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Conserved domains on  [gi|2065789932|gb|KAG7558402|]
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Bet v I/Major latex protein [Arabidopsis thaliana x Arabidopsis arenosa]

Protein Classification

MLP family protein( domain architecture ID 10660088)

MLP family protein similar to major latex protein that is a laticifer-specific, low-molecular-weight polypeptide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bet_v_1 smart01037
Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major ...
 2-151 1.75e-86

Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10.- Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1, an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens.


:

Pssm-ID: 198105  Cd Length: 151  Bit Score: 249.22  E-value: 1.75e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932    2 ATSGTYVTEVPLKGSAEKHYKRWRSENHLFPDAIGHHIQGVTIHDGEWDSHGAIKIWNYTCDGKPEVFKERRE-IDDENM 80
Cdd:smart01037   1 ALSGTLETEVPIKGSAEKFFKRFVSRNHHFPKATGHHIQGVDLHEGDWGSHGSIKIWNYTVDGKEEVFKERIEaVDDEKK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2065789932   81 AVTFRGLEGHVMEQLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVLKA 151
Cdd:smart01037  81 TITFRVLEGDVMEEYKSFKGTIQVTPKSGGGSVVKWTLEYEKINEDVPEPEKYMDFVVELTKDIDEHLLKE 151
 
Name Accession Description Interval E-value
Bet_v_1 smart01037
Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major ...
 2-151 1.75e-86

Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10.- Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1, an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens.


Pssm-ID: 198105  Cd Length: 151  Bit Score: 249.22  E-value: 1.75e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932    2 ATSGTYVTEVPLKGSAEKHYKRWRSENHLFPDAIGHHIQGVTIHDGEWDSHGAIKIWNYTCDGKPEVFKERRE-IDDENM 80
Cdd:smart01037   1 ALSGTLETEVPIKGSAEKFFKRFVSRNHHFPKATGHHIQGVDLHEGDWGSHGSIKIWNYTVDGKEEVFKERIEaVDDEKK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2065789932   81 AVTFRGLEGHVMEQLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVLKA 151
Cdd:smart01037  81 TITFRVLEGDVMEEYKSFKGTIQVTPKSGGGSVVKWTLEYEKINEDVPEPEKYMDFVVELTKDIDEHLLKE 151
Bet_v_1 pfam00407
Pathogenesis-related protein Bet v 1 family; This family is named after Bet v 1, the major ...
 3-151 1.55e-81

Pathogenesis-related protein Bet v 1 family; This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1, an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens.


Pssm-ID: 395330  Cd Length: 149  Bit Score: 236.83  E-value: 1.55e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932   3 TSGTYVTEVPLKGSAEKHYKRWRSENHLFPDAIgHHIQGVTIHDGEWDSHGAIKIWNYTCDGKPEVFKERREIDDE-NMA 81
Cdd:pfam00407   1 LVGTYETEVEIKGSAEKFYKALRSENHHIPKAT-HHIQGVEVHEGEWDSHGSIKKWNYTEDGKPEVFKEKIEVDDEeNKT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932  82 VTFRGLEGHVMEQLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVLKA 151
Cdd:pfam00407  80 ITYRVLEGDVLKEYKSYKVTLQVIPKSNGGCVVKWTLEYEKIGDDVPEPEKYLKFVVELTKDIEAHLLSE 149
Bet_v1-like cd07816
Ligand-binding bet_v_1 domain of major pollen allergen of white birch (Betula verrucosa), Bet ...
 5-149 1.57e-37

Ligand-binding bet_v_1 domain of major pollen allergen of white birch (Betula verrucosa), Bet v 1, and related proteins; This family includes the ligand binding domain of Bet v 1 (the major pollen allergen of white birch, Betula verrucosa) and related proteins. In addition to birch Bet v 1, this family includes other plant intracellular pathogenesis-related class 10 (PR-10) proteins, norcoclaurine synthases (NCSs), cytokinin binding proteins (CSBPs), major latex proteins (MLPs), and ripening-related proteins. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Members of this family binds a diverse range of ligands. Bet v 1 can bind brassinosteroids, cytokinins, flavonoids and fatty acids. Hyp-1, a PR-10 from Hypericum perforatum/St. John's wort, catalyzes the condensation of two molecules of emodin to the bioactive naphthodianthrone hypericin. NCSs catalyze the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. The role of MLPs is unclear; however, they are associated with fruit and flower development and in pathogen defense responses. A number of PR-10 proteins in this subgroup, including Bet v 1, have in vitro RNase activity, the biological significance of which is unclear. Bet v 1 family proteins have a conserved glycine-rich P (phosphate-binding)-loop proximal to the entrance of the ligand-binding pocket. However, its conformation differs from that of the canonical P-loop structure found in nucleotide-binding proteins. Several PR-10 members including Bet v1 are allergenic. Cross-reactivity of Bet v 1 with homologs from plant foods results in birch-fruit syndrome.


Pssm-ID: 176858  Cd Length: 148  Bit Score: 125.38  E-value: 1.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932   5 GTYVTEVPLKGSAEKHYKRWRSENHLFPDAIGHHIQGVTIHDGEwDSHGAIKIWNYTCDGKPEVFKERRE-IDDENMAVT 83
Cdd:cd07816     1 GTLEHEVELKVPAEKLWKAFVLDSHLLPPKLPPVIKSVELLEGD-GGPGSIKLITFGPGGKVKYVKERIDaVDEENKTYK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2065789932  84 FRGLEGHVME-QLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVL 149
Cdd:cd07816    80 YTVIEGDVLKdGYKSYKVEIKFVPKGDGGCVVKWTIEYEKKGDAEPPEEEIKAGKEKALKMFKAVEA 146
 
Name Accession Description Interval E-value
Bet_v_1 smart01037
Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major ...
 2-151 1.75e-86

Pathogenesis-related protein Bet v I family; This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10.- Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1, an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens.


Pssm-ID: 198105  Cd Length: 151  Bit Score: 249.22  E-value: 1.75e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932    2 ATSGTYVTEVPLKGSAEKHYKRWRSENHLFPDAIGHHIQGVTIHDGEWDSHGAIKIWNYTCDGKPEVFKERRE-IDDENM 80
Cdd:smart01037   1 ALSGTLETEVPIKGSAEKFFKRFVSRNHHFPKATGHHIQGVDLHEGDWGSHGSIKIWNYTVDGKEEVFKERIEaVDDEKK 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2065789932   81 AVTFRGLEGHVMEQLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVLKA 151
Cdd:smart01037  81 TITFRVLEGDVMEEYKSFKGTIQVTPKSGGGSVVKWTLEYEKINEDVPEPEKYMDFVVELTKDIDEHLLKE 151
Bet_v_1 pfam00407
Pathogenesis-related protein Bet v 1 family; This family is named after Bet v 1, the major ...
 3-151 1.55e-81

Pathogenesis-related protein Bet v 1 family; This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1, an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens.


Pssm-ID: 395330  Cd Length: 149  Bit Score: 236.83  E-value: 1.55e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932   3 TSGTYVTEVPLKGSAEKHYKRWRSENHLFPDAIgHHIQGVTIHDGEWDSHGAIKIWNYTCDGKPEVFKERREIDDE-NMA 81
Cdd:pfam00407   1 LVGTYETEVEIKGSAEKFYKALRSENHHIPKAT-HHIQGVEVHEGEWDSHGSIKKWNYTEDGKPEVFKEKIEVDDEeNKT 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932  82 VTFRGLEGHVMEQLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVLKA 151
Cdd:pfam00407  80 ITYRVLEGDVLKEYKSYKVTLQVIPKSNGGCVVKWTLEYEKIGDDVPEPEKYLKFVVELTKDIEAHLLSE 149
Bet_v1-like cd07816
Ligand-binding bet_v_1 domain of major pollen allergen of white birch (Betula verrucosa), Bet ...
 5-149 1.57e-37

Ligand-binding bet_v_1 domain of major pollen allergen of white birch (Betula verrucosa), Bet v 1, and related proteins; This family includes the ligand binding domain of Bet v 1 (the major pollen allergen of white birch, Betula verrucosa) and related proteins. In addition to birch Bet v 1, this family includes other plant intracellular pathogenesis-related class 10 (PR-10) proteins, norcoclaurine synthases (NCSs), cytokinin binding proteins (CSBPs), major latex proteins (MLPs), and ripening-related proteins. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Members of this family binds a diverse range of ligands. Bet v 1 can bind brassinosteroids, cytokinins, flavonoids and fatty acids. Hyp-1, a PR-10 from Hypericum perforatum/St. John's wort, catalyzes the condensation of two molecules of emodin to the bioactive naphthodianthrone hypericin. NCSs catalyze the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine. The role of MLPs is unclear; however, they are associated with fruit and flower development and in pathogen defense responses. A number of PR-10 proteins in this subgroup, including Bet v 1, have in vitro RNase activity, the biological significance of which is unclear. Bet v 1 family proteins have a conserved glycine-rich P (phosphate-binding)-loop proximal to the entrance of the ligand-binding pocket. However, its conformation differs from that of the canonical P-loop structure found in nucleotide-binding proteins. Several PR-10 members including Bet v1 are allergenic. Cross-reactivity of Bet v 1 with homologs from plant foods results in birch-fruit syndrome.


Pssm-ID: 176858  Cd Length: 148  Bit Score: 125.38  E-value: 1.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065789932   5 GTYVTEVPLKGSAEKHYKRWRSENHLFPDAIGHHIQGVTIHDGEwDSHGAIKIWNYTCDGKPEVFKERRE-IDDENMAVT 83
Cdd:cd07816     1 GTLEHEVELKVPAEKLWKAFVLDSHLLPPKLPPVIKSVELLEGD-GGPGSIKLITFGPGGKVKYVKERIDaVDEENKTYK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2065789932  84 FRGLEGHVME-QLKVYDVIFQFIQKSPDDIICKITMIWEKQNDDMPEPSNYMKFVKSLAADMDDHVL 149
Cdd:cd07816    80 YTVIEGDVLKdGYKSYKVEIKFVPKGDGGCVVKWTIEYEKKGDAEPPEEEIKAGKEKALKMFKAVEA 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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