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Conserved domains on  [gi|206725544|ref|NP_001128683|]
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inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
46-135 4.21e-24

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 93.80  E-value: 4.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544   46 VAPDASVLVKYSGYLEhMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPP 124
Cdd:pfam00254   5 AKKGDRVTVHYTGTLE-DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPP 83

                          90
                  ....*....|.
gi 206725544  125 NTTVLFEIELL 135
Cdd:pfam00254  84 NATLVFEVELL 94
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
216-297 4.94e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 4.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 295
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 206725544 296 RD 297
Cdd:COG0457   87 QA 88
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
46-135 4.21e-24

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 93.80  E-value: 4.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544   46 VAPDASVLVKYSGYLEhMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPP 124
Cdd:pfam00254   5 AKKGDRVTVHYTGTLE-DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPP 83

                          90
                  ....*....|.
gi 206725544  125 NTTVLFEIELL 135
Cdd:pfam00254  84 NATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 37-137 7.09e-21

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 85.62  E-value: 7.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544  37 VIREGAGDLVAPDASVLVKYSGYLehMD-RPFDSNYFRKTPRLMKLGED--ITlwGMELGLLSMRRGELARFLFKPNYAY 113
Cdd:COG0545    5 VLKEGTGAKPKAGDTVTVHYTGTL--LDgTVFDSSYDRGEPATFPLGVGqvIP--GWDEGLQGMKVGGKRRLVIPPELAY 80

                         90       100
                 ....*....|....*....|....
gi 206725544 114 GTLGCPPLIPPNTTVLFEIELLDF 137
Cdd:COG0545   81 GERGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 32-136 6.90e-11

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 61.70  E-value: 6.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544  32 GVLKDVIREGAGDlvAPDAS--VLVKYSGYLehMD-RPFDSNYFRKTPRLMKLGEDITLWgmELGLLSMRRGELARFLFK 108
Cdd:PRK10902 147 GLLYKVEKEGTGE--APKDSdtVVVNYKGTL--IDgKEFDNSYTRGEPLSFRLDGVIPGW--TEGLKNIKKGGKIKLVIP 220

                         90       100
                 ....*....|....*....|....*...
gi 206725544 109 PNYAYGTLGCPPlIPPNTTVLFEIELLD 136
Cdd:PRK10902 221 PELAYGKAGVPG-IPANSTLVFDVELLD 247
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-297 4.94e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 4.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 295
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 206725544 296 RD 297
Cdd:COG0457   87 QA 88
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
46-135 4.21e-24

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 93.80  E-value: 4.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544   46 VAPDASVLVKYSGYLEhMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPP 124
Cdd:pfam00254   5 AKKGDRVTVHYTGTLE-DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPP 83

                          90
                  ....*....|.
gi 206725544  125 NTTVLFEIELL 135
Cdd:pfam00254  84 NATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 37-137 7.09e-21

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 85.62  E-value: 7.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544  37 VIREGAGDLVAPDASVLVKYSGYLehMD-RPFDSNYFRKTPRLMKLGED--ITlwGMELGLLSMRRGELARFLFKPNYAY 113
Cdd:COG0545    5 VLKEGTGAKPKAGDTVTVHYTGTL--LDgTVFDSSYDRGEPATFPLGVGqvIP--GWDEGLQGMKVGGKRRLVIPPELAY 80

                         90       100
                 ....*....|....*....|....
gi 206725544 114 GTLGCPPLIPPNTTVLFEIELLDF 137
Cdd:COG0545   81 GERGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 32-136 6.90e-11

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 61.70  E-value: 6.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544  32 GVLKDVIREGAGDlvAPDAS--VLVKYSGYLehMD-RPFDSNYFRKTPRLMKLGEDITLWgmELGLLSMRRGELARFLFK 108
Cdd:PRK10902 147 GLLYKVEKEGTGE--APKDSdtVVVNYKGTL--IDgKEFDNSYTRGEPLSFRLDGVIPGW--TEGLKNIKKGGKIKLVIP 220

                         90       100
                 ....*....|....*....|....*...
gi 206725544 109 PNYAYGTLGCPPlIPPNTTVLFEIELLD 136
Cdd:PRK10902 221 PELAYGKAGVPG-IPANSTLVFDVELLD 247
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 37-138 2.27e-05

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 44.79  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544  37 VIREGAGDLVAPDASVLVKYSGYLehMDRP-FDSNYFRKTPRLMKLGEDITLWGMELGLlsMRRGELARFLFKPNYAYGT 115
Cdd:PRK11570 108 VLTQGEGAIPARTDRVRVHYTGKL--IDGTvFDSSVARGEPAEFPVNGVIPGWIEALTL--MPVGSKWELTIPHELAYGE 183

                         90       100
                 ....*....|....*....|...
gi 206725544 116 LGCPPLIPPNTTVLFEIELLDFL 138
Cdd:PRK11570 184 RGAGASIPPFSTLVFEVELLEIL 206
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-297 4.94e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 4.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 295
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 206725544 296 RD 297
Cdd:COG0457   87 QA 88
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-288 1.31e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 1.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNEL 288
Cdd:COG0457   44 ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-288 1.82e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNEL 288
Cdd:COG0457   78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
205-283 2.36e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 205 EQHLVEAAKL-----PVLLNLSFTYLKLDRPTIALCYgEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQP 279
Cdd:COG3063   12 EEYYEKALELdpdnaDALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90


                 ....
gi 206725544 280 FNHD 283
Cdd:COG3063   91 SALR 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
216-304 2.81e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCY 295
Cdd:COG0457  112 ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALA 191


                 ....*....
gi 206725544 296 RDYVDKEKE 304
Cdd:COG0457  192 AAEVLLALL 200
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 173-284 3.24e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 173 GNYLFRQNRFYDAkvrykrallllrrrsappeEQHLVEAAKL-----PVLLNLSFTYLKLDRPTIALCYGEQALIIDQKN 247
Cdd:COG3914  119 GNLLLALGRLEEA-------------------LAALRRALALnpdfaEAYLNLGEALRRLGRLEEAIAALRRALELDPDN 179

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 206725544 248 AKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDI 284
Cdd:COG3914  180 AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 216-303 5.30e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725544 216 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 295
Cdd:COG2956  146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPA---LPRLAELY 222


                 ....*...
gi 206725544 296 RDYVDKEK 303
Cdd:COG2956  223 EKLGDPEE 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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