

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 290.89  E-value: 1.89e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLL-RDKKTISFPACMGQLFIEH 103
Cdd:cd15916     3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15916    83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15916   163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15916   243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 26-289 4.19e-98

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 289.74  E-value: 4.19e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15227     4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLEL 185
Cdd:cd15227    84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 186 ACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFP 264
Cdd:cd15227   164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                         250       260
                  ....*....|....*....|....*..
gi 2076599778 265 --IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15227   244 slLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 25-296 5.00e-98

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 290.07  E-value: 5.00e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15429   243 SAlqEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 25-298 1.22e-97

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 288.84  E-value: 1.22e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15413     3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15413    83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGaiCMVIFTLL--LISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15413   163 LSCSDTHEKELIILIFAG--FNLISSLLivLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2076599778 262 T--FPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15413   241 ShsLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 10-298 1.50e-96

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 286.64  E-value: 1.50e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  10 FILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKT 89
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGP 169
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLF 248
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 249 FVPCIFMYVRPVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 25-289 1.66e-95

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 282.99  E-value: 1.66e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15232     3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15232    83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15232   163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15232   243 SPekDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 25-296 3.68e-95

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 282.68  E-value: 3.68e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15420     3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15420    83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15420   163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 P--IDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15420   243 SaeQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 23-289 1.93e-93

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 277.97  E-value: 1.93e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15947     1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15947    81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15947   161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 2076599778 262 TFPID--KSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15947   241 SYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 25-298 3.25e-93

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 277.65  E-value: 3.25e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15419     3 LFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15419    83 FGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRP--VS 261
Cdd:cd15419   163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgaVS 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 262 TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15419   243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 24-296 1.31e-92

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 275.85  E-value: 1.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15228     2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15228    82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15228   162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15228   242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 25-298 1.62e-92

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 275.82  E-value: 1.62e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15412     3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15412    83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS-- 261
Cdd:cd15412   163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSee 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 262 TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15412   243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 14-299 3.58e-92

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 275.40  E-value: 3.58e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  14 GLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFP 93
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  94 ACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVID 173
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 174 HFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPC 252
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 253 IFMYVRPVSTFPID--KSITVVFTVITPMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15406   241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 25-296 4.05e-91

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 272.38  E-value: 4.05e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15942     3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15942    83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15942   163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2076599778 264 PIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15942   243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 25-304 2.83e-90

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 270.45  E-value: 2.83e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15414     3 LFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15414    83 FVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15414   163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSS 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2076599778 264 P--IDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKLWCKKK 304
Cdd:cd15414   243 SldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 25-298 2.78e-89

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 267.74  E-value: 2.78e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15415     3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15415    83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15415   163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 264 PID--KSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15415   243 SLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 24-289 3.13e-88

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 264.53  E-value: 3.13e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15224     2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15224    82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRP--V 260
Cdd:cd15224   162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPkaI 241

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 261 STFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15224   242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 25-298 4.79e-88

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 264.67  E-value: 4.79e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15407     3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15407    83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVAdgGAICMVIFTLL--LISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15407   163 LSCSDIHISEIVLFF--LASFNVFFALLviLISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2076599778 262 TFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15407   241 SHSMdtDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 25-296 1.78e-87

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 263.13  E-value: 1.78e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15424     3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15424    83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15424   163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 P--IDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15424   243 TpdRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 10-299 1.97e-87

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 263.57  E-value: 1.97e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  10 FILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKT 89
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGP 169
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLF 248
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 249 FVPCIFMYVRPVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 25-289 1.10e-86

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 260.77  E-value: 1.10e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15914     3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15914    83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISY-GVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15914   163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYvKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15914   243 SLdyDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 24-296 8.34e-86

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 258.95  E-value: 8.34e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15428     2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd15428    82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS- 261
Cdd:cd15428   162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTvFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSs 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2076599778 262 -TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15428   242 tSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 23-296 1.08e-84

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 255.77  E-value: 1.08e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15434     1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15434    81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRP-- 259
Cdd:cd15434   161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPkn 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 260 VSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15434   241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 23-289 2.64e-83

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 252.29  E-value: 2.64e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15430     1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15430    81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15430   161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 2076599778 262 --TFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15430   241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 23-296 1.85e-81

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 247.78  E-value: 1.85e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 262 TFPIDKS--ITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15432   241 NSSHDRGkmVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 25-296 4.86e-81

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 246.68  E-value: 4.86e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRS-PMYFFLAYLSLMDAVYSTAVSPKMITDLLR-DKKTISFPACMGQLFIE 102
Cdd:cd15941     3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15941    83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15941   163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 262 TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15941   243 SQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 25-296 3.32e-80

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 244.63  E-value: 3.32e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15405     3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15405    83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVIL-NSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15405   163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILsNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 PID--KSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15405   243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 25-289 7.66e-80

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 243.38  E-value: 7.66e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15913     3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15913    83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYG-VILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15913   163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTlVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 P--IDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15913   243 StgMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 25-296 5.38e-79

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 241.33  E-value: 5.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15234     3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15234    83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDT-------YFVGIIVvaDGGAICMVIFtllliSYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMY 256
Cdd:cd15234   163 LACSDTlinniliYLATVIF--GGIPLSGIIF-----SYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVY 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 257 VRPVSTFPIDKSI--TVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15234   236 ISSAVTHSSRKTAvaSVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 22-299 1.04e-77

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 238.14  E-value: 1.04e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  22 QKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFI 101
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYP 181
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPV 260
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2076599778 261 S--TFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15418   241 SshTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 25-296 2.49e-77

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 237.00  E-value: 2.49e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15233     3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15233    83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYG-VILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15233   163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15233   243 SSdkDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 25-289 1.21e-74

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 230.06  E-value: 1.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15946     3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15946    83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15946   163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                         250       260
                  ....*....|....*....|....*...
gi 2076599778 264 PI--DKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd15946   243 SPerDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 26-296 4.08e-72

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 223.88  E-value: 4.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15236     4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLEL 185
Cdd:cd15236    84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 186 ACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFP 264
Cdd:cd15236   164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2076599778 265 IDKSI--TVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15236   244 SDKDIvaSVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 23-296 1.56e-70

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 219.66  E-value: 1.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15433     1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPL 182
Cdd:cd15433    81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15433   161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 262 TFPID--KSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15433   241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 25-296 8.29e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 202.52  E-value: 8.29e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15223     3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15223    83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDT---YFVGIIVvadggAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV- 257
Cdd:cd15223   163 LACGDTtinSIYGLAV-----AWLIVGSDIILIffSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLt 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2076599778 258 ----RPVSTFpIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15223   238 yrfgKTIPPD-VHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 29-288 1.76e-57

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 186.08  E-value: 1.76e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15950     7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15950    87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DTYFVGIIVVAdgGAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIF-MYV-RPVSTF 263
Cdd:cd15950   167 DPRPSSLYSIT--GSTLVVGTDSAFIavSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTqRFGQGV 244

                         250       260
                  ....*....|....*....|....*..
gi 2076599778 264 PIDKSITV--VFTVITPMLNPLIYTLR 288
Cdd:cd15950   245 PPHTQVLLadLYLLVPPMLNPIIYGMR 271
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 29-292 4.72e-57

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 185.28  E-value: 4.72e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15952     7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15952    87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DtyfVGIIVVADGGAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPI 265
Cdd:cd15952   167 S---IRINIIYGLFAISVLVLDVILIalSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNI 243

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2076599778 266 DKSITVV----FTVITPMLNPLIYTLRNSEM 292
Cdd:cd15952   244 PRYIHILlanlYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 29-292 7.54e-57

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 184.41  E-value: 7.54e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15917     7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15917    87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DTYFVGIIVVAdgGAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPI 265
Cdd:cd15917   167 DTRVNSIYGLF--VALLIVGFDLLFIalSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2076599778 266 DKSITVVFT----VITPMLNPLIYTLRNSEM 292
Cdd:cd15917   245 PPHVHILLAnlylLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 29-291 1.10e-52

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 174.02  E-value: 1.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15221    87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DT---YFVGIIVvadggAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15221   167 DItvnIWYGLTV-----ALLTVGLDVVLIavSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFG 241

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2076599778 263 FPIDKSITV----VFTVITPMLNPLIYTLRNSE 291
Cdd:cd15221   242 RHIPRHVHIllanLYVLVPPMLNPIVYGVKTKQ 274
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 25-291 2.07e-48

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 162.67  E-value: 2.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15222     3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLE 184
Cdd:cd15222    83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYF---VGIIVVAdggAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVrpV 260
Cdd:cd15222   163 LACSDTRVnsiYGLFVVL---STMGLDSLLILLSYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPMIGLSM--V 237

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 261 STFPIDKSITV------VFTVITPMLNPLIYTLRNSE 291
Cdd:cd15222   238 HRFGKHASPLVhvlmanVYLLVPPVLNPIIYSVKTKQ 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 29-291 4.43e-47

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 159.35  E-value: 4.43e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIM-NQRVCIVLLVVAWVGGFLHSVVQLLfVYNLPFCGPNVIDHFICDMYPLLELAC 187
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILtNSRIAKLGLVGLIRGVLLILPLPLL-LSRLPFCANRIIPHTYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 188 TDTYFVGI--IVVadggAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVrpvsT 262
Cdd:cd15953   166 GDTTINRIygLVV----ALLVVGLDLLLIalSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL----T 237

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 263 FPIDKSITV--------VFTVITPMLNPLIYTLRNSE 291
Cdd:cd15953   238 HRFGQGIAPhihiilanLYLLVPPMLNPIIYGVKTKE 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-289 1.69e-46

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 157.89  E-value: 1.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15951     7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIM-NQRVCIVLLVVAWVGGFLHSVVQLLfVYNLPFCGPNVIDHFICDMYPLLELAC 187
Cdd:cd15951    87 ESGIFVAMALDRYVAICNPLRHSTILtNSVVAKIGLAVVLRGGILVSPHPFL-LRRLPYCRTNIIPHTYCEHMAVVKLAC 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 188 TDTY---FVGIIVvadggAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV--RP 259
Cdd:cd15951   166 ADTRvsrAYGLSV-----AFLVGGLDVIFIavSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRF 240

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2076599778 260 VSTFPIDKSITV--VFTVITPMLNPLIYTLRN 289
Cdd:cd15951   241 GHNVPPHVHILIanVYLLVPPMLNPIIYGVRT 272
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 29-301 4.43e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 146.49  E-value: 4.43e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 D---TYFVGIIVVadggaICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV----- 257
Cdd:pfam13853 161 DikvNNIYGLFVV-----TSTFGIDSLLIvlSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhrfg 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 258 RPVSTFpIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKLWC 301
Cdd:pfam13853 236 HNVPPL-LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 29-293 9.10e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 143.12  E-value: 9.10e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15948     8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15948    88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DTYF---VGIIVvadggAICMVIFTLLLI--SYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV----- 257
Cdd:cd15948   168 DTRFnniYGIAV-----ALFIVGLDLMFIilSYVFILRAvLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhrfa 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2076599778 258 RPVSTFpIDKSITVVFTVITPMLNPLIYTLRNSEMK 293
Cdd:cd15948   243 RHVAPH-VHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 8-293 3.90e-40

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 141.84  E-value: 3.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778   8 TEFILLGLTQDPGGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDK 87
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  88 KTISFPACMGQLFIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFC 167
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 168 GPNVIDHFICDMYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKS-HSQEGRRKALSTCGSHITVVV 246
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRlATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 247 LFFVPC-----IFMYVRPVSTfPIDKSITVVFTVITPMLNPLIYTLRNSEMK 293
Cdd:cd15949   242 AFYVPIavsslIHRFGQNVPP-PTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 25-292 1.64e-38

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 137.30  E-value: 1.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15956     3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVC------IVLLVVAWVGGFlhsvvqLLFVYNLPFCGPNVIDHFICD 178
Cdd:cd15956    83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVakagllLALRGVAIVIPF------PLLVCRLSFCASHTIAHTYCE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 179 MYPLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV 257
Cdd:cd15956   157 HMAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVL 236

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2076599778 258 ----RPVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEM 292
Cdd:cd15956   237 mhrfGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 29-292 4.71e-36

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 130.71  E-value: 4.71e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15954     7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACT 188
Cdd:cd15954    87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKS-HSQEGRRKALSTCGSHITVVVLFFVPCIFMYV--RPVS---T 262
Cdd:cd15954   167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSlSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahRFGGhhiT 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 2076599778 263 FPIDKSITVVFTVITPMLNPLIYTLRNSEM 292
Cdd:cd15954   247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 39-285 4.34e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.41  E-value: 4.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  39 GNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLL-RDKKTISFPACMGQLFIEHFFGGAEVFLLVMMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 118 YDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNvidHFICDMYPLLELACTDTYFVGIIV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 198 VadgGAICMVIftLLLISYGVILNSLKSHSQEG--------RRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPIDKS- 268
Cdd:pfam00001 158 L---GFLLPLL--VILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSr 232

                         250       260
                  ....*....|....*....|....
gi 2076599778 269 -------ITVVFTVITPMLNPLIY 285
Cdd:pfam00001 233 lldkalsVTLWLAYVNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 29-292 2.95e-31

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 117.95  E-value: 2.95e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15955     7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCI-VLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELAC 187
Cdd:cd15955    87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLgIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 188 TDTYFVGIIVVADGGAICMVIFTLLLISYGVILNS-LKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPID 266
Cdd:cd15955   167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAvFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVA 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 2076599778 267 KSITV----VFTVITPMLNPLIYTLRNSEM 292
Cdd:cd15955   247 PYVHIllsnLYLLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 25-289 1.04e-26

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 105.83  E-value: 1.04e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLe 184
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 lactdTYFVGIIVVadggaICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSH------------ITVVVLFFV-- 250
Cdd:cd00637   160 -----AYTIFLFVL-----LFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcw 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 251 -PCIFMYV------RPVSTFPIDKSITVVFTVITPMLNPLIYTLRN 289
Cdd:cd00637   230 lPYFILLLldvfgpDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 25-296 1.59e-21

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 91.47  E-value: 1.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd14967     2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFlhsVVQLLFVYNLPFCGPNVIDHFICDMYPlle 184
Cdd:cd14967    82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSL---LISLPPLVGWRDETQPSVVDCECEFTP--- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 lactDTYFVGIIVVadggAICMVIFTLLLISYGVILNSLKSHsqegrRKALSTcgshITVVVLFFVPC-----IFMYVRP 259
Cdd:cd14967   156 ----NKIYVLVSSV----ISFFIPLLIMIVLYARIFRVARRE-----LKAAKT----LAIIVGAFLLCwlpffIIYLVSA 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2076599778 260 VSTFPIDKSITVVFTVITP----MLNPLIYTLRNSEMKNAM 296
Cdd:cd14967   219 FCPPDCVPPILYAVFFWLGylnsALNPIIYALFNRDFRRAF 259
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 31-295 2.82e-13

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 68.42  E-value: 2.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD---AVYStaVSPKMITDLlrdkkTISFPA----CMGQLFIEH 103
Cdd:cd15196     9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADllvALFN--VLPQLIWDI-----TYRFYGgdllCRLVKYLQV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVcIVLLVVAWVGGFLHSVVQlLFVYNLPFCGPNVIDhfiC--DMYP 181
Cdd:cd15196    82 VGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRV-HLMVAIAWVLSLLLSIPQ-LFIFSYQEVGSGVYD---CwaTFEP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLELACTDTYFVGIIVVAdggAICMVIFTLLLISYGVilnslkshsqegRRKALSTCGSHITVVVLFFV---PciFMYVR 258
Cdd:cd15196   157 PWGLRAYITWFTVAVFVV---PLIILAFCYGRICYVV------------WRAKIKTVKLTLVVVACYIVcwtP--FFVVQ 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 259 PVSTFPIDKSITVVFTVITPML-------NPLIYTLRNSEMKNA 295
Cdd:cd15196   220 MWAAWDPTAPIEGPAFVIIMLLaslnsctNPWIYLAFSGNLRRA 263
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 27-280 1.25e-12

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 66.89  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVtVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQL-----FI 101
Cdd:cd14978     5 YVLPVICIFGIIGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYP 181
Cdd:cd14978    84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLElacTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSH-------------ITVVVLF 248
Cdd:cd14978   164 LRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLSrsqrrerrttimlIAVVIVF 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2076599778 249 FV----PCIFMYVRPVSTFPIDKSITVVFTVITPML 280
Cdd:cd14978   241 LIcnlpAGILNILEAIFGESFLSPIYQLLGDISNLL 276
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 27-296 1.57e-12

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 66.46  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYlTIMNQRVCIVLLVVAWVGGFLHSVVQLL----FVYNLPF--CGPNVIDHFICDMy 180
Cdd:cd14969    85 LVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFgwssYVPEGGGtsCSVDWYSKDPNSL- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 181 pllelactdTYFVGIIVVadggaiCMVI-FTLLLISYGVILNSLKSHSQEGRRKALSTCGS-----------HITVVVLF 248
Cdd:cd14969   163 ---------SYIVSLFVF------CFFLpLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKrtkkaekkvakMVLVMIVA 227

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 249 FVPCIFMY--VRPVSTFPIDKSITVVFTVITPML-------NPLIYTLRNSEMKNAM 296
Cdd:cd14969   228 FLIAWTPYavVSLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 27-296 2.60e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 65.78  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFpacmGQLFIEHFF- 105
Cdd:cd14972     3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPA----TWLLRKGSLv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 --GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLhsvvqllfVYNLPFCGPNVIDHFICDMYPLL 183
Cdd:cd14972    79 lsLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL--------LALLPVLGWNCVLCDQESCSPLG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELAcTDTYFVGIIVVAdggAICMVIFTLLlisYGVILNSLKSHSQEGRRKALSTCGSH--------ITVVVLF--FVPC- 252
Cdd:cd14972   151 PGL-PKSYLVLILVFF---FIALVIIVFL---YVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKTVVIVLgvFLVCw 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 253 --IFMYVRPVSTFPIDKSI------TVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd14972   224 lpLLILLVLDVLCPSVCDIqavfyyFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 26-295 1.73e-11

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 63.43  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRdkKTISFPACmgqLFIEHF- 104
Cdd:cd14968     4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLG--LPTNFHGC---LFMACLv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 --FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFI-Cdmyp 181
Cdd:cd14968    79 lvLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGIqC---- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLELACTDTYFVGIIVVAdggaiCMVIFTLLLIS-----YGVILNSLK--------SHSQEGRRKALSTCGSHITVVVLF 248
Cdd:cd14968   155 LFEEVIPMDYMVYFNFFA-----CVLVPLLIMLViylriFRVIRKQLRqiesllrsRRSRSTLQKEVKAAKSLAIILFLF 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2076599778 249 FVP--------CIFMYVRPVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd14968   230 ALCwlplhiinCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 27-250 1.67e-10

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 60.77  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDL-LRDKKTISFPACMGQLFIEHFF 105
Cdd:cd14997     5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMCKLVPFVELTV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFV--YNLPFCGPNVIDhfICDMYPLL 183
Cdd:cd14997    85 AHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITefKEEDFNDGTPVA--VCRTPADT 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 184 ELACtdTYFVGIIVVadggaICMVIFTLLLISYGVILNSLKSH----SQEGRRKALSTCGSH-------ITVVVLFFV 250
Cdd:cd14997   163 FWKV--AYILSTIVV-----FFVVPLAILSGLYSVICRRLVGHpaleSRRADAANRHTLRSRrqvvymlITVVVLFFV 233
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 24-296 2.71e-10

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 59.97  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd14982     2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVvqLLFVYNLPFCGPNVIDHfiCDMYPLL 183
Cdd:cd14982    82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV--PLLLLRSTIAKENNSTT--CFEFLSE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVadggaICMVIFTLLLISYGVILNSL---KSHSQEG--RRKALSTCGSHITVVVLFFVP---CIFM 255
Cdd:cd14982   158 WLASAAPIVLIALVV-----GFLIPLLIILVCYSLIIRALrrrSKQSQKSvrKRKALRMILIVLAVFLVCFLPyhvTRIL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 256 YVRPVSTFPIDKS----------ITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd14982   233 YLLVRLSFIADCSarnslykayrITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 23-155 3.97e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 59.65  E-value: 3.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15083     1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd15083    81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVL 133
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 24-295 1.32e-09

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 57.82  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFL-LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15050     1 APLGIALsTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHsVVQLLFVYNLPFCGPNVIDHFICDmypl 182
Cdd:cd15050    81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFARGGERVVLEDKCE---- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 lelacTDTYFVGIIVVADGGAICMVIFTLLLISYGVILnslksHSQEGRRKALSTCGSHITVVVLFFVP--CIFMYVR-- 258
Cdd:cd15050   156 -----TDFHDVTWFKVLTAILNFYIPSLLMLWFYAKIF-----KAVNRERKAAKQLGFIMAAFILCWIPyfILFMVIAfc 225

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2076599778 259 PVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15050   226 KNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 26-152 1.53e-09

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 57.51  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15063     4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15063    84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 25-296 2.48e-09

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 57.07  E-value: 2.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD-AVYSTAVSPKMITDLLRDKKTISFpACMGQLFIEH 103
Cdd:cd15012     2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADlCVGIFCVLQNLSIYLIPSWPFGEV-LCRMYQFVHS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDhfiCDMYPLL 183
Cdd:cd15012    81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQ---EEEICVL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILnsLKSHSQEGRRKALSTCgshITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15012   158 DREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVL--WKSSSIEARRKVVRLL---VAVVVSFALCNLPYHARKMWQY 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 264 ------------PIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15012   233 wsepyrcdsnwnALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
 27-295 2.97e-09

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 56.67  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15060     5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPfcgpnviDHFICDMypllelA 186
Cdd:cd15060    85 TASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWP-------ENFTETT------P 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 187 CTDTYFVGIIVVADGGAicmvIFTLLLISYGVILNSLKSHSQEgrRKALSTCGSHITVVVLFFVPCIFMYV-RP-VSTFP 264
Cdd:cd15060   152 CTLTEEKGYVIYSSSGS----FFIPLLIMTIVYVKIFIATSKE--RRAARTLGIIMGVFVVCWLPFFLMYViLPfCETCS 225

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2076599778 265 IDKSITVVFT---VITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15060   226 PSAKVVNFITwlgYVNSALNPVIYTIFNLDFRRA 259
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 31-156 6.20e-09

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 56.21  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15065     8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVV 156
Cdd:cd15065    88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFL 133
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 31-148 9.14e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 55.54  E-value: 9.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15058     9 LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASI 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15058    89 ETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWI 126
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 30-148 1.02e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 55.49  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  30 LLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAE 109
Cdd:cd15336     8 LIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITS 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2076599778 110 VFLLVMMAYDRYVAICKPLHYLTIMN-QRVCIVLLVVaWV 148
Cdd:cd15336    88 MITLLAISLDRYLVITKPLASIRWVSkKRAMIIILLV-WL 126
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 24-154 1.02e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 55.44  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITdllrdkktiSFPAC--MGQLF 100
Cdd:cd15312     2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPySMVR---------SVESCwyFGDLF 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 101 ------IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHS 154
Cdd:cd15312    73 ckihssLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 24-295 1.35e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 54.64  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFL-LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15064     1 VLISVLLsLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFvynlpFCGPNVIDhficdmypl 182
Cdd:cd15064    81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG-----WRTPDSED--------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 lELACTDTYFVGIIVVADGGAIcMVIFTLLLISYGVIlnsLKSHSQEgrRKALSTCGSHITVVVL----FFVPCIFMYVR 258
Cdd:cd15064   147 -PSECLISQDIGYTIFSTFGAF-YIPLLLMLILYWKI---YRAAARE--RKAAKTLGIILGAFIVcwlpFFLVALIVPLC 219

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 259 PVSTFP-IDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15064   220 SHCWIPlALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 28-295 1.50e-08

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 54.53  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYV-VTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15327     5 VFLAIFIlMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPfcgpnvidhficdmyPLLELA 186
Cdd:cd15327    85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPP---------------PPDESI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 187 CTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKsHSQEgrRKALSTCGSHITVVVLFFVPciFMYVRPV-STFPI 265
Cdd:cd15327   150 CSITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALK-FSRE--KKAAKTLAIVVGVFILCWFP--FFFVLPLgSFFPA 224

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2076599778 266 DKSITVVFTVI------TPMLNPLIYTLRNSEMKNA 295
Cdd:cd15327   225 LKPSEMVFKVIfwlgyfNSCVNPIIYPCSSKEFKRA 260
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 25-295 1.62e-08

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 54.29  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15061     2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFlhsvvqllFVYNLPFCGPNviDHFicdmyPLLE 184
Cdd:cd15061    82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVGPS--WHG-----RRGL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVAdggAICMVIFTLLLISYGVILNSLKSHSQegrRKALSTcgshITVVVLFFVPC-----IFMYVRP 259
Cdd:cd15061   147 GSCYYTYDKGYRIYS---SMGSFFLPLLLMLFVYLRIFRVIAKE---RKTAKT----LAIVVGCFIVCwlpffIMYLIEP 216

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2076599778 260 VSTFPIDKSITVVFT---VITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15061   217 FCDCQFSEALSTAFTwlgYFNSVINPFIYAFYNKDFRRA 255
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 27-148 1.72e-08

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 54.40  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRD----KKTISFPA----CMGQ 98
Cdd:cd15350     5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADmgylNRRGPFETklddIMDS 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2076599778  99 LFIEHFFGgaEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15350    85 LFCLSLLG--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWT 132
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 24-178 3.73e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 53.76  E-value: 3.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKktiSFPACMGQL--F 100
Cdd:cd14993     2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPW---VFGEVLCKAvpY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 101 IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF--VYNLPFCGPNVIDHFICD 178
Cdd:cd14993    79 LQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVyeLEEIISSEPGTITIYICT 158
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 25-148 3.91e-08

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 53.61  E-value: 3.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITdllrdkkTISFPACMGQLF--- 100
Cdd:cd15317     3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfSMIR-------TVETCWYFGDLFckf 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 101 ---IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15317    76 htgLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 31-173 4.26e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 53.67  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYST-AVSPKMITDLlrdkkTISFPA----CMGQLFIEHFF 105
Cdd:cd15387     9 LILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGpdflCRLVKYLQVVG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLtimNQRVCIVLLVVAWVGGFLHSVVQlLFVYNLPFCGPNVID 173
Cdd:cd15387    84 MFASTYMLLLMSIDRCLAICQPLRSL---HRRSDRVYVLFSWLLSLVFSIPQ-VHIFSLREVGNGVYD 147
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 28-160 5.47e-08

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 52.88  E-value: 5.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQlFIEHFFGG 107
Cdd:cd15103     6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQ-HIDNVIDS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 108 -------AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15103    85 micssllASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIY 144
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 25-295 7.94e-08

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 52.59  E-value: 7.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15325     3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQlLFVYNLPfcgpnvidhficdmYPLLE 184
Cdd:cd15325    83 CCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGP-LFGWKEP--------------APEDE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKsHSQEgrRKALSTCGSHITVVVLFFVPciFMYVRPV-STF 263
Cdd:cd15325   148 TICQITEEPGYALFSALGSFYLPLAIILVMYCRVYVVALK-FSRE--KKAAKTLGIVVGCFVLCWLP--FFLVMPIgSIF 222

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 264 PIDKSITVVFTV------ITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15325   223 PAYKPSDTVFKItfwlgyFNSCINPIIYPCSSQEFKKA 260
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 31-147 1.03e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 52.46  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTI-SFPACMGQLFIEHFFGGAE 109
Cdd:cd15005     9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHS 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2076599778 110 VFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15005    89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 31-164 1.33e-07

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 52.13  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD-AVYSTAVSPKMITDLLRDKKTISFpACMGQLFIEHFFGGAE 109
Cdd:cd15385     9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADlVVAFFQVLPQLCWDITYRFYGPDF-LCRIVKHLQVLGMFAS 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2076599778 110 VFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLvVAWVGGFLHSVVQlLFVYNL 164
Cdd:cd15385    88 TYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIG-SAWALSFILSTPQ-YFIFSL 140
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 25-155 2.18e-07

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 51.19  E-value: 2.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIyvvtmVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15059     8 SVVILLII-----VGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd15059    83 FCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 27-152 2.61e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 51.22  E-value: 2.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLR-SPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15104     4 VILAVLSPLIITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITS 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15104    84 CAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGL 130
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 32-164 4.10e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.57  E-value: 4.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  32 IYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD-AVYSTAVSPKMITDLlrdkkTISFPA----CMGQLFIEHFFG 106
Cdd:cd15386    10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDlVVALFQVLPQLIWEI-----TYRFQGpdllCRAVKYLQVLSM 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIvLLVVAWVGGFLHSVVQlLFVYNL 164
Cdd:cd15386    85 FASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYL-MIGATWLLSCILSLPQ-VFIFSL 140
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
 26-160 4.52e-07

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 50.37  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15390     4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLhyLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15390    84 VAASVFTLMAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIWLASFLLALPQLLY 136
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 25-287 4.89e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 50.25  E-value: 4.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLayLSLmdavystAVSpkmitDLL--------RDKKTISFPACM 96
Cdd:cd15055     3 LYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLL--LSL-------AVA-----DFLvgllvmpfSMIRSIETCWYF 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  97 GQLF------IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFvyNLPFCGPN 170
Cdd:cd15055    69 GDTFcklhssLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYD--NLNQPGLI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 171 VIDHFICD-----MYPLLELACTDTYFVGIIVVAdggAICMVIFTLL---------LISYGVILNSLKSHSQEGRRKALS 236
Cdd:cd15055   147 RYNSCYGEcvvvvNFIWGVVDLVLTFILPCTVMI---VLYMRIFVVArsqarairsHTAQVSLEGSSKKVSKKSERKAAK 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 237 TCGSHITVVVLFFVP--CIFMYVRPVSTFPIDKSITVVFTVITPMLNPLIYTL 287
Cdd:cd15055   224 TLGIVVGVFLLCWLPyyIVSLVDPYISTPSSVFDVLIWLGYFNSCLNPLIYAL 276
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
 31-160 5.13e-07

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 49.97  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd17790     9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASV 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd17790    89 MNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILF 138
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 34-162 7.68e-07

