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Conserved domains on  [gi|2072334767|ref|XP_042530364|]
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tenascin-R [Dipodomys spectabilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 801-1009 2.88e-125

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 379.66  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  801 HPQDCAQHLMNGDTLSGVYTIFLNGERsQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLEDEFWLGLD 880
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  881 NIHRITSQGRYELRVDMRDG-QEAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 959
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2072334767  960 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1009
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-564 3.25e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.51  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  233 PGSRYEVSVSAVRGTNESNAAT----THFSTEIDAPKNLRVSSRTATSLELEWD-NSEAEVQEYKVVYSTLAGEQYhevl 307
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPF---- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  308 VPIGLGPTTRTTLTDLVPGTEYGVGISAIMN----SQQSVPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-ID 381
Cdd:COG3401    277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  382 HYRIT-FTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIS-HLHFS-----HV 452
Cdd:COG3401    357 GYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGeSLTASvdavpLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  453 TSSSVNITWSDPSPPADRLILNYSPRDEEeemmEVSLDATKRHTVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGID 532
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTG----NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVI 512

                          330       340       350
                   ....*....|....*....|....*....|..
gi 2072334767  533 PPKDITISNVTKDSLTVSWSPPAASFDYYRVS 564
Cdd:COG3401    513 GASAAAAVGGAPDGTPNVTGASPVTVGASTGD 544
fn3 pfam00041
Fibronectin type III domain;
532-611 5.39e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.21  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  532 DPPKDITISNVTKDSLTVSWSPPA---ASFDYYRVSYRPTQVGRLDSSV-VPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2072334767  608 ESER 611
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
83-163 1.91e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   83 STPQGLQFKAITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2072334767  159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 709-778 2.09e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 2.09e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   709 DPPTNLTASDITRQSALISWHPP-----RAEIENYILTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
174-250 3.18e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  174 PTQILVRDVSDTVAFVEWTPPRAR---VDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
fn3 pfam00041
Fibronectin type III domain;
621-693 2.89e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  621 DNPVGLTATNITPTEALLQWKAPV---GDVENYVIvlTYFAVAGE----TILVDGVSEEFQLVNLLPRTNYTVTMYAASG 693
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV--EYRPKNSGepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 801-1009 2.88e-125

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 379.66  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  801 HPQDCAQHLMNGDTLSGVYTIFLNGERsQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLEDEFWLGLD 880
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  881 NIHRITSQGRYELRVDMRDG-QEAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 959
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2072334767  960 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1009
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 801-1010 1.26e-123

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 375.46  E-value: 1.26e-123
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   801 HPQDCAQHLMNGDTLSGVYTIFLNGeRSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLEDEFWLGLD 880
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   881 NIHRITSQGRYELRVDMRD-GQEAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 958
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2072334767   959 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
802-1010 4.10e-103

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 321.78  E-value: 4.10e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  802 PQDCAQHLMNGDTLSGVYTIFLNGERSQkLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLE-DEFWLGLD 880
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  881 NIHRITSQGRYELRVDMRDGQ-EAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGD-------SLSYHQGRPFSTEDRDNDV 952
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2072334767  953 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-564 3.25e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.51  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  233 PGSRYEVSVSAVRGTNESNAAT----THFSTEIDAPKNLRVSSRTATSLELEWD-NSEAEVQEYKVVYSTLAGEQYhevl 307
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPF---- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  308 VPIGLGPTTRTTLTDLVPGTEYGVGISAIMN----SQQSVPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-ID 381
Cdd:COG3401    277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  382 HYRIT-FTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIS-HLHFS-----HV 452
Cdd:COG3401    357 GYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGeSLTASvdavpLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  453 TSSSVNITWSDPSPPADRLILNYSPRDEEeemmEVSLDATKRHTVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGID 532
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTG----NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVI 512

                          330       340       350
                   ....*....|....*....|....*....|..
gi 2072334767  533 PPKDITISNVTKDSLTVSWSPPAASFDYYRVS 564
Cdd:COG3401    513 GASAAAAVGGAPDGTPNVTGASPVTVGASTGD 544
fn3 pfam00041
Fibronectin type III domain;
532-611 5.39e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.21  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  532 DPPKDITISNVTKDSLTVSWSPPA---ASFDYYRVSYRPTQVGRLDSSV-VPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2072334767  608 ESER 611
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
354-433 9.66e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 9.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  354 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTP--SSGIASEVTVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPknSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2072334767  429 QSLES 433
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 532-610 2.29e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 2.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  532 DPPKDITISNVTKDSLTVSWSPPA---ASFDYYRVSYRPTQVGR-LDSSVVPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 2072334767  608 ESE 610
Cdd:cd00063     82 ESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 354-439 2.71e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 2.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  354 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTPSSGIASEV--TVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 2072334767  429 QSLESTVDAFT 439
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 354-430 3.98e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 3.98e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   354 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   429 QS 430
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
83-163 1.91e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   83 STPQGLQFKAITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2072334767  159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 709-778 2.09e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 2.09e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   709 DPPTNLTASDITRQSALISWHPP-----RAEIENYILTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 709-794 2.26e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  709 DPPTNLTASDITRQSALISWHPPR---AEIENYILTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQDTT 783
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2072334767  784 RS-SLTSTAFTT 794
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 532-609 2.57e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 2.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   532 DPPKDITISNVTKDSLTVSWSPPA-ASFDYYRVSYRPTQVGRLDSSV---VPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   608 ES 609
Cdd:smart00060   82 EG 83
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 805-844 1.45e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.49  E-value: 1.45e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2072334767  805 CAQ-HLMNGDTLSGVYTIFLNGERSQK-LQVYCDMTTDGGGW 844
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
fn3 pfam00041
Fibronectin type III domain;
709-778 2.26e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.26e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767  709 DPPTNLTASDITRQSALISWHPPR---AEIENYILTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
174-250 3.18e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  174 PTQILVRDVSDTVAFVEWTPPRAR---VDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-170 6.86e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   83 STPQGLQFKAITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2072334767  159 RSPPTSASVSTV 170
Cdd:cd00063     82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
621-693 2.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  621 DNPVGLTATNITPTEALLQWKAPV---GDVENYVIvlTYFAVAGE----TILVDGVSEEFQLVNLLPRTNYTVTMYAASG 693
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV--EYRPKNSGepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
500-803 2.59e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.62  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  500 GLQPATEYIVNLVAVHGTVTSEP----IVGSITTGIDPPKDITISNVTKDSLTVSWSP-PAASFDYYRVSYRPTQVGRLd 574
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPF- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  575 SSVVPNTVSEFTITRLYPATEYEISLNSVRGREESERICTLVHTAMDN-----PVGLTATNITPTEALLQWKAPVG-DVE 648
Cdd:COG3401    277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSSSITLSWTASSDaDVT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  649 NYVIVLTYFAVAGETILVDGVSE-EFQLVNLLPRTNYTVTMYA---------ASGPLTSGTISTNFSTLLDPPTNLTASD 718
Cdd:COG3401    357 GYNVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAvdaagnesaPSEEVSATTASAASGESLTASVDAVPLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  719 ITRQSALISWHPPRAEIENYILTYKSTDGSRKElivDAEDTWIRLEGLSENTDYTVLLQAAQDTTRSSLTSTAFTTGGRV 798
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTGNAVP---FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIG 513


                   ....*
gi 2072334767  799 FSHPQ 803
Cdd:COG3401    514 ASAAA 518
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 172-255 7.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 7.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  172 DGPTQILVRDVSDTVAFVEWTPPRARVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTN 248
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*..
gi 2072334767  249 ESNAATT 255
Cdd:cd00063     82 ESPPSES 88
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-153 2.79e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.79e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767    83 STPQGLQFKAITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 153
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 621-690 4.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 4.59e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   621 DNPVGLTATNITPTEALLQWKAPVGD-----VENYVIVLTYFAVAGETILVDGVSEEFQLVNLLPRTNYTVTMYA 690
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 172-250 5.80e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 5.80e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   172 DGPTQILVRDVSDTVAFVEWTPP-RARVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSVSAVRGTN 248
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   249 ES 250
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 621-702 7.71e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 7.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  621 DNPVGLTATNITPTEALLQWKAPVGD---VENYVIvlTYFAVAGETIL----VDGVSEEFQLVNLLPRTNYTVTMYA--- 690
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVV--EYREKGSGDWKevevTPGSETSYTLTGLKPGTEYEFRVRAvng 79

