|
Name |
Accession |
Description |
Interval |
E-value |
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
1-267 |
4.55e-173 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 477.98 E-value: 4.55e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 1 MIVPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLK 80
Cdd:PRK11172 1 MSIPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIPSLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 81 DSLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENIATNQIELSPYLQ 160
Cdd:PRK11172 81 ESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQIELSPYLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 NQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLT 240
Cdd:PRK11172 161 NRKVVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLD 240
|
250 260
....*....|....*....|....*..
gi 2072553571 241 PEQMQAITTLDRNAREVNPPELAPVWD 267
Cdd:PRK11172 241 AEDMAAIAALDRNGRLVSPEGLAPEWD 267
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
3-250 |
1.06e-143 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 402.89 E-value: 1.06e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19139 1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENIATNQIELSPYLQNQ 162
Cdd:cd19139 81 LEKLRTDYVDLTLIHWPSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAIATNQIELSPYLQNR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 KLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPE 242
Cdd:cd19139 161 KLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDAD 240
|
....*...
gi 2072553571 243 QMQAITTL 250
Cdd:cd19139 241 DMAAIAAL 248
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
3-261 |
2.39e-118 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 338.95 E-value: 2.39e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:COG0656 5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLAAFEES 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPalgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGlENIATNQIELSPYLQNQ 162
Cdd:COG0656 85 LERLGLDYLDLYLIHWPGP---GPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG-VKPAVNQVELHPYLQQR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 KLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPE 242
Cdd:COG0656 161 ELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDE 240
|
250
....*....|....*....
gi 2072553571 243 QMQAITTLDRNAREVNPPE 261
Cdd:COG0656 241 DMAAIDALDRGERLGPDPD 259
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
3-247 |
3.22e-107 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 310.36 E-value: 3.22e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19073 1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDRS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDhIGLENIATNQIELSPYLQNQ 162
Cdd:cd19073 81 LEKLGTDYVDLLLIHWPNPT--VPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALD-ISPLPIAVNQVEFHPFLYQA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 KLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPE 242
Cdd:cd19073 158 ELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSE 237
|
....*
gi 2072553571 243 QMQAI 247
Cdd:cd19073 238 DVAKI 242
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
3-250 |
1.03e-92 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 273.75 E-value: 1.03e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19140 8 IPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLASVEES 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLEnIATNQIELSPYLQNQ 162
Cdd:cd19140 88 LRKLRTDYVDLLLLHWPNKD--VPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAP-LFTNQVEYHPYLDQR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 KLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQK-GYAVIPSSTKREHLISNLKAQEIHLTP 241
Cdd:cd19140 165 KLLDAAREHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSD 244
|
....*....
gi 2072553571 242 EQMQAITTL 250
Cdd:cd19140 245 EEMARIAAL 253
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
3-247 |
1.63e-90 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 268.20 E-value: 1.63e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19071 1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPALGVDIPELMGH----LLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLEnIATNQIELSPY 158
Cdd:cd19071 81 LKDLGLDYLDLYLIHWPVPGKEGGSKEARLEtwraLEELVDEGLVRSIGVSNFNVEHLEELLAAARIK-PAVNQIELHPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 159 LQNQKLVNYLQTNNIDATSYMTLA--YGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQE 236
Cdd:cd19071 160 LQQKELVEFCKEHGIVVQAYSPLGrgRRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFD 239
|
250
....*....|.
gi 2072553571 237 IHLTPEQMQAI 247
Cdd:cd19071 240 FELSEEDMAAI 250
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
1-251 |
8.17e-71 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 218.40 E-value: 8.17e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 1 MIVPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLK 80
Cdd:cd19131 8 NTIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYDSTLRAFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 81 DSLIKLRTDAVNLTLIHWPAPALGVDIpELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENiATNQIELSPYLQ 160
Cdd:cd19131 88 ESLRKLGLDYVDLYLIHWPVPAQDKYV-ETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVP-VVNQIELHPRFQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 NQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLT 240
Cdd:cd19131 166 QRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELD 245
|
250
....*....|.
gi 2072553571 241 PEQMQAITTLD 251
Cdd:cd19131 246 ADDMQAIAGLD 256
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
3-257 |
4.82e-70 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 217.66 E-value: 4.82e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHE----SQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19123 12 IPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEvfkeGKVKREDLWITSKLWNNSHAPEDVLPA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWP-APALGVDIPE------------LMG---HLLEAKKQGLTEHIGVSNFNIELTQqaiDH 142
Cdd:cd19123 92 LEKTLADLQLDYLDLYLMHWPvALKKGVGFPEsgedllslspipLEDtwrAMEELVDKGLCRHIGVSNFSVKKLE---DL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 143 IGLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYG------------KVLQDPTLLNIAAEHQVTSAQIAL 208
Cdd:cd19123 169 LATARIkpAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGdrpaamkaegepVLLEDPVINKIAEKHGASPAQVLI 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2072553571 209 AWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREV 257
Cdd:cd19123 249 AWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
3-252 |
7.47e-70 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 215.60 E-value: 7.47e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19132 7 IPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEALRTIEES 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPALGVDIpELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGlENIATNQIELSPYLQNQ 162
Cdd:cd19132 87 LYRLGLDYVDLYLIHWPNPSRDLYV-EAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETG-VTPAVNQIELHPYFPQA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 KLVNYLQTNNIDATSYMTLAYG-KVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTP 241
Cdd:cd19132 165 EQRAYHREHGIVTQSWSPLGRGsGLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSD 244
|
250
....*....|.
gi 2072553571 242 EQMQAITTLDR 252
Cdd:cd19132 245 EDMAAIAALDR 255
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
3-250 |
4.79e-68 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 211.41 E-value: 4.79e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---ETVIHSVKtalEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSL 79
Cdd:cd19135 13 MPILGLGTSHSGGyshEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSDYGYESTKQAF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 80 KDSLIKLRTDAVNLTLIHWP-APALGVDIPEL-------MGHLLEakkQGLTEHIGVSNFNIEltqqaiDHIGLENIAT- 150
Cdd:cd19135 90 EASLKRLGVDYLDLYLLHWPdCPSSGKNVKETraetwraLEELYD---EGLCRAIGVSNFLIE------HLEQLLEDCSv 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 ----NQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKRE 226
Cdd:cd19135 161 vphvNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEE 240
|
250 260
....*....|....*....|....
gi 2072553571 227 HLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19135 241 RIKENCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
3-255 |
2.64e-66 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 207.91 E-value: 2.64e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG-ETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHE----SQVNRADIFLTTKIWTENYAADKLIP 77
Cdd:cd19116 11 IPAIALGTWKLKDdEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREkiaeGVVKREDLFITTKLWNSYHEREQVEP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 78 SLKDSLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLL--------------EAKKQGLTEHIGVSNFNIELTQQAIDhi 143
Cdd:cd19116 91 ALRESLKRLGLDYVDLYLIHWPVAFKENNDSESNGDGSlsdidyletwrgmeDLVKLGLTRSIGVSNFNSEQINRLLS-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 gLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAY---------GKVLQDPTLLNIAAEHQVTSAQIALAWAL 212
Cdd:cd19116 169 -NCNIkpAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRlvprgqtnpPPRLDDPTLVAIAKKYGKTTAQIVLRYLI 247
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2072553571 213 QKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19116 248 DRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQR 290
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
3-255 |
5.41e-66 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 206.47 E-value: 5.41e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRL-AGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKD 81
Cdd:cd19157 10 MPWLGLGVFKVeEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGYDSTLKAFEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLeakKQGLTEHIGVSNFNIEltqqaidHigLENIAT--------NQI 153
Cdd:cd19157 90 SLERLGLDYLDLYLIHWPVKGKYKETWKALEKLY---KDGRVRAIGVSNFQVH-------H--LEDLLAdaeivpmvNQV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 154 ELSPYLQNQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLK 233
Cdd:cd19157 158 EFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENAD 237
|
250 260
....*....|....*....|..
gi 2072553571 234 AQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19157 238 VFDFELSQEDMDKIDALNENLR 259
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
4-250 |
2.02e-64 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 202.09 E-value: 2.02e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAG-ETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHES----QVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19136 2 PILGLGTFRLRGeEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAPAlGVDiPELMGH----------LLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLEnI 148
Cdd:cd19136 82 CLGSLERLGTDYLDLYLIHWPGVQ-GLK-PSDPRNaelrreswraLEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVP-P 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 149 ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYG--KVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKRE 226
Cdd:cd19136 159 AVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGdlRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPE 238
|
250 260
....*....|....*....|....
gi 2072553571 227 HLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19136 239 RIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
3-251 |
2.54e-64 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 201.65 E-value: 2.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRL-AGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKD 81
Cdd:cd19133 9 MPILGFGVFQIpDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYEKAKKAFER 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAPalgvDIPELMGHLLEAKKQGLTEHIGVSNFNIEltqQAIDHIGLENI--ATNQIELSPYL 159
Cdd:cd19133 89 SLKRLGLDYLDLYLIHQPFG----DVYGAWRAMEELYKEGKIRAIGVSNFYPD---RLVDLILHNEVkpAVNQIETHPFN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 160 QNQKLVNYLQTNNIDATSYMTLAYGK--VLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEI 237
Cdd:cd19133 162 QQIEAVEFLKKYGVQIEAWGPFAEGRnnLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDF 241
|
250
....*....|....
gi 2072553571 238 HLTPEQMQAITTLD 251
Cdd:cd19133 242 ELSDEDMEAIAALD 255
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
3-251 |
7.30e-64 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 200.52 E-value: 7.30e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19130 10 IPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEPAAAFAES 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPALG--VDIPELMGHLLEAkkqGLTEHIGVSNFNIELTQQAIDHIGLENiATNQIELSPYLQ 160
Cdd:cd19130 90 LAKLGLDQVDLYLVHWPTPAAGnyVHTWEAMIELRAA---GRTRSIGVSNFLPPHLERIVAATGVVP-AVNQIELHPAYQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 NQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLT 240
Cdd:cd19130 166 QRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLT 245
|
250
....*....|.
gi 2072553571 241 PEQMQAITTLD 251
Cdd:cd19130 246 DTEIAAIDALD 256
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
3-247 |
8.32e-63 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 198.22 E-value: 8.32e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---------ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHEsqVNRADIFLTTKIWTENY 70
Cdd:cd19072 4 VPVLGLGTWGIGGgmskdysddKKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIKG--FDREDLFITTKVSPDHL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENIAT 150
Cdd:cd19072 82 KYDDVIKAAKESLKRLGTDYIDLYLIHWPNPS--IPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPIVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 NQIELSpyLQNQ----KLVNYLQTNNIDATSYMTLAYGKVL---QDPTLLNIAAEHQVTSAQIALAWALQK-GYAVIPSS 222
Cdd:cd19072 160 NQVEYN--LFDReeesGLLPYCQKNGIAIIAYSPLEKGKLSnakGSPLLDEIAKKYGKTPAQIALNWLISKpNVIAIPKA 237
|
250 260
....*....|....*....|....*
gi 2072553571 223 TKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19072 238 SNIEHLEENAGALGWELSEEDLQRL 262
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
3-255 |
7.26e-61 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 193.15 E-value: 7.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDS 82
Cdd:cd19134 11 MPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFTASQAACRAS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPALG--VDIpelMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGlENIATNQIELSPYLQ 160
Cdd:cd19134 91 LERLGLDYVDLYLIHWPAGREGkyVDS---WGGLMKLREEGLARSIGVSNFTAEHLENLIDLTF-FTPAVNQIELHPLLN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 NQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLT 240
Cdd:cd19134 167 QAELRKVNAQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELT 246
|
250
....*....|....*
gi 2072553571 241 PEQMQAITTLDRNAR 255
Cdd:cd19134 247 ADHMDALDGLDDGTR 261
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
3-256 |
9.27e-61 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 194.17 E-value: 9.27e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHES----QVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19154 12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELleegVVKREDLFITTKLWTHEHAPEDVEEA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAPA-----------LGVDIPELMGHL-----LE-AKKQGLTEHIGVSNFNIELTQQAID 141
Cdd:cd19154 92 LRESLKKLQLEYVDLYLIHAPAAFkddegesgtmeNGMSIHDAVDVEdvwrgMEkVYDEGLTKAIGVSNFNNDQIQRILD 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 142 hIGLENIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAY---------------GKVLQDPTLLNIAAEHQVTSAQI 206
Cdd:cd19154 172 -NARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpgranftkstgvspaPNLLQDPIVKAIAEKHGKTPAQV 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2072553571 207 ALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNARE 256
Cdd:cd19154 251 LLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRL 300
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
3-251 |
4.54e-60 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 190.73 E-value: 4.54e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRL-AGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKD 81
Cdd:cd19126 9 MPWLGLGVFQTpDGDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRARRTEDAFQE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAKKqglTEHIGVSNFNIELTQQAIDHIGLENiATNQIELSPYLQN 161
Cdd:cd19126 89 SLDRLGLDYVDLYLIHWPGKDKFIDTWKALEKLYASGK---VKAIGVSNFQEHHLEELLAHADVVP-AVNQVEFHPYLTQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 QKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTP 241
Cdd:cd19126 165 KELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSE 244
|
250
....*....|
gi 2072553571 242 EQMQAITTLD 251
Cdd:cd19126 245 DDMTAIDALN 254
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
2-255 |
1.46e-59 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 190.28 E-value: 1.46e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 2 IVPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTenyaADKLIP--SL 79
Cdd:PRK11565 14 VMPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLWN----DDHKRPreAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 80 KDSLIKLRTDAVNLTLIHWPAPALGVDIpELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENiATNQIELSPYL 159
Cdd:PRK11565 90 EESLKKLQLDYVDLYLMHWPVPAIDHYV-EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP-VINQIELHPLM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 160 QNQKLVNYLQTNNIDATSYMTLAYG--KVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEI 237
Cdd:PRK11565 168 QQRQLHAWNATHKIQTESWSPLAQGgkGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDF 247
|
250
....*....|....*...
gi 2072553571 238 HLTPEQMQAITTLDRNAR 255
Cdd:PRK11565 248 RLDKDELGEIAKLDQGKR 265
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
4-251 |
2.39e-59 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 189.54 E-value: 2.39e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKDSL 83
Cdd:cd19127 10 PALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYDKALRGFDASL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 84 IKLRTDAVNLTLIHWPAPAL---GVDIPELMGHLLEAKKqglTEHIGVSNFNIELTQQAIDHIGLENiATNQIELSPYLQ 160
Cdd:cd19127 90 RRLGLDYVDLYLLHWPVPNDfdrTIQAYKALEKLLAEGR---VRAIGVSNFTPEHLERLIDATTVVP-AVNQVELHPYFS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 NQKLVNYLQTNNIDATSYMTL------------AYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHL 228
Cdd:cd19127 166 QKDLRAFHRRLGIVTQAWSPIggvmrygasgptGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERI 245
|
250 260
....*....|....*....|...
gi 2072553571 229 ISNLKAQEIHLTPEQMQAITTLD 251
Cdd:cd19127 246 AENIDIFDFALSAEDMAAIDALD 268
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
3-255 |
3.53e-59 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 189.48 E-value: 3.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQAL----HESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19125 11 IPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALkklfEDGVVKREDLFITSKLWCTDHAPEDVPPA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPA----------PA--LGVDIPEL---MGHLLEAkkqGLTEHIGVSNFNIELTQqaiDHI 143
Cdd:cd19125 91 LEKTLKDLQLDYLDLYLIHWPVrlkkgahmpePEevLPPDIPSTwkaMEKLVDS---GKVRAIGVSNFSVKKLE---DLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 GLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSY-------MTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQK 214
Cdd:cd19125 165 AVARVppAVNQVECHPGWQQDKLHEFCKSKGIHLSAYsplgspgTTWVKKNVLKDPIVTKVAEKLGKTPAQVALRWGLQR 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2072553571 215 GYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19125 245 GTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRR 285
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
1-249 |
6.38e-59 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 188.21 E-value: 6.38e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 1 MIVPQFGVGT------FRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADK 74
Cdd:cd19120 4 IPAIAFGTGTawyksgDDDIQRDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSPGIKDPRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 75 lipSLKDSLIKLRTDAVNLTLIHWP--APALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHiGLENIATNQ 152
Cdd:cd19120 84 ---ALRKSLAKLGVDYVDLYLIHSPffAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDT-AKIKPAVNQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 153 IELSPYLQNQ--KLVNYLQTNNIDATSYMTL------AYGKVlqDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTK 224
Cdd:cd19120 160 IEFHPYLYPQqpALLEYCREHGIVVSAYSPLspltrdAGGPL--DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSK 237
|
250 260
....*....|....*....|....*
gi 2072553571 225 REHLISNLKAQEIHLTPEQMQAITT 249
Cdd:cd19120 238 EERMKEYLEAFDFELTEEEVEEIDK 262
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
3-255 |
3.39e-58 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 186.57 E-value: 3.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRL-AGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIWTENYAADKLIPSLKD 81
Cdd:cd19156 9 MPRLGLGVWRVqDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYESTLAAFEE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAKKqglTEHIGVSNFNIELTQQAIDHIGLENIaTNQIELSPYLQN 161
Cdd:cd19156 89 SLEKLGLDYVDLYLIHWPVKGKFKDTWKAFEKLYKEKK---VRAIGVSNFHEHHLEELLKSCKVAPM-VNQIELHPLLTQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 QKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTP 241
Cdd:cd19156 165 EPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTA 244
|
250
....*....|....
gi 2072553571 242 EQMQAITTLDRNAR 255
Cdd:cd19156 245 EEIRQIDGLNTDHR 258
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
3-255 |
9.52e-57 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 183.47 E-value: 9.52e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQA----LHESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19111 4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEAlkwwLKNGKLKREEVFITTKLPPVYLEFKDTEKS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPA-----------PALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIdHIGLEN 147
Cdd:cd19111 84 LEKSLENLKLPYVDLYLIHHPCgfvnkkdkgerELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKIL-AYAKVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 148 IATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL-AYGKV-----------LQDPTLLNIAAEHQVTSAQIALAWALQKG 215
Cdd:cd19111 163 PSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLgSPGRAnqslwpdqpdlLEDPTVLAIAKELDKTPAQVLLRFVLQRG 242
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2072553571 216 YAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19111 243 TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMK 282
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
3-247 |
5.19e-56 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 180.46 E-value: 5.19e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---------ETVIHSVKTALEVGYRAVDTAQIYA---NEAEVGQALHEsqVNRADIFLTTKIWTENY 70
Cdd:cd19137 4 IPALGLGTWGIGGfltpdysrdEEMVELLKTAIELGYTHIDTAEMYGgghTEELVGKAIKD--FPREDLFIVTKVWPTNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADKLIPSLKDSLIKLRTDAVNLTLIHWPAPALGVDipELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGlENIAT 150
Cdd:cd19137 82 RYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLE--ETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQ-TPIVC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 NQIELSPY---LQNQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYAV-IPSSTKRE 226
Cdd:cd19137 159 NQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKPNVVaIPKAGRVE 238
|
250 260
....*....|....*....|.
gi 2072553571 227 HLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19137 239 HLKENLKATEIKLSEEEMKLL 259
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
3-250 |
7.06e-56 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 181.07 E-value: 7.06e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQ-----VNRADIFLTTKIWTENYAADKLIP 77
Cdd:cd19118 7 IPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLkeepgVKREDLFITSKLWNNSHRPEYVEP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 78 SLKDSLIKLRTDAVNLTLIHWPA-----------PALGVDIPELM-----------GHLLEAKKQGLTEHIGVSNFNIEL 135
Cdd:cd19118 87 ALDDTLKELGLDYLDLYLIHWPVafkptgdlnplTAVPTNGGEVDldlsvslvdtwKAMVELKKTGKVKSIGVSNFSIDH 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 136 TQQAIDHIGlENIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL---AYGK--VLQDPTLLNIAAEHQVTSAQIALAW 210
Cdd:cd19118 167 LQAIIEETG-VVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnLAGLplLVQHPEVKAIAAKLGKTPAQVLIAW 245
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2072553571 211 ALQKGYAVIPSSTKREHLISNLkaQEIHLTPEQMQAITTL 250
Cdd:cd19118 246 GIQRGHSVIPKSVTPSRIRSNF--EQVELSDDEFNAVTAL 283
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
4-259 |
2.04e-55 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 180.27 E-value: 2.04e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHES-----QVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19106 8 PLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKvgpgkAVPREDLFVTSKLWNTKHHPEDVEPA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAPALGVDIP-----------------ELMGHLLEAKKQGLTEHIGVSNFNielTQQAID 141
Cdd:cd19106 88 LRKTLKDLQLDYLDLYLIHWPYAFERGDNPfpknpdgtirydsthykETWKAMEKLVDKGLVKAIGLSNFN---SRQIDD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 142 HIGLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL-----AYGK-----VLQDPTLLNIAAEHQVTSAQIALA 209
Cdd:cd19106 165 ILSVARIkpAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLgspdrPWAKpdepvLLEEPKVKALAKKYNKSPAQILLR 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2072553571 210 WALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREVNP 259
Cdd:cd19106 245 WQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVP 294
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
3-260 |
2.92e-55 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 179.99 E-value: 2.92e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHES----QVNRADIFLTTKIWTENYAadKLIPS 78
Cdd:cd19112 11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAfktgLVKREDLFITTKLWNSDHG--HVIEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAP-----------ALG--------VDIP-----ELMGHLLEAkkqGLTEHIGVSNFNIE 134
Cdd:cd19112 89 CKDSLKKLQLDYLDLYLVHFPVAtkhtgvgttgsALGedgvldidVTISlettwHAMEKLVSA---GLVRSIGISNYDIF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 135 LTQqaiDHIGLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLA--------YGKV--LQDPTLLNIAAEHQVT 202
Cdd:cd19112 166 LTR---DCLAYSKIkpAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGgaaanaewFGSVspLDDPVLKDLAKKYGKS 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2072553571 203 SAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREVNPP 260
Cdd:cd19112 243 AAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRTNQPA 300
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
3-250 |
4.30e-54 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 176.53 E-value: 4.30e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQVNRADIFLTTKIW-TENYAADKlipSLKD 81
Cdd:cd19117 14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLWcTWHRRVEE---ALDQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAP--------------ALGVDIP--------ELMGHLLeakKQGLTEHIGVSNFNIELTQQA 139
Cdd:cd19117 91 SLKKLGLDYVDLYLMHWPVPldpdgndflfkkddGTKDHEPdwdfiktwELMQKLP---ATGKVKAIGVSNFSIKNLEKL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 140 IDHIGLENI-ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL--AYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGY 216
Cdd:cd19117 168 LASPSAKIVpAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLgsTNAPLLKEPVIIKIAKKHGKTPAQVIISWGLQRGY 247
|
250 260 270
....*....|....*....|....*....|....
gi 2072553571 217 AVIPSSTKREHLISNLKAqeIHLTPEQMQAITTL 250
Cdd:cd19117 248 SVLPKSVTPSRIESNFKL--FTLSDEEFKEIDEL 279
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
7-251 |
3.42e-52 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 171.73 E-value: 3.42e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 7 GVGTFRLAG-------ETVIHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHESQVNRADIFLTTKI------WTENY 70
Cdd:pfam00248 2 GLGTWQLGGgwgpiskEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLEnIAT 150
Cdd:pfam00248 82 SKENIRKSLEESLKRLGTDYIDLYYLHWPDPD--TPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIP-IVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 NQIELSPY--LQNQKLVNYLQTNNIDATSYMTLAYG----KVLQDP-----------------------TLLNIAAEHQV 201
Cdd:pfam00248 159 VQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGlltgKYTRDPdkgpgerrrllkkgtplnlealeALEEIAKEHGV 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 202 TSAQIALAWALQ--KGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLD 251
Cdd:pfam00248 239 SPAQVALRWALSkpGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
1-250 |
1.18e-51 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 170.14 E-value: 1.18e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 1 MIVPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQ-----VNRADIFLTTKIWTENYAADKL 75
Cdd:cd19124 5 MPVIGMGTASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALrlglvKSRDELFVTSKLWCSDAHPDLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 76 IPSLKDSLIKLRTDAVNLTLIHWPAPA--------------LGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAID 141
Cdd:cd19124 85 LPALKKSLRNLQLEYVDLYLIHWPVSLkpgkfsfpieeedfLPFDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQELLS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 142 HiglENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL-AYGK------VLQDPTLLNIAAEHQVTSAQIALAWAL 212
Cdd:cd19124 165 F---ATIppAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLgAPGTkwgsnaVMESDVLKEIAAAKGKTVAQVSLRWVY 241
|
250 260 270
....*....|....*....|....*....|....*...
gi 2072553571 213 QKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19124 242 EQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
4-250 |
1.22e-50 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 167.31 E-value: 1.22e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHE----SQVNRADIFLTTKIWTENYAADKLIPSL 79
Cdd:cd19128 2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEifkdGGVKREDLFITSKLWPTMHQPENVKEQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 80 KDSLIKLRTDAVNLTLIHWP---------APALGVDIPELMGHLLE--------AKKQGLTEHIGVSNFNIELTQQAIDH 142
Cdd:cd19128 82 LITLQDLQLEYLDLFLIHWPlafdmdtdgDPRDDNQIQSLSKKPLEdtwrameqCVDEKLTKNIGVSNYSTKLLTDLLNY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 143 IGLENIaTNQIELSPYLQNQKLVNYLQTNNIDATSYMTL----AYGK--VLQDPTLLNIAAEHQVTSAQIALAWALQK-- 214
Cdd:cd19128 162 CKIKPF-MNQIECHPYFQNDKLIKFCIENNIHVTAYRPLggsyGDGNltFLNDSELKALATKYNTTPPQVIIAWHLQKwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 2072553571 215 -GYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19128 241 kNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
3-255 |
1.31e-49 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 165.48 E-value: 1.31e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFrlAGETVIHS-----VKTALEVGYRAVDTAQIYANEAEVGQALHES----QVNRADIFLTTKIWTENYAAD 73
Cdd:cd19108 11 IPVLGFGTY--APEEVPKSkaleaTKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKiadgTVKREDIFYTSKLWCTFHRPE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 74 KLIPSLKDSLIKLRTDAVNLTLIHWPAPALG-----------------VDIPELMGHLLEAKKQGLTEHIGVSNFNielt 136
Cdd:cd19108 89 LVRPALEKSLKKLQLDYVDLYLIHFPVALKPgeelfpkdengklifdtVDLCATWEAMEKCKDAGLAKSIGVSNFN---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 137 qqaidHIGLENI----------ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYGK-----------VLQDPTLLNI 195
Cdd:cd19108 165 -----RRQLEMIlnkpglkykpVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRdkewvdqnspvLLEDPVLCAL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 196 AAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19108 240 AKKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
3-247 |
7.63e-49 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 162.42 E-value: 7.63e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLaGE------TVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHESqvnRADIFLTTKIWTENYAAD 73
Cdd:cd19138 11 VPALGQGTWYM-GEdpakraQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSKVLPSNASRQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 74 KLIPSLKDSLIKLRTDAVNLTLIHWPApalGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENIATNQI 153
Cdd:cd19138 87 GTVRACERSLRRLGTDYLDLYLLHWRG---GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNCAANQV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 154 ELSpyLQNQ----KLVNYLQTNNIDATSYMTLAYG-----KVLQDPTLLNIAAEHQVTSAQIALAWAL-QKGYAVIPSST 223
Cdd:cd19138 164 LYN--LGSRgieyDLLPWCREHGVPVMAYSPLAQGgllrrGLLENPTLKEIAARHGATPAQVALAWVLrDGNVIAIPKSG 241
|
250 260
....*....|....*....|....
gi 2072553571 224 KREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19138 242 SPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
3-267 |
1.07e-48 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 163.39 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQ----ALHESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19113 11 MPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEgvnrAIDEGLVKREELFLTSKLWNNFHDPKNVETA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWP------------APAL-----------GVDIPELMGHLLEAKKQGLTEHIGVSNFNIEL 135
Cdd:cd19113 91 LNKTLSDLKLDYVDLFLIHFPiafkfvpieekyPPGFycgdgdnfvyeDVPILDTWKALEKLVDAGKIKSIGVSNFPGAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 136 TQQAIDHIGLENIATnQIELSPYLQNQKLVNYLQTNNIDATSY--------MTLAYGKVLQDPTLL------NIAAEHQV 201
Cdd:cd19113 171 ILDLLRGATIKPAVL-QIEHHPYLQQPKLIEYAQKAGITITAYssfgpqsfVELNQGRALNTPTLFehdtikSIAAKHNK 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2072553571 202 TSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREVNPpelapvWD 267
Cdd:cd19113 250 TPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFNDP------WD 309
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
3-255 |
2.88e-48 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 162.20 E-value: 2.88e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALH----ESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19107 4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQekikEQVVKREDLFIVSKLWCTFHEKGLVKGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWP-----------APALGVDIP---------ELMGHLLEakkQGLTEHIGVSNFNIELTQQ 138
Cdd:cd19107 84 CQKTLSDLKLDYLDLYLIHWPtgfkpgkelfpLDESGNVIPsdttfldtwEAMEELVD---EGLVKAIGVSNFNHLQIER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 139 AIDHIGLE-NIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLA-----YGK-----VLQDPTLLNIAAEHQVTSAQIA 207
Cdd:cd19107 161 ILNKPGLKyKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGspdrpWAKpedpsLLEDPKIKEIAAKHNKTTAQVL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2072553571 208 LAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19107 241 IRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWR 288
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
4-260 |
2.86e-47 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 159.51 E-value: 2.86e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQ----ALHESQVNRADIFLTTKIWTENYAADKLIPSL 79
Cdd:cd19115 14 PLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQgvarAIKEGIVKREDLFIVSKLWNTFHDGERVEPIC 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 80 KDSLIKLRTDAVNLTLIHWPAPALGVD----------------------IPELMGHLLEAKKQGLTEHIGVSNFNIELTq 137
Cdd:cd19115 94 RKQLADWGIDYFDLFLIHFPIALKYVDpavryppgwfydgkkvefsnapIQETWTAMEKLVDKGLARSIGVSNFSAQLL- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 138 qaIDHIGLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL--------------AYGKVLQDPTLLNIAAEHQV 201
Cdd:cd19115 173 --MDLLRYARIrpATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFgpqsfleldlpgakDTPPLFEHDVIKSIAEKHGK 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2072553571 202 TSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREVNPP 260
Cdd:cd19115 251 TPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFNNPL 309
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
3-257 |
1.28e-46 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 158.04 E-value: 1.28e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVI----HSVKTALEVGYRAVDTAQIYANEAEVGQALHES----QVNRADIFLTTKIWTENYAADK 74
Cdd:cd19109 4 IPIIGLGTYSEPKTTPKgacaEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKiaegKVKREDIFYCGKLWNTCHPPEL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 75 LIPSLKDSLIKLRTDAVNLTLIHWP-APALGVDI-------------PELMG--HLLEA-KKQGLTEHIGVSNFNIELTQ 137
Cdd:cd19109 84 VRPTLERTLKVLQLDYVDLYIIEMPmAFKPGDEIyprdengkwlyhkTNLCAtwEALEAcKDAGLVKSIGVSNFNRRQLE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 138 QAIDHIGLE-NIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYGK-----------VLQDPTLLNIAAEHQVTSAQ 205
Cdd:cd19109 164 LILNKPGLKhKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRdpiwvnvssppLLEDPLLNSIGKKYNKTAAQ 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 206 IALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREV 257
Cdd:cd19109 244 VVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYV 295
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
3-255 |
1.59e-46 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 157.43 E-value: 1.59e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALH----ESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19110 4 IPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIRekikEGVVRREDLFIVSKLWCTCHKKSLVKTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPA------PALGVD-----IPELMGHL--LEAKK----QGLTEHIGVSNFNIELTQQAID 141
Cdd:cd19110 84 CTRSLKALKLNYLDLYLIHWPMgfkpgePDLPLDrsgmvIPSDTDFLdtWEAMEdlviEGLVKNIGVSNFNHEQLERLLN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 142 HIGLE-NIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYG----KVLQDPTLLNIAAEHQVTSAQIALAWALQKGY 216
Cdd:cd19110 164 KPGLRvKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGScegvDLIDDPVIQRIAKKHGKSPAQILIRFQIQRNV 243
|
250 260 270
....*....|....*....|....*....|....*....
gi 2072553571 217 AVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19110 244 IVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLR 282
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
3-255 |
4.13e-46 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 156.53 E-value: 4.13e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHE----SQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19155 12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKwidsGKVKREELFIVTKLPPGGNRREKVEKF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAPALG-------------------VDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQA 139
Cdd:cd19155 92 LLKSLEKLQLDYVDLYLIHFPVGSLSkeddsgkldptgehkqdytTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 140 IDHIGLENiATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL-----------------AYGKVLQDPTLLNIAAEHQVT 202
Cdd:cd19155 172 LKNARIKP-ANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLgspgaahfspgtgspsgSSPDLLQDPVVKAIAERHGKS 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2072553571 203 SAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAR 255
Cdd:cd19155 251 PAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
3-260 |
4.31e-44 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 151.48 E-value: 4.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG-------ETVIHSVKTALEVGYRAVDTAQIYAN-EAE--VGQALHEsqVNRADIFLTTKI------- 65
Cdd:COG0667 13 VSRLGLGTMTFGGpwggvdeAEAIAILDAALDAGINFFDTADVYGPgRSEelLGEALKG--RPRDDVVIATKVgrrmgpg 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 -WTENYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHI- 143
Cdd:COG0667 91 pNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPD--TPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAe 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 GLENIATNQIELSpyLQNQK----LVNYLQTNNIDATSYMTLAYG----KVLQDPT------------------------ 191
Cdd:COG0667 169 GLPPIVAVQNEYS--LLDRSaeeeLLPAARELGVGVLAYSPLAGGlltgKYRRGATfpegdraatnfvqgylternlalv 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2072553571 192 --LLNIAAEHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAIttlDRNAREVNPP 260
Cdd:COG0667 247 daLRAIAAEHGVTPAQLALAWLLAQPGvtSVIPGARSPEQLEENLAAADLELSAEDLAAL---DAALAAVPAP 316
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
3-262 |
6.27e-44 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 150.79 E-value: 6.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVG----QALHESQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19114 4 MPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGrgirKAIQEGLVKREDLFIVTKLWNNFHGKDHVREA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWPAPALGVD----------IPELMGHLLEAK-------------KQGLTEHIGVSNFNIEL 135
Cdd:cd19114 84 FDRQLKDYGLDYIDLYLIHFPIPAAYVDpaenypflwkDKELKKFPLEQSpmqecwremeklvDAGLVRNIGIANFNVQL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 136 TqqaIDHIGLENI--ATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLA-------------YGKVLQDPTLLNIAAEHQ 200
Cdd:cd19114 164 I---LDLLTYAKIkpAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGnavytkvtkhlkhFTNLLEHPVVKKLADKHK 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 201 VTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAReVNPPEL 262
Cdd:cd19114 241 RDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANAR-FNDPVV 301
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
3-247 |
8.91e-43 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 146.91 E-value: 8.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHESQ---VNRADIFLTTKIWTENYaaDKLIPSL 79
Cdd:cd19121 12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIaggVKREDLFVTTKLWSTYH--RRVELCL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 80 KDSLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAK--------------------KQGLTEHIGVSNFNIELTQQA 139
Cdd:cd19121 90 DRSLKSLGLDYVDLYLVHWPVLLNPNGNHDLFPTLPDGSrdldwdwnhvdtwkqmekvlKTGKTKAIGVSNYSIPYLEEL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 140 IDHiGLENIATNQIELSPYLQNQKLVNYLQTNNIDATSYMTL--AYGKVLQDPTLLNIAAEHQVTSAQIALAWALQKGYA 217
Cdd:cd19121 170 LKH-ATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLgsTGSPLISDEPVVEIAKKHNVGPGTVLISYQVARGAV 248
|
250 260 270
....*....|....*....|....*....|
gi 2072553571 218 VIPSSTKREHLISNLkaQEIHLTPEQMQAI 247
Cdd:cd19121 249 VLPKSVTPDRIKSNL--EIIDLDDEDMNKL 276
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
3-249 |
5.08e-42 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 145.42 E-value: 5.08e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---------ETVIHSVKTALEVGYRAVDTAQIYAN-EAE--VGQALhesQVNRADIFLTTKIWTENY 70
Cdd:cd19085 1 VSRLGLGCWQFGGgywwgdqddEESIATIHAALDAGINFFDTAEAYGDgHSEevLGKAL---KGRRDDVVIATKVSPDNL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADKLIPSLKDSLIKLRTDAVNLTLIHWPAPalGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIgleNIAT 150
Cdd:cd19085 78 TPEDVRKSCERSLKRLGTDYIDLYQIHWPSS--DVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAG---RIDS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 NQIELSPYLQN--QKLVNYLQTNNIDATSYMTLA-------YGKVLQDPT-------------------------LLNIA 196
Cdd:cd19085 153 NQLPYNLLWRAieYEILPFCREHGIGVLAYSPLAqglltgkFSSAEDFPPgdartrlfrhfepgaeeetfealekLKEIA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2072553571 197 AEHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAITT 249
Cdd:cd19085 233 DELGVTMAQLALAWVLQQPGvtSVIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
3-247 |
9.54e-41 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 141.99 E-value: 9.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFR---LAGETViHSVKTALEVGYRAVDTAQIYANEAEVGQALHE-----SQVNRADIFLTTKIWTENYAADK 74
Cdd:cd19122 9 IPAVGFGTFAnegAKGETY-AAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDflkenPSVKREDLFICTKVWNHLHEPED 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 75 LIPSLKDSLIKLRTDAVNLTLIHWP---------APALGVD-----------IPELMGHLLEA-KKQGLTEHIGVSNFNI 133
Cdd:cd19122 88 VKWSIDNSLKNLKLDYIDLFLVHWPiaaekndqrSPKLGPDgkyvilkdlteNPEPTWRAMEEiYESGKAKAIGVSNWTI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 134 ELTQQAIDHIGLENiATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYG--------KVLQDPTLLNIAAEHQVTSAQ 205
Cdd:cd19122 168 PGLKKLLSFAKVKP-HVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQnqvpstgeRVSENPTLNEVAEKGGYSLAQ 246
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2072553571 206 IALAWALQKGYAVIPSSTKREHLISNLKAqeIHLTPEQMQAI 247
Cdd:cd19122 247 VLIAWGLRRGYVVLPKSSTPSRIESNFKS--IELSDEDFEAI 286
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
3-247 |
1.38e-38 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 136.43 E-value: 1.38e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALHE----SQVNRADIFLTTKIWTENYAADKLIPS 78
Cdd:cd19129 6 IPALGFGTLIPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRPERVKPA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIHWP---APA---------------LGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAI 140
Cdd:cd19129 86 FEASLKRLQLDYLDLYLIHTPfafQPGdeqdprdangnviydDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 141 DHIGLENiATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYG---KVLQDPTLLNIAAEHQVTSAQIALAWALQKGYA 217
Cdd:cd19129 166 EAARIKP-AVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGmepKLLEDPVITAIARRVNKTPAQVLLAWAIQRGTA 244
|
250 260 270
....*....|....*....|....*....|.
gi 2072553571 218 VIPSSTKREHLISNLkaqEIHLTPEQ-MQAI 247
Cdd:cd19129 245 LLTTSKTPSRIRENF---DISTLPEDaMREI 272
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
3-252 |
1.23e-36 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 131.47 E-value: 1.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTF--RLAGETVIHSVKTALEVGYRAVDTAQIYANEAEVGQALH----ESQVNRADIFLTTKIWTENYaaDKLI 76
Cdd:cd19119 12 IPALGLGTAspHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKraidDGSIKREELFITTKVWPTFY--DEVE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 77 PSLKDSLIKLRTDAVNLTLIHWPAP-----------------------ALGVDIPELMGHLLEAKKQGLTEHIGVSNFNI 133
Cdd:cd19119 90 RSLDESLKALGLDYVDLLLVHWPVCfekdsddsgkpftpvnddgktryAASGDHITTYKQLEKIYLDGRAKAIGVSNYSI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 134 ELTQQAIDHIGLENiATNQIELSPYLQNQKLVNYLQTNNIDATSYMTLAYGK--VLQDPTLLNIAAEHQVTSAQIALAWA 211
Cdd:cd19119 170 VYLERLIKECKVVP-AVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGapNLKNPLVKKIAEKYNVSTGDILISYH 248
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2072553571 212 LQKGYAVIPSSTKREHLISNLKAqeIHLTPEQMQAITTLDR 252
Cdd:cd19119 249 VRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
3-247 |
1.40e-35 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 128.80 E-value: 1.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG--------ETVIHSVKTALEVGYRAVDTAQIYAN-EAE--VGQALhesQVNRADIFLTTK---IWTE 68
Cdd:cd19084 4 VSRIGLGTWAIGGtwwgevddQESIEAIKAAIDLGINFFDTAPVYGFgHSEeiLGKAL---KGRRDDVVIATKcglRWDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 69 NYA------ADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDH 142
Cdd:cd19084 81 GKGvtkdlsPESIRKEVEQSLRRLQTDYIDLYQIHWPDPN--TPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 143 IgleNIATNQIELSPYLQN--QKLVNYLQTNNIDATSYMTLAYG----KVLQDPT------------------------- 191
Cdd:cd19084 159 G---PIVSLQPPYSMLEREieEELLPYCRENGIGVLPYGPLAQGlltgKYKKEPTfppddrrsrfpffrgenfeknleiv 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 192 --LLNIAAEHQVTSAQIALAWALQK--GYAVIPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19084 236 dkLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
4-233 |
1.91e-35 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 126.48 E-value: 1.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAG----ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHESQvNRADIFLTTKI--------WTE 68
Cdd:cd06660 1 SRLGLGTMTFGGdgdeEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLKGRG-NRDDVVIATKGghppggdpSRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 69 NYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDH---IGL 145
Cdd:cd06660 80 RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPS--TPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYakaHGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 146 ENIATNQIELS---PYLQNQKLVNYLQTNNIDATSYMTLAYGkvlqdptllniaaehqvtSAQIALAWALQKGY--AVIP 220
Cdd:cd06660 158 PGFAAVQPQYSlldRSPMEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSQPFvtVPIV 219
|
250
....*....|...
gi 2072553571 221 SSTKREHLISNLK 233
Cdd:cd06660 220 GARSPEQLEENLA 232
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
3-240 |
3.86e-34 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 123.87 E-value: 3.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG----------ETVIHSVKTALEVGYRAVDTAQIYA---NEAEVGQALHESqvnRADIFLTTKI---- 65
Cdd:cd19088 1 VSRLGYGAMRLTGpgiwgppadrEEAIAVLRRALELGVNFIDTADSYGpdvNERLIAEALHPY---PDDVVIATKGglvr 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 -----WTENYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPalGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAI 140
Cdd:cd19088 78 tgpgwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDP--KVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEAR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 141 DHIGlenIATNQIELSP-YLQNQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLL-NIAAEHQVTSAQIALAWALQKG--Y 216
Cdd:cd19088 156 AIVR---IVSVQNRYNLaNRDDEGVLDYCEAAGIAFIPWFPLGGGDLAQPGGLLaEVAARLGATPAQVALAWLLARSpvM 232
|
250 260
....*....|....*....|....
gi 2072553571 217 AVIPSSTKREHLISNLKAQEIHLT 240
Cdd:cd19088 233 LPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
3-243 |
1.42e-33 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 123.05 E-value: 1.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG-----ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHESQVNRADIFLTTK---------- 64
Cdd:cd19092 6 VSRLVLGCMRLADwgesaEELLSLIEAALELGITTFDHADIYGGgkcEELFGEALALNPGLREKIEIQTKcgirlgddpr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 65 -IWTENY--AADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFN---IELTQQ 138
Cdd:cd19092 86 pGRIKHYdtSKEHILASVEGSLKRLGTDYLDLLLLHRPDPL--MDPEEVAEAFDELVKSGKVRYFGVSNFTpsqIELLQS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 139 AIDhiglENIATNQIELSPY---LQNQKLVNYLQTNNIDATSYMTLAYGKVL--QDP-------TLLNIAAEHQVTSAQI 206
Cdd:cd19092 164 YLD----QPLVTNQIELSLLhteAIDDGTLDYCQLLDITPMAWSPLGGGRLFggFDErfqrlraALEELAEEYGVTIEAI 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 2072553571 207 ALAWALQKGYAVIP--SSTKREHLISNLKAQEIHLTPEQ 243
Cdd:cd19092 240 ALAWLLRHPARIQPilGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
3-247 |
4.66e-32 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 119.25 E-value: 4.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTF-----------RLAGETVIHSVKTALEVGYRAVDTAQIYAN-EAE--VGQALHESQvNRADIFLTTKI--- 65
Cdd:cd19093 2 VSPLGLGTWqwgdrlwwgygEYGDEDLQAAFDAALEAGVNLFDTAEVYGTgRSErlLGRFLKELG-DRDEVVIATKFapl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 -WTENyaADKLIPSLKDSLIKLRTDAVNLTLIHWPAPALGvDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHI- 143
Cdd:cd19093 81 pWRLT--RRSVVKALKASLERLGLDSIDLYQLHWPGPWYS-QIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKALk 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 --GLEnIATNQIE---LSPYLQNQKLVNYLQTNNIDATSYMTLAYG-----------------------KVLQDPTLLN- 194
Cdd:cd19093 158 erGVP-LASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAQGlltgkyspenpppggrrrlfgrkNLEKVQPLLDa 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2072553571 195 ---IAAEHQVTSAQIALAWALQKGYAVIPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19093 237 leeIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAEL 292
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
3-243 |
9.84e-32 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 118.72 E-value: 9.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG-----ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHESQVNRADIFLTTK--IWTE---- 68
Cdd:COG4989 13 VSRIVLGCMRLGEwdlspAEAAALIEAALELGITTFDHADIYGGytcEALFGEALKLSPSLREKIELQTKcgIRLPsear 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 69 -------NYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPaLgVDIPELMGHLLEAKKQGLTEHIGVSNFN---IELTQQ 138
Cdd:COG4989 93 dnrvkhyDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDP-L-MDPEEVAEAFDELKASGKVRHFGVSNFTpsqFELLQS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 139 AIDHigleNIATNQIELSPyLQNQKL----VNYLQTNNIDATSYMTLAYGKVL--QDP-------TLLNIAAEHQVTSAQ 205
Cdd:COG4989 171 ALDQ----PLVTNQIELSL-LHTDAFddgtLDYCQLNGITPMAWSPLAGGRLFggFDEqfprlraALDELAEKYGVSPEA 245
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2072553571 206 IALAWALQKGYAVIP--SSTKREHLISNLKAQEIHLTPEQ 243
Cdd:COG4989 246 IALAWLLRHPAGIQPviGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
16-250 |
8.15e-27 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 105.58 E-value: 8.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIYA---NEAEVGQALHESqvNRADIFLTTKIWTENYAADKLI--------PSLKDSLI 84
Cdd:cd19083 33 EEGKDLVREALDNGVNLLDTAFIYGlgrSEELVGEVLKEY--NRNEVVIATKGAHKFGGDGSVLnnspeflrSAVEKSLK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 85 KLRTDAVNLTLIHWPAPALGVDipELMGHLLEAKKQGLTEHIGVSNFNIELTQQAiDHIGLENIATNQIELSPYLQNQKL 164
Cdd:cd19083 111 RLNTDYIDLYYIHFPDGETPKA--EAVGALQELKDEGKIRAIGVSNFSLEQLKEA-NKDGYVDVLQGEYNLLQREAEEDI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 165 VNYLQTNNIDATSYMTLAY----GKVLQDPT---------------------------LLNIAAEHQVTSAQIALAWALQ 213
Cdd:cd19083 188 LPYCVENNISFIPYFPLASgllaGKYTKDTKfpdndlrndkplfkgerfsenldkvdkLKSIADEKGVTVAHLALAWYLT 267
|
250 260 270
....*....|....*....|....*....|....*....
gi 2072553571 214 KGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19083 268 RPAidVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
18-250 |
2.20e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 104.29 E-value: 2.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 18 VIHSVKTALEVGYRAVDTAQIYA---NEAEVGQALHESqvnRADIFLTTK---IWTEN------YAADKLIPSLKDSLIK 85
Cdd:cd19102 28 SIAAIRAALDLGINWIDTAAVYGlghSEEVVGRALKGL---RDRPIVATKcglLWDEEgrirrsLKPASIRAECEASLRR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 86 LRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQ--QAIDHiglenIATNQIELSPYLQN-- 161
Cdd:cd19102 105 LGVDVIDLYQIHWPDPD--EPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKrcQAIHP-----IASLQPPYSLLRRGie 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 QKLVNYLQTNNIDATSYMTLAYG-----------------------KVLQDP----------TLLNIAAEHQVTSAQIAL 208
Cdd:cd19102 178 AEILPFCAEHGIGVIVYSPMQSGlltgkmtpervaslpaddwrrrsPFFQEPnlarnlalvdALRPIAERHGRTVAQLAI 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2072553571 209 AWALQKG--YAVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19102 258 AWVLRRPevTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
4-234 |
3.46e-22 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 92.30 E-value: 3.46e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAGETVIHSVK-------TALEVGYRAVDTAQIYAN-EAEVGQALheSQVNRADIFLTTKIWTEN------ 69
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPSEAeaarllnTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGTHGeggrdr 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 70 --YAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELtqqaIDHIGLEN 147
Cdd:cd19095 79 kdFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDD--ELTGEVLETLEDLKAAGKVRYIGVSGDGEEL----EAAIASGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 148 IATNQIELSPYLQNQK-LVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEH-----------QVTSAQIALAWALQKG 215
Cdd:cd19095 153 FDVVQLPYNVLDREEEeLLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYarrpefaaeigGATWAQAALRFVLSHP 232
|
250 260
....*....|....*....|.
gi 2072553571 216 Y--AVIPSSTKREHLISNLKA 234
Cdd:cd19095 233 GvsSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
27-248 |
8.60e-22 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 92.28 E-value: 8.60e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 27 EVGYRAVDTAQIYAN----------EAEVGQALhESQVNRADIFLTTKIWTENYAADK------LIPSLKDSLIKLRTDA 90
Cdd:cd19081 37 DAGGNFIDTADVYSAwvpgnaggesETIIGRWL-KSRGKRDRVVIATKVGFPMGPNGPglsrkhIRRAVEASLRRLQTDY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 91 VNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDhigleniATNQIELSPYLQNQKLVNYL-- 168
Cdd:cd19081 116 IDLYQAHWDDPA--TPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALE-------LSRQHGLPRYVSLQPEYNLVdr 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 169 -----------QTNNIDATSYMTLAYG-------------------------------KVLQdpTLLNIAAEHQVTSAQI 206
Cdd:cd19081 187 esfegellplcREEGIGVIPYSPLAGGfltgkyrseadlpgstrrgeaakrylnerglRILD--ALDEVAAEHGATPAQV 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2072553571 207 ALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAIT 248
Cdd:cd19081 265 ALAWLLARPGvtAPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
2-250 |
4.74e-21 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 90.37 E-value: 4.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 2 IVPQFGVGTFRLAGETVIHS-------------VKTALEVGYRAVDTAQIYAN-EAEV--GQALHEsqvNRADIFLTTKI 65
Cdd:cd19091 12 KVSELALGTMTFGGGGGFFGawggvdqeeadrlVDIALDAGINFFDTADVYSEgESEEilGKALKG---RRDDVLIATKV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 --WTENYAAD------KLIPSLKDSLIKLRTDAVNLTLIHWPAPALGVDipELMGHLLEAKKQGLTEHIGVSNFN---IE 134
Cdd:cd19091 89 rgRMGEGPNDvglsrhHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLE--ETLRALDDLVRQGKVRYIGVSNFSawqIM 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 135 LTQQAIDHIGLENIATNQI-----------ELSPYLQNQK---LV------NYLQ------TNNIDATSYMTLAYGKVLQ 188
Cdd:cd19091 167 KALGISERRGLARFVALQAyysllgrdlehELMPLALDQGvglLVwsplagGLLSgkyrrgQPAPEGSRLRRTGFDFPPV 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 189 DP--------TLLNIAAEHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19091 247 DRergydvvdALREIAKETGATPAQVALAWLLSRPTvsSVIIGARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
3-234 |
1.55e-20 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 87.53 E-value: 1.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG--------ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHEsqvNRADIFLTTKI------ 65
Cdd:cd19086 3 VSEIGFGTWGLGGdwwgdvddAEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKG---RRDKVVIATKFgnrfdg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 ---WTENYAADKLIPSLKDSLIKLRTDAVNLTLIH-WPAPALgvDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAID 141
Cdd:cd19086 80 gpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLHnPPDEVL--DNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 142 HiglENIATNQIELSPYLQN--QKLVNYLQTNNIDATSYMTLAYGkvlqdptLLniaaehqvTS--AQIALAWAL-QKGY 216
Cdd:cd19086 158 R---GGIDVVQVIYNLLDQRpeEELFPLAEEHGVGVIARVPLASG-------LL--------TGklAQAALRFILsHPAV 219
|
250
....*....|....*....
gi 2072553571 217 A-VIPSSTKREHLISNLKA 234
Cdd:cd19086 220 StVIPGARSPEQVEENAAA 238
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-248 |
2.67e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 88.04 E-value: 2.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG--------ETVIHSVKTALEVGYRAVDTAQIYAN-EAEVGQALHE---SQVNRADIFLTTKiWTENY 70
Cdd:cd19101 2 ISRVINGMWQLSGghggirdeDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGEFRKRlrrERDAADDVQIHTK-WVPDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADKLIPS-----LKDSLIKLRTDAVNLTLIHWPAPALG--VDIpelMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHi 143
Cdd:cd19101 81 GELTMTRAyveaaIDRSLKRLGVDRLDLVQFHWWDYSDPgyLDA---AKHLAELQEEGKIRHLGLTNFDTERLREILDA- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 GLEnIATNQIELS-----PylqNQKLVNYLQTNNIDATSYMTLAYG---------------------------------- 184
Cdd:cd19101 157 GVP-IVSNQVQYSlldrrP---ENGMAALCEDHGIKLLAYGTLAGGllsekylgvpeptgpaletrslqkyklmidewgg 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2072553571 185 -----KVLQdpTLLNIAAEHQVTSAQIALAWALQK--GYAVIPSSTKREHLISNLKAQEIHLTPEQMQAIT 248
Cdd:cd19101 233 wdlfqELLR--TLKAIADKHGVSIANVAVRWVLDQpgVAGVIVGARNSEHIDDNVRAFSFRLDDEDRAAID 301
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-234 |
3.81e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 86.48 E-value: 3.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 6 FGVGTFRLAGETVIHsvkTALEVGYRAVDTAQIYAN---EAEVGQALheSQVNRADIFLTTKIWTENYAADK--LIPSLK 80
Cdd:cd19105 18 FGGGGLPRESPELLR---RALDLGINYFDTAEGYGNgnsEEIIGEAL--KGLRRDKVFLATKASPRLDKKDKaeLLKSVE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 81 DSLIKLRTDAVNLTLIH---WPAPALGVDipELMGHLLEAKKQGLTEHIGVS--NFNIELTQQAIDHIGLE------NIA 149
Cdd:cd19105 93 ESLKRLQTDYIDIYQLHgvdTPEERLLNE--ELLEALEKLKKEGKVRFIGFSthDNMAEVLQAAIESGWFDvimvayNFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 150 TNQIELspylqnQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHqvTSAQIALAWALQKGY--AVIPSSTKREH 227
Cdd:cd19105 171 NQPAEL------EEALAAAAEKGIGVVAMKTLAGGYLQPALLSVLKAKGF--SLPQAALKWVLSNPRvdTVVPGMRNFAE 242
|
....*..
gi 2072553571 228 LISNLKA 234
Cdd:cd19105 243 LEENLAA 249
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
22-250 |
4.32e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 87.39 E-value: 4.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIY---ANEAEVGQALheSQVNRADIFLTTKiWTENYA---ADKLIPSLKDSLIKLRTDAVNLTL 95
Cdd:cd19103 38 FDKAMAAGLNLWDTAAVYgmgASEKILGEFL--KRYPREDYIISTK-FTPQIAgqsADPVADMLEGSLARLGTDYIDIYW 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 96 IHWPApalgvDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIdhiglENIATNQIELSPyLQNQ-----------KL 164
Cdd:cd19103 115 IHNPA-----DVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRAN-----EILAKAGVSLSA-VQNHysllyrsseeaGI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 165 VNYLQTNNIDATSYMTL-----------------------AYGKVLQD-----PTLLNIAAEHQVTSAQIALAWALQKGY 216
Cdd:cd19103 184 LDYCKENGITFFAYMVLeqgalsgkydtkhplpegsgraeTYNPLLPQleeltAVMAEIGAKHGASIAQVAIAWAIAKGT 263
|
250 260 270
....*....|....*....|....*....|....
gi 2072553571 217 AVIPSSTKREHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19103 264 TPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
16-249 |
4.67e-20 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 87.29 E-value: 4.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHESqvnRADIFLTTKIWTENYAADKLIPSLK-----------D 81
Cdd:cd19078 25 EEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF---RDQVVIATKFGFKIDGGKPGPLGLDsrpehirkaveG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 82 SLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAidHiGLENIATNQIELSPYLQN 161
Cdd:cd19078 102 SLKRLQTDYIDLYYQHRVDPN--VPIEEVAGTMKELIKEGKIRHWGLSEAGVETIRRA--H-AVCPVTAVQSEYSMMWRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 --QKLVNYLQTNNIDATSYMTLAYG----KVLQDPT--------------------------LLN-IAAEHQVTSAQIAL 208
Cdd:cd19078 177 peKEVLPTLEELGIGFVPFSPLGKGfltgKIDENTKfdegddraslprftpealeanqalvdLLKeFAEEKGATPAQIAL 256
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2072553571 209 AWAL-QKGYAV-IPSSTKREHLISNLKAQEIHLTPEQMQAITT 249
Cdd:cd19078 257 AWLLaKKPWIVpIPGTTKLSRLEENIGAADIELTPEELREIED 299
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
16-247 |
8.87e-20 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 86.50 E-value: 8.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHEsqvNRADIFLTTKIWTENYAADKLIP----------SLKDS 82
Cdd:cd19076 32 EESIATLHRALELGVTFLDTADMYgpgTNEELLGKALKD---RRDEVVIATKFGIVRDPGSGFRGvdgrpeyvraACEAS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAidHiGLENIATNQIELSPYLQNQ 162
Cdd:cd19076 109 LKRLGTDVIDLYYQHRVDPN--VPIEETVGAMAELVEEGKVRYIGLSEASADTIRRA--H-AVHPITAVQSEYSLWTRDI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 163 -------------KLVNY------LQTNNIDATSYM---------------TLAYGKVLQDPtLLNIAAEHQVTSAQIAL 208
Cdd:cd19076 184 edevlptcrelgiGFVAYsplgrgFLTGAIKSPEDLpeddfrrnnprfqgeNFDKNLKLVEK-LEAIAAEKGCTPAQLAL 262
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2072553571 209 AWALQKGYAV--IPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19076 263 AWVLAQGDDIvpIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
19-247 |
1.10e-19 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 86.56 E-value: 1.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 19 IHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHEsqvNRADIFLTTK---IWTE----------------NYAADKLI 76
Cdd:cd19149 36 IRTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKG---RRDKVVLATKcglRWDReggsfffvrdgvtvykNLSPESIR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 77 PSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHiglENIATNQIE-- 154
Cdd:cd19149 113 EEVEQSLKRLGTDYIDLYQTHWQDVE--TPIEETMEALEELKRQGKIRAIGASNVSVEQIKEYVKA---GQLDIIQEKys 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 155 -LSPYLQNqKLVNYLQTNNIDATSYMTLAYG----KVLQDPT---------------------------LLNIAAEHQVT 202
Cdd:cd19149 188 mLDRGIEK-ELLPYCKKNNIAFQAYSPLEQGlltgKITPDREfdagdarsgipwfspenrekvlallekWKPLCEKYGCT 266
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2072553571 203 SAQIALAWALQKG--YAVIPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19149 267 LAQLVIAWTLAQPgiTSALCGARKPEQAEENAKAGDIRLSAEDIATM 313
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
4-142 |
8.21e-19 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 83.37 E-value: 8.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAG-------ETVIHSVKTALEVGYRAVDTAQIYAN-EAEVGQALheSQVNRADIFLTTKI-----WTENY 70
Cdd:cd19090 1 SALGLGTAGLGGvfggvddDEAVATIRAALDLGINYIDTAPAYGDsEERLGLAL--AELPREPLVLSTKVgrlpeDTADY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072553571 71 AADKLIPSLKDSLIKLRTDAVNLTLIH---WPAPALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDH 142
Cdd:cd19090 79 SADRVRRSVEESLERLGRDRIDLLMIHdpeRVPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRRAIET 153
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
3-259 |
2.70e-18 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 83.33 E-value: 2.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---ETVIHSVKTALEVGYRAVDTAQIYAN-EAEVGQALhesQVNRADIFLTTKI--WTENyaADKLI 76
Cdd:COG1453 13 VSVLGFGGMRLPRkdeEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKAL---KGPRDKVILATKLppWVRD--PEDMR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 77 PSLKDSLIKLRTDAVNLTLIHwpapalGVDIPE----------LMGHLLEAKKQGLTEHIGVSNFN-IELTQQAIDhigl 145
Cdd:COG1453 88 KDLEESLKRLQTDYIDLYLIH------GLNTEEdlekvlkpggALEALEKAKAEGKIRHIGFSTHGsLEVIKEAID---- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 146 eniaTNQIElspYLQNQklVNYLQTNNIDATSYMTLAY--------------GKVLQDPTLLNIAAEHQVTSAQIALAWA 211
Cdd:COG1453 158 ----TGDFD---FVQLQ--YNYLDQDNQAGEEALEAAAekgigviimkplkgGRLANPPEKLVELLCPPLSPAEWALRFL 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 212 LQKGYAVIPSS--TKREHLISNLKAQE--IHLTPEQMQAITTLDRNAREVNP 259
Cdd:COG1453 229 LSHPEVTTVLSgmSTPEQLDENLKTADnlEPLTEEELAILERLAEELGELLK 280
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
26-247 |
5.67e-18 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 81.50 E-value: 5.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 26 LEVGYRAVDTAQIYAN---EAEVGQALHEsqvNRADIFLTTKiWTENYAADK----------LIPSLKDSLIKLRTDAVN 92
Cdd:cd19080 41 VEAGGNFIDTANNYTNgtsERLLGEFIAG---NRDRIVLATK-YTMNRRPGDpnaggnhrknLRRSVEASLRRLQTDYID 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 93 LTLIHWP---APalgvdIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQA---IDHIGLENIATNQIELS---------- 156
Cdd:cd19080 117 LLYVHAWdftTP-----VEEVMRALDDLVRAGKVLYVGISDTPAWVVARAntlAELRGWSPFVALQIEYSllertperel 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 157 -PYLQNQKLV--------------NYLQTNNIDATSYMTLAYGKVLQDP-------TLLNIAAEHQVTSAQIALAWALQK 214
Cdd:cd19080 192 lPMARALGLGvtpwsplggglltgKYQRGEEGRAGEAKGVTVGFGKLTErnwaivdVVAAVAEELGRSAAQVALAWVRQK 271
|
250 260 270
....*....|....*....|....*....|....*
gi 2072553571 215 GYAVIPS--STKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19080 272 PGVVIPIigARTLEQLKDNLGALDLTLSPEQLARL 306
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
3-257 |
1.26e-17 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 80.40 E-value: 1.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAGETV----------IHSVKTALEVGYRAVDTAQIYA----NEAeVGQALHESqvnRADIFLTTKI--- 65
Cdd:PRK10376 17 VNRLGYGAMQLAGPGVfgppkdrdaaIAVLREAVALGVNHIDTSDFYGphvtNQL-IREALHPY---PDDLTIVTKVgar 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 ------WTENYAADKLIPSLKDSLIKLRTDA---VNLTL---IHWPAPAlgvDIPELMGHLLEAKKQGLTEHIGVSNFNI 133
Cdd:PRK10376 93 rgedgsWLPAFSPAELRRAVHDNLRNLGLDVldvVNLRLmgdGHGPAEG---SIEEPLTVLAELQRQGLVRHIGLSNVTP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 134 ELTQQAidhiglENIAT-----NQIELSpYLQNQKLVNYLQTNNIDATSYMTLAYGKVLQDPTLLNIAAEHQVTSAQIAL 208
Cdd:PRK10376 170 TQVAEA------RKIAEivcvqNHYNLA-HRADDALIDALARDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVAL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2072553571 209 AWALQKG--YAVIPSSTKREHLISNLKAQEIHLTPEQMqaiTTLDRNAREV 257
Cdd:PRK10376 243 AWLLQRSpnILLIPGTSSVAHLRENLAAAELVLSEEVL---AELDGIAREA 290
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
22-247 |
4.77e-17 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 79.17 E-value: 4.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIYAN-EAE--VGQALHEsQVNRADIFLTTKI---WTENYAADKL-----IPSLKDSLIKLRTDA 90
Cdd:cd19079 41 IKRALDLGINFFDTANVYSGgASEeiLGRALKE-FAPRDEVVIATKVyfpMGDGPNGRGLsrkhiMAEVDASLKRLGTDY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 91 VNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNF---NIELTQQAIDHIGLENIATNQI-----------ELS 156
Cdd:cd19079 120 IDLYQIHRWDYE--TPIEETLEALHDVVKSGKVRYIGASSMyawQFAKALHLAEKNGWTKFVSMQNhynllyreeerEMI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 157 PYLQNQKLV--------------NYLQTN----NIDATSYMTLAYGKVLQDPTLLN---IAAEHQVTSAQIALAWALQKG 215
Cdd:cd19079 198 PLCEEEGIGvipwsplargrlarPWGDTTerrrSTTDTAKLKYDYFTEADKEIVDRveeVAKERGVSMAQVALAWLLSKP 277
|
250 260 270
....*....|....*....|....*....|....
gi 2072553571 216 YAVIP--SSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19079 278 GVTAPivGATKLEHLEDAVAALDIKLSEEEIKYL 311
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
24-236 |
3.73e-16 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 76.44 E-value: 3.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 24 TALEVGYRAVDTAQIYAN-------EAEVGQALHESQvNRADIFLTTK--------IWTENYAADKLIPSLKDSLIKLRT 88
Cdd:cd19082 25 AFVELGGNFIDTARVYGDwvergasERVIGEWLKSRG-NRDKVVIATKgghpdledMSRSRLSPEDIRADLEESLERLGT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 89 DAVNLTLIHWPAPALGVDipELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDH---IGLENIATNQIELS------PYL 159
Cdd:cd19082 104 DYIDLYFLHRDDPSVPVG--EIVDTLNELVRAGKIRAFGASNWSTERIAEANAYakaHGLPGFAASSPQWSlarpnePPW 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 160 QNQKLV-------NYLQTNNIDATSYMTLAYG--------KVLQDPTLLN----------------IAAEHQVTSAQIAL 208
Cdd:cd19082 182 PGPTLVamdeemrAWHEENQLPVFAYSSQARGffskraagGAEDDSELRRvyyseenferlerakeLAEEKGVSPTQIAL 261
|
250 260 270
....*....|....*....|....*....|
gi 2072553571 209 AWALQKGYAVIP--SSTKREHLISNLKAQE 236
Cdd:cd19082 262 AYVLNQPFPTVPiiGPRTPEQLRDSLAAAD 291
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
12-242 |
3.88e-16 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 76.48 E-value: 3.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 12 RLAGETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALheSQVNRADIFLTTKI-W-TENYAADK------LIPSLK 80
Cdd:cd19074 18 QVDDEDAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKAL--KGWPRESYVISTKVfWpTGPGPNDRglsrkhIFESIH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 81 DSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQA---IDHIGLENIATNQIELSp 157
Cdd:cd19074 96 ASLKRLQLDYVDIYYCHRYDPE--TPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAhdlARQFGLIPPVVEQPQYN- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 158 YLQNQKLVNYLQT---NNIDATSYMTLAYG-------------------------------------KVLQdptLLNIAA 197
Cdd:cd19074 173 MLWREIEEEVIPLcekNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrdkkrrlltdenleKVKK---LKPIAD 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2072553571 198 EHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPE 242
Cdd:cd19074 250 ELGLTLAQLALAWCLRNPAvsSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
25-259 |
1.43e-15 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 75.17 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 25 ALEVGYRAVDTAQIYA-NEAEVGQALHESQVNRADIFLTTKI-----------WTENyAADKLIPSLKDSLIKLRTDAVN 92
Cdd:cd19144 43 AFELGCTFWDTADIYGdSEELIGRWFKQNPGKREKIFLATKFgieknvetgeySVDG-SPEYVKKACETSLKRLGVDYID 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 93 LTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIdhiGLENIATNQIELSPYL----QNQK-LVNY 167
Cdd:cd19144 122 LYYQHRVDGK--TPIEKTVAAMAELVQEGKIKHIGLSECSAETLRRAH---AVHPIAAVQIEYSPFSldieRPEIgVLDT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 168 LQTNNIDATSYMTLAYG------------------------------KVLQ--DpTLLNIAAEHQVTSAQIALAWALQKG 215
Cdd:cd19144 197 CRELGVAIVAYSPLGRGfltgairspddfeegdfrrmaprfqaenfpKNLElvD-KIKAIAKKKNVTAGQLTLAWLLAQG 275
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2072553571 216 YAV--IPSSTKREHLISNLKAQEIHLTPEQMQAITTLDRNAREVNP 259
Cdd:cd19144 276 DDIipIPGTTKLKRLEENLGALKVKLTEEEEKEIREIAEEAEVVGE 321
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
26-234 |
3.72e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 73.52 E-value: 3.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 26 LEVGYRAVDTAQIYA----------NEAEVGQALHEsQVNRADIFLTTKI---------WTENY---AADKLIPSLKDSL 83
Cdd:cd19752 27 VAAGGNFLDTANNYAfwteggvggeSERLIGRWLKD-RGNRDDVVIATKVgagprdpdgGPESPeglSAETIEQEIDKSL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 84 IKLRTDAVNLTLIHWPAPalGVDIPELMGHLLEAKKQGLTEHIGVSNF---NIELTQQAIDHIGLENIATNQIELSpYLQ 160
Cdd:cd19752 106 RRLGTDYIDLYYAHVDDR--DTPLEETLEAFNELVKAGKVRAIGASNFaawRLERARQIARQQGWAEFSAIQQRHS-YLR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 161 -------------NQKLVNYLQTN-NIDATSYMTLAYG------KVLQDP-----------TLLNIAAEHQVTSAQIALA 209
Cdd:cd19752 183 prpgadfgvqrivTDELLDYASSRpDLTLLAYSPLLSGaytrpdRPLPEQydgpdsdarlaVLEEVAGELGATPNQVVLA 262
|
250 260
....*....|....*....|....*..
gi 2072553571 210 WALQKGYAVIP--SSTKREHLISNLKA 234
Cdd:cd19752 263 WLLHRTPAIIPllGASTVEQLEENLAA 289
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-233 |
4.04e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 72.51 E-value: 4.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLAG---ETVIHSVKTALEVGYRAVDTAQIYAN-EAEVGQALhesQVNRADIFLTTKIWTENYaaDKLIPS 78
Cdd:cd19100 11 VSRLGFGGGPLGRlsqEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKAL---KGRRDKVFLATKTGARDY--EGAKRD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 79 LKDSLIKLRTDAVNLTLIH------WPAPALGVDipELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLENI--AT 150
Cdd:cd19100 86 LERSLKRLGTDYIDLYQLHavdteeDLDQVFGPG--GALEALLEAKEEGKIRFIGISGHSPEVLLRALETGEFDVVlfPI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 151 NQIELSPYLQNQKLVNYLQTNNIdATSYM-TLAYGKVLQDPTLlniaaehqvtSAQIALAWALQKGY--AVIPSSTKREH 227
Cdd:cd19100 164 NPAGDHIDSFREELLPLAREKGV-GVIAMkVLAGGRLLSGDPL----------DPEQALRYALSLPPvdVVIVGMDSPEE 232
|
....*.
