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Conserved domains on  [gi|2063789486|emb|CAG7572073|]
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Ribonuclease P protein component (RNaseP protein) (RNase P protein) (EC (Protein C5) [Mycoplasmoides pneumoniae M129]

Protein Classification

ribonuclease P protein component( domain architecture ID 10015528)

ribonuclease P catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus, and can also cleave other RNA substrates such as 4.5S RNA

CATH:  3.30.230.10
EC:  3.1.26.5
Gene Ontology:  GO:0004526|GO:0042781|GO:0000049|GO:0030677|GO:0008033
PubMed:  12831883
SCOP:  4000954

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rnpA TIGR00188
ribonuclease P protein component, eubacterial; This peptide is the protein component of a ...
 3-113 2.77e-39

ribonuclease P protein component, eubacterial; This peptide is the protein component of a ribonucleoprotein that cleaves the leader sequence from each tRNA precursor to leave the mature 5'-terminus. The catalytic site is in the RNA component, M1 RNA. The yeast mitochondrial RNase P protein component gene RPM2 has no obvious sequence similarity to rnpA, but resembles eukaryotic nuclear RNase P instead. [Transcription, RNA processing]


:

Pssm-ID: 211560  Cd Length: 111  Bit Score: 127.04  E-value: 2.77e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   3 AKTKHHLRDRKVFAALLRSKRRFFSTFLMAYFMPNRVRTWRAAVSISKTKYKLAVERNLIRRQVKAIMREQFCNLNAVDV 82
Cdd:TIGR00188   1 LKKPRRLRLKSEFQKVFQQGTRAFNPFLTIYVLKNELDHPRVGLSVSKKKVKNAVERNRIKRLIREVFRERQEELKALDV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2063789486  83 LVIINQGFLELTFKEKQTIFLNLCQKLQELD 113
Cdd:TIGR00188  81 VVIVRKGFSELTYEALLKLLLQLFLRCKRLD 111
 
Name Accession Description Interval E-value
rnpA TIGR00188
ribonuclease P protein component, eubacterial; This peptide is the protein component of a ...
 3-113 2.77e-39

ribonuclease P protein component, eubacterial; This peptide is the protein component of a ribonucleoprotein that cleaves the leader sequence from each tRNA precursor to leave the mature 5'-terminus. The catalytic site is in the RNA component, M1 RNA. The yeast mitochondrial RNase P protein component gene RPM2 has no obvious sequence similarity to rnpA, but resembles eukaryotic nuclear RNase P instead. [Transcription, RNA processing]


Pssm-ID: 211560  Cd Length: 111  Bit Score: 127.04  E-value: 2.77e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   3 AKTKHHLRDRKVFAALLRSKRRFFSTFLMAYFMPNRVRTWRAAVSISKTKYKLAVERNLIRRQVKAIMREQFCNLNAVDV 82
Cdd:TIGR00188   1 LKKPRRLRLKSEFQKVFQQGTRAFNPFLTIYVLKNELDHPRVGLSVSKKKVKNAVERNRIKRLIREVFRERQEELKALDV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2063789486  83 LVIINQGFLELTFKEKQTIFLNLCQKLQELD 113
Cdd:TIGR00188  81 VVIVRKGFSELTYEALLKLLLQLFLRCKRLD 111
RnpA COG0594
RNase P protein component [Translation, ribosomal structure and biogenesis];
9-107 7.18e-17

RNase P protein component [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440359  Cd Length: 99  Bit Score: 69.77  E-value: 7.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   9 LRDRKVFAALLRSKRRFFSTFLMAYFMPNRVRTWRAAVSISKtKYKLAVERNLIRRQVKAIMREQFCNL-NAVDVLVIIN 87
Cdd:COG0594     1 LKKRKDFQRVFRKGKRVSSRYFVLYYLPNDLDPPRLGFSVSK-KVGNAVVRNRIKRRLREAFRLNKPELpPGYDIVVIAR 79

                          90       100
                  ....*....|....*....|
gi 2063789486  88 QGFLELTFKEKQTIFLNLCQ 107
Cdd:COG0594    80 PGAAELDFAELEKELEKLLK 99
Ribonuclease_P pfam00825
Ribonuclease P;
6-110 5.97e-13

Ribonuclease P;


Pssm-ID: 425888  Cd Length: 107  Bit Score: 59.90  E-value: 5.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   6 KHHLRDRKVFAALLRSKRRFFSTFLMAYFMPN-RVRTWRAAVSISKTKYKlAVERNLIRRQVKAIMRE-QFCNLNAVDVL 83
Cdd:pfam00825   2 KERLKKRSEFQRVFRKGKRVASRHFVLYYLPNdLDHPPRLGISVSKKVGK-AVVRNRIKRLIREAFRLnKDELPPGLDIV 80

                          90       100
                  ....*....|....*....|....*..
gi 2063789486  84 VIINQGFLELTFKEKQTIFLNLCQKLQ 110
Cdd:pfam00825  81 VIARPGAADADFAELLKELEKLLKKAG 107
 
Name Accession Description Interval E-value
rnpA TIGR00188
ribonuclease P protein component, eubacterial; This peptide is the protein component of a ...
 3-113 2.77e-39

ribonuclease P protein component, eubacterial; This peptide is the protein component of a ribonucleoprotein that cleaves the leader sequence from each tRNA precursor to leave the mature 5'-terminus. The catalytic site is in the RNA component, M1 RNA. The yeast mitochondrial RNase P protein component gene RPM2 has no obvious sequence similarity to rnpA, but resembles eukaryotic nuclear RNase P instead. [Transcription, RNA processing]


Pssm-ID: 211560  Cd Length: 111  Bit Score: 127.04  E-value: 2.77e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   3 AKTKHHLRDRKVFAALLRSKRRFFSTFLMAYFMPNRVRTWRAAVSISKTKYKLAVERNLIRRQVKAIMREQFCNLNAVDV 82
Cdd:TIGR00188   1 LKKPRRLRLKSEFQKVFQQGTRAFNPFLTIYVLKNELDHPRVGLSVSKKKVKNAVERNRIKRLIREVFRERQEELKALDV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2063789486  83 LVIINQGFLELTFKEKQTIFLNLCQKLQELD 113
Cdd:TIGR00188  81 VVIVRKGFSELTYEALLKLLLQLFLRCKRLD 111
RnpA COG0594
RNase P protein component [Translation, ribosomal structure and biogenesis];
9-107 7.18e-17

RNase P protein component [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440359  Cd Length: 99  Bit Score: 69.77  E-value: 7.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   9 LRDRKVFAALLRSKRRFFSTFLMAYFMPNRVRTWRAAVSISKtKYKLAVERNLIRRQVKAIMREQFCNL-NAVDVLVIIN 87
Cdd:COG0594     1 LKKRKDFQRVFRKGKRVSSRYFVLYYLPNDLDPPRLGFSVSK-KVGNAVVRNRIKRRLREAFRLNKPELpPGYDIVVIAR 79

                          90       100
                  ....*....|....*....|
gi 2063789486  88 QGFLELTFKEKQTIFLNLCQ 107
Cdd:COG0594    80 PGAAELDFAELEKELEKLLK 99
Ribonuclease_P pfam00825
Ribonuclease P;
6-110 5.97e-13

Ribonuclease P;


Pssm-ID: 425888  Cd Length: 107  Bit Score: 59.90  E-value: 5.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2063789486   6 KHHLRDRKVFAALLRSKRRFFSTFLMAYFMPN-RVRTWRAAVSISKTKYKlAVERNLIRRQVKAIMRE-QFCNLNAVDVL 83
Cdd:pfam00825   2 KERLKKRSEFQRVFRKGKRVASRHFVLYYLPNdLDHPPRLGISVSKKVGK-AVVRNRIKRLIREAFRLnKDELPPGLDIV 80

                          90       100
                  ....*....|....*....|....*..
gi 2063789486  84 VIINQGFLELTFKEKQTIFLNLCQKLQ 110
Cdd:pfam00825  81 VIARPGAADADFAELLKELEKLLKKAG 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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