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Conserved domains on  [gi|2062575202|gb|QXG19107|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Drosophila auraria]

Protein Classification

NADH dehydrogenase subunit 4L( domain architecture ID 10009597)

NADH dehydrogenase subunit 4L is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 4-92 1.34e-24

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177218  Cd Length: 89  Bit Score: 88.29  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  4 ILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIR 83
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2062575202 84 THGNDYFQS 92
Cdd:MTH00162  81 SHGNDYFSS 89
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 4-92 1.34e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 88.29  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  4 ILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIR 83
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2062575202 84 THGNDYFQS 92
Cdd:MTH00162  81 SHGNDYFSS 89
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-96 5.34e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 48.71  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 11 MILFILGLFCFVSnRKHLLSMLLSLEFIVL--MLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIRTHGND 88
Cdd:pfam00420  7 GLLFLIGLYGLLL-RRNLLRVLLSLELMLNavNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTD 85


                 ....*...
gi 2062575202 89 YFQSFSIM 96
Cdd:pfam00420 86 DVDSLNLL 93
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-87 1.89e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 34.27  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  1 MIMILYWSLPMILFILGLFCFVSnRKHLLSMLLSLEFIVL--MLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSIL 78
Cdd:COG0713    1 IPLEHYLILAAILFAIGLYGVLT-RRNLIVVLMSIELMLNavNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAII 79


                 ....*....
gi 2062575202 79 VSMIRTHGN 87
Cdd:COG0713   80 VALYRNRGT 88
 
Name Accession Description Interval E-value
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 4-92 1.34e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 88.29  E-value: 1.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  4 ILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIR 83
Cdd:MTH00162   1 MMMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIR 80


                 ....*....
gi 2062575202 84 THGNDYFQS 92
Cdd:MTH00162  81 SHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 2-96 3.83e-15

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 64.61  E-value: 3.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  2 IMILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSM 81
Cdd:MTH00188   1 MFFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLSLVLLTFAACEASVGLALLVSL 80

                         90
                 ....*....|....*
gi 2062575202 82 IRTHGNDYFQSFSIM 96
Cdd:MTH00188  81 IRSHGSDYVSSLNLI 95
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 2-94 4.23e-15

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 64.48  E-value: 4.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  2 IMILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSM 81
Cdd:MTH00149   1 SMFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSL 80

                         90
                 ....*....|...
gi 2062575202 82 IRTHGNDYFQSFS 94
Cdd:MTH00149  81 IRLHGNDYVSSLS 93
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 14-96 1.90e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 57.67  E-value: 1.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 14 FILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFS--MMFLTFSVCEGALGLSILVSMIRTHGNDYFQ 91
Cdd:MTH00126  12 FILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAapMLLLAFSACEASAGLALLVATARTHGTDRLQ 91


                 ....*
gi 2062575202 92 SFSIM 96
Cdd:MTH00126  92 NLNLL 96
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 14-95 1.16e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 52.93  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 14 FILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFSM--MFLTFSVCEGALGLSILVSMIRTHGNDYFQ 91
Cdd:MTH00125  12 FMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMpiILLTFSACEAGTGLALLVATTRTHGSDHLK 91


                 ....
gi 2062575202 92 SFSI 95
Cdd:MTH00125  92 NLNL 95
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 14-96 1.35e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 50.37  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 14 FILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESYFS--MMFLTFSVCEGALGLSILVSMIRTHGNDYFQ 91
Cdd:MTH00067  12 FLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSlpMFMLTFSACEASTGLALMVATTRTHGTDHLK 91


                 ....*
gi 2062575202 92 SFSIM 96
Cdd:MTH00067  92 NLNLL 96
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
11-96 5.34e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 48.71  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 11 MILFILGLFCFVSnRKHLLSMLLSLEFIVL--MLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIRTHGND 88
Cdd:pfam00420  7 GLLFLIGLYGLLL-RRNLLRVLLSLELMLNavNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTHGTD 85


                 ....*...
gi 2062575202 89 YFQSFSIM 96
Cdd:pfam00420 86 DVDSLNLL 93
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 7-95 5.36e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 48.79  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  7 WSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFF--MLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSMIRT 84
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLllALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|.
gi 2062575202 85 HGNDYFQSFSI 95
Cdd:MTH00181  82 HGSDHLLKFNL 92
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 3-96 1.85e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 42.21  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  3 MILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLNYESY--FSMMFLTFSVCEGALGLSILVS 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNlsFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*.
gi 2062575202 81 MIRTHGNDYFQSFSIM 96
Cdd:MTH00043  81 LSRNHNSDLVASLNLL 96
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 6-94 2.19e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 42.05  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  6 YWSLPMILFILGLFC---FVSNRKHLLSMLLSLEFIVL-MLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSILVSM 81
Cdd:MTH00013   1 MMSPLFILSISPFISmfnLSLQRKHLLMSLLSLEAMILsLALFIPLSLMFANQVNGMLAIVLLTFGACEASLGLSLLVLM 80

                         90
                 ....*....|...
gi 2062575202 82 IRTHGNDYFQSFS 94
Cdd:MTH00013  81 TRSYGNDMLKSLT 93
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 11-96 7.06e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 37.99  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202 11 MILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMlfIYLNMLNYESYFSMMF----LTFSVCEGALGLSILVSMIRTHG 86
Cdd:MTH00107   9 MLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIM--ATLTILNTHFTLASMMpiilLVFAACEAAVGLALLVMVSNTYG 86

                         90
                 ....*....|
gi 2062575202 87 NDYFQSFSIM 96
Cdd:MTH00107  87 TDYVQNLNLL 96
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-87 1.89e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 34.27  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  1 MIMILYWSLPMILFILGLFCFVSnRKHLLSMLLSLEFIVL--MLFFMLFIYLNMLNYESYFSMMFLTFSVCEGALGLSIL 78
Cdd:COG0713    1 IPLEHYLILAAILFAIGLYGVLT-RRNLIVVLMSIELMLNavNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAII 79


                 ....*....
gi 2062575202 79 VSMIRTHGN 87
Cdd:COG0713   80 VALYRNRGT 88
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 2-86 6.34e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 33.08  E-value: 6.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2062575202  2 IMILYWSLPMILFILGLFCFVSNRKHLLSMLLSLEFIVLMLFFMLFIYLNMLN--YESYFSMMFLTFSVCEGALGLSILV 79
Cdd:MTH00180   1 MYYEYLTVGIILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDnlIGQIFTIMILTVAAAESAIGLAILV 80


                 ....*..
gi 2062575202 80 SMIRTHG 86
Cdd:MTH00180  81 AYYRIRG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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