gi 2072553571 228 LISNLK 233
Cdd:cd19100 233 LDENLA 238
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
22-247 |
1.15e-14 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 72.24 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIYAN-EAEV--GQALHESQVNRADIFLTTKI---WTENYAADK------LIPSLKDSLIKLRTD 89
Cdd:cd19143 37 MKAAYDAGVNFFDNAEVYANgQSEEimGQAIKELGWPRSDYVVSTKIfwgGGGPPPNDRglsrkhIVEGTKASLKRLQLD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 90 AVNLTLIHWPAPAlgVDIPEL---MGHLLEakkQGLTEHIGVSNFNIELTQQAI---DHIGLENIATNQIELSpYLQNQK 163
Cdd:cd19143 117 YVDLVFCHRPDPA--TPIEETvraMNDLID---QGKAFYWGTSEWSAQQIEEAHeiaDRLGLIPPVMEQPQYN-LFHRER 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 164 L-VNYLQ------------------------TNNIDATSYMTLAYGKVLQDPT-------------LLNIAAEHQVTSAQ 205
Cdd:cd19143 191 VeVEYAPlyekyglgtttwsplasglltgkyNNGIPEGSRLALPGYEWLKDRKeelgqekiekvrkLKPIAEELGCSLAQ 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2072553571 206 IALAWALQKGY--AVIPSSTKREHLISNLKAQEI--HLTPEQMQAI 247
Cdd:cd19143 271 LAIAWCLKNPNvsTVITGATKVEQLEENLKALEVlpKLTPEVMEKI 316
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
6-234 |
3.98e-14 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 70.66 E-value: 3.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 6 FGVGTFRLAG-----ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHESQvnraDIFLTTKI---WTENYAADK 74
Cdd:cd19075 5 LGTMTFGSQGrfttaEAAAELLDAFLERGHTEIDTARVYPDgtsEELLGELGLGER----GFKIDTKAnpgVGGGLSPEN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 75 LIPSLKDSLIKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIdHI----------- 143
Cdd:cd19075 81 VRKQLETSLKRLKVDKVDVFYLHAPDRS--TPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIV-EIckengwvlptv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 --GLENIATNQIElspylqnQKLVNYLQTNNIDATSYMTLA-------------------------YGKVLQD----PTL 192
Cdd:cd19075 158 yqGMYNAITRQVE-------TELFPCLRKLGIRFYAYSPLAggfltgkykysedkagggrfdpnnaLGKLYRDrywkPSY 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2072553571 193 L-------NIAAEHQVTSAQIALAW-----ALQ--KGYAVI--PSSTkrEHLISNLKA 234
Cdd:cd19075 231 FealekveEAAEKEGISLAEAALRWlyhhsALDgeKGDGVIlgASSL--EQLEENLAA 286
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
7-134 |
2.28e-13 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 68.49 E-value: 2.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 7 GVGTFRLAG--------ETVIHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHESQVnRADIFLTTKI---WTE---- 68
Cdd:cd19148 8 ALGTWAIGGwmwggtdeKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYGK-RDRVVIATKVgleWDEggev 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2072553571 69 --NYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPalGVDIPELMGHLLEAKKQGLTEHIGVSNFNIE 134
Cdd:cd19148 87 vrNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDP--LVPIEETAEALKELLDEGKIRAIGVSNFSPE 152
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
4-212 |
4.66e-13 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 67.20 E-value: 4.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAG--------ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALheSQVNRADIFLTTKI--WTENY 70
Cdd:cd19096 1 SVLGFGTMRLPEsdddsideEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEAL--KEGPREKFYLATKLppWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 71 AADkLIPSLKDSLIKLRTDAVNLTLIH------WPAPALGVDIPELMghlLEAKKQGLTEHIGVSnF--NIELTQQAIDH 142
Cdd:cd19096 79 AED-FRRILEESLKRLGVDYIDFYLLHglnspeWLEKARKGGLLEFL---EKAKKEGLIRHIGFS-FhdSPELLKEILDS 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2072553571 143 IGLENIatnQIELS----PYLQNQKLVNYLQTNNIdATSYMT-LAYGKVLQDPT-LLNIAAEHQVTSAQIALAWAL 212
Cdd:cd19096 154 YDFDFV---QLQYNyldqENQAGRPGIEYAAKKGM-GVIIMEpLKGGGLANNPPeALAILCGAPLSPAEWALRFLL 225
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-234 |
6.55e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 66.78 E-value: 6.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIYAN-EAEVGQALHESQvnraDIFLTTKI----WTENYAADKLIPSLKDSLIKLRTDA 90
Cdd:cd19097 26 KEAKKILEYALKAGINTLDTAPAYGDsEKVLGKFLKRLD----KFKIITKLpplkEDKKEDEAAIEASVEASLKRLKVDS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 91 VNLTLIHWPApALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHIGLE------NIATNQIELSPYLqnQKL 164
Cdd:cd19097 102 LDGLLLHNPD-DLLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDiiqlpfNILDQRFLKSGLL--AKL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 165 VN----------YLQ----TNNIDATSYMTLAYGKVLQdptLLNIAAEHQVTSAQIALAWALQKG---YAVIPSSTkREH 227
Cdd:cd19097 179 KKkgieiharsvFLQglllMEPDKLPAKFAPAKPLLKK---LHELAKKLGLSPLELALGFVLSLPeidKIVVGVDS-LEQ 254
|
....*..
gi 2072553571 228 LISNLKA 234
Cdd:cd19097 255 LKEIIAA 261
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
27-247 |
2.39e-12 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 65.91 E-value: 2.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 27 EVGYRAVDTAQIY-ANEAE--VGQALhESQVNRADIFLTTKIWT-----------ENYA---ADKLIPSLKDSLIKLRTD 89
Cdd:cd19146 46 EQGGNFIDTANNYqGEESErwVGEWM-ASRGNRDEMVLATKYTTgyrrggpikikSNYQgnhAKSLRLSVEASLKKLQTS 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 90 AVNLTLIHWPApaLGVDIPELMGHLLEAKKQGLTEHIGVSN----FNIELTQQAIDHI--------GLENIATNQIE--- 154
Cdd:cd19146 125 YIDILYVHWWD--YTTSIPELMQSLNHLVAAGKVLYLGVSDtpawVVSKANAYARAHGltqfvvyqGHWSAAFRDFErdi 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 155 ----------LSPY--LQNQKLVNYLQTNNIDAT-SYM---TLAYGKVlqDPTLLNIAAEHQVTSAQIALAWALQKGYAV 218
Cdd:cd19146 203 lpmceaegmaLAPWgvLGQGQFRTEEEFKRRGRSgRKGgpqTEKERKV--SEKLEKVAEEKGTAITSVALAYVMHKAPYV 280
|
250 260 270
....*....|....*....|....*....|.
gi 2072553571 219 IP--SSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19146 281 FPivGGRKVEHLKGNIEALGISLSDEEIQEI 311
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
22-243 |
3.17e-12 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 65.36 E-value: 3.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIY-----ANEAEVGQALHESQVNRAD-IFLTTKIWTE-------NYAADK-LIPSLKDSLIKLR 87
Cdd:cd19089 35 LRTAFDLGITHFDLANNYgpppgSAEENFGRILKRDLRPYRDeLVISTKAGYGmwpgpygDGGSRKyLLASLDQSLKRMG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 88 TDAVNLTLIHWPAPalgvDIP--ELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDhiGLEN----IATNQIELSPYLQN 161
Cdd:cd19089 115 LDYVDIFYHHRYDP----DTPleETMTALADAVRSGKALYVGISNYPGAKARRAIA--LLRElgvpLIIHQPRYSLLDRW 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 --QKLVNYLQTNNIDATSYMTLAYG----KVLQDPTLLN---------------------------IAAEHQVTSAQIAL 208
Cdd:cd19089 189 aeDGLLEVLEEAGIGFIAFSPLAQGlltdKYLNGIPPDSrraaeskflteealtpekleqlrklnkIAAKRGQSLAQLAL 268
|
250 260 270
....*....|....*....|....*....|....*...
gi 2072553571 209 AWALQKGY--AVIPSSTKREHLISNLKA-QEIHLTPEQ 243
Cdd:cd19089 269 SWVLRDPRvtSVLIGASSPSQLEDNVAAlKNLDFSEEE 306
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
22-165 |
5.71e-12 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 64.48 E-value: 5.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIYAN---EAEVGQALHESQVNRADIFLTTKI-----WTENYAADKLIPSLKDSLIKLRTDAVNL 93
Cdd:cd19153 39 VAEAFAAGINHFDTSPYYGAessEAVLGKALAALQVPRSSYTVATKVgryrdSEFDYSAERVRASVATSLERLHTTYLDV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 94 TLIH-WPAPALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAID--------------HIGLENIATNqiELSPY 158
Cdd:cd19153 119 VYLHdIEFVDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRrcspgsldavlsycHLTLQDARLE--SDAPG 196
|
....*..
gi 2072553571 159 LQNQKLV 165
Cdd:cd19153 197 LVRGAGP 203
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
25-247 |
1.74e-11 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 63.35 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 25 ALEVGYRAVDTAQIYA----------NEAEVGQALhESQVNRADIFLTTKI--------W----TENYAADKLIPSLKDS 82
Cdd:cd19094 27 AFDEGVNFIDTAEMYPvppspetqgrTEEIIGSWL-KKKGNRDKVVLATKVagpgegitWprggGTRLDRENIREAVEGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 83 LIKLRTDAVNLTLIHWPA---PALG-------------VDIPELMGHLLEAKKQGLTEHIGVSN---FNI-ELTQQAIDH 142
Cdd:cd19094 106 LKRLGTDYIDLYQLHWPDrytPLFGggyytepseeedsVSFEEQLEALGELVKAGKIRHIGLSNetpWGVmKFLELAEQL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 143 iGLENIATNQIELSpyLQNQKLVNYL----QTNNIDATSYMTLAYG----KVLQDPT----------------------- 191
Cdd:cd19094 186 -GLPRIVSIQNPYS--LLNRNFEEGLaeacHRENVGLLAYSPLAGGvltgKYLDGAArpeggrlnlfpgymaryrspqal 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2072553571 192 -----LLNIAAEHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19094 263 eavaeYVKLARKHGLSPAQLALAWVRSRPFvtSTIIGATTLEQLKENIDAFDVPLSDELLAEI 325
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
27-247 |
2.13e-11 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 62.92 E-value: 2.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 27 EVGYRAVDTAQIYANEAE---VGQALhESQVNRADIFLTTKIWTE------------NYAAD---KLIPSLKDSLIKLRT 88
Cdd:cd19147 45 EAGGNFIDTANNYQDEQSetwIGEWM-KSRKNRDQIVIATKFTTDykayevgkgkavNYCGNhkrSLHVSVRDSLRKLQT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 89 DAVNLTLIHWpaPALGVDIPELMGHLLEAKKQGLTEHIGVSNF--------NIELTQQAID----HIGLENIATNQIE-- 154
Cdd:cd19147 124 DWIDILYVHW--WDYTTSIEEVMDSLHILVQQGKVLYLGVSDTpawvvsaaNYYATAHGKTpfsvYQGRWNVLNRDFErd 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 155 -----------LSPY-------LQNQKLVNYLQTNNIDATSYMT---LAYGKVLQDPTLLNIAAEHQVTS-AQIALAWAL 212
Cdd:cd19147 202 iipmarhfgmaLAPWdvlgggkFQSKKAVEERKKNGEGLRSFVGgteQTPEEVKISEALEKVAEEHGTESvTAIALAYVR 281
|
250 260 270
....*....|....*....|....*....|....*..
gi 2072553571 213 QKGYAVIPS--STKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19147 282 SKAPNVFPLvgGRKIEHLKDNIEALSIKLTPEEIEYL 318
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
105-247 |
2.97e-11 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 62.26 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 105 VDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDhigLENIATNQIELSPyLQNQKLVN-YLQT---NNIDATSY-- 178
Cdd:cd19077 125 VPIEETIKALKELVKEGKIRGIGLSEVSAETIRRAHA---VHPIAAVEVEYSL-FSREIEENgVLETcaeLGIPIIAYsp 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 179 ----------------------------------MTLAYGKVLQDptllnIAAEHQVTSAQIALAWALQKGYAVI---PS 221
Cdd:cd19077 201 lgrglltgriksladipegdfrrhldrfngenfeKNLKLVDALQE-----LAEKKGCTPAQLALAWILAQSGPKIipiPG 275
|
170 180
....*....|....*....|....*.