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 49.47  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15318    12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 114 VMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVggfLHSVVQLLFVY 162
Cdd:cd15318    92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWL---VPTVYTSVFLY 137
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
 24-295 1.13e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 49.16  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYvvTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15323     4 AAVVGFLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPfcgpnvidhfICDMYPLL 183
Cdd:cd15323    82 LFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP----------EGDVYPQC 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELAcTDTYFVGIIVVADGGAICMVIFTLLLISYGVilnslkshsQEGRRKALSTCgshITVVVLFFVPCIFMYVRPVSTF 263
Cdd:cd15323   152 KLN-DETWYILSSCIGSFFAPCLIMILVYIRIYRV---------AKAREKRFTFV---LAVVMGVFVVCWFPFFFSYSLY 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 264 PIDKSITVVFTVI----------TPMLNPLIYTLRNSEMKNA 295
Cdd:cd15323   219 GICREACEVPEPLfkfffwigycNSSLNPVIYTIFNQDFRRS 260
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
 23-296 1.17e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 49.01  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMitdLLRDKKTISFPACM-----G 97
Cdd:cd15102     1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANI---LLSGARTLRLSPAQwflreG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  98 QLFIEHffgGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVcIVLLVVAWVGGflhsvvqlLFVYNLPFCGPNVIDHF-- 175
Cdd:cd15102    78 SMFVAL---SASVFSLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWLIS--------LLLGGLPILGWNCLGALda 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 176 ---ICDMYPLLELACTDTYFVGIIVvadggAICMV---IFTLllisygVILNSLKSHSQEGRRKALSTCGShITVVVLFF 249
Cdd:cd15102   146 cstVLPLYSKHYVLFCVTIFAGILA-----AIVALyarIYCL------VRASGRKATRASASPRSLALLKT-VLIVLLVF 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 250 VPC--------IFMYVRPVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15102   214 IACwgplfillLLDVACPVKTCPIlyKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 31-159 1.25e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 48.91  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAvspKMITDLLRDKkTISFPA----CMGQLFIEHFFG 106
Cdd:cd14986     9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFF---TVLTQIIWEA-TGEWVAgdvlCRIVKYLQVVGL 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTimNQRVCIVLLVVAWVGGFLHSVVQLL 159
Cdd:cd14986    85 FASTYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLV 135
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 27-285 1.29e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 48.83  E-value: 1.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYsTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd14970     5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNV--IDHFICDMYPLLE 184
Cdd:cd14970    84 FTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTIscNLQWPDPPDYWGR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 LACTDTYFVGIIVVadggaicmviFTLLLISYGVILNSLKSHSQEGRRKALSTCGSH------ITVVVLFFVPC-----I 253
Cdd:cd14970   164 VFTIYTFVLGFAVP----------LLVITVCYSLIIRRLRSSRNLSTSGAREKRRARrkvtrlVLVVVAVFVVCwlpfhV 233

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2076599778 254 FMYVRPVSTFPIDKSITVVFTVITPM------LNPLIY 285
Cdd:cd14970   234 FQIVRLLIDPPETLTVVGVFLFCIALsyanscLNPILY 271
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 27-295 1.31e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 48.88  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTiSFPACMGQLFI--EHF 104
Cdd:cd15053     5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKW-YLGPILCDIYIamDVM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVidhfiCDMYplle 184
Cdd:cd15053    84 CSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEE-----CRFY---- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 185 lactDTYFVGIIVVadggaICMVI-FTLLLISYGVILNSLKShsqegRRKALSTCGSHITVVVLFFVP----------CI 253
Cdd:cd15053   155 ----NPDFIIYSSI-----SSFYIpCIVMLLLYYRIFRALRR-----EKKATKTLAIVLGVFLFCWLPfftlnilnaiCP 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 254 FMYVRPVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15053   221 KLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 29-155 1.35e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 48.89  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK-TISFPACMGQLFIEHFFGG 107
Cdd:cd14979     7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACTY 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 108 AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd14979    87 ATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 32-295 1.39e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 48.64  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  32 IYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVF 111
Cdd:cd15062    10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 112 LLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYnlpfcgpnvidhficDMYPLLELACTDTY 191
Cdd:cd15062    90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWK---------------EPAPADEQACGVNE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 192 FVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQegrRKALSTCGSHITVVVLFFVPciFMYVRPV-STFPIDKSIT 270
Cdd:cd15062   155 EPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSRE---KKAAKTLGIVVGAFVLCWFP--FFVVLPLgSLFSTLKPPE 229

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2076599778 271 VVFTVI------TPMLNPLIYTLRNSEMKNA 295
Cdd:cd15062   230 PVFKVVfwlgyfNSCLNPIIYPCSSREFKRA 260
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
 23-160 1.61e-06

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 48.79  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFL--LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLF 100
Cdd:cd15299     2 QVVLIAFLtgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 101 IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15299    82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILF 141
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
 24-148 1.73e-06

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 48.37  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15401     2 VLAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15401    82 LSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWV 126
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
 24-148 1.81e-06

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 48.62  E-value: 1.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15209     2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15209    82 LSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 27-164 1.85e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 48.62  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd14971     5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSvVQLLFVYNL 164
Cdd:cd14971    85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA-APVLALHRL 141
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
 24-152 2.14e-06

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 48.45  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15048     2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15048    82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFL 130
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
 24-160 2.42e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 48.19  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd14977     2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd14977    82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVL 138
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 34-295 2.45e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 47.96  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15326    12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 114 VMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLlfvynLPFCGPNVIDHFICDMypllelacTDTYFV 193
Cdd:cd15326    92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPL-----LGWKEPAPPDDKVCEI--------TEEPFY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 194 GIIvvADGGAICMVIFTLLLISYGVILNSLKsHSQEgrRKALSTCGSHITVVVLFFVPciFMYVRPVSTF-----PIDKS 268
Cdd:cd15326   159 ALF--SSLGSFYIPLIVILVMYCRVYIVALK-FSRE--KKAAKTLGIVVGMFILCWLP--FFIALPLGSLfshlkPPETL 231

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 269 ITVVFTV--ITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15326   232 FKIIFWLgyFNSCLNPIIYPCSSKEFKRA 260
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 26-155 2.69e-06

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 47.66  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15001     3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTI-MNQRVCIVLLVVaWVGGFLHSV 155
Cdd:cd15001    83 FICSVLTLTAISIERYYVILHPMKAKSFcTIGRARKVALLI-WILSAILAS 132
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
 29-156 3.44e-06

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 47.37  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15066     6 MTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVV 156
Cdd:cd15066    86 SILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFL 133
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
 25-251 3.54e-06

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 47.85  E-value: 3.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLlIVVTVFASSSLRSPMYFFLAYLSLMDAVYsTAVSPKMITDLLRDKKTISFPAC--MGQLFIE 102
Cdd:PHA03087   43 LIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACkiVSGLYYI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGaeVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSvVQLLFVYNLpfcgPNVIDHFICDMYpl 182
Cdd:PHA03087  121 GFYNS--MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIET-TPILFVYTT----KKDHETLICCMF-- 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 183 lelACTDTYFVGIIVVADGGAICMVI-FTLLLISYGVILNSLKSHSQEGR-RKALSTCGSHITVVVLFFVP 251
Cdd:PHA03087  192 ---YNNKTMNWKLFINFEINIIGMLIpLTILLYCYSKILITLKGINKSKKnKKAIKLVLIIVILFVIFWLP 259
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
 31-294 3.59e-06

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 47.78  E-value: 3.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15195     9 VLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 111 FLLVMMAYDRYVAICKPlhyLTIMNQRV-CIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFICDMYPLLELACTD 189
Cdd:cd15195    89 FMLVVIALDRVFAILSP---LSANQARKrVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFHQCVDFGSAPTKKQER 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 190 TY-FVGIIVVADGGAICMVIFTLLLI------------SYGVILNSLKSHSQEGRRKALSTCGSHITVVVL-----FFVP 251
Cdd:cd15195   166 LYyFFTMILSFVIPLIITVTCYLLILfeiskmakrardTPISNRRRSRTNSLERARMRTLRMTALIVLTFIvcwgpYYVL 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 252 CIFMYVRPVSTFPIDKSITV---VFTVITPMLNPLIYTLRNSEMKN 294
Cdd:cd15195   246 GLWYWFDKESIKNLPPALSHimfLLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 27-151 3.65e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 47.62  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLL---RDKKTISFPACMGQLFIEh 103
Cdd:cd15069     5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLgfcTDFHSCLFLACFVLVLTQ- 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 104 ffggAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGF 151
Cdd:cd15069    84 ----SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAF 127
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
 26-147 3.84e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.64  E-value: 3.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK-TISFPACMGQLFIEHF 104
Cdd:cd15217     4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15217    84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 26-155 4.52e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 47.42  E-value: 4.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAvspKMITDLLRdKKTISFPA----CMGQLFI 101
Cdd:cd15197     4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLI---NVLTDIIW-RITVEWRAgdfaCKVIRYL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTimNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd15197    80 QVVVTYASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSI 131
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
 24-152 5.20e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 47.09  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15296     2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQ-RVCIVLLVVAWVGGFL 152
Cdd:cd15296    82 LLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFL 131
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
 24-296 6.05e-06

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 46.76  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLR-SPMYFFLAYLSLMDAVYST-------------AVSPKMITDLLRDKKT 89
Cdd:cd15341     2 AIAVLCTLCGLLCILENVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVvfacsfvdfhvfhGVDSSAIFLLKLGGVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLfiehffggaevfllVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGflhsvvqlLFVYNLPFCGP 169
Cdd:cd15341    82 MSFTASLGSL--------------LLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLT--------ALIAYLPLMGW 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NV--IDHFICDMYPLLElactDTYFVGIIVvadggaICMVIFTLLLISYGVILNSLKSH--------SQEGRRKA----- 234
Cdd:cd15341   140 NCcpLNSPCSELFPLIP----NDYLLSWLL------LVAILLSGIIYTYGHVLWKAHKHvvymekhqDQQGPGNArmrld 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 235 ---LSTCGSHITVVVLFFVPCIFMYVRPVsTFPIDKSITVVFT------VITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15341   210 vrlAKTLGLVLAVLLICWSPVLALMMHSL-FTSLSDHIKKAFAfcstlcLVNSMVNPIIYALRSRELRSSL 279
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 24-295 6.09e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 46.94  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15051     2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDH-FICDM--- 179
Cdd:cd15051    82 MLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGDTpNQCRFeln 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 180 --YPLLELACtdTYFVGIIVvadggaICMVIFTLLLI-----------SYGVILNSLKSHSQEGRRKALSTCGShitvVV 246
Cdd:cd15051   162 ppYVLLVAIG--TFYLPLLI------MCGVYLRIFRIareqakrinalTPASTANSSKSAATAREHKATVTLAA----VL 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 247 LFFVPCIFMY-----VRPVSTFPIDK---SITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15051   230 GAFIICWFPYftyftYRGLCGDNINEtalSVVLWLGYANSALNPILYAFLNRDFRRA 286
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 31-148 6.21e-06

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 47.10  E-value: 6.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15056     9 LVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASI 88

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2076599778 111 FLLVMMAYDRYVAIC-KPLHYLtiMNQRVCIVLLVVAWV 148
Cdd:cd15056    89 MHLCCIALDRYYAICcQPLVYK--MTPLRVAVMLGGCWV 125
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 34-296 7.54e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 46.65  E-value: 7.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15073    12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 114 VMMAYDRYVAICKPLHYLTiMNQRVCIVLLVVAWVGGFlhsvvqllFVYNLPFCGPNVIDHFICDMYPLLELACTDTYFV 193
Cdd:cd15073    92 TVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAF--------FWAAMPLVGWASYALDPTGATCTINWRKNDSSFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 194 GIIVVADggAIC-MVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPI------- 265
Cdd:cd15073   163 SYTMSVI--VVNfIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIvclwasf 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2076599778 266 --DKSITVVFTVITPML-------NPLIYTLRNSEMKNAM 296
Cdd:cd15073   241 gePKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
 25-180 7.64e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 46.49  E-value: 7.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACmgqlfieHF 104
Cdd:cd15329     3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILC-------DV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFL-------LVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGP--NVIDHF 175
Cdd:cd15329    76 WISFDVLLctasilnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGvcQVSQDF 155


                  ....*
gi 2076599778 176 ICDMY 180
Cdd:cd15329   156 GYQIY 160
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 26-294 8.65e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.38  E-value: 8.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIyVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15085     5 FLMFLNA-TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVaWVGGFLHSVVQLLfvyNLPFCGPNVIdHFICDMYPLLEL 185
Cdd:cd15085    84 GIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFI-WLFCLFWAVAPLF---GWSSYGPEGV-QTSCSIGWEERS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 186 ACTDTYFVGIIVVadggaiCMVIFTLLL-ISYGVILNSLKSHSQEGRRKALSTCGS---HITVVVLFFVPCIFMYVRPVS 261
Cdd:cd15085   159 WSNYSYLILYFLM------CFVIPVAIIgFSYGNVLRSLHKLNKKIEQQGGKNCPEeeeRAVIMVLAMVIAFLICWLPYT 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 262 TF-------------PIDKSITVVFTVITPMLNPLIYTLRNSEMKN 294
Cdd:cd15085   233 VFalivvvnpelsisPLAATMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 23-296 9.89e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 46.37  E-value: 9.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLR-SPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK------------- 88
Cdd:cd15099     1 KAIAVLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVFHQRdsrnlflfklggv 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  89 TISFPACMGQLFiehffggaevfllvMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCG 168
Cdd:cd15099    81 TMAFTASVGSLL--------------LTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTWDS 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 169 PnvidhfICDMYPLLElactDTYFVGIIVVAdggaicMVIFTLLLISYGVILNSLKSHS------QEGRRKA-------- 234
Cdd:cd15099   147 P------CSRLFPYID----RHYLASWTGLQ------LVLLFLIIYAYPYILWKAHRHEanmggpKLGRQQVkgqarmrm 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 235 ----LSTCGSHITVVVLFFVPCIFMYVRPVSTFPIDKSITV-----VFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15099   211 dirlAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMfafcsMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 28-147 1.07e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 45.95  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGG 107
Cdd:cd15054     6 FLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2076599778 108 AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15054    86 ASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 27-298 1.27e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 45.98  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15306     5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWvggflhsVVQLLFVYNLPFCGPNVIDHFICDMYPLLEl 185
Cdd:cd15306    85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNNITCVLT- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 186 acTDTYfvGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFPI 265
Cdd:cd15306   157 --KERF--GDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSC 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2076599778 266 DKS-------ITVVFTVITPMLNPLIYTLRNSEMKNAMEK 298
Cdd:cd15306   233 NQTtlqmlmeIFVWIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
 26-159 1.29e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  26 FVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15214     3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWvggfLHSVVQLL 159
Cdd:cd15214    83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIW----LHSLIGCL 132
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 25-295 1.37e-05

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 45.71  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK-TISFPACMGQLFIEH 103
Cdd:cd15328     3 VLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRwQLGRSLCQVWISFDV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNlpfcgpnvidhficDMYPLL 183
Cdd:cd15328    83 LCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWG--------------ETYSED 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 184 ELACTDTYFVGIIVVADGGA----ICMVIFTlllisYGVILNSlkshSQEGRRKALsTCGSHITVVVLFFVPciFMYVRP 259
Cdd:cd15328   149 SEECQVSQEPSYTVFSTFGAfylpLCVVLFV-----YWKIYKA----AQKEKRAAL-MVGILIGVFVLCWIP--FFLTEL 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 260 VSTF------PIDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15328   217 ISPLcscdipPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNA 258
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
 25-152 1.74e-05

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 45.59  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVvTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15295     4 LFLMSLLALV-IVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVA-WVGGFL 152
Cdd:cd15295    83 LCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTQMVAvWVLAFL 131
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 28-148 1.77e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 45.27  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGG 107
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 108 ------AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15352    86 icislvASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 27-148 1.90e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 45.31  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSS--LRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTI-SFPACMGQLFIEH 103
Cdd:cd14981     5 APPALMFVFGVLGNLLALIVLARSSKshKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDgGQPLCDYFGFMMS 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd14981    85 FFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWA 129
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 32-295 2.16e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 44.97  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  32 IYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVF 111
Cdd:cd15330    10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 112 LLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFvYNLP--FCGPNvidhficdmypllelACTD 189
Cdd:cd15330    90 HLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLG-WRTPedRSDPD---------------ACTI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 190 TYFVGIIVVADGGAIcMVIFTLLLISYGVIlnsLKSHSQEgrRKALSTCGSHITVVVLFFVPciFMYVRPVSTFPIDKSI 269
Cdd:cd15330   154 SKDPGYTIYSTFGAF-YIPLILMLVLYGRI---FKAAARE--RKTVKTLGIIMGTFILCWLP--FFIVALVLPFCESTCH 225

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2076599778 270 --TVVFTVIT------PMLNPLIYTLRNSEMKNA 295
Cdd:cd15330   226 mpELLGAIINwlgysnSLLNPIIYAYFNKDFQSA 259
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 31-155 2.31e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 45.00  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYStAVS--PKMITDLLRDKKTISFPACMGQLFIEHFFGGA 108
Cdd:cd15337     9 IVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFS-AVNgfPLKTISSFNKKWIWGKVACELYGFAGGIFGFM 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd15337    88 SITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI 134
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 31-156 2.43e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 45.11  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMY-FFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFpaCMGQLFIEHFFGGA 108
Cdd:cd15057     9 LLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPwAAVNEVAGYWPFGSF--CDVWVSFDIMCSTA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVV 156
Cdd:cd15057    87 SILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFI 134
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 30-296 2.48e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.17  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  30 LLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDaVYSTAVSPKMITDLLRDKKTISFPA-CMGQLFIEHFFGGA 108
Cdd:cd15928     8 SVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSD-LLIFLVLPLDLYRLWRYRPWRFGDLlCRLMYFFSETCTYA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYnlpfcgpnvIDHfICDMYPLLELACT 188
Cdd:cd15928    87 SILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVG---------VEH-IQGQQTPRGFECT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DTYF---VGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSH-------ITVVVLFFVPC------ 252
Cdd:cd15928   157 VVNVssgLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNhrqtvrmLAVIVLAFVLCwlpfhv 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 253 ---IFMYVRPVSTFPIDKS-----ITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15928   237 grvIFNHSRASTKHLHYVSqyfnlVSFVLFYLSAAINPILYNLMSKRYRYAV 288
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 27-159 3.11e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.93  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITdllrdKKTISFPACMGQLFIEHF-- 104
Cdd:cd15068     5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT-----ISTGFCAACHGCLFIACFvl 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2076599778 105 -FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLL 159
Cdd:cd15068    80 vLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 135
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
 28-131 3.15e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 44.56  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVsPKMITDLLRDKKTISFPACMGQLFIEHFFGG 107
Cdd:cd15091     6 VYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLMNSWPFGDVLCKIVISIDYYNMF 84

                          90       100
                  ....*....|....*....|....
gi 2076599778 108 AEVFLLVMMAYDRYVAICKPLHYL 131
Cdd:cd15091    85 TSIFTLTMMSVDRYIAVCHPVKAL 108
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 25-147 3.23e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 44.54  E-value: 3.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPkmiTDLLRdkktiSFPACM--GQLF-- 100
Cdd:cd15314     3 LYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMP---PSMVR-----SVETCWyfGDLFck 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 101 ----IEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15314    75 ihssFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISW 125
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 28-293 3.34e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 44.51  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMI-------TDLLRDKKTISFPACMGQLF 100
Cdd:cd15353     6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVvitllngNDTDAQSFTVNIDNVIDSVI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 101 IEHFFggAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVqllfvynlpfcgpnvidhFICDMY 180
Cdd:cd15353    86 CSSLL--ASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVL------------------FIIYSD 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 181 PLLELACTDTYFVGIIVVADGGAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVL----FFVPCIFMY 256
Cdd:cd15353   146 SSVVIICLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAITLTILLGVFVVcwapFFLHLIFYI 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2076599778 257 VRPVSTFPI----DKSITVVFTVITPMLNPLIYTLRNSEMK 293
Cdd:cd15353   226 SCPRNPYCVcfmsHFNMYLILIMCNSVIDPLIYAFRSQELR 266
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
 40-154 3.44e-05

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 44.36  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  40 NLLIVVTVFASSSLRSPMYFFlaYLSLMDAVYSTAVSPKMITDLLRDKKtISFPACMGQLFIEHFFGGAEVFLLVMMAYD 119
Cdd:cd15905    16 NLFIILGIACNRKLHNTANYF--FLSLLLADLLTGVALPFIPGMSNESR-RGYHSCLFVYVAPNFLFLSFLANLLMVHYE 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076599778 120 RYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHS 154
Cdd:cd15905    93 RYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFA 127
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 27-289 3.64e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 44.73  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFpACMGQLFIEHFF 105
Cdd:cd14992     5 VALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPfNFTYVVSLSWEYGHF-LCKIVNYLRTVS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPF---CGPNVIdhFICDMYPL 182
Cdd:cd14992    84 VYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLfsvKNQEKI--FCCQIPPV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVVadggaICMVIFTLLLISYGVILNSLKSHSQEG-------------RRKALSTCgshITVVVLFF 249
Cdd:cd14992   162 DNKTYEKVYFLLIFVV-----IFVLPLIVMTLAYARISRELWFRKVPGfsikeverkrlkcKRRVIKML---VCVVVLFV 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 250 VpC-----IFMYVRPVST-FPIDKSITVVFTVI------TPMLNPLIYTLRN 289
Cdd:cd14992   234 I-CwlpfhLFFLLRDFFPlIMKEKHTLQVYYFLhwiamsNSMYNPIIYVTLN 284
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 24-148 3.67e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 44.55  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15322     2 TLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15322    82 LFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV 126
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 24-155 3.67e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 44.23  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIyVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15052     3 AALLLLLLV-IATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLD 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV 155
Cdd:cd15052    82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISS 134
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 24-144 3.71e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 44.53  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYvvTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15321    10 AAAITFLILF--TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDV 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQR--VCIVLLV 144
Cdd:cd15321    88 LFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRriKCIILIV 130
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
 24-166 4.55e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 44.12  E-value: 4.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15402     2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLhSVVQLLFVYNLPF 166
Cdd:cd15402    82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVA-AIVPNLFVGSLQY 143
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
 20-148 4.58e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 44.02  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  20 GGQKALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQL 99
Cdd:cd15333     2 GLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 100 FIEHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15333    82 SSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV 130
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 27-295 4.64e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 44.15  E-value: 4.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15304     5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWvggflhsVVQLLFVYNLPFCGpnVIDHfiCDMYPLLEL 185
Cdd:cd15304    85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFG--LQDD--SKVFKEGSC 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 186 ACTDTYFVGIivvadGGAICMVI-FTLLLISYGVILNSLKsHSQEGRRKALSTCGSHITVVVLFFVPCIFMYVRPVSTFP 264
Cdd:cd15304   154 LLADENFVLI-----GSFVAFFIpLTIMVITYFLTIKSLQ-QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKE 227

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2076599778 265 IDKSITV-----VFTVI---TPMLNPLIYTLRNSEMKNA 295
Cdd:cd15304   228 SCNEVVIggllnVFVWIgylSSAVNPLVYTLFNKTYRSA 266
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 31-148 5.89e-05

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 43.71  E-value: 5.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15324     9 VIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSI 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15324    89 VHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWV 126
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 25-257 6.87e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 43.57  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYStaVSPKMITDLLRDKKTISFPA--CMGQLFIE 102
Cdd:cd14964     1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLAS--LVVLVLFFLLGLTEASSRPQalCYLIYLLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLP-FCGPNVIDHFICDMYP 181
Cdd:cd14964    79 YGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPrYNTLTGSCYLICTTIY 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2076599778 182 LLELACTDTYFVGIIVVadggAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPCIFMYV 257
Cdd:cd14964   159 LTWGFLLVSFLLPLVAF----LVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFI 230
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 24-148 8.32e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 43.11  E-value: 8.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKkTISFPACMGQLF--I 101
Cdd:cd15067     1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGG-YWLFGRDWCDVWhsF 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15067    80 DVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
 27-250 8.33e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 43.36  E-value: 8.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYstAVS-PKMITDLLRDKKTISFPaC--MGQLFIEH 103
Cdd:cd14984     5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLF--VLTlPFWAVYAADGWVFGSFL-CklVSALYTIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGaeVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFvYNLPFCGpnviDHFICDMYPLL 183
Cdd:cd14984    82 FYSG--ILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIF-SQVSEEN----GSSICSYDYPE 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 184 ELACTDTYFVGIIVVADGGAICMVIFtllLISYGVILNSLKSHSQEGRRKALSTCgshITVVVLFFV 250
Cdd:cd14984   155 DTATTWKTLLRLLQNILGFLLPLLVM---LFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFFL 215
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 30-299 8.92e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 43.40  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  30 LLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAE 109
Cdd:cd15307     8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 110 VFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVggflhsvvqLLFVYNLPFCGPNVIDHficdMYPLLELACTD 189
Cdd:cd15307    88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWL---------LSIAMSLPLSLMYSKDH----ASVLVNGTCQI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 190 TYFVGIIVvadGGAICMVI-FTLLLISYGVILNSL-KSHSQEGR-----RKALSTCGSHITVVVLFFVPCIFMYVRPVST 262
Cdd:cd15307   155 PDPVYKLV---GSIVCFYIpLGVMLLTYCLTVRLLaRQRSRHGRiirleQKATKVLGVVFFTFVILWSPFFVLNLLPTVC 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 263 FPIDKSIT-VVFTVIT------PMLNPLIYTLRNSEMKNAMEKL 299
Cdd:cd15307   232 AECEERIShWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKV 275
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 28-160 9.14e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 43.24  E-value: 9.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLF---IEHF 104
Cdd:cd15351     6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvIDTM 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2076599778 105 FGGAEVF---LLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15351    86 ICSSVVSslsFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 24-148 1.34e-04

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 42.92  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15400     2 ALSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15400    82 LSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWA 126
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 27-152 1.53e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 42.46  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMItdLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15070     5 SIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15070    83 HASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFL 128
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 28-147 1.72e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 42.23  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTIsfpaCMGQLFIEHFFG- 106
Cdd:cd15354     6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL----VIEDAFVRHIDNv 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 ---------GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15354    82 fdslicisvVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
 24-148 1.74e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 42.63  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVySTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15089     2 AITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15089    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWV 125
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 27-250 1.91e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 42.32  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVY-STAVSPKMITDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15134     5 IIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLlILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSV-----VQLLFVYNLPFCGPNVIDHFICDM- 179
Cdd:cd15134    85 SYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqTRIVYLEYPPTSGEALEESAFCAMl 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 180 ------YPLLELACTdTYFVgiivvadggaICMVIFTLLLISYGVIL------------NSLKSHSQEGRRKALSTCgsh 241
Cdd:cd15134   165 neippiTPVFQLSTF-LFFI----------IPMIAIIVLYVLIGLQLrrstllrrgqrsVSGGRRSSQSRRTVLRML--- 230


                  ....*....
gi 2076599778 242 ITVVVLFFV 250
Cdd:cd15134   231 VAVVVAFFI 239
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
 31-152 1.92e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 42.32  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15300     9 VVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASV 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15300    89 MNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFI 130
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
 32-294 2.27e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 42.07  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  32 IYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYST-AVSPKM---ITDLLRDKKTIsfpaCMGQLFIEHFFGG 107
Cdd:cd15388    10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQLvwdITDRFRGPDVL----CRLVKYLQVVGMF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 108 AEVFLLVMMAYDRYVAICKPLHYLTIMNQRvCIVLLVVAWVGGFLHSVVQlLFVYNLPFCGPNVIDHFICDMYPL-LELA 186
Cdd:cd15388    86 ASSYMIVAMTFDRHQAICRPMVTFQKGRAR-WNGPVCVAWAISLILSLPQ-VFIFSKVEVAPGVYECWACFIEPWgLKAY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 187 CTDTYFVGIIVVADGGAICMV------IFTLLLISYGVILNSLKSHSQEGR-------RKALSTCGSHITVVVLFFVPCI 253
Cdd:cd15388   164 VTWITLVVFVLPTLIITVCQVlifkeiHINIYLKSQIIVAVVKKKQLLSSRassvaevSKAMIKTVKMTLVIVLVYVLCW 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 254 --FMYVRPVST-FPIDKSITVVFTVItpML--------NPLIYTLRNSEMKN 294
Cdd:cd15388   244 apFFLVQLWSVwDPKAPTEGATFTIL--MLlaslnsctNPWIYMAFSSSVSK 293
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
 27-148 2.38e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 42.16  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYsTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15092     5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15092    84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWA 125
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
 25-148 2.67e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 41.77  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15316     3 LYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVS 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15316    83 FCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
 25-160 2.82e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 41.67  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMY-FFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15219     2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLET 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15219    82 FLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
 27-128 3.22e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 41.72  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD--AVYSTAVSpKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15198     5 IFLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADllVIGGTALS-QIIWELLGDRWMAGDVACRLLKLLQAS 83

                          90       100
                  ....*....|....*....|....
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPL 128
Cdd:cd15198    84 ARGASANLVVLLALDRHQAIRAPL 107
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
 24-148 3.44e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 41.35  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15301     2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15301    82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWI 126
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
 31-295 3.47e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 41.45  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15335     9 LITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVI----DHFICDMYPLLela 186
Cdd:cd15335    89 LHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCiiqhDHVIYTIYSTF--- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 187 ctdtyfvgiivvadgGAIcMVIFTLLLISYGVILNSLKSHSQEGRRKALsTCGSHITVVVLFFVPCIFMYVRPVSTFPID 266
Cdd:cd15335   166 ---------------GAF-YIPLTLILILYYRIYHAASRERKAARILGL-ILGAFILSWLPFFIKELIVGLSVMTVSPEV 228

                         250       260
                  ....*....|....*....|....*....
gi 2076599778 267 KSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15335   229 ADFLTWLGYVNSLVNPLLYTSFNEDFKLA 257
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 27-159 3.60e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.49  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15074     5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVlLVVAWVGGFLHSVVQLL 159
Cdd:cd15074    85 CCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIV-IVAIWLYALFWAVAPLV 136
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
 39-158 3.61e-04

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 41.35  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  39 GNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLLVMMAY 118
Cdd:cd15391    17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2076599778 119 DRYVAICKPLHYLTIMNQRVCIVLLVvaWVGGFLHSVVQL 158
Cdd:cd15391    97 DRFFAVIFPLRSRHTKSRTKCIIASI--WAISFSLSSVQL 134
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 28-163 3.84e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 41.41  E-value: 3.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLL---IVVTVFASS-SLRSPMYFFLAYLSLMD---------AVYSTAVSPKMITDLLRDkktisFPA 94
Cdd:cd15079     2 LLGFIYIFLGIVSLLgngLVIYIFSTTkSLRTPSNMLVVNLAISDflmmikmpiFIYNSFYEGWALGPLGCQ-----IYA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2076599778  95 CMGQLFiehffGGAEVFLLVMMAYDRYVAICKPLHyLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYN 163
Cdd:cd15079    77 FLGSLS-----GIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGWG 139
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
 24-293 3.87e-04

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 41.34  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVspkMITDLLRDKKTISFPACmgQLFIEH 103
Cdd:cd15347     2 VASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAF---IANILLSGSVTFRLTPV--QWFIRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFG----GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVcIVLLVVAWVGGFLhsvvqllfVYNLPFCGPNVIDHfICDM 179
Cdd:cd15347    77 GTAfitlSASVFSLLAIAIERHVAITKVKLYGSDKNCRM-VLLIGACWVISIV--------LGGLPILGWNCIGN-LEDC 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 180 YPLLELacTDTYFVGIIVvadggAICMVIFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHITVVVLFFVPC------- 252
Cdd:cd15347   147 STVLPL--YSKHYILFVV-----TIFSIILLSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVTIVLGVFIVCwlpafii 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2076599778 253 -IFMYVRPVSTFPIDKSITVVFTVIT--PMLNPLIYTLRNSEMK 293
Cdd:cd15347   220 lLLDTSCKVKSCPILYKADYFFSVATlnSALNPVIYTLRSKDMR 263
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 27-301 4.09e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 41.39  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVfASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15084    16 LMGMVVALASFVNGLVIVVSI-KYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTiMNQRVCIVLLVVAWVGGFLHSVVQLL-FVYNLP-----FCGPNVidhficdmy 180
Cdd:cd15084    95 IVGLWSLAILAFERYLVICKPMGDFR-FQQRHAVSGCAFTWGWSLLWTSPPLFgWSSYVPeglrtSCGPNW--------- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 181 pLLELACTDTYFVGIIVVADGGAICMVIFtllliSYGVILNSLKS-----HSQEGRRKALSTCGSHITVVVLFFVPCIFM 255
Cdd:cd15084   165 -YTGGTNNNSYILALFVTCFALPLSTIIF-----SYSNLLLTLRAvaaqqKESETTQRAEKEVTRMVIAMVMAFLICWLP 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2076599778 256 YV---------RPVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNAMEKLWC 301
Cdd:cd15084   239 YAtfamvvatnKDVVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLC 293
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 28-156 5.55e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 41.10  E-value: 5.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMY-FFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFpaCMGQLFIEHFF 105
Cdd:cd15319     6 LLSLLILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLFVALLVMPwKAVAEVAGYWPFGAF--CDVWVAFDIMC 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVV 156
Cdd:cd15319    84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFI 134
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
 27-154 5.64e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.60  E-value: 5.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15215     4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHS 154
Cdd:cd15215    84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
 27-152 6.12e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 40.94  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVG---NLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15082    15 VLAALMFVVTSLSlaeNFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVT 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVaWVGGFL 152
Cdd:cd15082    95 FFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFV-WTFSFI 142
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
 34-152 6.82e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 40.38  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15049    12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNL 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2076599778 114 VMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15049    92 LLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFV 130
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
 34-160 7.08e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 40.33  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15297    12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 114 VMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15297    92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILF 138
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 27-147 7.67e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 40.27  E-value: 7.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK-TISFPACMGQLFIEHFF 105
Cdd:cd15305     5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAW 147
Cdd:cd15305    85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW 126
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 27-160 7.99e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.42  E-value: 7.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRdKKTISFPACMGQLFIehFFG 106
Cdd:cd15392     5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLI-LQYWPFGEFMCPVVN--YLQ 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 107 GAEVFL----LVMMAYDRYVAICKPLHylTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15392    82 AVSVFVsaftLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAIT 137
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
 23-295 8.94e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 40.24  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  23 KALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMitdLLRDKKTISFPACM-----G 97
Cdd:cd15346     1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANL---LLSGATTYKLTPTQwflreG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  98 QLFIEHffgGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVcIVLLVVAWVGGflhsvvqlLFVYNLPFCGPNVIDHF-- 175
Cdd:cd15346    78 SMFVAL---SASVFSLLAIAIERYITMLKMKLHNGSNSFRS-FLLISACWVIS--------LILGGLPIMGWNCISALss 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 176 ICDMYPLlelactdtYFVGIIVvadggaICMVIFTLLLIS----YGVILNSLKSHS------QEGRRKALSTCGS----- 240
Cdd:cd15346   146 CSTVLPL--------YHKHYIL------FCTTVFTLLLLSivilYCRIYSLVRTRSrrltfrKNIRKASRSSEKSmallk 211

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2076599778 241 HITVVVLFFVPC-----IFMYVR---PVSTFPI--DKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15346   212 TVIIVLSVFIACwaplfILLLLDvgcKVKTCSIlfKAEYFLVLAVLNSATNPIIYTLTNKEMRRA 276
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
 30-148 9.36e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 40.14  E-value: 9.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  30 LLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPA-CMGQLFIEHFFGGA 108
Cdd:cd15212     8 LAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDRlCLANGFFNACFGIV 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLtiMNQRVCIVLLVVAWV 148
Cdd:cd15212    88 STLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWL 125
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
 27-159 1.14e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 39.94  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15210     5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLV 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTImNQRVCIVLLVVA-WVGGFLHSVVQLL 159
Cdd:cd15210    85 AVSLLTLVLITLNRYILIAHPSLYPRI-YTRRGLALMIAGtWIFSFGSFLPLWL 137
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 31-148 1.23e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 39.89  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEV 110
Cdd:cd15959     9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2076599778 111 FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15959    89 ETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWA 126
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
 28-148 1.32e-03

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 39.59  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVySTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGG 107
Cdd:cd15090     6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2076599778 108 AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15090    85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWI 125
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
 25-295 1.41e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 39.66  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15213     3 LAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLtimNQRVCIVLLVVAWVGGFLHSVVQLLFV--YNLPFCGPNVIdhficdmYPL 182
Cdd:cd15213    83 FVLEGVAILLIISVDRYLIIVQRQDKL---NPHRAKILIAVSWVLSFCVSFPPLVGWgkYEFPPRAPQCV-------LGY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 183 LELACTDTYFVGIIVvadggAICMVIFTLLLISYGVILNSLKSHsqegRRKALSTcgshITVVVLFFVPC---------I 253
Cdd:cd15213   153 TESPADRIYVVLLLV-----AVFFIPFLIMLYSYFCILNTVRSF----KTRAFTT----ILILFIGFSVCwlpytvyslL 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 254 FMYVRPVSTFPIDKSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15213   220 SVFSRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 24-295 1.43e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 39.68  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDkktISFPACMGQLFie 102
Cdd:cd15206     2 LIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPfTLVGQLLRN---FIFGEVMCKLI-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 103 HFFGGAEV----FLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNvidHFICD 178
Cdd:cd15206    77 PYFQAVSVsvstFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPG---GHKCR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 179 MYPLLELAcTDTYFVGIIVvadggaICMVIFTLLLI-SYGVILNSLKshsqEGRRKALSTCgshITVVVLFFVPCIFMYV 257
Cdd:cd15206   154 EVWPNEIA-EQAWYVFLDL------MLLVIPGLVMSvAYGLISWTLL----EAKKRVIRML---FVIVVEFFICWTPLYV 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 258 -------------RPVSTFPIdkSITVVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15206   220 intwkafdppsaaRYVSSTTI--SLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
 34-160 1.58e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  34 VVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFGGAEVFLL 113
Cdd:cd15298    12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 114 VMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLF 160
Cdd:cd15298    92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILF 138
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 31-156 1.73e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 39.60  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  31 LIYVVTMVGNLLIVVTVFASSSLRSPMY-FFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFpaCMGQLFIEHFFGGA 108
Cdd:cd15320    10 VLILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIMCSTA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2076599778 109 EVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVV 156
Cdd:cd15320    88 SILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFI 135
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
 27-295 1.85e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 39.42  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVspkMITDLLRDKKTISFPACM-----GQLFI 101
Cdd:cd15345     5 IFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAY---KVNILMSGKKTFSLSPTQwflreGSMFV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 102 EHffgGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVcIVLLVVAWVGGFLHSVvqllfvynLPFCGPNVIDHfICDMYP 181
Cdd:cd15345    82 AL---GASTFSLLAIAIERHLTMIKMRPYDANKRYRV-FLLIGTCWLISVLLGA--------LPILGWNCLDN-LPDCST 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 182 LLELAcTDTYFvgiivvadggAICMVIFTLLLIS----YGVILNSLKSHSQE-----GRRKALSTCGSHITVVVLF---F 249
Cdd:cd15345   149 ILPLY-SKKYV----------AFCISIFIAILVAivilYARIYILVKSSSRRvtnhrNSERSMALLRTVVIVVGVFiacW 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2076599778 250 VPCIFMYVRPVSTFPIDKSIT------VVFTVITPMLNPLIYTLRNSEMKNA 295
Cdd:cd15345   218 SPLFILLLIDVACEVKQCPILykadwfIALAVLNSAMNPIIYTLASKEMRRA 269
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
 24-164 2.04e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 39.06  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITdlLRDKKTISFPACMGQLFIEH 103
Cdd:cd15071     2 AYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAII--INIGPQTEFYSCLMVACPVL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNL 164
Cdd:cd15071    80 ILTQSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNL 140
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
 24-295 2.07e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 39.12  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRS-PMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKK-------------T 89
Cdd:cd15340     2 AIAVLSLTLGTFTVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKdspnvflfklggvT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  90 ISFPACMGQLFiehffggaevfllvMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVvqllfvynLPFCGP 169
Cdd:cd15340    82 ASFTASVGSLF--------------LTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAV--------LPLLGW 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 170 NVID-HFIC-DMYPLLElactDTYFVGIIVVADggaicmviFTLLLISYGVILNSLKSHSQEGRRKALSTCGSHI----- 242
Cdd:cd15340   140 NCKKlNSVCsDIFPLID----ETYLMFWIGVTS--------VLLLFIVYAYMYILWKAHHHAVRMLQRGTQKSIIvytse 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 243 --------------------TVVVLFFVPCI----FMYVRPVSTF-PIDKSITVVFT------VITPMLNPLIYTLRNSE 291
Cdd:cd15340   208 dgkvqttrpdqtrmdirlakTLVLILVVLIIcwgpLLAIMVYDVFgKMNKLIKTVFAfcsmlcLLNSTVNPIIYALRSKD 287


                  ....
gi 2076599778 292 MKNA 295
Cdd:cd15340   288 LRHA 291
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
 27-256 2.11e-03

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 39.02  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLR--SPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd14976     5 VVYMVVFTVGLLGNLLVLYLLKSNKKLRqqSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNlpfcGPNVIDHFICDM-YPLL 183
Cdd:cd14976    85 NMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTD----TWSSVNHTLCLLrFPKN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076599778 184 ELACTDTYFVGI-----IVVADGGAICMVIFtllliSYGVILNSLKSHSQEGRRKaLSTCGSHITVVVLFFVPCIFMY 256
Cdd:cd14976   161 SSVTRWYNWLGMyqlqkVVLGFFLPLGIITL-----SYLLLLRFLQRKRGGSKRR-KSRVTKSVFIVVLSFFICWLPN 232
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
 28-152 2.38e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.95  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  28 MFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVySTAVSPKM--ITDLLRDKKTISFpACMGQLFIEHFF 105
Cdd:cd15000     5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLL-TLLVCPWMflVHDFFQNYVLGSV-GCKLEGFLEGSL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHylTIMNQRVCIVLLVVAWVGGFL 152
Cdd:cd15000    83 LLASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLL 127
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 110-296 2.47e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 38.72  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 110 VFLLVMMAYDRYVAICKPLHYLTImNQRVCIVLLVVAWVGGFLHSVVQLLFV-YNLPFCGPNVIdhfiCdmyplLELACT 188
Cdd:cd15137    95 VLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLLAVLPLLPWdYFGNFYGRSGV----C-----LPLHIT 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 189 DT------YFVGIIVVadggaICMVIFTLLLISYGVILNSLK-SHSQEGRRKALSTC--GSHITVVVL--FF--VPCIFM 255
Cdd:cd15137   165 DErpagweYSVFVFLG-----LNFLAFVFILLSYIAMFISIRrTRKAAASRKSKRDMavAKRFFLIVLtdFLcwIPIIVI 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 256 YVRPVSTFPIDKSI---TVVFTV-ITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15137   240 GILALSGVPIPGEVyawVAVFVLpINSALNPILYTLSTPKFRKKL 284
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 27-148 3.00e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 38.82  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15096     5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15096    85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWI 126
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 24-181 3.49e-03

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 38.34  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15124     2 AIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHFI-CDMYP 181
Cdd:cd15124    82 TSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVsCAPYP 160
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
 27-170 3.51e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 38.61  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLrdkKTISFPACMGQLF-----I 101
Cdd:cd15094     5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMIL---KYWPFGAAMCKIYmvltsI 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2076599778 102 EHFfggAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPN 170
Cdd:cd15094    82 NQF---TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRY 147
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 25-128 4.29e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 38.26  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  25 LFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHF 104
Cdd:cd15202     3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82

                          90       100
                  ....*....|....*....|....
gi 2076599778 105 FGGAEVFLLVMMAYDRYVAICKPL 128
Cdd:cd15202    83 SVHVSAYTLTAIAVDRYQAIMHPL 106
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
 24-148 4.42e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 38.19  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIyvVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15302     4 ALITAILSI--ITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPfYTVYVLNGDYWPLGWVLCDLWLSVD 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15302    82 YTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWI 127
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 27-128 4.53e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 37.87  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLrdkKTISFPACMGQLfIEHFF 105
Cdd:cd15979     5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPfTLIPNLM---GTFIFGEVICKA-VAYLM 80

                          90       100
                  ....*....|....*....|....*.
gi 2076599778 106 G---GAEVFLLVMMAYDRYVAICKPL 128
Cdd:cd15979    81 GvsvSVSTFSLVAIAIERYSAICNPL 106
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
 29-296 4.65e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 37.96  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  29 FLLIYVVT--MVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEHFFG 106
Cdd:cd15081    17 VWMIFVVFasVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 GAEVFLLVMMAYDRYVAICKPLHYLTiMNQRVCIVLLVVAWVGGFLHSVVQLL-----FVYNLPF-CGPNVidhFICDMY 180
Cdd:cd15081    97 ITGLWSLTIISWERWVVVCKPFGNIK-FDGKLAIVGIIFSWVWSAVWCAPPIFgwsryWPHGLKTsCGPDV---FSGSSD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 181 PllelaCTDTYFVGIIVVAdggaiCMVIFTLLLISYGVILNSLKSHSQ-----EGRRKALSTCGSHITVVVLFFVPC--- 252
Cdd:cd15081   173 P-----GVQSYMIVLMITC-----CIIPLAIIILCYLQVWLAIRAVAQqqkesESTQKAEKEVSRMVVVMIFAYCFCwgp 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2076599778 253 -----IFMYVRPVSTF-PIDKSITVVFTVITPMLNPLIYTLRNSEMKNAM 296
Cdd:cd15081   243 ytffaCFAAANPGYAFhPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCI 292
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
 24-148 4.76e-03

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 37.94  E-value: 4.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVM-FLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIE 102
Cdd:cd15980     1 AVFIAsYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPL-HYLTImnqRVCIVLLVVAWV 148
Cdd:cd15980    81 GISVSASVFTLVAIAVDRFRCIVYPFkQKLTI---STAVVIIVIIWV 124
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 27-295 4.91e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 37.78  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLiVVTVFASS---SLRSPMYFFLAYLSLMDAVYSTAVSPKMITdlLRDKKTISFPACMGQlFIEH 103
Cdd:cd15098     5 VVFGLIFCLGVLGNSL-VITVLARVkpgKRRSTTNVFILNLSIADLFFLLFCVPFQAT--IYSLPEWVFGAFMCK-FVHY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGG---AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLlfVYNLPFCGPNVIDHFIC-DM 179
Cdd:cd15098    81 FFTVsmlVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVA--VHQDLVHHWTASNQTFCwEN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 180 YPllELACTDTYFVGIIVVAdggaicmVIFTLLLIS--YGVILNSLKSHSQEGRRKALST---CGSHITVVVLFFVPC-- 252
Cdd:cd15098   159 WP--EKQQKPVYVVCTFVFG-------YLLPLLLITfcYAKVLNHLHKKLKNMSKKSERSkkkTAQTVLVVVVVFGISwl 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 253 ----IFMYVRpVSTFPIDkSITVVFTVITPML-------NPLIYTLRNSEMKNA 295
Cdd:cd15098   230 phhiIHLWVE-FGDFPLT-QASFVLRITAHCLayanscvNPIIYAFLSENFRKA 281
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 24-184 5.06e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 37.98  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15123     2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSVVQLLFVYNLPFCGPNVIDHF-ICDMYPL 182
Cdd:cd15123    82 TSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFeACAPYPV 161


                  ..
gi 2076599778 183 LE 184
Cdd:cd15123   162 SE 163
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
 24-148 5.84e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 37.84  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSP-KMITDLLRDKKTISFpACMGQLFIE 102
Cdd:cd15205     2 AFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPfTLLQNISSNWLGGAF-MCKMVPFVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15205    81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWI 126
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 24-158 6.21e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 37.75  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMD-AVYSTAVSPKMITDLLrDKKTISFPACMGQLFIE 102
Cdd:cd15208     2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADfLVIIICLPATLLVDVT-ETWFFGQVLCKIIPYLQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2076599778 103 HFFGGAEVFLLVMMAYDRYVAICKPLHY-LTIMNQRVCIVLLvvaWVGGFLHSVVQL 158
Cdd:cd15208    81 TVSVSVSVLTLSCIALDRWYAICHPLMFkSTAKRARVSILII---WIVSLLIMIPQA 134
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
 27-252 6.26e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 37.75  E-value: 6.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPAC--MGQLFIEHF 104
Cdd:cd15160     5 VVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCkvVGFFFYTNI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 105 FggAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV--GGFLHSVVQLLFVYNLPFcgpnviDHFIC-DMYP 181
Cdd:cd15160    85 Y--ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVleLGTHSVFLGHDELFRDEP------NHTLCyEKYP 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2076599778 182 LlelactDTYFVGI--IVVADGGAICMViftLLLISYGVILNSLK-SHSQEGRRKAlSTCGSHITVVVLFFVPC 252
Cdd:cd15160   157 M------EGWQASYnyARFLVGFLIPLS---LILFFYRRVLRAVRqSPSLEREEKR-KIIGLLLSIVVIFLLCF 220
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
 27-285 7.21e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 37.36  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYsTAVSPKMITDLLRDKKTiSFPACMGQLFIEHFFG 106
Cdd:cd14985     5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPLWATYTANQYDW-PFGAFLCKVSSYVISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 107 G--AEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGG-------FLHSVVQLLFVYNLPFCGpnvidhfic 177
Cdd:cd14985    83 NmfASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVAcllslptFLLRSLQAIENLNKTACI--------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778 178 dmypllELACTDTYFVGIIVVADGGAIcMVIFTLLLISYGVILNSLKSHSQEGR--RKALSTCGSHITVVVLFFVPC--- 252
Cdd:cd14985   154 ------MLYPHEAWHFGLSLELNILGF-VLPLLIILTCYFHIARSLRKRYERTGknGRKRRKSLKIIFALVVAFLVCwlp 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2076599778 253 --------IFMYVRPVSTFPIDKSITVVFTVITPM------LNPLIY 285
Cdd:cd14985   227 fhffkfldFLAQLGAIRPCFWELFLDLGLPIATCLaftnscLNPFIY 273
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
 27-163 8.77e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 37.26  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMI-TDLLRDKKTISFPACMGQLFIEHFF 105
Cdd:cd15310     5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMM 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076599778 106 GGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVC---IVLLVVAWVGGFLHSvVQLLFVYN 163
Cdd:cd15310    85 CTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCrrvSLMITAVWVLAFAVS-CPLLFGFN 144
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
 24-148 9.50e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.15  E-value: 9.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  24 ALFVMFLLIYVVTMVGNLLIVVTVFASSSLRSPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISFPACMGQLFIEH 103
Cdd:cd15957     2 GMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2076599778 104 FFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWV 148
Cdd:cd15957    82 LCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWI 126
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 27-177 9.53e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 37.13  E-value: 9.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076599778  27 VMFLLIYVVTMVGNLLIVVTVFASSSLR---SPMYFFLAYLSLMDAVYSTAVSPKMITDLLRDKKTISF--PACMGQLFI 101
Cdd:cd15355     5 AIYLALFVVGTVGNSITLYTLARKKSLQhlqSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFgdAACRGYYFL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2076599778 102 EHFFGGAEVFLLVMMAYDRYVAICKPLHYLTIMNQRVCIVLLVVAWVGGFLHSvVQLLFVYNLPFCGPNVIDHFIC 177
Cdd:cd15355    85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLA-IPMLFTMGEQNRSGTHPGGLIC 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH