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Conserved domains on  [gi|2072385182|ref|XP_042556580|]
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cadherin-1 [Dipodomys spectabilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 4.69e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


:

Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.56  E-value: 4.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 158 IPPISCPENEKGPfpKDLVQIKSNRDKETKVFYSITGQGADKPPvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 2072385182 238 NGNAVEDPMEIVITVTDQNDN 258
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 28-117 2.18e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 134.76  E-value: 2.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  28 PCYPGFGAESYTFLVPRwHLERGHVLGRVSFEGCTGRPRTVYFSDDSRFKVATDGVVSVKRPLQLHKVETSFLVHTWDST 107
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPR-RLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 2072385182 108 Y-KKFSVKVTL 117
Cdd:pfam08758  80 GeKMASVKVTV 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 266 IFEGSVMEGALPGTSVMQVSATDADDDVNtynAAIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVV 345
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 346 QAADLNGEGLSTTAKAVINVMDINDN 371
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 818-877 4.66e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 101.46  E-value: 4.66e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 818 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 877
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-591 1.05e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 493 VEVPEDFGVGLEITSYTAREPDVFMKQTITYRIWRDTA-NWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNG 571
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 2072385182 572 SPVATGTGTLLLVLSDVNDN 591
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-482 1.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 379 TYEGQVYEN-EVNAVITTLKVTDADTPhtPAWQAVYTILNDQEQQ-FVIvtDPQTndGILKTAKGLDFETKQQYILQVTV 456
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 457 QNVDAFAvslLTSTATITVDVIDVNE 482
Cdd:cd11304    75 TDGGGPP---LSSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 604-686 2.35e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 604 QRNPQPQVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaQESLILKPKKHL---ELGDYKINLKLMDN--QNKDQV 678
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 2072385182 679 TTLDVIVC 686
Cdd:pfam00028  85 ATVTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 4.69e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.56  E-value: 4.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 158 IPPISCPENEKGPfpKDLVQIKSNRDKETKVFYSITGQGADKPPvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 2072385182 238 NGNAVEDPMEIVITVTDQNDN 258
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 28-117 2.18e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 134.76  E-value: 2.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  28 PCYPGFGAESYTFLVPRwHLERGHVLGRVSFEGCTGRPRTVYFSDDSRFKVATDGVVSVKRPLQLHKVETSFLVHTWDST 107
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPR-RLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 2072385182 108 Y-KKFSVKVTL 117
Cdd:pfam08758  80 GeKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-115 1.94e-33

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 123.54  E-value: 1.94e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182   29 CYPGFGAESYTFLVPRwHLERGHVLGRVSFEGCTGRPRTVYFSDDSRFKVATDGVVSVKRPLQLHKVETSFLVHTWDSTY 108
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 2072385182  109 K-KFSVKV 115
Cdd:smart01055  80 QeKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 266 IFEGSVMEGALPGTSVMQVSATDADDDVNtynAAIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVV 345
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 346 QAADLNGEGLSTTAKAVINVMDINDN 371
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 818-877 4.66e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 101.46  E-value: 4.66e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 818 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 877
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
267-365 9.40e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 9.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 267 FEGSVMEGALPGTSVMQVSATDADDDVNTYnaaIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVVQ 346
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPG----GNFRIDPDTGDIST-TKPLDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 2072385182 347 AADLNGEGLSTTAKAVINV 365
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-373 1.17e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  285 SATDADDDVNtynAAIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVVQAADLNGEGLSTTAKAVIN 364
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGNDD----GLFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 2072385182  365 VMDINDNAP 373
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-591 1.05e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 493 VEVPEDFGVGLEITSYTAREPDVFMKQTITYRIWRDTA-NWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNG 571
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 2072385182 572 SPVATGTGTLLLVLSDVNDN 591
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-482 1.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 379 TYEGQVYEN-EVNAVITTLKVTDADTPhtPAWQAVYTILNDQEQQ-FVIvtDPQTndGILKTAKGLDFETKQQYILQVTV 456
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 457 QNVDAFAvslLTSTATITVDVIDVNE 482
Cdd:cd11304    75 TDGGGPP---LSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
159-253 7.17e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 7.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 159 PPISCPENEK-GPFPKDLVQIKSNRDKETKVFYSITGQGADkppvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 2072385182 238 NGNAVEDPMEIVITVT 253
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-593 1.67e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  509 TAREPDVFMKQTITYRIWRDTA-NWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNGSPVATGTGTLLLVLSD 587
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 2072385182  588 VNDNAP 593
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-260 2.48e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.48e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2072385182  187 KVFYSITGQGADkppvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKP 260
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
380-478 9.76e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 380 YEGQVYENE-VNAVITTLKVTDADTPhtPAWQAVYTILND-QEQQFVIvtdpQTNDGILKTAKGLDFETKQQYILQVTVQ 457
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 2072385182 458 NVDAFAvslLTSTATITVDVI 478
Cdd:pfam00028  75 DSGGPP---LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-484 6.07e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 6.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  397 KVTDADTPhtPAWQAVYTIL-NDQEQQFVIvtDPQTndGILKTAKGLDFETKQQYILQVTVQNVDafaVSLLTSTATITV 475
Cdd:smart00112   1 SATDADSG--ENGKVTYSILsGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG---GPPLSSTATVTI 71


                   ....*....
gi 2072385182  476 DVIDVNEAP 484
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
493-581 1.17e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 493 VEVPEDFGVGLEITSYTAREPDVFMKQTITYRIWRD-TANWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNG 571
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 2072385182 572 SPVATGTGTL 581
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
604-686 2.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 604 QRNPQPQVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaQESLILKPKKHL---ELGDYKINLKLMDN--QNKDQV 678
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 2072385182 679 TTLDVIVC 686
Cdd:pfam00028  85 ATVTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-258 4.69e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.56  E-value: 4.69e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 158 IPPISCPENEKGPfpKDLVQIKSNRDKETKVFYSITGQGADKPPvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 2072385182 238 NGNAVEDPMEIVITVTDQNDN 258
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 28-117 2.18e-37

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 134.76  E-value: 2.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  28 PCYPGFGAESYTFLVPRwHLERGHVLGRVSFEGCTGRPRTVYFSDDSRFKVATDGVVSVKRPLQLHKVETSFLVHTWDST 107
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPR-RLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 2072385182 108 Y-KKFSVKVTL 117
Cdd:pfam08758  80 GeKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-115 1.94e-33

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 123.54  E-value: 1.94e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182   29 CYPGFGAESYTFLVPRwHLERGHVLGRVSFEGCTGRPRTVYFSDDSRFKVATDGVVSVKRPLQLHKVETSFLVHTWDSTY 108
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQG 79


                   ....*...
gi 2072385182  109 K-KFSVKV 115
Cdd:smart01055  80 QeKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 266-371 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.18  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 266 IFEGSVMEGALPGTSVMQVSATDADDDVNtynAAIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVV 345
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 346 QAADLNGEGLSTTAKAVINVMDINDN 371
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 818-877 4.66e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 101.46  E-value: 4.66e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 818 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 877
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
267-365 9.40e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 9.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 267 FEGSVMEGALPGTSVMQVSATDADDDVNTYnaaIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVVQ 346
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPG----GNFRIDPDTGDIST-TKPLDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 2072385182 347 AADLNGEGLSTTAKAVINV 365
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 285-373 1.17e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.72  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  285 SATDADDDVNtynAAIGYSILSQEPEepdrNMFTINKETGVISVfTTGLDRESYPTYTLVVQAADLNGEGLSTTAKAVIN 364
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGNDD----GLFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 2072385182  365 VMDINDNAP 373
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-591 1.05e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 493 VEVPEDFGVGLEITSYTAREPDVFMKQTITYRIWRDTA-NWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNG 571
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 2072385182 572 SPVATGTGTLLLVLSDVNDN 591
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 379-482 1.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.59  E-value: 1.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 379 TYEGQVYEN-EVNAVITTLKVTDADTPhtPAWQAVYTILNDQEQQ-FVIvtDPQTndGILKTAKGLDFETKQQYILQVTV 456
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 2072385182 457 QNVDAFAvslLTSTATITVDVIDVNE 482
Cdd:cd11304    75 TDGGGPP---LSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
159-253 7.17e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 7.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 159 PPISCPENEK-GPFPKDLVQIKSNRDKETKVFYSITGQGADkppvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 2072385182 238 NGNAVEDPMEIVITVT 253
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-593 1.67e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  509 TAREPDVFMKQTITYRIWRDTA-NWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNGSPVATGTGTLLLVLSD 587
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 2072385182  588 VNDNAP 593
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 187-260 2.48e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.48e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2072385182  187 KVFYSITGQGADkppvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKP 260
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 161-258 5.04e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 5.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 161 ISCPENEKGPFPkdLVQIK-SNRDKET--KVFYSITGQGADkppvGVFIIERETGWLKVTEPLDREDIAKYILYSHAVSS 237
Cdd:cd11304     4 VSVPENAPPGTV--VLTVSaTDPDSGEngEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 2072385182 238 NGNAVEDPMEIVITVTDQNDN 258
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
380-478 9.76e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 380 YEGQVYENE-VNAVITTLKVTDADTPhtPAWQAVYTILND-QEQQFVIvtdpQTNDGILKTAKGLDFETKQQYILQVTVQ 457
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
gi 2072385182 458 NVDAFAvslLTSTATITVDVI 478
Cdd:pfam00028  75 DSGGPP---LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 397-484 6.07e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 6.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182  397 KVTDADTPhtPAWQAVYTIL-NDQEQQFVIvtDPQTndGILKTAKGLDFETKQQYILQVTVQNVDafaVSLLTSTATITV 475
Cdd:smart00112   1 SATDADSG--ENGKVTYSILsGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGG---GPPLSSTATVTI 71


                   ....*....
gi 2072385182  476 DVIDVNEAP 484
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
493-581 1.17e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 493 VEVPEDFGVGLEITSYTAREPDVFMKQTITYRIWRD-TANWLKIDPETGAIFTLAEMDREdlehvKNSTYTALIIATDNG 571
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 2072385182 572 SPVATGTGTL 581
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
604-686 2.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072385182 604 QRNPQPQVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaQESLILKPKKHL---ELGDYKINLKLMDN--QNKDQV 678
Cdd:pfam00028  10 PVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSST 84


                  ....*...
gi 2072385182 679 TTLDVIVC 686
Cdd:pfam00028  85 ATVTITVL 92
Cadherin_3 pfam16184
Cadherin-like;
363-430 1.26e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.12  E-value: 1.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2072385182 363 INVMDINDNAP-IFNPTTYegQVYENEVnAVITT--LKVTDADTPhtpawqavytilnDQEQQFVIVTDPQ 430
Cdd:pfam16184   9 ITIIPVNDEAPvLTTNTGL--RLWEGSS-RPITPdlLQAEDPDTP-------------PEDLTYTVVQGPS 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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