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Conserved domains on  [gi|2064944608|gb|KAG7461344|]
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hypothetical protein MATL_G00209050 [Megalops atlanticus]

Protein Classification

LamG domain-containing protein( domain architecture ID 10430211)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules; similar to Oncorhynchus mykiss sex hormone-binding globulin beta form that may participate in the local control of ovarian functions in salmonids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.23e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 360.80  E-value: 3.23e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  972 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNAVDFSGTFFINTDRDDDYAGFVFGYQSSARFYVVMWKQITQTYWSNT 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608 1052 PTRAQGYSGLSIKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2064944608 1132 MADSGSIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 25-219 9.67e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 122.47  E-value: 9.67e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608    25 DDNSVYDLFELvqvnkNHGVNLVKGEDPYSPAYKILNPdliPPVPETSfRDIIDAIHAErGFLLLANFKQFKRTRGSILT 104
Cdd:smart00210    3 DLLQVFDLPSL-----SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLFA 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608   105 VEKQDGSgPIFEIISNGKANTLDIVYSTEN-KQQVVSIEDADLATGHWKNITLFVQEERAQLYVGCEEINTSEMDVqinR 183
Cdd:smart00210   73 IYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDR---P 148

                           170       180       190
                    ....*....|....*....|....*....|....*.
gi 2064944608   184 ILTQEVPGVARLRIGKAAVKDRFMGVLQNVRFVFGT 219
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 2.87e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.87e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   495 WGPWSPWDTCTVTCGAGVQSRKRLCNDPPPKHGGKECMGDAKTTQRCNKKDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.97e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.09  E-value: 3.97e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   438 WSHWSPWSSCSVTCGAGVITRIRLCNSPTPQMGGKSCQGEGRQTEKCQQSSCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 317-371 4.87e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 73.23  E-value: 4.87e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2064944608  317 CLHNGIVHKNKDEWTVDDCTECTCQNSATVCRKVSCPLIPCANAT--VPDGECCPRC 371
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 6.04e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 6.04e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   382 WSPWSEWTRCSVTCGRGVQQRGRSCDRINNN-----CEGTSVQTRDCYLRECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 1.59e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2064944608  846 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 7.75e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 7.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2064944608  786 TDTDNNGEGDVCAVDIDGDDILNEKDNCPYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 920-949 2.97e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.74  E-value: 2.97e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2064944608  920 DSDGDGRGDACKDDFDQDNVPDIYDVCPEN 949
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 9.79e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 9.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2064944608  650 CIDGSHDCNKNARCNYlghfSDPMFRCECKPGYAGNGHIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 9.90e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 9.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  692 DSDLDGWPNEDLECVENATYHCKKDNCPNLPNSGQEDYDKDGIGDACDNDDDNDGIPDDRDNCQFVFNPRQYDYDRDDVG 771
Cdd:NF033609   623 DSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  772 DRCDNCPYNSNPDqTDTDNNGEGDVcavDIDGD-DILNEKDNCPYVYNVDQRDTDLDGVGDQCDNCPLEHNPDQlDSDSD 850
Cdd:NF033609   703 DSDSDSDSDSDSD-SDSDSDSDSDS---DSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSD 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  851 RVGDKcDSNQDIDEDghqnnldncpyipnaNQADHDKDGKGDACDHDDDNDGIPDDKDNCRLAFNPDQLDSDGDGRGDAC 930
Cdd:NF033609   778 SDSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 2064944608  931 KD-DFDQDNVPDIYDVCPENFDiSETDFRKFQMVPLDPK-GTSQIDPN 976
Cdd:NF033609   842 SDsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.23e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 360.80  E-value: 3.23e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  972 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNAVDFSGTFFINTDRDDDYAGFVFGYQSSARFYVVMWKQITQTYWSNT 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608 1052 PTRAQGYSGLSIKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2064944608 1132 MADSGSIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 25-219 9.67e-32

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 122.47  E-value: 9.67e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608    25 DDNSVYDLFELvqvnkNHGVNLVKGEDPYSPAYKILNPdliPPVPETSfRDIIDAIHAErGFLLLANFKQFKRTRGSILT 104
Cdd:smart00210    3 DLLQVFDLPSL-----SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLFA 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608   105 VEKQDGSgPIFEIISNGKANTLDIVYSTEN-KQQVVSIEDADLATGHWKNITLFVQEERAQLYVGCEEINTSEMDVqinR 183
Cdd:smart00210   73 IYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDR---P 148

                           170       180       190
                    ....*....|....*....|....*....|....*.
gi 2064944608   184 ILTQEVPGVARLRIGKAAVKDRFMGVLQNVRFVFGT 219
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 2.87e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.87e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   495 WGPWSPWDTCTVTCGAGVQSRKRLCNDPPPKHGGKECMGDAKTTQRCNKKDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.97e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.09  E-value: 3.97e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   438 WSHWSPWSSCSVTCGAGVITRIRLCNSPTPQMGGKSCQGEGRQTEKCQQSSCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 317-371 4.87e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 73.23  E-value: 4.87e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2064944608  317 CLHNGIVHKNKDEWTVDDCTECTCQNSATVCRKVSCPLIPCANAT--VPDGECCPRC 371
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 2.60e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.60e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  439 SHWSPWSSCSVTCGAGVITRIRLCNSPTPqmGGKSCQGEGRQTEKCQQSSC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
317-371 1.36e-13

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 66.39  E-value: 1.36e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2064944608   317 CLHNGIVHKNKDEWTVDDCTECTCQNSATV-CRKVSCPL-IPCANAT--VPDGECCPRC 371
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 6.04e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 6.04e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   382 WSPWSEWTRCSVTCGRGVQQRGRSCDRINNN-----CEGTSVQTRDCYLRECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 4.42e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.67  E-value: 4.42e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  496 GPWSPWDTCTVTCGAGVQSRKRLCNDPPPkhGGKECMGDAKTTQRCNKKDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 2.70e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 59.35  E-value: 2.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2064944608  383 SPWSEWTRCSVTCGRGVQQRGRSCD---RINNNCEGTSVQTRDCYLREC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKspfPGGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 1.59e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2064944608  846 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 7.75e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 7.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2064944608  786 TDTDNNGEGDVCAVDIDGDDILNEKDNCPYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 920-949 2.97e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.74  E-value: 2.97e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2064944608  920 DSDGDGRGDACKDDFDQDNVPDIYDVCPEN 949
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 9.79e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 9.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2064944608  650 CIDGSHDCNKNARCNYlghfSDPMFRCECKPGYAGNGHIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 494-549 1.41e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 46.11  E-value: 1.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2064944608  494 NWGPWSPWDTCTVTCGAGVQSRKRlcndpPPKHGGkeCMgdAKTTQRCNKKDCPID 549
Cdd:PTZ00441   239 SCGPWDEWTPCSVTCGKGTHSRSR-----PILHEG--CT--THMVEECEEEECPVE 285
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 384-428 6.08e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 6.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2064944608  384 PWSEWTRCSVTCGRGVQQRGRSCdrINNNCegTSVQTRDCYLREC 428
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSRPI--LHEGC--TTHMVEECEEEEC 282
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 9.90e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 9.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  692 DSDLDGWPNEDLECVENATYHCKKDNCPNLPNSGQEDYDKDGIGDACDNDDDNDGIPDDRDNCQFVFNPRQYDYDRDDVG 771
Cdd:NF033609   623 DSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  772 DRCDNCPYNSNPDqTDTDNNGEGDVcavDIDGD-DILNEKDNCPYVYNVDQRDTDLDGVGDQCDNCPLEHNPDQlDSDSD 850
Cdd:NF033609   703 DSDSDSDSDSDSD-SDSDSDSDSDS---DSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSD 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  851 RVGDKcDSNQDIDEDghqnnldncpyipnaNQADHDKDGKGDACDHDDDNDGIPDDKDNCRLAFNPDQLDSDGDGRGDAC 930
Cdd:NF033609   778 SDSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 2064944608  931 KD-DFDQDNVPDIYDVCPENFDiSETDFRKFQMVPLDPK-GTSQIDPN 976
Cdd:NF033609   842 SDsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 972-1169 3.23e-117

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 360.80  E-value: 3.23e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  972 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNAVDFSGTFFINTDRDDDYAGFVFGYQSSARFYVVMWKQITQTYWSNT 1051
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608 1052 PTRAQGYSGLSIKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1131
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2064944608 1132 MADSGSIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1169
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 25-219 9.67e-32

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 122.47  E-value: 9.67e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608    25 DDNSVYDLFELvqvnkNHGVNLVKGEDPYSPAYKILNPdliPPVPETSfRDIIDAIHAErGFLLLANFKQFKRTRGSILT 104
Cdd:smart00210    3 DLLQVFDLPSL-----SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLFA 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608   105 VEKQDGSgPIFEIISNGKANTLDIVYSTEN-KQQVVSIEDADLATGHWKNITLFVQEERAQLYVGCEEINTSEMDVqinR 183
Cdd:smart00210   73 IYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDR---P 148

                           170       180       190
                    ....*....|....*....|....*....|....*.
gi 2064944608   184 ILTQEVPGVARLRIGKAAVKDRFMGVLQNVRFVFGT 219
Cdd:smart00210  149 GQPPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 495-547 2.87e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.87e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   495 WGPWSPWDTCTVTCGAGVQSRKRLCNDPPPKHGGKECMGDAKTTQRCNKKDCP 547
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 3.97e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.09  E-value: 3.97e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   438 WSHWSPWSSCSVTCGAGVITRIRLCNSPTPQMGGKSCQGEGRQTEKCQQSSCP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 317-371 4.87e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 73.23  E-value: 4.87e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2064944608  317 CLHNGIVHKNKDEWTVDDCTECTCQNSATVCRKVSCPLIPCANAT--VPDGECCPRC 371
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 2.60e-14

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 68.21  E-value: 2.60e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  439 SHWSPWSSCSVTCGAGVITRIRLCNSPTPqmGGKSCQGEGRQTEKCQQSSC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
317-371 1.36e-13

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 66.39  E-value: 1.36e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2064944608   317 CLHNGIVHKNKDEWTVDDCTECTCQNSATV-CRKVSCPL-IPCANAT--VPDGECCPRC 371
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 6.04e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 64.53  E-value: 6.04e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2064944608   382 WSPWSEWTRCSVTCGRGVQQRGRSCDRINNN-----CEGTSVQTRDCYLRECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
496-546 4.42e-12

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 61.67  E-value: 4.42e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  496 GPWSPWDTCTVTCGAGVQSRKRLCNDPPPkhGGKECMGDAKTTQRCNKKDC 546
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 2.70e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 59.35  E-value: 2.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2064944608  383 SPWSEWTRCSVTCGRGVQQRGRSCD---RINNNCEGTSVQTRDCYLREC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKspfPGGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 846-882 1.59e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.59e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2064944608  846 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 882
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 439-489 9.98e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 52.28  E-value: 9.98e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  439 SHWSPWSSCSVTCGAGVITRIRLCNSPtPQMGGKSCqGEGRQTEKCQQSSC 489
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 786-821 7.75e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 7.75e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2064944608  786 TDTDNNGEGDVCAVDIDGDDILNEKDNCPYVYNVDQ 821
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 383-428 9.88e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 49.59  E-value: 9.88e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2064944608  383 SPWSEWTRCSVTCGRGVQQR-----------GRSCdrinnnceGTSVQTRDCYLREC 428
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPC--------PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 920-949 2.97e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.74  E-value: 2.97e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2064944608  920 DSDGDGRGDACKDDFDQDNVPDIYDVCPEN 949
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 496-546 4.09e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.66  E-value: 4.09e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2064944608  496 GPWSPWDTCTVTCGAGVQSRKR---LcndpPPKHGGKECmGDAKTTQRCNKKDC 546
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtviV----EPQNGGRPC-PELLERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 650-689 9.79e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 9.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2064944608  650 CIDGSHDCNKNARCNYlghfSDPMFRCECKPGYAGNGHIC 689
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-546 5.41e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 42.05  E-value: 5.41e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2064944608  496 GPWSPwdtCTVTCGAGVQSRKRLCNDPPPK--HGGKECMGDAK--TTQRCNKKDC 546
Cdd:pfam19030    4 GPWGE---CSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 494-549 1.41e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 46.11  E-value: 1.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2064944608  494 NWGPWSPWDTCTVTCGAGVQSRKRlcndpPPKHGGkeCMgdAKTTQRCNKKDCPID 549
Cdd:PTZ00441   239 SCGPWDEWTPCSVTCGKGTHSRSR-----PILHEG--CT--THMVEECEEEECPVE 285
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 334-380 4.48e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 44.30  E-value: 4.48e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2064944608  334 DCTECTCQNSAT---VCRKVS--CPLIPCANATVPDGECCPRCG----TPSDYAED 380
Cdd:pfam14828  193 DPSGCGCGNDENlerICANVLqrCPPPHCLSPLRPEGHCCDVCGaivsLDYSSCFD 248
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 384-428 6.08e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 6.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2064944608  384 PWSEWTRCSVTCGRGVQQRGRSCdrINNNCegTSVQTRDCYLREC 428
Cdd:PTZ00441   242 PWDEWTPCSVTCGKGTHSRSRPI--LHEGC--TTHMVEECEEEEC 282
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 386-428 1.08e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 37.70  E-value: 1.08e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2064944608  386 SEWTRCSVTCGRGVQQRgrscdRINNNCEGTSV-QTRDCYLREC 428
Cdd:pfam19035    6 TEWSPCSKTCGMGVSTR-----VSNDNAECKLVtETRLCQLRPC 44
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 443-489 4.27e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 4.27e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2064944608  443 PWSSCSVTCGAGVITRIRLCNSPTPQ--MGGKSCQGEGR--QTEKCQQSSC 489
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 442-489 5.96e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 35.77  E-value: 5.96e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2064944608  442 SPWSSCSVTCGAGVITRIRLCNsptpqmggKSCQGEgRQTEKCQQSSC 489
Cdd:pfam19035    6 TEWSPCSKTCGMGVSTRVSNDN--------AECKLV-TETRLCQLRPC 44
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
317-384 6.28e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 36.39  E-value: 6.28e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2064944608   317 CLHNGIVHKNKDEWtVDDCTECTCQNSATVCRKVSCPLIPCANATVpDGECCPRCGTPSDYAEDGWSP 384
Cdd:smart00215    1 CWNNGSYYPPGAKW-DDDCNRCTCLNGRVSCTKVWCGPKPCLLHNL-SGECPLGQGCVPSLSDCLSSP 66
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 388-428 6.53e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 6.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2064944608  388 WTRCSVTCGRGVQQR----GRSCDRI---NNNCEGTS--VQTRDCYLREC 428
Cdd:pfam19030    6 WGECSVTCGGGVQTRlvqcVQKGGGSivpDSECSAQKkpPETQSCNLKPC 55
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 692-976 9.90e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 9.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  692 DSDLDGWPNEDLECVENATYHCKKDNCPNLPNSGQEDYDKDGIGDACDNDDDNDGIPDDRDNCQFVFNPRQYDYDRDDVG 771
Cdd:NF033609   623 DSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  772 DRCDNCPYNSNPDqTDTDNNGEGDVcavDIDGD-DILNEKDNCPYVYNVDQRDTDLDGVGDQCDNCPLEHNPDQlDSDSD 850
Cdd:NF033609   703 DSDSDSDSDSDSD-SDSDSDSDSDS---DSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSD 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064944608  851 RVGDKcDSNQDIDEDghqnnldncpyipnaNQADHDKDGKGDACDHDDDNDGIPDDKDNCRLAFNPDQLDSDGDGRGDAC 930
Cdd:NF033609   778 SDSDS-DSDSDSDSD---------------SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 2064944608  931 KD-DFDQDNVPDIYDVCPENFDiSETDFRKFQMVPLDPK-GTSQIDPN 976
Cdd:NF033609   842 SDsDSDSDSDSDSDSESDSNSD-SESGSNNNVVPPNSPKnGTNASNKN 888
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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