NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|205830662|sp|Q9NRA1|]
View 

RecName: Full=Platelet-derived growth factor C; Short=PDGF-C; AltName: Full=Fallotein; AltName: Full=Spinal cord-derived growth factor; Short=SCDGF; AltName: Full=VEGF-E; Contains: RecName: Full=Platelet-derived growth factor C, latent form; Short=PDGFC latent form; Contains: RecName: Full=Platelet-derived growth factor C, receptor-binding form; Short=PDGFC receptor-binding form; Flags: Precursor

Protein Classification

CUB domain-containing protein( domain architecture ID 10035934)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 3.66e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 102.45  E-value: 3.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPKtgvRGLHKSLTD 326
Cdd:cd00135    1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPK---RKPRSKLVE 72

                         90
                 ....*....|....
gi 205830662 327 VALEHHEECDCVCR 340
Cdd:cd00135   73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 9.13e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 94.02  E-value: 9.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662  49 IITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVwIQLTFDErFGLEDPEDdiCKYDFVEVEE--PSDGTILGRWCGS 126
Cdd:cd00041    4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYR-IRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 205830662 127 gTVPGKQISKGNQIRIRFVSDEYFPSePGFCIHYNI 162
Cdd:cd00041   80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 3.66e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 102.45  E-value: 3.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPKtgvRGLHKSLTD 326
Cdd:cd00135    1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPK---RKPRSKLVE 72

                         90
                 ....*....|....
gi 205830662 327 VALEHHEECDCVCR 340
Cdd:cd00135   73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 9.13e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 94.02  E-value: 9.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662  49 IITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVwIQLTFDErFGLEDPEDdiCKYDFVEVEE--PSDGTILGRWCGS 126
Cdd:cd00041    4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYR-IRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 205830662 127 gTVPGKQISKGNQIRIRFVSDEYFPSePGFCIHYNI 162
Cdd:cd00041   80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
CUB pfam00431
CUB domain;
55-148 2.59e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 2.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662   55 NGSIHSPRFPHTYPRNTVLVWRLVAvEENVWIQLTFDErFGLEDpeDDICKYDFVEV--EEPSDGTILGRWCGSGtVPGK 132
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRA-PPGFRVKLTFQD-FELED--HDECGYDYVEIrdGPSASSPLLGRFCGSG-IPED 83

                          90
                  ....*....|....*.
gi 205830662  133 QISKGNQIRIRFVSDE 148
Cdd:pfam00431  84 IVSSSNQMTIKFVSDA 99
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 56-160 1.03e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.52  E-value: 1.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662    56 GSIHSPRFPHTYPRNTVLVWRLVAVEENVwIQLTFDErFGLEDPEDdiCKYDFVEVEE--PSDGTILGRWCGSGTVPGKQ 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYR-IELQFTD-FDLESSDN--CEYDYVEIYDgpSASSPLLGRFCGSEAPPPVI 76

                           90       100
                   ....*....|....*....|....*..
gi 205830662   134 ISKGNQIRIRFVSDEYFPSEpGFCIHY 160
Cdd:smart00042  77 SSSSNSLTLTFVSDSSVQKR-GFSARY 102
PDGF pfam00341
PDGF/VEGF domain;
250-337 2.02e-15

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 70.39  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662  250 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPKTGVRGlhKSLTDVA 328
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 205830662  329 LEHHEECDC 337
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 250-337 2.08e-10

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 56.66  E-value: 2.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662   250 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPktgvrGLHKSLTDVA 328
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 205830662   329 LEHHEECDC 337
Cdd:smart00141  73 FEEHTKCEC 81
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 249-343 1.45e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 38.45  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662 249 SCTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGlhkSLTDV 327
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGG---CCNDESQICTPTETSNVTVTVMLTSVSGSTGATS---NFQTI 120

                         90
                 ....*....|....*.
gi 205830662 328 ALEHHEECDCVCRGST 343
Cdd:PHA02661 121 SVEEHTKCKCEFKTTP 136
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 248-340 3.66e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 102.45  E-value: 3.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662 248 YSCTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPKtgvRGLHKSLTD 326
Cdd:cd00135    1 SSCKPRETLVEISEELPdETNTIFKPPCVEVKRCGG---CC--NDESLECVPTETSNVTMQVLKISPK---RKPRSKLVE 72

                         90
                 ....*....|....
gi 205830662 327 VALEHHEECDCVCR 340
Cdd:cd00135   73 ISFEEHTECECRPR 86
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 49-162 9.13e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 94.02  E-value: 9.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662  49 IITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVwIQLTFDErFGLEDPEDdiCKYDFVEVEE--PSDGTILGRWCGS 126
Cdd:cd00041    4 TLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYR-IRLTFED-FDLESSPN--CSYDYLEIYDgpSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 205830662 127 gTVPGKQISKGNQIRIRFVSDEYFPSePGFCIHYNI 162
Cdd:cd00041   80 -TLPPPIISSGNSLTVRFRSDSSVTG-RGFKATYSA 113
CUB pfam00431
CUB domain;
55-148 2.59e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 2.59e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662   55 NGSIHSPRFPHTYPRNTVLVWRLVAvEENVWIQLTFDErFGLEDpeDDICKYDFVEV--EEPSDGTILGRWCGSGtVPGK 132
Cdd:pfam00431   9 SGSISSPNYPNPYPPNKDCVWLIRA-PPGFRVKLTFQD-FELED--HDECGYDYVEIrdGPSASSPLLGRFCGSG-IPED 83

                          90
                  ....*....|....*.
gi 205830662  133 QISKGNQIRIRFVSDE 148
Cdd:pfam00431  84 IVSSSNQMTIKFVSDA 99
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 56-160 1.03e-20

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 85.52  E-value: 1.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662    56 GSIHSPRFPHTYPRNTVLVWRLVAVEENVwIQLTFDErFGLEDPEDdiCKYDFVEVEE--PSDGTILGRWCGSGTVPGKQ 133
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYR-IELQFTD-FDLESSDN--CEYDYVEIYDgpSASSPLLGRFCGSEAPPPVI 76

                           90       100
                   ....*....|....*....|....*..
gi 205830662   134 ISKGNQIRIRFVSDEYFPSEpGFCIHY 160
Cdd:smart00042  77 SSSSNSLTLTFVSDSSVQKR-GFSARY 102
PDGF pfam00341
PDGF/VEGF domain;
250-337 2.02e-15

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 70.39  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662  250 CTPRNFSVSIREELK-RTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPKTGVRGlhKSLTDVA 328
Cdd:pfam00341   1 CKPRETLVEIRRELPdETNAFFKPSCVEVQRCSG---CC--NDEGLECVPTETHNVTMQVLKIEYAPRRPS--PELVEVS 73


                  ....*....
gi 205830662  329 LEHHEECDC 337
Cdd:pfam00341  74 FEEHVQCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 250-337 2.08e-10

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 56.66  E-value: 2.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662   250 CTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCClhNCNECQCVPSKVTKKYHEVLQLRPktgvrGLHKSLTDVA 328
Cdd:smart00141   3 CKPRETVVEVSREYpDETNFLFKPPCVTVKRCGG---CC--NDEGLECVPTETSNVTMQLLEISR-----PLSQHLVEVS 72


                   ....*....
gi 205830662   329 LEHHEECDC 337
Cdd:smart00141  73 FEEHTKCEC 81
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 249-343 1.45e-03

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 38.45  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205830662 249 SCTPRNFSVSIREEL-KRTDTIFWPGCLLVKRCGGncaCCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGlhkSLTDV 327
Cdd:PHA02661  47 SCQPRDTVVQLSDEYpGNTNDRYNPRCVTVRRCGG---CCNDESQICTPTETSNVTVTVMLTSVSGSTGATS---NFQTI 120

                         90
                 ....*....|....*.
gi 205830662 328 ALEHHEECDCVCRGST 343
Cdd:PHA02661 121 SVEEHTKCKCEFKTTP 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH