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Conserved domains on  [gi|20564165|ref|NP_620768|]
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putative viral polymerase [Tobacco streak virus]

Protein Classification

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List of domain hits

Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
255-626 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


:

Pssm-ID: 438102  Cd Length: 332  Bit Score: 666.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 255 DIDLEVTSCDLDMSTFNDWTKGvDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFDHDDVLNRCVTRFITH 334
Cdd:cd23252   1 DISLDVDHCRLDQSDFNDWTKP-DGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 335 VVDKTRLsklnpisgeelhyfnqylenknpplseykgpvplvalDKYMHMIKTTLKPVEEDNLHIERPIPATITYHKKGV 414
Cdd:cd23252  80 VIDVDRL-------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 415 VMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHF 494
Cdd:cd23252 123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 495 VTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSNPNILFVAASGDDSLIGSIEPLPREK 574
Cdd:cd23252 203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 20564165 575 EDLCVSLFNFETKFPHNQPFICSKFLLVVECDDgsEEVLAVPNPLKLLQKLG 626
Cdd:cd23252 283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEFGD--ENVFSVPDPLKLLQRLG 332
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
255-626 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 666.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 255 DIDLEVTSCDLDMSTFNDWTKGvDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFDHDDVLNRCVTRFITH 334
Cdd:cd23252   1 DISLDVDHCRLDQSDFNDWTKP-DGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 335 VVDKTRLsklnpisgeelhyfnqylenknpplseykgpvplvalDKYMHMIKTTLKPVEEDNLHIERPIPATITYHKKGV 414
Cdd:cd23252  80 VIDVDRL-------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 415 VMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHF 494
Cdd:cd23252 123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 495 VTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSNPNILFVAASGDDSLIGSIEPLPREK 574
Cdd:cd23252 203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 20564165 575 EDLCVSLFNFETKFPHNQPFICSKFLLVVECDDgsEEVLAVPNPLKLLQKLG 626
Cdd:cd23252 283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEFGD--ENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
253-689 0e+00

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 535.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   253 THDIDLEVTSCDLDMSTFNDWTKGVDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFDHDDVLNRCVTRFI 332
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   333 THVVDKTRLSKLNPIS--GEELHYFNQYLENKNP--PLSEYKGPVPLVALDKYMHMIKTTLKPVEEDNLHIERPIPATIT 408
Cdd:pfam00978  81 KSFLDKEKLDKLDPIIntTENVSRWLDKQSGKKAaqLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   409 YHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLAL 488
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   489 GIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSnpNILFVAASGDDSLIGSIE 568
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLE--KIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   569 PlPREKEDLCVSLFNFETKFP-HNQPFICSKFLLVVECDDgseevLAVPNPLKLLQKLGPKNLQ--VTVLDDYYQSLCDI 645
Cdd:pfam00978 319 P-IEDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDGGA-----FFVPDPLKLLQKLGKKKIPddEQHLDEIFTSLCDL 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 20564165   646 LWVFNDADVCRRTAELAEYRRFK----GTKKCLFLESALLSLPSLVAN 689
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYYKyapeGYAALCALHKALSSFTLFFSL 440
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
255-626 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 666.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 255 DIDLEVTSCDLDMSTFNDWTKGvDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFDHDDVLNRCVTRFITH 334
Cdd:cd23252   1 DISLDVDHCRLDQSDFNDWTKP-DGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 335 VVDKTRLsklnpisgeelhyfnqylenknpplseykgpvplvalDKYMHMIKTTLKPVEEDNLHIERPIPATITYHKKGV 414
Cdd:cd23252  80 VIDVDRL-------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 415 VMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHF 494
Cdd:cd23252 123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 495 VTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSNPNILFVAASGDDSLIGSIEPLPREK 574
Cdd:cd23252 203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 20564165 575 EDLCVSLFNFETKFPHNQPFICSKFLLVVECDDgsEEVLAVPNPLKLLQKLG 626
Cdd:cd23252 283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEFGD--ENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
253-689 0e+00

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 535.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   253 THDIDLEVTSCDLDMSTFNDWTKGVDTRLVPNMSVGGLSHRVPTQREALLAIKKRNMNVPELQSNFDHDDVLNRCVTRFI 332
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKDKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   333 THVVDKTRLSKLNPIS--GEELHYFNQYLENKNP--PLSEYKGPVPLVALDKYMHMIKTTLKPVEEDNLHIERPIPATIT 408
Cdd:pfam00978  81 KSFLDKEKLDKLDPIIntTENVSRWLDKQSGKKAaqLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   409 YHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLAL 488
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   489 GIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSnpNILFVAASGDDSLIGSIE 568
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDLE--KIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165   569 PlPREKEDLCVSLFNFETKFP-HNQPFICSKFLLVVECDDgseevLAVPNPLKLLQKLGPKNLQ--VTVLDDYYQSLCDI 645
Cdd:pfam00978 319 P-IEDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDGGA-----FFVPDPLKLLQKLGKKKIPddEQHLDEIFTSLCDL 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 20564165   646 LWVFNDADVCRRTAELAEYRRFK----GTKKCLFLESALLSLPSLVAN 689
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYYKyapeGYAALCALHKALSSFTLFFSL 440
Mayoviridae_RdRp cd23256
RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense ...
373-630 1.35e-67

RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Mayoviridae, order Martellivirales. The Mayoviridae family consists of two genera, Idaeovirus and Pteridovirus. The genus Idaeovirus contains Raspberry bushy dwarf virus (RBDV), named after the host with which it was first associated (red raspberry, Rubus idaeu) and the disease which is characterized by bushiness (stunting and proliferation of canes); RBDV has recently been found causing an infection in grapevines. RBDV occurs in all tissues of the plant, including seed and pollen, and is transmitted in association with pollen, both vertically to the seed and horizontally to the pollinated plant; this is the only known method of natural spread of RBDV. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438106  Cd Length: 329  Bit Score: 226.93  E-value: 1.35e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 373 VPLVALDKYMHMIKTTLKPVEEDNLHIERPIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQ--M 450
Cdd:cd23256  27 LALTSLNKYSHMIKRDRKPVLTTAVQSEYTKAATITYHDKDITQVATPIFRQFKTRLLACKKSNLCIPLDHDHDISGwlT 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 451 NPELLKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTY 530
Cdd:cd23256 107 NRHLGSENGTFTEIDFSKFDKSQGELHQLIQDLILLRFGCDPEFVSLWSTAHRSSSIKDQNVGISFKTDFQRRTGDAFTF 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 531 LGNTLVTLSVLSYVYDLSN-PNILFVAASGDDSLIGSIEPLPREKEDLCvSLFNFETK-FPHNQPFICSKFLLVVEcddg 608
Cdd:cd23256 187 LGNSLVTAVMLAYVLSFEDeKKIRYMLVGGDDSLICSYGPISVPLEPLS-TIFNMSCKlIQPSCPYFASRYIIRVG---- 261
                       250       260
                ....*....|....*....|..
gi 20564165 609 sEEVLAVPNPLKLLQKLGPKNL 630
Cdd:cd23256 262 -DEILCVPDPYKLLVKMGRKDI 282
Kitaviridae_RdRp cd23254
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of ...
381-644 5.65e-64

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus leprosis virus C2 (genus Cilevirus); and Hibiscus green spot virus 2 (genus Higrevirus). Although related, there are considerable physical and genetic distinctions between members of the different genera. For example, cile- and higreviruses are associated with a bacilliform virion, whereas a spherical virion has been observed for the lone blunervirus for which microscopy has been reported. Moreover, the replication-associated polyproteins are encoded by a single genomic RNA for cile- and higreviruses, but are split between two genomic RNAs for blunerviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438104  Cd Length: 267  Bit Score: 215.09  E-value: 5.65e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 381 YMHMIKTTLKPVEEDNLHIERPIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQ------MNPEL 454
Cdd:cd23254   3 YSFMIKRNPKPNLTVDAAYKYPALQTIAYHDKDINAIFCPIFRELKKRLLAVLKPNFVIFTDMSPEDFEellnrrFPPEV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 455 LKHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNT 534
Cdd:cd23254  83 LSKLLHKLEIDISKYDKSQGELALLFECKLMRRFGVPEELVELWFNAHVLTTLYDRTNKLKALVEYQRKSGDASTFFGNT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 535 LVTLSVLSYVYDLSnpNILFVAASGDDSLIGSIEPLPREKEDLCVSLFNFETKFPH-NQPFICSKFLLVVEcddgsEEVL 613
Cdd:cd23254 163 LFLMAVLADLFDLS--DLELALFSGDDSLLFGRNLLDYDDSQHFALKFNLESKFLNyKYPYFCSKFLLPVG-----GRWY 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 20564165 614 AVPNPLKLLQKLGPKNLQVTV-LDDYYQSLCD 644
Cdd:cd23254 236 FVPDPVKLLTKLGRHDLVNWEhVEEYRISLKD 267
Virgaviridae_RdRp cd23251
RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense ...
236-644 1.63e-53

RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Virgaviridae, order Martellivirales. The Virgaviridae is a family of plant viruses with rod-shaped virions, a (+)ssRNA genome with a 3'-terminal tRNA-like structure and a replication protein similar to those of the alpha-like supergroup. Plants serve as natural hosts. The name of the family is derived from the Latin word virga (rod), as all viruses in this family are rod-shaped. There are currently 59 species in this family, divided among seven genera: Goravirus, Furovirus, Hordeivirus, Pecluvirus, Pomovirus, Tobamovirus, and Tobravirus. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438101  Cd Length: 427  Bit Score: 191.68  E-value: 1.63e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 236 FPHHHSVDDRFFQEWVETHDIDLEVTSCDLDmstFNDWTKGVDTR--LVPNMSVGGLSHRVPTQREALLAIKKRNMNVPE 313
Cdd:cd23251   1 FPGNSTRDSDFDGYTVATSDINLNVEDCTLD---PSKSVKVWQEKegLKPVLRTAMPEKRQNGLLESLLALIKRNMAAPK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 314 LQSNFDHDDVLNRCVTRFITHVVDKTRLSKlNPISGEElhYFNQYLENKNPP----LSEYKGPVPLVALDKYMHMIKTTL 389
Cdd:cd23251  78 LQGAVNEFETIERVIKKAKDVFFDEDLIDR-SPLSTRE--SFLRWWDKQSTTaraqLLADDRVLDEIDVCTYNFMIKNDV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 390 KPVEEDNLHIERPIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTgkyhqifQMNPELL---------KHSKE 460
Cdd:cd23251 155 KPKLDLSPQSEYAALQTVVYPDKIVNALFGPIFKEINERILSALDPHVVFNT-------RMTAEELnetvefldpDEEYD 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 461 FKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLSV 540
Cdd:cd23251 228 ALEIDFSKFDKSKTSLHIRAVIELYKLFGLDGMLAFLWEKSQCQTTVKDRQNGIKAYLLYQQKSGNCDTYGSNTWSAALA 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 541 LSYVYDLSnpNILFVAASGDDSLIgsiePLPR--EKEDLC---VSLFNFETK-FPHNQPFICSKFLLVVecDDGSEevlA 614
Cdd:cd23251 308 LLSMLPLE--KAIFMIFGGDDSLI----LFPKglVIPDPCrrlASLWNFECKlFKFKYGYFCGKFLLKH--GDGYI---F 376
                       410       420       430
                ....*....|....*....|....*....|.
gi 20564165 615 VPNPLKLLQKLGPKNLQ-VTVLDDYYQSLCD 644
Cdd:cd23251 377 YPDPLKLITKLGRKDIKdGEHLSEIFVSICD 407
ps-ssRNAv_Martellivirales_RdRp cd23208
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of ...
379-564 3.70e-52

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Martellivirales, class Alsuviricetes. The order Martellivirales consists of seven families: Bromoviridae, Closteroviridae, Endornaviridae, Kitaviridae, Mayoviridae, Togaviridae, and Virgaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438058 [Multi-domain]  Cd Length: 190  Bit Score: 179.87  E-value: 3.70e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 379 DKYMHMIKTTLKPVEEDNLHIERPIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYH--QIFQMNPEL-L 455
Cdd:cd23208   1 DKYEMMIKSDVKPKLDLTAQQEYPKLQTIVYHDKNITAIFCPIFKELFERLLSCLKKKVVIYTGMMTsaELNDFISALhL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 456 KHSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTL 535
Cdd:cd23208  81 ESGYYVLEIDFSKFDKSQGALHLLTELLILRRLGVDEPLLVLWEFAHTQSTTRDINNGISFETAYQRKSGDAFTYFGNTL 160
                       170       180
                ....*....|....*....|....*....
gi 20564165 536 VTLSVLSYVYDLSnpNILFVAASGDDSLI 564
Cdd:cd23208 161 VTMAALLDVLDLE--KIVCIAFGGDDSLI 187
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
384-645 2.82e-50

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 177.37  E-value: 2.82e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 384 MIKTTLKPVEEDNLHIERPIPATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIF--QMNPELLKHSKEF 461
Cdd:cd23253   6 MVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSGMNLEELasLIRSKLGDPLDEY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 462 K--EIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLGNTLVTLS 539
Cdd:cd23253  86 KtvEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFSCRATSDSGVSLELGAQRRTGSPNTWLGNTLVTLG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 540 VLSYVYDLSNPNILFVaaSGDDSLIGSIEPLPREKEDLCVSlFNFETKFPHNQ-PFICSKFLlvVECDDgseEVLAVPNP 618
Cdd:cd23253 166 ILSSSYDLDDIDLLLV--SGDDSLIFSKKPLPNKANEINLD-FGFEAKFIENSvPYFCSKFI--IEDRG---KIKVVPDP 237
                       250       260
                ....*....|....*....|....*....
gi 20564165 619 LKLLQKLG-PKNLQV-TVLDDYYQSLCDI 645
Cdd:cd23253 238 VKLFEKLSvPIRLEDeTLLKERFTSFKDL 266
ps-ssRNAv_Alsuviricetes_RdRp cd23182
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of ...
381-564 5.78e-19

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the class Alsuviricetes, phylum: Kitrinoviricota. Alsuviricetes is a class of [(+)ssRNA] viruses which infect eukaryotes. The name of the group is a syllabic abbreviation of "alpha supergroup" with the suffix -viricetes indicating a virus class. The class Alsuviricetes includes three orders: Hepelivirales, Martellivirales, and Tymovirales. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438032 [Multi-domain]  Cd Length: 187  Bit Score: 85.34  E-value: 5.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 381 YMHMIKTTLKPVEEDnlhierPIPA-----TITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVV---PTGKYHQIFQMNP 452
Cdd:cd23182   3 IDFLIKTQQKVSPKT------PFNTgkagqTIAAHSKSINFVLGPWIRYLEERLRDGSRTHRYSnglMDEEEAMLSQWKI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 453 ELLKHSKeFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRDCGIGFSVDYQRRTGDACTYLG 532
Cdd:cd23182  77 NHVPHAT-FVSNDYTAFDKSHNGESLLLEAAIMRRIGTPAAAPNLFIELHGKRTLRAKVLGGSGELDGMRDSGAAWTYCR 155
                       170       180       190
                ....*....|....*....|....*....|..
gi 20564165 533 NTLVTLSVLSYVYDLSNPNILFvaaSGDDSLI 564
Cdd:cd23182 156 NTDYNLAVMLSLYRLKVKPAAF---SGDDSLL 184
Endornaviridae_RdRp cd23255
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of ...
407-566 1.45e-11

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Endornaviridae, order Martellivirales. The family Endornaviridae includes viruses with linear (+)ssRNA genomes that range from 9.7 to 17.6 kb. The family consists of two genera, Alphaendornavirus and Betaendornavirus. Alphaendornavirus includes species whose members infect plants, fungi and oomycetes, while the genus Betaendornavirus includes species whose members infect ascomycete fungi. Plant endornaviruses are transmitted only through the gametes. A conserved RNA-dependent RNA polymerase domain located in the C-terminal region of the polyprotein is a feature common to all endornaviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438105  Cd Length: 237  Bit Score: 65.25  E-value: 1.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 407 ITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGkyhqifqMNPE-------LLKHSKEFKEIDFSKFDKSQGrlHH- 478
Cdd:cd23255  61 IVWQRKGICAIFSPIFNEAKKRLKSLLKPKVVYADG-------LTPDelsarlrLVKNVKYFFEDDLSKQDRQTD--KPi 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 479 -DVQFRLFLALGIPEHFVTTWFNSHEKSYIRdrdcGIGFSV--DYQRRTGDACTYLGNTLVTLSVLSYVYDLSNPNILFV 555
Cdd:cd23255 132 iDVEMELYKLLGVDPNVIELWREVHENWRFK----GKGVRGvgDAMRLTGQATTALGNVITNLLVHSRLVKRNGSNLKLM 207
                       170
                ....*....|.
gi 20564165 556 AASGDDSLIGS 566
Cdd:cd23255 208 LVLGDDNLILT 218
ps-ssRNAv_Hepelivirales_RdRp cd23209
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of ...
407-564 4.14e-11

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Hepelivirales, class Alsuviricetes. This Hepelivirales order consists of four families: Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438059 [Multi-domain]  Cd Length: 183  Bit Score: 62.51  E-value: 4.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 407 ITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGkyhqiFQMNPELLK----HSKEFKEIDFSKFDKSQGRLHHDVQF 482
Cdd:cd23209  28 ISAWSKELCFVFGPWFRALEKILRRALKPNVLYANG-----HEAEPFVDKinqaHSAVFIENDFTEFDSTQNLFSLLVEL 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 483 RLFLALGIPEHFVTTWFNSHEKSYIRDRdcGIGFSVDYQRRTGDACTYLGNTLVTLSVLSYVYDLSNPNilFVAASGDDS 562
Cdd:cd23209 103 EILEACGMPPALAELYRALRAKWTLQAR--EGSLEGTCKKTSGEPGTLLHNTIWNMAVMMHMVRGGVRK--AAAFKGDDS 178

                ..
gi 20564165 563 LI 564
Cdd:cd23209 179 VV 180
RNA_dep_RNAP cd01699
RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the ...
377-564 5.87e-05

RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are products of processing of polyproteins. Some RdRps consist of one polypeptide chain, and others are complexes of several subunits. The domain organization and the 3D structure of the catalytic center of a wide range of RdRps, including those with a low overall sequence homology, are conserved. The catalytic center is formed by several motifs containing a number of conserved amino acid residues. This subfamily represents the RNA-dependent RNA polymerases from all positive-strand RNA eukaryotic viruses with no DNA stage.


Pssm-ID: 238843 [Multi-domain]  Cd Length: 278  Bit Score: 45.74  E-value: 5.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 377 ALDKYMHMIKTTLKPVEEDNLHIE-RPIpATITYHKKGVVMMTSPYFLCAMVRLLYVLKSKFVVPTGKYHQIFQMNP--- 452
Cdd:cd01699   4 AVESLEDLPLIRPDLVFTTFLKDElRPL-EKVEAGKTRLIQPRPLDYNIALRMYLGPFEAKLMKNRGGLPIAVGINPysr 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 453 ---ELLKHSKEFK----EIDFSKFDKSQGR--LHHDVQFRLFLALGIPEHFVTTWFNSheksyIRDRDCGIGFSVDYQRR 523
Cdd:cd01699  83 dwtILANKLRSFSpvaiALDYSRFDSSLSPqlLEAEHSIYNALYDDDDELERRNLLRS-----LTNNSLHIGFNEVYKVR 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 20564165 524 ----TGDACTYLGNTLVTLSVLSYVYDLSNPNILFVAAS----GDDSLI 564
Cdd:cd01699 158 ggrpSGDPLTSIGNSIINCILVRYAFRKLGGKSFFKNVRllnyGDDCLL 206
ps-ssRNA_RdRp_Tymovirales cd23207
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of ...
465-564 1.31e-04

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Tymovirales. The Tymovirales order contains viruses that mostly infect plants, have a single molecule of (+)ssRNA, and which are united by the similarities in their replication-associated polyproteins. Tymovirales contains five families (Alpha-, Beta-, Delta- and Gammaflexiviridae and Tymoviridae) and groups mostly plant-infecting agents, although a few Tymovirales members have either fungal or insect hosts. Botrytis virus F (BVF), isolated from the fungus Botrytis cinerea, is a flexuous mycovirus that is typical of members of the genus Mycoflexivirus (family Gammaflexiviridae). The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438057 [Multi-domain]  Cd Length: 188  Bit Score: 43.55  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 465 DFSKFDKSQgrlHHD-VQFRLFLA--LGIPEHFVTTWfnSHEKSYIrdrDCGIGfSVDYQRRTGDACTYLGNTLVTLSVL 541
Cdd:cd23207  94 DYTAFDQSQ---DGEfVVFEVLLMrhLHIPDDLIELY--VDIKTNA---YSHLG-PLSIMRLTGEPGTFDFNTDYNLALT 164
                        90       100
                ....*....|....*....|....
gi 20564165 542 SYVYDLSNPN-ILFvaaSGDDSLI 564
Cdd:cd23207 165 YAKYDLPPGTpICF---SGDDSVA 185
Gammaflexiviridae_RdRp cd23249
RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense ...
457-566 1.40e-04

