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Conserved domains on  [gi|2064413182|gb|KAG7391553|]
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hypothetical protein PHYPSEUDO_004623 [Phytophthora pseudosyringae]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 413-764 0e+00

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member PTZ00126:

Pssm-ID: 469580 [Multi-domain]  Cd Length: 383  Bit Score: 603.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 413 KPSALSPEERYAVARSVGEECIQENELQALLEKKEHPVCYDGFEPSGRMHIAQGVLRTVNVNKLTSTGSVFRFWVADWFA 492
Cdd:PTZ00126   31 PQSKLSLEERVKLCLSIGEECIQPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 493 MLNNKMGGDLDKIRLVGQYMVEIWKSVGMDMTNVEFLWASKEIISHSASYWLRVMDIARRTTIARTLKCCTIMGRKEKEG 572
Cdd:PTZ00126  111 LLNNKMGGDLEKIRKVGEYFIEVWKAAGMDMDNVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 573 MQAAQILYPLMQCADIFNLKADICQLGIDQRKINMLARDYCDQAKIRFKPVILSHHMLMGLKEGQEKMSKSDPESAIFME 652
Cdd:PTZ00126  191 QPCAQILYPCMQCADIFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFME 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 653 DAADDVSRKIEKAFCPEGVVEANPILDYMKHIICPRYAAQGVTAKLVDGSDKTFSAYQELEDAFVARQVNGADLKTALTK 732
Cdd:PTZ00126  271 DSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAFNSFTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAK 350

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2064413182 733 YLNEILEPVREHFSKG-EAKELLAKVRSFRITR 764
Cdd:PTZ00126  351 YLNLMLQPVRDHFQNNpEAKSLLSEVKSYKVTK 383
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 56-388 5.06e-136

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member PTZ00126:

Pssm-ID: 469580 [Multi-domain]  Cd Length: 383  Bit Score: 407.15  E-value: 5.06e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  56 HEAQLRALFAEKAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVE 135
Cdd:PTZ00126   53 QPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFALLNNKMGGDLEKIRKVGEYFIE 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 136 VWKALGLDADklpNLEIMLASTETARHAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDD---AAhntnRILYPLMQLAD 212
Cdd:PTZ00126  133 VWKAAGMDMD---NVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDeqpCA----QILYPCMQCAD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 213 GFLLQADIYQLGADQEAGNELAREYIAQKELPKKPVFLTHPLLLGLKQEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYC 292
Cdd:PTZ00126  206 IFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFMEDSEEDVNRKIKKAYC 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 293 VPGEVEGNPVLNYLKFLVFPLHAEgITLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLEPVRQHFA 372
Cdd:PTZ00126  286 PPGVIEGNPILAYFKSIVFPAFNS-FTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAKYLNLMLQPVRDHFQ 364

                         330
                  ....*....|....*..
gi 2064413182 373 SGP-LKTMLSSIKKLKV 388
Cdd:PTZ00126  365 NNPeAKSLLSEVKSYKV 381
 
Name Accession Description Interval E-value
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 413-764 0e+00

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 603.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 413 KPSALSPEERYAVARSVGEECIQENELQALLEKKEHPVCYDGFEPSGRMHIAQGVLRTVNVNKLTSTGSVFRFWVADWFA 492
Cdd:PTZ00126   31 PQSKLSLEERVKLCLSIGEECIQPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 493 MLNNKMGGDLDKIRLVGQYMVEIWKSVGMDMTNVEFLWASKEIISHSASYWLRVMDIARRTTIARTLKCCTIMGRKEKEG 572
Cdd:PTZ00126  111 LLNNKMGGDLEKIRKVGEYFIEVWKAAGMDMDNVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 573 MQAAQILYPLMQCADIFNLKADICQLGIDQRKINMLARDYCDQAKIRFKPVILSHHMLMGLKEGQEKMSKSDPESAIFME 652
Cdd:PTZ00126  191 QPCAQILYPCMQCADIFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFME 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 653 DAADDVSRKIEKAFCPEGVVEANPILDYMKHIICPRYAAQGVTAKLVDGSDKTFSAYQELEDAFVARQVNGADLKTALTK 732
Cdd:PTZ00126  271 DSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAFNSFTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAK 350

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2064413182 733 YLNEILEPVREHFSKG-EAKELLAKVRSFRITR 764
Cdd:PTZ00126  351 YLNLMLQPVRDHFQNNpEAKSLLSEVKSYKVTK 383
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 56-388 5.06e-136

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 407.15  E-value: 5.06e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  56 HEAQLRALFAEKAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVE 135
Cdd:PTZ00126   53 QPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFALLNNKMGGDLEKIRKVGEYFIE 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 136 VWKALGLDADklpNLEIMLASTETARHAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDD---AAhntnRILYPLMQLAD 212
Cdd:PTZ00126  133 VWKAAGMDMD---NVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDeqpCA----QILYPCMQCAD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 213 GFLLQADIYQLGADQEAGNELAREYIAQKELPKKPVFLTHPLLLGLKQEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYC 292
Cdd:PTZ00126  206 IFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFMEDSEEDVNRKIKKAYC 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 293 VPGEVEGNPVLNYLKFLVFPLHAEgITLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLEPVRQHFA 372
Cdd:PTZ00126  286 PPGVIEGNPILAYFKSIVFPAFNS-FTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAKYLNLMLQPVRDHFQ 364

                         330
                  ....*....|....*..
gi 2064413182 373 SGP-LKTMLSSIKKLKV 388
Cdd:PTZ00126  365 NNPeAKSLLSEVKSYKV 381
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
444-739 2.37e-50

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 178.24  E-value: 2.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 444 EKKEHPVCYDGFEPSGRMHIAQ-GVLRtvNVNKLTSTGSVFRFWVADWFAMLNNKMGGDLDKIRLVGQYMV---EIWKSV 519
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLGYlVPLM--KLRQFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLSRETVLEnaiKAQLAC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 520 GMDMTNVEFLWASkEIISHSaSYWLRVMDIARRTTIARTLKCCTIMGR-KEKEGMQAAQILYPLMQCADIFNLKADICQL 598
Cdd:pfam00579  79 GLDPEKAEIVNNS-DWLEHL-ELAWLLRDLGKHFSLNRMLQFKDVKKRlEQGPGISLGEFTYPLLQAYDILLLKADLQPG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 599 GIDQRKINMLARDYCDQA--KIRFKPVILSHHMLMGLkEGQEKMSKSDPESAIFMEDAADDVSRKIEKAFC-PEGVVEAn 675
Cdd:pfam00579 157 GSDQWGNIELGRDLARRFnkKIFKKPVGLTNPLLTGL-DGGKKMSKSAGNSAIFLDDDPESVYKKIQKAYTdPDREVRK- 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2064413182 676 piLDYMKHIICP----RYAAqgvtaklvDGSDKTFSAYQELEDAFVARQVNGADLKTALTKYLNEILE 739
Cdd:pfam00579 235 --DLKLFTFLSNeeieILEA--------ELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
66-365 5.37e-43

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 157.82  E-value: 5.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  66 EKAHPIAYDGFEPSGRVTLA-AGLLRALNaqRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVEV---WKALG 141
Cdd:pfam00579   2 KNRPLRVYSGIDPTGPLHLGyLVPLMKLR--QFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 142 LDADKLpnlEIMLASTETArHAGAYWsqVL-DAAGRFTVERVQQCAPIMGRRMDDAAHNTNRILYPLMQLADGFLLQADI 220
Cdd:pfam00579  80 LDPEKA---EIVNNSDWLE-HLELAW--LLrDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 221 YQLGADQEAGNELAREYI--AQKELPKKPVFLTHPLLLGLKQEQfKMTTTDAESAIYVDDTAAEVKTKIKKAYCVPGevE 298
Cdd:pfam00579 154 QPGGSDQWGNIELGRDLArrFNKKIFKKPVGLTNPLLTGLDGGK-KMSKSAGNSAIFLDDDPESVYKKIQKAYTDPD--R 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2064413182 299 GNPVLNYLKFLVFPLhaegiTLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLE 365
Cdd:pfam00579 231 EVRKDLKLFTFLSNE-----EIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 452-737 4.59e-35

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 134.27  E-value: 4.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 452 YDGFEPSG-RMHIAQGVLrTVNVNKLTSTGSVFRFWVADWFAMLNNKMG-------GDLDKIRLVGQYMVEIWKSVGmdm 523
Cdd:cd00805     4 YIGFDPTApSLHLGHLVP-LMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENAKYYKKQLKAIL--- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 524 tnvEFLWASKEIISHSAS-----YWLRVMDIARRTTIARTLKCCTIMGR-KEKEGMQAAQILYPLMQCADIFNLKADICQ 597
Cdd:cd00805    80 ---DFIPPEKAKFVNNSDwllslYTLDFLRLGKHFTVNRMLRRDAVKVRlEEEEGISFSEFIYPLLQAYDFVYLDVDLQL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 598 LGIDQRKINMLARDYcdQAKIRFKPVI-LSHHMLMGLKEGqeKMSKSDPESA-IFMEDAADDVSRKIEKAFCPegvvean 675
Cdd:cd00805   157 GGSDQRGNITLGRDL--IRKLGYKKVVgLTTPLLTGLDGG--KMSKSEGNAIwDPVLDSPYDVYQKIRNAFDP------- 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2064413182 676 PILDYMKHIICPRYaaqgvtaklvdgsdktfSAYQELEDAFVARqVNGADLKTALTKYLNEI 737
Cdd:cd00805   226 DVLEFLKLFTFLDY-----------------EEIEELEEEHAEG-PLPRDAKKALAEELTKL 269
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 72-363 1.36e-28

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 115.78  E-value: 1.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  72 AYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFG-------GDLKKLQSVSTYMVEVWKALGLDA 144
Cdd:cd00805     3 VYIGFDPTAPSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENAKYYKKQLKAILDFI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 145 DkLPNLEIMLASTETarhAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDDAAHNTNRILYPLMQLADGFLLQADIYQLG 224
Cdd:cd00805    83 P-PEKAKFVNNSDWL---LSLYTLDFLRLGKHFTVNRMLRRDAVKVRLEEEEGISFSEFIYPLLQAYDFVYLDVDLQLGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 225 ADQEAGNELAREYIaqKELPKKPVF-LTHPLLLGLKQEqfKMTTTDAESA-IYVDDTAAEVKTKIKKAYCVpgevegnPV 302
Cdd:cd00805   159 SDQRGNITLGRDLI--RKLGYKKVVgLTTPLLTGLDGG--KMSKSEGNAIwDPVLDSPYDVYQKIRNAFDP-------DV 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2064413182 303 LNYLKFLVFPLhaegitlerseknggnltFATYDELEAAFAgEKVHPADLKPCLTKYINAL 363
Cdd:cd00805   228 LEFLKLFTFLD------------------YEEIEELEEEHA-EGPLPRDAKKALAEELTKL 269
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 452-753 3.80e-19

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 89.31  E-value: 3.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 452 YDGFEPSGRMHIAqgvlrtvnvNKLtstGSVFRFW-----------VADWFAMLnnKMGGDLDKIRLVGQYMVEIWKSVG 520
Cdd:TIGR00233   6 LTGIQPSGKMHLG---------HYL---GAIQTKWlqqfgvelficIADLHAIT--VKQTDPDALRKAREELAADYLAVG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 521 MDMTNVEFLWASkEIISHSASYWLrvmdIARRTTIARTLKCCTIMGRKEKEGMQAAQILYPLMQCADIFNLKADICQLGI 600
Cdd:TIGR00233  72 LDPEKTFIFLQS-DYPEHYELAWL----LSCQVTFGELKRMTQFKDKSQAENVPIGLLSYPVLQAADILLYQADLVPVGI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 601 DQRKINMLARDYCDQAKIRFK-----PVILSHHM---LMGLKEgqEKMSKSDPESAIFMEDAADDVSRKIEKA------- 665
Cdd:TIGR00233 147 DQDQHLELTRDLAERFNKKFKnffpkPESLISKFfprLMGLSG--KKMSKSDPNSAIFLTDTPKQIKKKIRKAatdggrv 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 666 --FCPE---GVVEANPILDYM-KHIICpryaaqgvtaklvdgSDKTFSAYQEledaFVARQVNGADLKTALTKYLNEILE 739
Cdd:TIGR00233 225 tlFEHRekpGVPNLLVIYQYLsFFLID---------------DDKLKEIYEA----YKSGKLGYGECKKALIEVLQEFLK 285

                         330
                  ....*....|....
gi 2064413182 740 PVREHFSKGEAKEL 753
Cdd:TIGR00233 286 EIQERRAEIAEEIL 299
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 67-372 6.62e-19

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 89.38  E-value: 6.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  67 KAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGD-LKKLQS-----VSTYMVEVWKAL 140
Cdd:TIGR00234  29 ERPLKLYLGFDPTAPSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDPTGKSeVRKILTreevqENAENIKKQIAR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 141 GLDADKlpnLEIMLASTetarhagaYWSQ------VLDAAGRFTVERvqqcapiMGRRMDDAA-----HNTNRILYPLMQ 209
Cdd:TIGR00234 109 FLDFEK---AKFVYNSE--------WLLKlnytdfIRLLGKIFTVNR-------MLRRDAFSSrfeenISLHEFIYPLLQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 210 LADGFLLQADIyQLGADQEAGNELAREYIAQKELPKKPVFLTHPLLLGLKQEQF------KMTTTDAESA--IYVDDTAA 281
Cdd:TIGR00234 171 AYDFVYLNVDL-QLGGSDQWFNIRKGRDLARENLPSLQFGLTVPLLTPADGEKMgkslggAVSLDEGKYDfyQKVINTPD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 282 EVKTKIKKAYCVPG----------------EVEGNPVLNYLKFLVFPLHA-----------------EGITLERSEKNGG 328
Cdd:TIGR00234 250 ELVKKYLKLFTFLGleeieqlvelkgpnprEVKENLALEITKYVHGPEAAlaaeeiseaifsgglnpDEVPIFRPEKFGG 329

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2064413182 329 NLTFATYDELEAAFAGEKVHPADLK---PCLTKYINALLEPVRQHFA 372
Cdd:TIGR00234 330 PITLADLLVLSGLFPSKSEARRDIKnggVYINGEKVEDLEPIRKELE 376
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 580-755 2.60e-13

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 71.62  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 580 YPLMQCADIFNLKADICQLGIDQ-----------RKINMLARDYcdqakirFK---PVILSHHM-LMGLkEGQEKMSKSD 644
Cdd:COG0180   129 YPVLMAADILLYKADLVPVGEDQkqhleltrdiaRRFNHRYGEV-------FPepeALIPEEGArIPGL-DGRKKMSKSY 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 645 pESAIFMEDAADDVSRKIEKA--------FCPEGVVEANPILDYMKhiicpryaaqgvtakLVDGSDKTfsayQELEDAF 716
Cdd:COG0180   201 -GNTINLLDDPKEIRKKIKSAvtdserlrYDDPGKPEVCNLFTIYS---------------AFSGKEEV----EELEAEY 260

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2064413182 717 VARQVNGADLKTALTKYLNEILEPVREhfskgEAKELLA 755
Cdd:COG0180   261 RAGGIGYGDLKKALAEAVVEFLAPIRE-----RRAELLA 294
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 78-372 2.41e-09

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 59.68  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  78 PSGRVTLA--AGLLRalNAQRLMD-AGCHVrlLVADTHALLNNKfggDLKKLQSvSTY-MVEVWKALGLDADKlpnleim 153
Cdd:COG0180    12 PTGRLHLGnyLGALK--NWVELQDeYECFF--FIADLHALTTPQ---DPEELRE-NTReVAADYLAAGLDPEK------- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 154 laST--------EtarHAGAYWsqVLdaagrftvervqQC-APiMGR--RM----DDAAHNTNRIL------YPLMQLAD 212
Cdd:COG0180    77 --STifvqsdvpE---HAELAW--LL------------SClTP-LGEleRMpqfkDKSAKNGKENVnaglltYPVLMAAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 213 GFLLQADIYQLGADQEAGNELAREyIAQK---------ELPKkPVFLTH-PLLLGLkqE-QFKMTTTDAeSAIYVDDTAA 281
Cdd:COG0180   137 ILLYKADLVPVGEDQKQHLELTRD-IARRfnhrygevfPEPE-ALIPEEgARIPGL--DgRKKMSKSYG-NTINLLDDPK 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 282 EVKTKIKKAYC--------VPGEVEGNPVLNYLKFLvfplhaegitlerSEKnggnltfATYDELEAAFAGEKVHPADLK 353
Cdd:COG0180   212 EIRKKIKSAVTdserlrydDPGKPEVCNLFTIYSAF-------------SGK-------EEVEELEAEYRAGGIGYGDLK 271

                         330
                  ....*....|....*....
gi 2064413182 354 PCLTKYINALLEPVRQHFA 372
Cdd:COG0180   272 KALAEAVVEFLAPIRERRA 290
 
Name Accession Description Interval E-value
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 413-764 0e+00

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 603.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 413 KPSALSPEERYAVARSVGEECIQENELQALLEKKEHPVCYDGFEPSGRMHIAQGVLRTVNVNKLTSTGSVFRFWVADWFA 492
Cdd:PTZ00126   31 PQSKLSLEERVKLCLSIGEECIQPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 493 MLNNKMGGDLDKIRLVGQYMVEIWKSVGMDMTNVEFLWASKEIISHSASYWLRVMDIARRTTIARTLKCCTIMGRKEKEG 572
Cdd:PTZ00126  111 LLNNKMGGDLEKIRKVGEYFIEVWKAAGMDMDNVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 573 MQAAQILYPLMQCADIFNLKADICQLGIDQRKINMLARDYCDQAKIRFKPVILSHHMLMGLKEGQEKMSKSDPESAIFME 652
Cdd:PTZ00126  191 QPCAQILYPCMQCADIFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFME 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 653 DAADDVSRKIEKAFCPEGVVEANPILDYMKHIICPRYAAQGVTAKLVDGSDKTFSAYQELEDAFVARQVNGADLKTALTK 732
Cdd:PTZ00126  271 DSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAFNSFTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAK 350

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2064413182 733 YLNEILEPVREHFSKG-EAKELLAKVRSFRITR 764
Cdd:PTZ00126  351 YLNLMLQPVRDHFQNNpEAKSLLSEVKSYKVTK 383
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 417-761 1.05e-159

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 479.01  E-value: 1.05e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 417 LSPEERYAVARSVGEECIQENELQALLEKKEHPVCYDGFEPSGRMHIAQGVLRTVNVNKLTSTGSVFRFWVADWFAMLNN 496
Cdd:PTZ00348    1 MNTDERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTQAGCEFVFWVADWFALMND 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 497 KMGGDLDKIRLVGQYMVEIWKSVGMDMTNVEFLWASKEIISHSASYWLRVMDIARRTTIARTLKCCTIMGRKEKEgMQAA 576
Cdd:PTZ00348   81 KVGGELEKIRIVGRYLIEVWKAAGMDMDKVLFLWSSEEITNHANTYWRTVLDIGRQNTIARIKKCCTIMGKTEGT-LTAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 577 QILYPLMQCADIFNLKADICQLGIDQRKINMLARDYCDQAKIRFKPVILSHHMLMGLKEGQEKMSKSDPESAIFMEDAAD 656
Cdd:PTZ00348  160 QVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLIGRKLKPVILSHHMLAGLKQGQAKMSKSDPDSAIFMEDTEE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 657 DVSRKIEKAFCPE---------------GVVEANPILDYMKHIIcprYAAQGVTAkLVDGSdkTFSAYQELEDAFVARQV 721
Cdd:PTZ00348  240 DVARKIRQAYCPRvkqsaseitddgapvATDDRNPVLDYFQCVV---YARPGAVA-TIDGT--TYATYEDLEQAFVSDEV 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2064413182 722 NGADLKTALTKYLNEILEPVREHF-SKGEAKELLAKVRSFR 761
Cdd:PTZ00348  314 SEEALKSCLIDEVNALLEPVRQHFaSNPEAHELLEAVKSYR 354
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 56-388 5.06e-136

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 407.15  E-value: 5.06e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  56 HEAQLRALFAEKAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVE 135
Cdd:PTZ00126   53 QPEELRELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLTKAGCVFVFWVADWFALLNNKMGGDLEKIRKVGEYFIE 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 136 VWKALGLDADklpNLEIMLASTETARHAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDD---AAhntnRILYPLMQLAD 212
Cdd:PTZ00126  133 VWKAAGMDMD---NVRFLWASEEINKNPNDYWLRVMDIARSFNITRIKRCSQIMGRSEGDeqpCA----QILYPCMQCAD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 213 GFLLQADIYQLGADQEAGNELAREYIAQKELPKKPVFLTHPLLLGLKQEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYC 292
Cdd:PTZ00126  206 IFYLKADICQLGMDQRKVNMLAREYCDKKKIKKKPIILSHHMLPGLLEGQEKMSKSDPNSAIFMEDSEEDVNRKIKKAYC 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 293 VPGEVEGNPVLNYLKFLVFPLHAEgITLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLEPVRQHFA 372
Cdd:PTZ00126  286 PPGVIEGNPILAYFKSIVFPAFNS-FTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAKYLNLMLQPVRDHFQ 364

                         330
                  ....*....|....*..
gi 2064413182 373 SGP-LKTMLSSIKKLKV 388
Cdd:PTZ00126  365 NNPeAKSLLSEVKSYKV 381
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 420-754 5.36e-105

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 324.90  E-value: 5.36e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 420 EERYA-VARSVgEECIQENELQALLEKKEHPVCYDGFEPSGRMHIaqGVLRTVN-VNKLTSTGSVFRFWVADWFAMLNNK 497
Cdd:PRK08560    2 EERLElITRNT-EEVVTEEELRELLESKEEPKAYIGFEPSGKIHL--GHLLTMNkLADLQKAGFKVTVLLADWHAYLNDK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 498 mgGDLDKIRLVGQYMVEIWKSVGMDMTNVEFLWASKeiISHSASYWLRVMDIARRTTIARTLKCCTIMGRKEKEGMqAAQ 577
Cdd:PRK08560   79 --GDLEEIRKVAEYNKKVFEALGLDPDKTEFVLGSE--FQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPD-VSK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 578 ILYPLMQCADIFNLKADICQLGIDQRKINMLARDYCDqaKIRF-KPVILSHHMLMGLKEGQEKMSKSDPESAIFMEDAAD 656
Cdd:PRK08560  154 LVYPLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLP--KLGYkKPVCIHTPLLTGLDGGGIKMSKSKPGSAIFVHDSPE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 657 DVSRKIEKAFCPEGVVEANPILDYMKHIICPRYAAQGVTAKLVDGSDKTFSAYQELEDAFVARQVNGADLKTALTKYLNE 736
Cdd:PRK08560  232 EIRRKIKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIE 311

                         330
                  ....*....|....*...
gi 2064413182 737 ILEPVREHFSKGEAKELL 754
Cdd:PRK08560  312 ILEPVREYLEEGPELLEL 329
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 56-759 6.99e-96

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 312.61  E-value: 6.99e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  56 HEAQLRALFAEKAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVE 135
Cdd:PTZ00348   19 QESELRNLIEKKPLIRCYDGFEPSGRMHIAQGIFKAVNVNKCTQAGCEFVFWVADWFALMNDKVGGELEKIRIVGRYLIE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 136 VWKALGLDADKlpnLEIMLASTETARHAGAYWSQVLDAAGRFTVERVQQCAPIMGRRmdDAAHNTNRILYPLMQLADGFL 215
Cdd:PTZ00348   99 VWKAAGMDMDK---VLFLWSSEEITNHANTYWRTVLDIGRQNTIARIKKCCTIMGKT--EGTLTAAQVLYPLMQCADIFF 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 216 LQADIYQLGADQEAGNELAREY---IAQKelpKKPVFLTHPLLLGLKQEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYC 292
Cdd:PTZ00348  174 LKADICQLGLDQRKVNMLAREYcdlIGRK---LKPVILSHHMLAGLKQGQAKMSKSDPDSAIFMEDTEEDVARKIRQAYC 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 293 ----------------VPGEvEGNPVLNYLKFLVFPLHAEGITLERSeknggnlTFATYDELEAAFAGEKVHPADLKPCL 356
Cdd:PTZ00348  251 prvkqsaseitddgapVATD-DRNPVLDYFQCVVYARPGAVATIDGT-------TYATYEDLEQAFVSDEVSEEALKSCL 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 357 TKYINALLEPVRQHFASGP-----LKTMLSSIKKLKVSPipdgdkLANLSLPGFPE---AVKeWKPSALSPEERYAVARS 428
Cdd:PTZ00348  323 IDEVNALLEPVRQHFASNPeahelLEAVKSYRKGGATLP------LAETALPAAPEkphACM-WMPALIKVPLDVAEGMI 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 429 vgeeciqeNELQALLEkkEHPvcydgfepsgrmhiaqgvlrtvnvnkltsTGSVFrFWVADWFAMLNNKMGGDLDKIRLV 508
Cdd:PTZ00348  396 --------DATKDFIA--AHS-----------------------------DGTVT-LVLPDWSAVASDEITGEEKDISAA 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 509 GQYMVEIWKSVGMDmTNVEFLWASKEIISHSASYWLRVMDIARRTTIARTLKCCTimgrkeKEGMQAAQILYPLMQCADI 588
Cdd:PTZ00348  436 LEVNCALLKAYGLP-SEVKIVRENEVILGNPNDFWVSVIGIARKNLLSHVEELYG------GELRNAGQVIAALMRVATA 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 589 FNLKADICQLGIDQRKINMLARDYCDqAKIRFKPVilshhmlmglKEGQ-EKMSKSDPESAI-------FMEDAADDVSR 660
Cdd:PTZ00348  509 LMLSASHVISTSLDGGINEFAREYTK-GRIECIQA----------LEGRvPALHRPGAAPAVlgaddvlYLDDNDMDIRR 577

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 661 KIEKAFCPEGvVEANPILDYMKHIICPRyAAQGVTAKLVDGSDKTFSAYQELEDAFVARQVNGADLKTALTKYLNEILEP 740
Cdd:PTZ00348  578 KIKKAYSAPN-EEANPVISVAQHLLAQQ-GALSIERGEANGGNVAYNTPEALVADCGSGALHPADLKAAVSQLLLDRSAA 655

                         730
                  ....*....|....*....
gi 2064413182 741 VREHFSkGEAKELLAKVRS 759
Cdd:PTZ00348  656 ARALLS-GELKKNMQTLRN 673
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 54-377 3.55e-93

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 294.08  E-value: 3.55e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  54 TEHEaqLRALFAEKAHPIAYDGFEPSGRVTLAaGLLRALNAQRLMDAGCHVRLLVADTHALLNNKfgGDLKKLQSVSTYM 133
Cdd:PRK08560   17 TEEE--LRELLESKEEPKAYIGFEPSGKIHLG-HLLTMNKLADLQKAGFKVTVLLADWHAYLNDK--GDLEEIRKVAEYN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 134 VEVWKALGLDADKLpnlEIMLASTetARHAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDDAahNTNRILYPLMQLADG 213
Cdd:PRK08560   92 KKVFEALGLDPDKT---EFVLGSE--FQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEP--DVSKLVYPLMQVADI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 214 FLLQADIYQLGADQEAGNELAREyIAQKELPKKPVFLTHPLLLGLKQEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYCV 293
Cdd:PRK08560  165 FYLDVDIAVGGMDQRKIHMLARE-VLPKLGYKKPVCIHTPLLTGLDGGGIKMSKSKPGSAIFVHDSPEEIRRKIKKAYCP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 294 PGEVEGNPVLNYLKFLVFPLHAEgITLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLEPVRQHFAS 373
Cdd:PRK08560  244 PGEVEGNPVLEIAKYHIFPRYDP-FVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPVREYLEE 322


                  ....
gi 2064413182 374 GPLK 377
Cdd:PRK08560  323 GPEL 326
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
444-739 2.37e-50

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 178.24  E-value: 2.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 444 EKKEHPVCYDGFEPSGRMHIAQ-GVLRtvNVNKLTSTGSVFRFWVADWFAMLNNKMGGDLDKIRLVGQYMV---EIWKSV 519
Cdd:pfam00579   1 KKNRPLRVYSGIDPTGPLHLGYlVPLM--KLRQFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLSRETVLEnaiKAQLAC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 520 GMDMTNVEFLWASkEIISHSaSYWLRVMDIARRTTIARTLKCCTIMGR-KEKEGMQAAQILYPLMQCADIFNLKADICQL 598
Cdd:pfam00579  79 GLDPEKAEIVNNS-DWLEHL-ELAWLLRDLGKHFSLNRMLQFKDVKKRlEQGPGISLGEFTYPLLQAYDILLLKADLQPG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 599 GIDQRKINMLARDYCDQA--KIRFKPVILSHHMLMGLkEGQEKMSKSDPESAIFMEDAADDVSRKIEKAFC-PEGVVEAn 675
Cdd:pfam00579 157 GSDQWGNIELGRDLARRFnkKIFKKPVGLTNPLLTGL-DGGKKMSKSAGNSAIFLDDDPESVYKKIQKAYTdPDREVRK- 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2064413182 676 piLDYMKHIICP----RYAAqgvtaklvDGSDKTFSAYQELEDAFVARQVNGADLKTALTKYLNEILE 739
Cdd:pfam00579 235 --DLKLFTFLSNeeieILEA--------ELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
66-365 5.37e-43

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 157.82  E-value: 5.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  66 EKAHPIAYDGFEPSGRVTLA-AGLLRALNaqRLMDAGCHVRLLVADTHALLNNKFGGDLKKLQSVSTYMVEV---WKALG 141
Cdd:pfam00579   2 KNRPLRVYSGIDPTGPLHLGyLVPLMKLR--QFQQAGHEVFFLIGDLHAIIGDPSKSPERKLLSRETVLENAikaQLACG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 142 LDADKLpnlEIMLASTETArHAGAYWsqVL-DAAGRFTVERVQQCAPIMGRRMDDAAHNTNRILYPLMQLADGFLLQADI 220
Cdd:pfam00579  80 LDPEKA---EIVNNSDWLE-HLELAW--LLrDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 221 YQLGADQEAGNELAREYI--AQKELPKKPVFLTHPLLLGLKQEQfKMTTTDAESAIYVDDTAAEVKTKIKKAYCVPGevE 298
Cdd:pfam00579 154 QPGGSDQWGNIELGRDLArrFNKKIFKKPVGLTNPLLTGLDGGK-KMSKSAGNSAIFLDDDPESVYKKIQKAYTDPD--R 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2064413182 299 GNPVLNYLKFLVFPLhaegiTLERSEKNGGNLTFATYDELEAAFAGEKVHPADLKPCLTKYINALLE 365
Cdd:pfam00579 231 EVRKDLKLFTFLSNE-----EIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLLQ 292
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 452-737 4.59e-35

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 134.27  E-value: 4.59e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 452 YDGFEPSG-RMHIAQGVLrTVNVNKLTSTGSVFRFWVADWFAMLNNKMG-------GDLDKIRLVGQYMVEIWKSVGmdm 523
Cdd:cd00805     4 YIGFDPTApSLHLGHLVP-LMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENAKYYKKQLKAIL--- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 524 tnvEFLWASKEIISHSAS-----YWLRVMDIARRTTIARTLKCCTIMGR-KEKEGMQAAQILYPLMQCADIFNLKADICQ 597
Cdd:cd00805    80 ---DFIPPEKAKFVNNSDwllslYTLDFLRLGKHFTVNRMLRRDAVKVRlEEEEGISFSEFIYPLLQAYDFVYLDVDLQL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 598 LGIDQRKINMLARDYcdQAKIRFKPVI-LSHHMLMGLKEGqeKMSKSDPESA-IFMEDAADDVSRKIEKAFCPegvvean 675
Cdd:cd00805   157 GGSDQRGNITLGRDL--IRKLGYKKVVgLTTPLLTGLDGG--KMSKSEGNAIwDPVLDSPYDVYQKIRNAFDP------- 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2064413182 676 PILDYMKHIICPRYaaqgvtaklvdgsdktfSAYQELEDAFVARqVNGADLKTALTKYLNEI 737
Cdd:cd00805   226 DVLEFLKLFTFLDY-----------------EEIEELEEEHAEG-PLPRDAKKALAEELTKL 269
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 72-363 1.36e-28

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 115.78  E-value: 1.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  72 AYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFG-------GDLKKLQSVSTYMVEVWKALGLDA 144
Cdd:cd00805     3 VYIGFDPTAPSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSGkseerklLDLELIRENAKYYKKQLKAILDFI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 145 DkLPNLEIMLASTETarhAGAYWSQVLDAAGRFTVERVQQCAPIMGRRMDDAAHNTNRILYPLMQLADGFLLQADIYQLG 224
Cdd:cd00805    83 P-PEKAKFVNNSDWL---LSLYTLDFLRLGKHFTVNRMLRRDAVKVRLEEEEGISFSEFIYPLLQAYDFVYLDVDLQLGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 225 ADQEAGNELAREYIaqKELPKKPVF-LTHPLLLGLKQEqfKMTTTDAESA-IYVDDTAAEVKTKIKKAYCVpgevegnPV 302
Cdd:cd00805   159 SDQRGNITLGRDLI--RKLGYKKVVgLTTPLLTGLDGG--KMSKSEGNAIwDPVLDSPYDVYQKIRNAFDP-------DV 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2064413182 303 LNYLKFLVFPLhaegitlerseknggnltFATYDELEAAFAgEKVHPADLKPCLTKYINAL 363
Cdd:cd00805   228 LEFLKLFTFLD------------------YEEIEELEEEHA-EGPLPRDAKKALAEELTKL 269
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 452-666 3.63e-20

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 91.49  E-value: 3.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 452 YDGFEPSGRMHIAqgvlrtvnvNKLTStgsvFRFWV-------------ADWFAMLNNKMggDLDKIRLVGQYMVEIWKS 518
Cdd:cd00806     3 LSGIQPSGSLHLG---------HYLGA----FRFWVwlqeagyelfffiADLHALTVKQL--DPEELRQNTRENAKDYLA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 519 VGMDMTNVEFLWASkEIISHSASYWLrvmdIARRTTIARtLKCCTimGRKEKEGMQ----AAQILYPLMQCADIFNLKAD 594
Cdd:cd00806    68 CGLDPEKSTIFFQS-DVPEHYELAWL----LSCVVTFGE-LERMT--GFKDKSAQGesvnIGLLTYPVLQAADILLYKAC 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 595 ICQLGIDQ----RkinmLARDYCDQAKIRF-----KPVILSHHM--LMGLKEGQEKMSKSDPESAIFMEDAADDVSRKIE 663
Cdd:cd00806   140 LVPVGIDQdphlE----LTRDIARRFNKLYgeifpKPAALLSKGafLPGLQGPSKKMSKSDPNNAIFLTDSPKEIKKKIM 215


                  ...
gi 2064413182 664 KAF 666
Cdd:cd00806   216 KAA 218
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 452-753 3.80e-19

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 89.31  E-value: 3.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 452 YDGFEPSGRMHIAqgvlrtvnvNKLtstGSVFRFW-----------VADWFAMLnnKMGGDLDKIRLVGQYMVEIWKSVG 520
Cdd:TIGR00233   6 LTGIQPSGKMHLG---------HYL---GAIQTKWlqqfgvelficIADLHAIT--VKQTDPDALRKAREELAADYLAVG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 521 MDMTNVEFLWASkEIISHSASYWLrvmdIARRTTIARTLKCCTIMGRKEKEGMQAAQILYPLMQCADIFNLKADICQLGI 600
Cdd:TIGR00233  72 LDPEKTFIFLQS-DYPEHYELAWL----LSCQVTFGELKRMTQFKDKSQAENVPIGLLSYPVLQAADILLYQADLVPVGI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 601 DQRKINMLARDYCDQAKIRFK-----PVILSHHM---LMGLKEgqEKMSKSDPESAIFMEDAADDVSRKIEKA------- 665
Cdd:TIGR00233 147 DQDQHLELTRDLAERFNKKFKnffpkPESLISKFfprLMGLSG--KKMSKSDPNSAIFLTDTPKQIKKKIRKAatdggrv 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 666 --FCPE---GVVEANPILDYM-KHIICpryaaqgvtaklvdgSDKTFSAYQEledaFVARQVNGADLKTALTKYLNEILE 739
Cdd:TIGR00233 225 tlFEHRekpGVPNLLVIYQYLsFFLID---------------DDKLKEIYEA----YKSGKLGYGECKKALIEVLQEFLK 285

                         330
                  ....*....|....
gi 2064413182 740 PVREHFSKGEAKEL 753
Cdd:TIGR00233 286 EIQERRAEIAEEIL 299
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 67-372 6.62e-19

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 89.38  E-value: 6.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  67 KAHPIAYDGFEPSGRVTLAAGLLRALNAQRLMDAGCHVRLLVADTHALLNNKFGGD-LKKLQS-----VSTYMVEVWKAL 140
Cdd:TIGR00234  29 ERPLKLYLGFDPTAPSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDPTGKSeVRKILTreevqENAENIKKQIAR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 141 GLDADKlpnLEIMLASTetarhagaYWSQ------VLDAAGRFTVERvqqcapiMGRRMDDAA-----HNTNRILYPLMQ 209
Cdd:TIGR00234 109 FLDFEK---AKFVYNSE--------WLLKlnytdfIRLLGKIFTVNR-------MLRRDAFSSrfeenISLHEFIYPLLQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 210 LADGFLLQADIyQLGADQEAGNELAREYIAQKELPKKPVFLTHPLLLGLKQEQF------KMTTTDAESA--IYVDDTAA 281
Cdd:TIGR00234 171 AYDFVYLNVDL-QLGGSDQWFNIRKGRDLARENLPSLQFGLTVPLLTPADGEKMgkslggAVSLDEGKYDfyQKVINTPD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 282 EVKTKIKKAYCVPG----------------EVEGNPVLNYLKFLVFPLHA-----------------EGITLERSEKNGG 328
Cdd:TIGR00234 250 ELVKKYLKLFTFLGleeieqlvelkgpnprEVKENLALEITKYVHGPEAAlaaeeiseaifsgglnpDEVPIFRPEKFGG 329

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2064413182 329 NLTFATYDELEAAFAGEKVHPADLK---PCLTKYINALLEPVRQHFA 372
Cdd:TIGR00234 330 PITLADLLVLSGLFPSKSEARRDIKnggVYINGEKVEDLEPIRKELE 376
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 430-754 2.38e-15

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 78.59  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 430 GEECIQENELQALLEKKE-HPVCYDGFEPSG-RMHIAQgvlrTVNVNKLT---STGSVFRFWVADWFAMLNNKMGgdLDK 504
Cdd:TIGR00234  12 GLEVQTPEEEKDLLKLLErPLKLYLGFDPTApSLHLGH----LVPLLKLRdfqQAGHEVIVLLGDFTALIGDPTG--KSE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 505 IR------LVGQYMVEIWKSVGMdmtnveFLWASKEIISHSASYWLR------VMDIARRTTIARTLKCCTIMGRkEKEG 572
Cdd:TIGR00234  86 VRkiltreEVQENAENIKKQIAR------FLDFEKAKFVYNSEWLLKlnytdfIRLLGKIFTVNRMLRRDAFSSR-FEEN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 573 MQAAQILYPLMQCADIFNLKADiCQL-GIDQ----RKINMLARDY--CDQAKIRFKPVILSHHMLMGlKEGQEKMSKSDP 645
Cdd:TIGR00234 159 ISLHEFIYPLLQAYDFVYLNVD-LQLgGSDQwfniRKGRDLARENlpSLQFGLTVPLLTPADGEKMG-KSLGGAVSLDEG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 646 ESA--IFMEDAADDVSRKIEKAFCPEGV----------------VEANPILDYMKHIICPRYA--AQGVTAKLVDGsdkt 705
Cdd:TIGR00234 237 KYDfyQKVINTPDELVKKYLKLFTFLGLeeieqlvelkgpnpreVKENLALEITKYVHGPEAAlaAEEISEAIFSG---- 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2064413182 706 fsayQELEDAFVARQVNGADLKTALTKYLNEI-LEPvrehfSKGEAKELL 754
Cdd:TIGR00234 313 ----GLNPDEVPIFRPEKFGGPITLADLLVLSgLFP-----SKSEARRDI 353
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 70-372 9.90e-14

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 73.13  E-value: 9.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  70 PIAYDGFEPSGRVTLAaGLLRALNAQRLMDAGCHVRLLVADTHALLNnKFGGDLKKLQSVSTYmVEVWKALGLDADKLpn 149
Cdd:TIGR00233   3 FRVLTGIQPSGKMHLG-HYLGAIQTKWLQQFGVELFICIADLHAITV-KQTDPDALRKAREEL-AADYLAVGLDPEKT-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 150 lEIMLASTETARHAGAYWSQVLDAAGRftVERVQQcapiMGRRMDDAAHNTNRILYPLMQLADGFLLQADIYQLGADQEA 229
Cdd:TIGR00233  78 -FIFLQSDYPEHYELAWLLSCQVTFGE--LKRMTQ----FKDKSQAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 230 GNELAREyIAQ------KELPKKPVFLTH---PLLLGLkqEQFKMTTTDAESAIYVDDTAAEVKTKIKKAYCVPGEV--- 297
Cdd:TIGR00233 151 HLELTRD-LAErfnkkfKNFFPKPESLISkffPRLMGL--SGKKMSKSDPNSAIFLTDTPKQIKKKIRKAATDGGRVtlf 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 298 -----EGNP-VLNYLKFLVFPL--HAEGITLERSEKNGGNLTfatydeleaafagekvhpADLKPCLTKYINALLEPVRQ 369
Cdd:TIGR00233 228 ehrekPGVPnLLVIYQYLSFFLidDDKLKEIYEAYKSGKLGY------------------GECKKALIEVLQEFLKEIQE 289


                  ...
gi 2064413182 370 HFA 372
Cdd:TIGR00233 290 RRA 292
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 580-755 2.60e-13

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 71.62  E-value: 2.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 580 YPLMQCADIFNLKADICQLGIDQ-----------RKINMLARDYcdqakirFK---PVILSHHM-LMGLkEGQEKMSKSD 644
Cdd:COG0180   129 YPVLMAADILLYKADLVPVGEDQkqhleltrdiaRRFNHRYGEV-------FPepeALIPEEGArIPGL-DGRKKMSKSY 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 645 pESAIFMEDAADDVSRKIEKA--------FCPEGVVEANPILDYMKhiicpryaaqgvtakLVDGSDKTfsayQELEDAF 716
Cdd:COG0180   201 -GNTINLLDDPKEIRKKIKSAvtdserlrYDDPGKPEVCNLFTIYS---------------AFSGKEEV----EELEAEY 260

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2064413182 717 VARQVNGADLKTALTKYLNEILEPVREhfskgEAKELLA 755
Cdd:COG0180   261 RAGGIGYGDLKKALAEAVVEFLAPIRE-----RRAELLA 294
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 559-755 2.98e-13

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 71.66  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 559 LKCCTIMGR-------KEKEGMQAAQI-----LYPLMQCADIFNLKADICQLGIDQRKINMLARDYCdqakIRF------ 620
Cdd:PRK00927   93 LNCITPLGElermtqfKDKSAKQKENVsaglfTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIA----RRFnnlyge 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 621 -----KPVILSHHM-LMGLKEGQEKMSKSDPE--SAIFMEDAADDVSRKIEKA-----------FCPEGVVEANPILDYM 681
Cdd:PRK00927  169 vfpvpEPLIPKVGArVMGLDGPTKKMSKSDPNdnNTINLLDDPKTIAKKIKKAvtdserlreirYDLPNKPEVSNLLTIY 248

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2064413182 682 KHIicpryaaqgvtaklvdgSDKTFsayQELEDAFVARQVNGADLKTALTKYLNEILEPVREhfskgEAKELLA 755
Cdd:PRK00927  249 SAL-----------------SGESI---EELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRE-----RYEELLA 297
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 439-666 1.41e-12

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 69.89  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 439 LQALLEKKEHPVcYDGFEPSGRMHIAqgvlrtvnvNKLT---------STGSVFrFWVADWFAMLNNKMggDLDKIRLVG 509
Cdd:PRK12285   58 LEAYRNGKPFAV-YTGFMPSGPMHIG---------HKMVfdelkwhqeFGANVY-IPIADDEAYAARGL--SWEETREWA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 510 -QYMVEIWkSVGMDMTNVEFLWASKEIishsASYWLRVMdIARRTTIArTLKccTIMGRKEKEGMqaAQILYPLMQCADI 588
Cdd:PRK12285  125 yEYILDLI-ALGFDPDKTEIYFQSENI----KVYDLAFE-LAKKVNFS-ELK--AIYGFTGETNI--GHIFYPATQAADI 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 589 FNLKAD------ICQLGIDQ----RkinmLARDYCDQAKIRF---KPVILSHHMLMGLKEGqeKMSKSDPESAIFMEDAA 655
Cdd:PRK12285  194 LHPQLEegpkptLVPVGIDQdphiR----LTRDIAERLHGGYgfiKPSSTYHKFMPGLTGG--KMSSSKPESAIYLTDDP 267

                         250
                  ....*....|.
gi 2064413182 656 DDVSRKIEKAF 666
Cdd:PRK12285  268 ETVKKKIMKAL 278
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 78-372 2.41e-09

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 59.68  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182  78 PSGRVTLA--AGLLRalNAQRLMD-AGCHVrlLVADTHALLNNKfggDLKKLQSvSTY-MVEVWKALGLDADKlpnleim 153
Cdd:COG0180    12 PTGRLHLGnyLGALK--NWVELQDeYECFF--FIADLHALTTPQ---DPEELRE-NTReVAADYLAAGLDPEK------- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 154 laST--------EtarHAGAYWsqVLdaagrftvervqQC-APiMGR--RM----DDAAHNTNRIL------YPLMQLAD 212
Cdd:COG0180    77 --STifvqsdvpE---HAELAW--LL------------SClTP-LGEleRMpqfkDKSAKNGKENVnaglltYPVLMAAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 213 GFLLQADIYQLGADQEAGNELAREyIAQK---------ELPKkPVFLTH-PLLLGLkqE-QFKMTTTDAeSAIYVDDTAA 281
Cdd:COG0180   137 ILLYKADLVPVGEDQKQHLELTRD-IARRfnhrygevfPEPE-ALIPEEgARIPGL--DgRKKMSKSYG-NTINLLDDPK 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 282 EVKTKIKKAYC--------VPGEVEGNPVLNYLKFLvfplhaegitlerSEKnggnltfATYDELEAAFAGEKVHPADLK 353
Cdd:COG0180   212 EIRKKIKSAVTdserlrydDPGKPEVCNLFTIYSAF-------------SGK-------EEVEELEAEYRAGGIGYGDLK 271

                         330
                  ....*....|....*....
gi 2064413182 354 PCLTKYINALLEPVRQHFA 372
Cdd:COG0180   272 KALAEAVVEFLAPIRERRA 290
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 108-369 7.86e-09

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 58.18  E-value: 7.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 108 VADTHALLNNKFGGDLKKlqsvSTY-MVEVWKALGLDADKlpnleimlaST-----ETARHAGAYWsqVLdaagrftver 181
Cdd:PRK00927   39 IADLHALTVPQDPEELRE----NTReLAADYLACGIDPEK---------STifvqsHVPEHAELAW--IL---------- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 182 vqQC-APiMGR--RM----DDAAHNTNRI-----LYPLMQLADGFLLQADIYQLGADQEAGNELAREyIAQK-------- 241
Cdd:PRK00927   94 --NCiTP-LGEleRMtqfkDKSAKQKENVsaglfTYPVLMAADILLYKADLVPVGEDQKQHLELTRD-IARRfnnlygev 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 242 -ELPKkPVFL-THPLLLGLKQEQFKMTTTD--AESAIYVDDTAAEVKTKIKKA-----------YCVPGEVEGNPVLNYL 306
Cdd:PRK00927  170 fPVPE-PLIPkVGARVMGLDGPTKKMSKSDpnDNNTINLLDDPKTIAKKIKKAvtdserlreirYDLPNKPEVSNLLTIY 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2064413182 307 KFLvfplhaegitlerSEKnggnltfaTYDELEAAFAGEKVHPADLKPCLTKYINALLEPVRQ 369
Cdd:PRK00927  249 SAL-------------SGE--------SIEELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRE 290
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 205-369 1.68e-07

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 53.70  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 205 YPLMQLADGFLLQADIYQLGADQ----EAGNELAREY--IAQKEL--PKKPVFLTHPLLLGLKQEQfKMTTTDAeSAIYV 276
Cdd:PRK12282  130 YPVSQAADITAFKATLVPVGDDQlpmiEQTREIVRRFnsLYGTDVlvEPEALLPEAGRLPGLDGKA-KMSKSLG-NAIYL 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 277 DDTAAEVKTKIKKAY------CV--PGEVEGNPVLNYLKflVFPLHAEGItlerseknggnltfatyDELEAAFAGEKVH 348
Cdd:PRK12282  208 SDDADTIKKKVMSMYtdpnhiRVedPGKVEGNVVFTYLD--AFDPDKAEV-----------------AELKAHYQRGGLG 268

                         170       180
                  ....*....|....*....|.
gi 2064413182 349 PADLKPCLTKYINALLEPVRQ 369
Cdd:PRK12282  269 DVKCKRYLEEVLQELLAPIRE 289
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 449-743 2.37e-07

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 53.32  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 449 PVCYDGFEPSGRMHIAQ--GVLRtvNVNKLTSTGSVFrFWVADWFAMLNNkmGGDLDKIR-----LVGQYMveiwkSVGM 521
Cdd:PRK12282    3 PIILTGDRPTGKLHLGHyvGSLK--NRVALQNEHEQF-VLIADQQALTDN--AKNPEKIRrnileVALDYL-----AVGI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 522 DMTNVEFLWAS--KEIISHSASYwlrvMDIArrtTIAR-----TLKCcTIMGRKEKEGMQAAQILYPLMQCADIFNLKAD 594
Cdd:PRK12282   73 DPAKSTIFIQSqiPELAELTMYY----MNLV---TVARlernpTVKT-EIAQKGFGRSIPAGFLTYPVSQAADITAFKAT 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 595 ICQLGIDQ-----------RKINMLardYCDQAKIRFKPVILSHHMLMGLkEGQEKMSKSDpESAIFMEDAADDVSRKIE 663
Cdd:PRK12282  145 LVPVGDDQlpmieqtreivRRFNSL---YGTDVLVEPEALLPEAGRLPGL-DGKAKMSKSL-GNAIYLSDDADTIKKKVM 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 664 KAFC-P-------EGVVEANPILDYMKhIICPRYAaqgvtaklvdgsdktfsAYQELEDAFVARQVNGADLKTALTKYLN 735
Cdd:PRK12282  220 SMYTdPnhirvedPGKVEGNVVFTYLD-AFDPDKA-----------------EVAELKAHYQRGGLGDVKCKRYLEEVLQ 281


                  ....*...
gi 2064413182 736 EILEPVRE 743
Cdd:PRK12282  282 ELLAPIRE 289
PLN02486 PLN02486
aminoacyl-tRNA ligase
 195-289 2.02e-06

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 50.90  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 195 DAAHNTNRILYPLMQLADGF------LLQADIyQLGA------DQEAGNELAREyIAQKELPKKPVFLTHPLLLGLKQEQ 262
Cdd:PLN02486  186 SGEDNIGKISFPAVQAAPSFpssfphLFGGKD-KLRClipcaiDQDPYFRMTRD-VAPRLGYYKPALIESRFFPALQGES 263

                          90       100
                  ....*....|....*....|....*..
gi 2064413182 263 FKMTTTDAESAIYVDDTAAEVKTKIKK 289
Cdd:PLN02486  264 GKMSASDPNSAIYVTDTPKEIKNKINK 290
PLN02486 PLN02486
aminoacyl-tRNA ligase
 576-666 5.34e-06

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 49.36  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 576 AQILYPLMQCA--------DIFNLKADICQL---GIDQRKINMLARDYCDQAKIRfKPVILSHHMLMGLKEGQEKMSKSD 644
Cdd:PLN02486  192 GKISFPAVQAApsfpssfpHLFGGKDKLRCLipcAIDQDPYFRMTRDVAPRLGYY-KPALIESRFFPALQGESGKMSASD 270

                          90       100
                  ....*....|....*....|...
gi 2064413182 645 PESAIFMEDAADDVSRKIEK-AF 666
Cdd:PLN02486  271 PNSAIYVTDTPKEIKNKINKyAF 293
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 203-291 8.51e-06

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 48.71  E-value: 8.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2064413182 203 ILYPLMQLADGFLLQAD------IYQLGADQEAGNELAREyIAQKELPK----KPVFLTHPLLLGLKQEqfKMTTTDAES 272
Cdd:PRK12285  183 IFYPATQAADILHPQLEegpkptLVPVGIDQDPHIRLTRD-IAERLHGGygfiKPSSTYHKFMPGLTGG--KMSSSKPES 259

                          90
                  ....*....|....*....
gi 2064413182 273 AIYVDDTAAEVKTKIKKAY 291
Cdd:PRK12285  260 AIYLTDDPETVKKKIMKAL 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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