gi 2072553571 222 STKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19077 276 STTLERVEENLKAANVELTDEELKEI 301
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
6-171 |
5.49e-11 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 61.52 E-value: 5.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 6 FGVGTFRLAGETVIHS------VKTALEVGYRAVDTAQIYAN-EAEVGQALH--ESQVNRADIFLTTK-----IWTENYA 71
Cdd:cd19164 18 FGAATFSYQYTTDPESippvdiVRRALELGIRAFDTSPYYGPsEIILGRALKalRDEFPRDTYFIITKvgrygPDDFDYS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 72 ADKLIPSLKDSLIKLRTDAVNLTLIH---WPAPAlgvDIPELMGHLLEAKKQGLTEHIGVSNFNIE----LTQQAIDHIG 144
Cdd:cd19164 98 PEWIRASVERSLRRLHTDYLDLVYLHdveFVADE---EVLEALKELFKLKDEGKIRNVGISGYPLPvllrLAELARTTAG 174
|
170 180 190
....*....|....*....|....*....|...
gi 2072553571 145 --LENIatnqieLSpY----LQNQKLVNYLQTN 171
Cdd:cd19164 175 rpLDAV------LS-YchytLQNTTLLAYIPKF 200
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-245 |
8.48e-10 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 57.95 E-value: 8.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 1 MIVPQFGVGT------FRLAGET-VIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALheSQVNRADIFLTTKI----- 65
Cdd:cd19163 11 LKVSKLGFGAsplggvFGPVDEEeAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKAL--KGIPRDSYYLATKVgrygl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 66 -WTE--NYAADKLIPSLKDSLIKLRTDAVNLTLIHWP--APALGVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAI 140
Cdd:cd19163 89 dPDKmfDFSAERITKSVEESLKRLGLDYIDIIQVHDIefAPSLDQILNETLPALQKLKEEGKVRFIGITGYPLDVLKEVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 141 DHigleniATNQIE--LSpY----LQNQ---KLVNYLQTNNIDATSYMTLAYG----KVLQD-----PTLLNIAA----- 197
Cdd:cd19163 169 ER------SPVKIDtvLS-YchytLNDTsllELLPFFKEKGVGVINASPLSMGllteRGPPDwhpasPEIKEACAkaaay 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 198 --EHQVTSAQIALAWALQ-KGYAV-IPSSTKREHLISNLKAQEIHLTPEQMQ 245
Cdd:cd19163 242 ckSRGVDISKLALQFALSnPDIATtLVGTASPENLRKNLEAAEEPLDAHLLA 293
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
23-250 |
9.05e-10 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 57.97 E-value: 9.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 23 KTALEVGYRAVDTAQIYAN---EAEVGQALHESqvnRADIFLTTK--------IWTENYAADKLIPSLKDSLIKLRTDAV 91
Cdd:cd19087 37 DRALDAGINFFDTADVYGGgrsEEIIGRWIAGR---RDDIVLATKvfgpmgddPNDRGLSRRHIRRAVEASLRRLQTDYI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 92 NLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNF---NIELTQQAIDHIGLE---------NIATNQIELspyl 159
Cdd:cd19087 114 DLYQMHHFDRD--TPLEETLRALDDLVRQGKIRYIGVSNFaawQIAKAQGIAARRGLLrfvseqpmyNLLKRQAEL---- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 160 qnqKLVNYLQTNNIDATSYMTLA-------YGKVLQDPT------------------------LLNIAAEHQVTSAQIAL 208
Cdd:cd19087 188 ---EILPAARAYGLGVIPYSPLAgglltgkYGKGKRPESgrlveraryqarygleeyrdiaerFEALAAEAGLTPASLAL 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2072553571 209 AWAL-QKGY--AVIPSSTKrEHLISNLKAQEIHLTPEQMQAITTL 250
Cdd:cd19087 265 AWVLsHPAVtsPIIGPRTL-EQLEDSLAALEITLTPELLAEIDEL 308
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
16-247 |
1.94e-08 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 53.98 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIY---ANEAEVGQALHESQvnRADIFLTTKIWTENYAADKLI---------PSLKDSL 83
Cdd:cd19145 33 EEGIALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGP--REKVQLATKFGIHEIGGSGVEvrgdpayvrAACEASL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 84 IKLRTDAVNLTLIHWPAPAlgVDIPELMGHLLEAKKQGLTEHIGVSNFNIELTQQAidHiGLENIATNQIELSPYLQN-- 161
Cdd:cd19145 111 KRLDVDYIDLYYQHRIDTT--VPIEITMGELKKLVEEGKIKYIGLSEASADTIRRA--H-AVHPITAVQLEWSLWTRDie 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 162 QKLVNYLQTNNIDATSYMTLAYG------KVLQDPT-------------------------LLNIAAEHQVTSAQIALAW 210
Cdd:cd19145 186 EEIIPTCRELGIGIVPYSPLGRGffagkaKLEELLEnsdvrkshprfqgenleknkvlyerVEALAKKKGCTPAQLALAW 265
|
250 260 270
....*....|....*....|....*....|....*....
gi 2072553571 211 ALQKGYAV--IPSSTKREHLISNLKAQEIHLTPEQMQAI 247
Cdd:cd19145 266 VLHQGEDVvpIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-142 |
7.85e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 52.27 E-value: 7.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 16 ETVIHSVKTALEVGYRAVDTAQIYAN-EAEV--GQALHEsqvNRADIFLTTKIWTENYAADKLIP----SLKDSLIKLRT 88
Cdd:cd19104 32 EEQIAAVRRALDLGINFFDTAPSYGDgKSEEnlGRALKG---LPAGPYITTKVRLDPDDLGDIGGqierSVEKSLKRLKR 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2072553571 89 DAVNLTLIH------------WPAPALGVDIPELMGHLLEA-KKQGLTEHIGVSNF-NIELTQQAIDH 142
Cdd:cd19104 109 DSVDLLQLHnrigderdkpvgGTLSTTDVLGLGGVADAFERlRSEGKIRFIGITGLgNPPAIRELLDS 176
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
4-129 |
1.10e-06 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 48.89 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLA-----GET-VIHSVKTALEVGYRAVDTAQIY-ANEAE--VGQALHESQvnRADIFLTTK---------- 64
Cdd:cd19162 1 PRLGLGAASLGnlaraGEDeAAATLDAAWDAGIRYFDTAPLYgLGLSErrLGAALARHP--RAEYVVSTKvgrllepgaa 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2072553571 65 --------IWteNYAADKLIPSLKDSLIKLRTDAVNLTLIHWPAPALGVDIPELMGHLLEAKKQGLTEHIGVS 129
Cdd:cd19162 79 grpagadrRF--DFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLQALTDAFPALEELRAEGVVGAIGVG 149
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
3-252 |
1.41e-06 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 48.70 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTFRLA---GETVIHS-VKTALEVGYRAVDTAQIYA----------NEAEVGQALhESQVNRADIFLTTKIWTE 68
Cdd:PRK10625 13 VSTLGLGTMTFGeqnSEADAHAqLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWL-AKRGSREKLIIASKVSGP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 69 NYAADKLI------------PSLKDSLIKLRTDAVNLTLIHWP-----------------APAlgVDIPELMGHLLEAKK 119
Cdd:PRK10625 92 SRNNDKGIrpnqaldrknirEALHDSLKRLQTDYLDLYQVHWPqrptncfgklgyswtdsAPA--VSLLETLDALAEQQR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 120 QGLTEHIGVSN---FNIELTQQAIDHIGLENIATNQielSPY-LQNQK----LVNYLQTNNIDATSYMTLAY----GKVL 187
Cdd:PRK10625 170 AGKIRYIGVSNetaFGVMRYLHLAEKHDLPRIVTIQ---NPYsLLNRSfevgLAEVSQYEGVELLAYSCLAFgtltGKYL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 188 QDP-------TLLN-------------------IAAEHQVTSAQIALAWALQKGY--AVIPSSTKREHLISNLKAQEIHL 239
Cdd:PRK10625 247 NGAkpagarnTLFSrftrysgeqtqkavaayvdIAKRHGLDPAQMALAFVRRQPFvaSTLLGATTMEQLKTNIESLHLTL 326
|
330
....*....|...
gi 2072553571 240 TPEQMQAITTLDR 252
Cdd:PRK10625 327 SEEVLAEIEAVHQ 339
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
22-234 |
2.52e-06 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 47.78 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIY-----ANEAEVGQALHES-QVNRADIFLTTK----IWTENY----AADKLIPSLKDSLIKLR 87
Cdd:cd19151 36 LRRAFDLGITHFDLANNYgpppgSAEENFGRILKEDlKPYRDELIISTKagytMWPGPYgdwgSKKYLIASLDQSLKRMG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 88 TDAVNLTLIHWPAPalgvDIP--ELMGHLLEAKKQGLTEHIGVSNFNIELTQQAIDHI---------------------- 143
Cdd:cd19151 116 LDYVDIFYHHRPDP----ETPleETMGALDQIVRQGKALYVGISNYPPEEAREAAAILkdlgtpclihqpkysmfnrwve 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 144 -GLENIATNQ----IELSPYLQNQKLVNYLqtNNIDATSYMTLAYG---------KVLQDPTLLN-IAAEHQVTSAQIAL 208
Cdd:cd19151 192 eGLLDVLEEEgigcIAFSPLAQGLLTDRYL--NGIPEDSRAAKGSSflkpeqiteEKLAKVRRLNeIAQARGQKLAQMAL 269
|
250 260
....*....|....*....|....*...
gi 2072553571 209 AWALQKG--YAVIPSSTKREHLISNLKA 234
Cdd:cd19151 270 AWVLRNKrvTSVLIGASKPSQIEDAVGA 297
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
4-97 |
7.62e-04 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 40.39 E-value: 7.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 4 PQFGVGTFRLAG-------ETVIHSVKTALEVGYRAVDTAQIYAN---EAEVGQALHEsqVNRADIFLTTKI-------- 65
Cdd:cd19161 1 SELGLGTAGLGNlytavsnADADATLDAAWDSGIRYFDTAPMYGHglaEHRLGDFLRE--KPRDEFVLSTKVgrllkpar 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2072553571 66 ---------WTE--------NYAADKLIPSLKDSLIKLRTDAVNLTLIH 97
Cdd:cd19161 79 egsvpdpngFVDplpfeivyDYSYDGIMRSFEDSLQRLGLNRIDILYVH 127
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
3-129 |
8.39e-04 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 40.12 E-value: 8.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 3 VPQFGVGTF-----RLAGETVIHSVKTALEVGYRAVDTAQIYA-NEAEV--GQALHESQVNRADIFLTTKI-W-----TE 68
Cdd:cd19141 12 VSCLGLGTWvtfgsQISDEVAEELVTLAYENGINLFDTAEVYAaGKAEIvlGKILKKKGWRRSSYVITTKIfWggkaeTE 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2072553571 69 NYAADK-LIPSLKDSLIKLRTDAVNLTLIHWPAPALGV-DIPELMGHLLEakkQGLTEHIGVS 129
Cdd:cd19141 92 RGLSRKhIIEGLKASLERLQLEYVDIVFANRPDPNTPMeEIVRAFTHVIN---QGMAMYWGTS 151
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
22-131 |
4.82e-03 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 37.83 E-value: 4.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072553571 22 VKTALEVGYRAVDTAQIYAN---EAEVGQALHESQVNRADIFLTTKIWTENYAADK------LIPSLKDSLIKLRTDAVN 92
Cdd:cd19142 37 VTLAYENGINYFDTSDAFTSgqaETELGRILKKKGWKRSSYIVSTKIYWSYGSEERglsrkhIIESVRASLRRLQLDYID 116
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2072553571 93 LTLIHWPAPALGVD-IPELMGHLLeakKQGLTEHIGVSNF 131
Cdd:cd19142 117 IVIIHKADPMCPMEeVVRAMSYLI---DNGLIMYWGTSRW 153
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
192-261 |
5.13e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 37.71 E-value: 5.13e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2072553571 192 LLNIAAEHQVTSAQIALAWALQKGYA--VIPSSTKREHLISNLKAQEIHLTPEQMQAITTLdrnareVNPPE 261
Cdd:cd19098 241 LKAVADRLGVTPDALALAAVLAQPFVdvVLSGAATPEQLRSNLRALDVSLDLELLAALADL------AEPPE 306
|
|
| |