                           90
                   ....*....|....
gi 2072334767  691 --ASGPLTSGTIST 702
Cdd:cd00063     80 ggESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 801-1009 2.88e-125

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 379.66  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  801 HPQDCAQHLMNGDTLSGVYTIFLNGERsQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLEDEFWLGLD 880
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  881 NIHRITSQGRYELRVDMRDG-QEAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 959
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2072334767  960 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1009
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 801-1010 1.26e-123

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 375.46  E-value: 1.26e-123
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   801 HPQDCAQHLMNGDTLSGVYTIFLNGeRSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLEDEFWLGLD 880
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   881 NIHRITSQGRYELRVDMRD-GQEAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 958
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2072334767   959 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
802-1010 4.10e-103

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 321.78  E-value: 4.10e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  802 PQDCAQHLMNGDTLSGVYTIFLNGERSQkLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRAGFGNLE-DEFWLGLD 880
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATKP-FEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  881 NIHRITSQGRYELRVDMRDGQ-EAVFAHYDKFSVEDSRNLYKLRIGGYNGTAGD-------SLSYHQGRPFSTEDRDNDV 952
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2072334767  953 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1010
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
233-564 3.25e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.51  E-value: 3.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  233 PGSRYEVSVSAVRGTNESNAAT----THFSTEIDAPKNLRVSSRTATSLELEWD-NSEAEVQEYKVVYSTLAGEQYhevl 307
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPF---- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  308 VPIGLGPTTRTTLTDLVPGTEYGVGISAIMN----SQQSVPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP-ID 381
Cdd:COG3401    277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAdVT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  382 HYRIT-FTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISITA--ERGRQQSLESTVDAFTGFRPIS-HLHFS-----HV 452
Cdd:COG3401    357 GYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSATTASAASGeSLTASvdavpLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  453 TSSSVNITWSDPSPPADRLILNYSPRDEEeemmEVSLDATKRHTVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGID 532
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTG----NAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVI 512

                          330       340       350
                   ....*....|....*....|....*....|..
gi 2072334767  533 PPKDITISNVTKDSLTVSWSPPAASFDYYRVS 564
Cdd:COG3401    513 GASAAAAVGGAPDGTPNVTGASPVTVGASTGD 544
fn3 pfam00041
Fibronectin type III domain;
532-611 5.39e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.21  E-value: 5.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  532 DPPKDITISNVTKDSLTVSWSPPA---ASFDYYRVSYRPTQVGRLDSSV-VPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2072334767  608 ESER 611
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
354-433 9.66e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 9.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  354 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTP--SSGIASEVTVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPknSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2072334767  429 QSLES 433
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 532-610 2.29e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 2.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  532 DPPKDITISNVTKDSLTVSWSPPA---ASFDYYRVSYRPTQVGR-LDSSVVPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 2072334767  608 ESE 610
Cdd:cd00063     82 ESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 354-439 2.71e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 2.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  354 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTPSSGIASEV--TVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 2072334767  429 QSLESTVDAFT 439
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 354-430 3.98e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 3.98e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   354 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISITAERGRQ 428
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   429 QS 430
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
83-163 1.91e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 1.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   83 STPQGLQFKAITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2072334767  159 RSPPT 163
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 709-778 2.09e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 2.09e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   709 DPPTNLTASDITRQSALISWHPP-----RAEIENYILTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
443-522 2.21e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 2.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  443 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDEEEEMMEVSLDATKRHTVLMGLQPATEYIVNLVAVHGTV 518
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 2072334767  519 TSEP 522
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 709-794 2.26e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  709 DPPTNLTASDITRQSALISWHPPR---AEIENYILTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQDTT 783
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2072334767  784 RS-SLTSTAFTT 794
Cdd:cd00063     82 ESpPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 262-346 2.52e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 2.52e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  262 DAPKNLRVSSRTATSLELEWD---NSEAEVQEYKVVYSTLAGEQYHEVLVPIGlgPTTRTTLTDLVPGTEYGVGISAIMN 338
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEVEVTPG--SETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 2072334767  339 SQQSVPAT 346
Cdd:cd00063     80 GGESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 532-609 2.57e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.62  E-value: 2.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   532 DPPKDITISNVTKDSLTVSWSPPA-ASFDYYRVSYRPTQVGRLDSSV---VPNTVSEFTITRLYPATEYEISLNSVRGRE 607
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   608 ES 609
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
262-336 6.92e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 6.92e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2072334767  262 DAPKNLRVSSRTATSLELEW---DNSEAEVQEYKVVYSTLAGEQY-HEVLVPiglGPTTRTTLTDLVPGTEYGVGISAI 336
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 805-844 1.45e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.49  E-value: 1.45e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2072334767  805 CAQ-HLMNGDTLSGVYTIFLNGERSQK-LQVYCDMTTDGGGW 844
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
fn3 pfam00041
Fibronectin type III domain;
709-778 2.26e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.26e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767  709 DPPTNLTASDITRQSALISWHPPR---AEIENYILTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 778
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
174-250 3.18e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  174 PTQILVRDVSDTVAFVEWTPPRAR---VDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNES 250
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 83-170 6.86e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   83 STPQGLQFKAITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 158
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2072334767  159 RSPPTSASVSTV 170
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 262-336 1.51e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.51e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   262 DAPKNLRVSSRTATSLELEW-----DNSEAEVQEYKVVYSTlAGEQYHEVLVPiglGPTTRTTLTDLVPGTEYGVGISAI 336
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWepppdDGITGYIVGYRVEYRE-EGSEWKEVNVT---PSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 443-529 2.39e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  443 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDEEEEMMEVSLDATKRHTVLMGLQPATEYIVNLVAVHGTVT 519
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 2072334767  520 SEPI-VGSITT 529
Cdd:cd00063     83 SPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
621-693 2.89e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 2.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  621 DNPVGLTATNITPTEALLQWKAPV---GDVENYVIvlTYFAVAGE----TILVDGVSEEFQLVNLLPRTNYTVTMYAASG 693
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEV--EYRPKNSGepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 443-514 4.91e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 4.91e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   443 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSP--RDEEEEMMEVSLDATKRHTVLMGLQPATEYIVNLVAV 514
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
500-803 2.59e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.62  E-value: 2.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  500 GLQPATEYIVNLVAVHGTVTSEP----IVGSITTGIDPPKDITISNVTKDSLTVSWSP-PAASFDYYRVSYRPTQVGRLd 574
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPF- 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  575 SSVVPNTVSEFTITRLYPATEYEISLNSVRGREESERICTLVHTAMDN-----PVGLTATNITPTEALLQWKAPVG-DVE 648
Cdd:COG3401    277 TKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSSSITLSWTASSDaDVT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  649 NYVIVLTYFAVAGETILVDGVSE-EFQLVNLLPRTNYTVTMYA---------ASGPLTSGTISTNFSTLLDPPTNLTASD 718
Cdd:COG3401    357 GYNVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAvdaagnesaPSEEVSATTASAASGESLTASVDAVPLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  719 ITRQSALISWHPPRAEIENYILTYKSTDGSRKElivDAEDTWIRLEGLSENTDYTVLLQAAQDTTRSSLTSTAFTTGGRV 798
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTGNAVP---FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIG 513


                   ....*
gi 2072334767  799 FSHPQ 803
Cdd:COG3401    514 ASAAA 518
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 172-255 7.71e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 7.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  172 DGPTQILVRDVSDTVAFVEWTPPRARVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTN 248
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*..
gi 2072334767  249 ESNAATT 255
Cdd:cd00063     82 ESPPSES 88
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 83-153 2.79e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 2.79e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767    83 STPQGLQFKAITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 153
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 621-690 4.59e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 4.59e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2072334767   621 DNPVGLTATNITPTEALLQWKAPVGD-----VENYVIVLTYFAVAGETILVDGVSEEFQLVNLLPRTNYTVTMYA 690
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 172-250 5.80e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 5.80e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   172 DGPTQILVRDVSDTVAFVEWTPP-RARVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSVSAVRGTN 248
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2072334767   249 ES 250
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 621-702 7.71e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 7.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  621 DNPVGLTATNITPTEALLQWKAPVGD---VENYVIvlTYFAVAGETIL----VDGVSEEFQLVNLLPRTNYTVTMYA--- 690
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVV--EYREKGSGDWKevevTPGSETSYTLTGLKPGTEYEFRVRAvng 79

                           90
                   ....*....|....
gi 2072334767  691 --ASGPLTSGTIST 702
Cdd:cd00063     80 ggESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
37-402 2.77e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 2.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767   37 QQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLST----PQGLQFKAITETTVEVQWEP-FSFSFDG 111
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTppsaPTGLTATADTPGSVTLSWDPvTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  112 WEISFipKNNEGGVIAQLPS-DVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDG-----PTQILVRDVSDT 185
Cdd:COG3401    264 YRVYR--SNSGDGPFTKVATvTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  186 VAFVEWTPPRA---------RVDFILLKYGLVGGEGGKTTFR---LQPPLS-QYSVQALRPGSRYEVSVSAVRGTNESNA 252
Cdd:COG3401    342 SITLSWTASSDadvtgynvyRSTSGGGTYTKIAETVTTTSYTdtgLTPGTTyYYKVTAVDAAGNESAPSEEVSATTASAA 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  253 ATTHFSTEIDAPKNLRVSSRTATSLELEWDNSeaevqeykVVYSTLAGEQYHEVLVPIGLGPTTRTTLTDLVPGTEYGVG 332
Cdd:COG3401    422 SGESLTASVDAVPLTDVAGATAAASAASNPGV--------SAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTT 493

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  333 ISAIMNSQQSVPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGIASEVTVPKD 402
Cdd:COG3401    494 GSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSG 563
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
505-773 4.50e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  505 TEYIVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSLTVSWSPPAASFDYYRVSYRPTQVGRLDSSVVPNTVSE 584
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  585 FTITRLYPATEYEISLNSVRGREESERICTLVHTAMDNPVGLTATNITPTEALLQWKAPVGDVENYVIVLTYFAVAGETI 664
Cdd:COG3401    102 SVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  665 LVDGVSEEFQLV----NLLPRTNYTVTMYA---ASGPLTSGTIS-TNFSTLLDPPTNLTASDITRQSALISWHP-PRAEI 735
Cdd:COG3401    182 TTSLTVTSTTLVdgggDIEPGTTYYYRVAAtdtGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDA 261

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 2072334767  736 ENYILTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYT 773
Cdd:COG3401    262 TGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY 299
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
161-359 5.46e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.17  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  161 PPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRARVDF-ILLKYGlvggeGGKTTFRLQPPLSQYSVQALRPGsRYEV 239
Cdd:COG4733    528 PPQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAYeVEWRRD-----DGNWVSVPRTSGTSFEVPGIYAG-DYEV 601

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072334767  240 SVSAVRGTNESNAATTHFSTEID-------APKNLRVSSRTaTSLELEWDNS-EAEVQEYKVVYSTLAGEQyhEVLVPIG 311
Cdd:COG4733    602 RVRAINALGVSSAWAASSETTVTgktapppAPTGLTATGGL-GGITLSWSFPvDADTLRTEIRYSTTGDWA--SATVAQA 678

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2072334767  312 LGPTTRTTLTDLVPGTEYGVGISAIMNSQQSVPATMNARTELDSPRDL 359
Cdd:COG4733    679 LYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGIL 726
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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