hypothetical protein KOW79_006053 [Hemibagrus wyckioides]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||||||
| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3431-3466 | 1.41e-14 | |||||||||
Low-density lipoprotein receptor domain class A; : Pssm-ID: 395011 Cd Length: 37 Bit Score: 69.97 E-value: 1.41e-14
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3607-3641 | 3.16e-14 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 69.16 E-value: 3.16e-14
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3645-3680 | 8.99e-14 | |||||||||
Low-density lipoprotein receptor domain class A; : Pssm-ID: 395011 Cd Length: 37 Bit Score: 67.66 E-value: 8.99e-14
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3554-3585 | 3.46e-13 | |||||||||
Low-density lipoprotein receptor domain class A; : Pssm-ID: 395011 Cd Length: 37 Bit Score: 66.12 E-value: 3.46e-13
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
3728-3762 | 4.98e-13 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 65.73 E-value: 4.98e-13
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3475-3508 | 2.01e-11 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.07 E-value: 2.01e-11
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
3764-3794 | 7.57e-10 | |||||||||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.87 E-value: 7.57e-10
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3939-3979 | 8.77e-10 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. : Pssm-ID: 459654 Cd Length: 42 Bit Score: 56.78 E-value: 8.77e-10
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3688-3718 | 1.56e-08 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure : Pssm-ID: 238060 Cd Length: 35 Bit Score: 52.98 E-value: 1.56e-08
|
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3963-4005 | 4.00e-08 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 51.83 E-value: 4.00e-08
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3877-3918 | 9.65e-07 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. : Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 47.98 E-value: 9.65e-07
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
4083-4121 | 3.50e-06 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 3.50e-06
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2159-2768 | 7.20e-04 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; : Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 45.84 E-value: 7.20e-04
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2511-3111 | 2.55e-03 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; : Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 43.91 E-value: 2.55e-03
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| Ldl_recept_b super family | cl44468 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
4026-4066 | 4.76e-03 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. The actual alignment was detected with superfamily member pfam00058: Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.52 E-value: 4.76e-03
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| Name | Accession | Description | Interval | E-value | |||||||||
| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3431-3466 | 1.41e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 69.97 E-value: 1.41e-14
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3607-3641 | 3.16e-14 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 69.16 E-value: 3.16e-14
|
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3432-3464 | 5.22e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 68.43 E-value: 5.22e-14
|
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3645-3680 | 8.99e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 67.66 E-value: 8.99e-14
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3433-3465 | 1.63e-13 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 66.85 E-value: 1.63e-13
|
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3554-3585 | 3.46e-13 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 66.12 E-value: 3.46e-13
|
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
3728-3762 | 4.98e-13 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 65.73 E-value: 4.98e-13
|
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3607-3641 | 7.62e-13 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 65.35 E-value: 7.62e-13
|
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3607-3638 | 1.72e-12 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 64.19 E-value: 1.72e-12
|
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3554-3585 | 2.21e-12 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 63.81 E-value: 2.21e-12
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3554-3586 | 3.23e-12 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 63.38 E-value: 3.23e-12
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3646-3680 | 6.53e-12 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 62.61 E-value: 6.53e-12
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3475-3508 | 2.01e-11 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.07 E-value: 2.01e-11
|
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3474-3508 | 1.34e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 58.80 E-value: 1.34e-10
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3645-3677 | 3.07e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 57.64 E-value: 3.07e-10
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
3764-3794 | 7.57e-10 | |||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.87 E-value: 7.57e-10
|
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3474-3505 | 7.77e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 7.77e-10
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3939-3979 | 8.77e-10 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 56.78 E-value: 8.77e-10
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
3764-3803 | 4.09e-09 | |||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.57 E-value: 4.09e-09
|
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3688-3718 | 1.56e-08 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 52.98 E-value: 1.56e-08
|
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3685-3718 | 2.60e-08 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.25 E-value: 2.60e-08
|
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3963-4005 | 4.00e-08 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 51.83 E-value: 4.00e-08
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3684-3718 | 2.40e-07 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 49.55 E-value: 2.40e-07
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3877-3918 | 9.65e-07 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 47.98 E-value: 9.65e-07
|
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
3726-3762 | 2.85e-06 | |||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.47 E-value: 2.85e-06
|
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
4083-4121 | 3.50e-06 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 3.50e-06
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
3726-3762 | 1.27e-05 | |||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 1.27e-05
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3919-3962 | 2.91e-05 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 43.74 E-value: 2.91e-05
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| EGF_CA | pfam07645 | Calcium-binding EGF domain; |
3764-3792 | 1.15e-04 | |||||||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 41.84 E-value: 1.15e-04
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| YvrE | COG3386 | Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
3847-4023 | 1.75e-04 | |||||||||
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 46.42 E-value: 1.75e-04
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3897-3934 | 3.99e-04 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.61 E-value: 3.99e-04
|
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2159-2768 | 7.20e-04 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 45.84 E-value: 7.20e-04
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3984-4025 | 8.51e-04 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 39.84 E-value: 8.51e-04
|
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2511-3111 | 2.55e-03 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 43.91 E-value: 2.55e-03
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| C_rich_MXAN6577 | NF041328 | MXAN_6577-like cysteine-rich domain; |
3433-3516 | 4.16e-03 | |||||||||
MXAN_6577-like cysteine-rich domain; Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 4.16e-03
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
4026-4066 | 4.76e-03 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.52 E-value: 4.76e-03
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| Name | Accession | Description | Interval | E-value | |||||||||
| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3431-3466 | 1.41e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 69.97 E-value: 1.41e-14
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3607-3641 | 3.16e-14 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 69.16 E-value: 3.16e-14
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3432-3464 | 5.22e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 68.43 E-value: 5.22e-14
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3645-3680 | 8.99e-14 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 67.66 E-value: 8.99e-14
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3433-3465 | 1.63e-13 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 66.85 E-value: 1.63e-13
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3554-3585 | 3.46e-13 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 66.12 E-value: 3.46e-13
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
3728-3762 | 4.98e-13 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 65.73 E-value: 4.98e-13
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3607-3641 | 7.62e-13 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 65.35 E-value: 7.62e-13
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3607-3638 | 1.72e-12 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 64.19 E-value: 1.72e-12
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3554-3585 | 2.21e-12 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 63.81 E-value: 2.21e-12
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3554-3586 | 3.23e-12 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 63.38 E-value: 3.23e-12
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3646-3680 | 6.53e-12 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 62.61 E-value: 6.53e-12
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3475-3508 | 2.01e-11 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 61.07 E-value: 2.01e-11
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3474-3508 | 1.34e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 58.80 E-value: 1.34e-10
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3645-3677 | 3.07e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 57.64 E-value: 3.07e-10
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
3764-3794 | 7.57e-10 | |||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 56.87 E-value: 7.57e-10
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3474-3505 | 7.77e-10 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 7.77e-10
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3939-3979 | 8.77e-10 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 56.78 E-value: 8.77e-10
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
3764-3803 | 4.09e-09 | |||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 54.57 E-value: 4.09e-09
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| LDLa | cd00112 | Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ... |
3688-3718 | 1.56e-08 | |||||||||
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure Pssm-ID: 238060 Cd Length: 35 Bit Score: 52.98 E-value: 1.56e-08
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| LDLa | smart00192 | Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ... |
3685-3718 | 2.60e-08 | |||||||||
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia. Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.25 E-value: 2.60e-08
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3963-4005 | 4.00e-08 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 51.83 E-value: 4.00e-08
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| Ldl_recept_a | pfam00057 | Low-density lipoprotein receptor domain class A; |
3684-3718 | 2.40e-07 | |||||||||
Low-density lipoprotein receptor domain class A; Pssm-ID: 395011 Cd Length: 37 Bit Score: 49.55 E-value: 2.40e-07
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3877-3918 | 9.65e-07 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 47.98 E-value: 9.65e-07
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
3726-3762 | 2.85e-06 | |||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 46.47 E-value: 2.85e-06
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| FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
4083-4121 | 3.50e-06 | |||||||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 3.50e-06
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| EGF | smart00181 | Epidermal growth factor-like domain; |
3767-3803 | 8.01e-06 | |||||||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 45.20 E-value: 8.01e-06
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
3726-3762 | 1.27e-05 | |||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 1.27e-05
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
3767-3802 | 1.51e-05 | |||||||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 44.39 E-value: 1.51e-05
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| LY | smart00135 | Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ... |
3919-3962 | 2.91e-05 | |||||||||
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin. Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 43.74 E-value: 2.91e-05
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
3727-3762 | 4.00e-05 | |||||||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 43.23 E-value: 4.00e-05
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| EGF | smart00181 | Epidermal growth factor-like domain; |
3727-3762 | 7.35e-05 | |||||||||
Epidermal growth factor-like domain; Pssm-ID: 214544 Cd Length: 35 Bit Score: 42.50 E-value: 7.35e-05
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| EGF_CA | pfam07645 | Calcium-binding EGF domain; |
3764-3792 | 1.15e-04 | |||||||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 41.84 E-value: 1.15e-04
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| YvrE | COG3386 | Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
3847-4023 | 1.75e-04 | |||||||||
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 46.42 E-value: 1.75e-04
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
3723-3755 | 2.33e-04 | |||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 2.33e-04
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3897-3934 | 3.99e-04 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.61 E-value: 3.99e-04
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2159-2768 | 7.20e-04 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 45.84 E-value: 7.20e-04
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
3984-4025 | 8.51e-04 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 39.84 E-value: 8.51e-04
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2344-2959 | 1.17e-03 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 45.07 E-value: 1.17e-03
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| YjdB | COG5492 | Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction ... |
2511-3111 | 2.55e-03 | |||||||||
Uncharacterized conserved protein YjdB, contains Ig-like domain [General function prediction only]; Pssm-ID: 444243 [Multi-domain] Cd Length: 613 Bit Score: 43.91 E-value: 2.55e-03
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| C_rich_MXAN6577 | NF041328 | MXAN_6577-like cysteine-rich domain; |
3433-3516 | 4.16e-03 | |||||||||
MXAN_6577-like cysteine-rich domain; Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 4.16e-03
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| Ldl_recept_b | pfam00058 | Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ... |
4026-4066 | 4.76e-03 | |||||||||
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure. Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.52 E-value: 4.76e-03
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| cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
3748-3767 | 7.36e-03 | |||||||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 36.62 E-value: 7.36e-03
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| EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
3769-3796 | 9.41e-03 | |||||||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 36.42 E-value: 9.41e-03
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| hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
3731-3754 | 9.98e-03 | |||||||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 36.16 E-value: 9.98e-03
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| Blast search parameters | ||||
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