RNA-dependent RNA polymerase (RdRp) in the family Gammaflexiviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the RdRp of RNA viruses belonging to the family Gammaflexiviridae, order Tymovirales. Virions within the Gammaflexiviridae family are flexuous filaments of 720 nm modal length and about 13 nm in diameter. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438099  Cd Length: 354  Bit Score: 44.89  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 457 HSKEFKEIDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFnshekSYIRDRDCGIGfSVDYQRRTGDACTYLGNTLV 536
Cdd:cd23249 149 FTRESTEGDYTAFDASQDADFLNFETLLMRALGVPLDLIEAYL-----EMKASITSHLG-PLAIMRFSGEVWTYLFNTLG 222
                        90       100       110
                ....*....|....*....|....*....|
gi 20564165 537 TLSVLSYVYDLSNPNILfvAASGDDSLIGS 566
Cdd:cd23249 223 NMAYTAAKYEVPPPVPR--VYGGDDKSINS 250
Alphatetraviridae_RdRp cd23258
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Alphatetraviridae of ...
456-564 1.03e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Alphatetraviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Alphatetraviridae, order Hepelivirales. The Alphatetraviridae is a family of (+)ssRNA viruses with nonenveloped icosahedral T=4 viral particles; they restrictively infect insects, particularly the Lepidoptera. The Alphatetraviridae family includes two genera representing viruses with a monopartite (Betatetravirus) and bipartite (Omegatetravirus) genome organization. Under a previous classification, this Alphatetraviridae family was included in a single group of tetraviruses along with two other families: Carmotetraviridae (single species) and Permutotetraviridae. Neither of these two families is now included in this Alphatetraviridae family: Carmotetraviridae is now classified into a different order, Tolivirales; Permutotetraviridae is a permuted RdRp and not included in this RdRp hierarchy. Alphatetravirus replicases include three conserved functional domains, namely methytransferase (MT), helicase (HEL) and RdRp domains, that are characteristic of all members of the alpha-like virus superfamily. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438108  Cd Length: 184  Bit Score: 41.11  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 456 KHSKEFKEIDFSKFDKSqgrlHHDVQFRLFLAL----GIPEHFVTTWFNSHEKSYIRDRDCGiGFSVDYQRRTGDACTYL 531
Cdd:cd23258  78 VPHATFVSADWTEFDTA----HNNVSELLFAALleriGTPAAAVNLFRERCGKRTLRAKGLG-SVEVDGLLDSGAVWTIC 152
                        90       100       110
                ....*....|....*....|....*....|...
gi 20564165 532 GNTLVTLSVLSYVYDlsnpNILFVAASGDDSLI 564
Cdd:cd23258 153 RNTIFSAGVMLTLFR----GVKFAAFKGDDSLL 181
Tymoviridae_RdRp cd23247
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of ...
465-569 2.38e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Tymoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses, in the order Tymovirales; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Tymoviridae, order Tymovirales. Virions of the family Tymoviridae are isometric, non-enveloped, about 30 nm in diameter, and contain a single molecule of (+)ssRNA constituting 25#35% of the particle weight. There are 42 species in this family, assigned to three genera (Maculavirus, Marafivirus, and Tymovirus), with two species unassigned to a genus. Members of the Tymovirales order are mainly plant pathogens that are characterized by similarities in their replication-associated polyproteins, which account for the majority of their genomic coding capacity. They are considered to form a group, phylogenetically, referred to as flexiviruses, with filamentous virions. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438097  Cd Length: 373  Bit Score: 41.02  E-value: 2.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 465 DFSKFDKSQgrlHHD-VQF-RLFL-ALGIPEHFVTtwFNSHEKSyirdrdcgigfSVDYQ-------RRTGDACTYLGNT 534
Cdd:cd23247 173 DYTAFDQSQ---HGEaVVFeRLKMeRLSIPQHLID--LHVHLKT-----------NVSTQfgpltcmRLTGEPGTYDDNT 236
                        90       100       110
                ....*....|....*....|....*....|....*
gi 20564165 535 LVTLSVLSYVYDLSNPNILFvaaSGDDSLIGSIEP 569
Cdd:cd23247 237 DYNLAVIYSQYDISSTPIMV---SGDDSVIDGVPP 268
Benyviridae_RdRp cd23257
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Benyviridae of ...
464-561 5.25e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Benyviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Benyviridae, order Hepelivirales. The Benyviridae is a family of plant viruses with rod-shaped virions. Their genomes are multipartite (+)ssRNAs with 5' m7G-cap and 3' poly(A) and there is post-translational cleavage of the viral replicase. Beet necrotic yellow vein virus belongs to the genus Benyvirus and is the cause of 'rhizomania' disease of sugar beet. This widespread soil-borne disease can severely reduce sugar beet growth and beet sucrose production. BNYVV RNA1 contains one open reading frame (ORF) encoding a replicase protein that harbors motifs for methyltransferase, helicase, papain-like protease, and RdRp. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438107 [Multi-domain]  Cd Length: 188  Bit Score: 38.75  E-value: 5.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20564165 464 IDFSKFDKSQGRLHHDVQFRLFLALGIPEHFVTTWFNSHEKSYIRDRdcGIGFSVDYQRRTGDACTYLGNTLVTLSVLSY 543
Cdd:cd23257  89 IDAAACDSGQGVFTQLIERYIYAALGISDFFLDWYFSFREKYVMQSR--YVRAHMSYVKTSGEPGTLLGNTILMGAMLNA 166
                        90
                ....*....|....*...
gi 20564165 544 VYDLSNPniLFVAASGDD 561
Cdd:cd23257 167 MLRGTGP--FCMAMKGDD 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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