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Conserved domains on  [gi|2054268674|emb|CAG2254586|]
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WNT9 [Mytilus edulis]

Protein Classification

wnt family protein( domain architecture ID 14443622)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 11-269 4.94e-126

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381715  Cd Length: 299  Bit Score: 360.06  E-value: 4.94e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  11 RYSESLKKRehlGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLK 89
Cdd:cd19341    45 KYRINLLKK---GYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  90 RAKRNGKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANR 169
Cdd:cd19341   122 LKKKSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATG 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 170 KTahKRRSTKMSVVANKMPPRRMEMIHIDSSPSFCRQSRYSEGTKARECIKDRNCNSICCGRGYNVQTKTVSRPCKCEVV 249
Cdd:cd19341   202 GS--QLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVV 279

                         250       260
                  ....*....|....*....|
gi 2054268674 250 WCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19341   280 WCCQVECKTCTEREEIYTCK 299
 
Name Accession Description Interval E-value
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 11-269 4.94e-126

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 360.06  E-value: 4.94e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  11 RYSESLKKRehlGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLK 89
Cdd:cd19341    45 KYRINLLKK---GYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  90 RAKRNGKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANR 169
Cdd:cd19341   122 LKKKSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATG 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 170 KTahKRRSTKMSVVANKMPPRRMEMIHIDSSPSFCRQSRYSEGTKARECIKDRNCNSICCGRGYNVQTKTVSRPCKCEVV 249
Cdd:cd19341   202 GS--QLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVV 279

                         250       260
                  ....*....|....*....|
gi 2054268674 250 WCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19341   280 WCCQVECKTCTEREEIYTCK 299
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 23-269 3.34e-99

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 292.15  E-value: 3.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQN--EEAWRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLA 100
Cdd:pfam00110  62 GTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 101 RVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNhanrktahkRRSTKM 180
Cdd:pfam00110 142 LMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN---------KRGRLV 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 181 SVVANKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQF 254
Cdd:pfam00110 213 PRNSRFKPPTKNDLVYLEKSPDYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYV 292

                         250
                  ....*....|....*
gi 2054268674 255 RCQQCLIDEEIHSCK 269
Cdd:pfam00110 293 KCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
23-269 1.26e-75

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 232.21  E-value: 1.26e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674   23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLAR 101
Cdd:smart00097  61 GTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRKRGRaGGRGWKWGGCSDNIDFGIRFSREFVD-ARERGKDARAL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  102 VNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTKms 181
Cdd:smart00097 140 MNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNSTFK-- 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  182 vvankmPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVVWCCQFR 255
Cdd:smart00097 218 ------PPTETDLVYLESSPDFCEKNPKtgSLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVK 291

                          250
                   ....*....|....
gi 2054268674  256 CQQCLIDEEIHSCK 269
Cdd:smart00097 292 CKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 11-269 4.94e-126

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 360.06  E-value: 4.94e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  11 RYSESLKKRehlGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLK 89
Cdd:cd19341    45 KYRINLLKK---GYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  90 RAKRNGKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANR 169
Cdd:cd19341   122 LKKKSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATG 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 170 KTahKRRSTKMSVVANKMPPRRMEMIHIDSSPSFCRQSRYSEGTKARECIKDRNCNSICCGRGYNVQTKTVSRPCKCEVV 249
Cdd:cd19341   202 GS--QLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVV 279

                         250       260
                  ....*....|....*....|
gi 2054268674 250 WCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19341   280 WCCQVECKTCTEREEIYTCK 299
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 11-269 7.03e-105

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 306.58  E-value: 7.03e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  11 RYSESLKKRehlGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFTRRFLkr 90
Cdd:cd19353    46 RYRASLLKR---GFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFL-- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  91 AKRNGKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRK 170
Cdd:cd19353   121 GRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 171 TAHKRrsTKMSVVANKMP-PRRMEMIHIDSSPSFCRQSRYSEGTKARECIKDRNCNSICCGRGYNVQTKTVSRPCKCEVV 249
Cdd:cd19353   201 GDISP--PKKSGAGHSDQiPRTTDLVYIDDSPSFCLMSRFSPGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVR 278

                         250       260
                  ....*....|....*....|
gi 2054268674 250 WCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19353   279 WCCYVECKQCTQREEVYTCK 298
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 8-269 6.87e-102

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 298.74  E-value: 6.87e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674   8 KSVRYSESLKKREHL---GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFT 84
Cdd:cd19354    35 RSERWNCSLEGRGSLlkrGFKETAFLYAVSSAALTHSLAKACSSGRMERCTCDDSPGLENREAWQWGVCGDNLKYSTKFL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  85 RRFLkRAKRNGKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDN 164
Cdd:cd19354   115 KNFL-GQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHSVT 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 165 NHANRKTAHKRRSTKMSVVANKMPpRRMEMIHIDSSPSFCRQSRYSEGTKARECIKDRNCNSICCGRGYNVQTKTVSRPC 244
Cdd:cd19354   194 NDATGETELWSPERHGHTLKGHSP-RSTDLVYLEDSPSFCRPSKYSPGTAGRTCSRETNCDSLCCGRGYNTQSRLVTFSC 272

                         250       260
                  ....*....|....*....|....*
gi 2054268674 245 KCEVVWCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19354   273 HCQVQWCCYVECQQCVQEEEVYTCK 297
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 23-269 3.34e-99

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 292.15  E-value: 3.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQN--EEAWRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLA 100
Cdd:pfam00110  62 GTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 101 RVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNhanrktahkRRSTKM 180
Cdd:pfam00110 142 LMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRN---------KRGRLV 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 181 SVVANKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQF 254
Cdd:pfam00110 213 PRNSRFKPPTKNDLVYLEKSPDYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYV 292

                         250
                  ....*....|....*
gi 2054268674 255 RCQQCLIDEEIHSCK 269
Cdd:pfam00110 293 KCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 21-268 4.11e-92

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 273.79  E-value: 4.11e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  21 HLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESK-NLQNEEAWRWGGCGDNIKFGLKFTRRFL-KRAKRNGKDV 98
Cdd:cd13113    41 KRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTRqGPEGQGDWTWGGCSDNIKFGIKFSRKFLdAREKKKGSDA 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  99 LARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRST 178
Cdd:cd13113   121 RSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRLVPKRSRF 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 179 KmsvvankmPPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCC 252
Cdd:cd13113   201 R--------SPTETDLVYLEESPDYCEPnpTLGSLGTAGRECNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCC 272

                         250
                  ....*....|....*.
gi 2054268674 253 QFRCQQCLIDEEIHSC 268
Cdd:cd13113   273 EVKCETCRRTVERYTC 288
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 21-269 4.03e-81

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 246.38  E-value: 4.03e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  21 HLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFL----KRAKRNG 95
Cdd:cd19344    55 SRGTKETAFIYAITSAGVVHAVTRACSAGNLTDCSCDSRRQGQsASEGWKWGGCSDNVDYGIWFARKFVdapeKSERKRS 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  96 KDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSqqVEIDNNHANRKTAHKR 175
Cdd:cd19344   135 RDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENS--IQIATKKSKRRLRRRE 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 176 RSTKmsvvanKMPPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVV 249
Cdd:cd19344   213 RRKR------KVPISKDELVYIHKSPNYCVRdpKKGILGTSGRECNRTSTgpdsCDLLCCGRGYNTQVVRHVERCNCKFV 286

                         250       260
                  ....*....|....*....|
gi 2054268674 250 WCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19344   287 WCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 23-269 1.36e-78

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 240.24  E-value: 1.36e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNE--EAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLA 100
Cdd:cd19342    69 GYRETAFAYAISAAGVAHQVARACSLGKLLSCGCDRSRRGKRSsgNDWKWGGCSHNLDFGEKFSRKFLD-SREKARDIHS 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 101 RVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTKm 180
Cdd:cd19342   148 RMNLHNNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSNLNNGARRRRLTRRKR- 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 181 svvanKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQF 254
Cdd:cd19342   227 -----RRRPPKTDLVYYERSPNFCEADPSldSPGTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYV 301

                         250
                  ....*....|....*
gi 2054268674 255 RCQQCLIDEEIHSCK 269
Cdd:cd19342   302 VCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 25-269 1.15e-77

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 237.51  E-value: 1.15e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQN-EEAWRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLARVN 103
Cdd:cd19338    69 RETAFVYAITSAGVTYSVTRACSMGELLQCGCDKSKRGKStEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRSDIRTLMN 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 104 RHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNnhanrktahkRRSTKMSVV 183
Cdd:cd19338   149 LHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSN----------DGKSLIPEG 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 184 ANKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKD----RNCNSICCGRGYNVQTKTVSRPCKCEVVWCCQFRCQ 257
Cdd:cd19338   219 KTIKPPTKEDLVYLEESPDFCEPNKKtgSLGTRGRECNRTsmgvDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCE 298

                         250
                  ....*....|..
gi 2054268674 258 QCLIDEEIHSCK 269
Cdd:cd19338   299 TCKVRKEIHTCN 310
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 23-269 1.36e-76

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 234.84  E-value: 1.36e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFTRRF----LKRAKRNGKDV 98
Cdd:cd19343    57 GTREQAFVYALSSAALTHTIARACASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFtdapEKKKKKKKRQA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  99 LARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSqqVEIDNNHANRKTAHKRRST 178
Cdd:cd19343   137 RALMNLHNNRVGRKAVRDSLETQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARA--VEVVSRKVGSRRKLVPKSL 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 179 KMSVVankmppRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVVWCC 252
Cdd:cd19343   215 KVRPY------TKDDLIYLTKSPDYCLPDEKlgSLGTRGRECNKTSVgsdsCDSMCCGRGYRTYTVEVVERCHCKYHWCC 288

                         250
                  ....*....|....*..
gi 2054268674 253 QFRCQQCLIDEEIHSCK 269
Cdd:cd19343   289 YVKCKTCRRTVEVHVCK 305
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 21-269 3.52e-76

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 234.06  E-value: 3.52e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  21 HLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTC---DESKNLQNEeaWRWGGCGDNIKFGLKFTRRFLK-----RAK 92
Cdd:cd19337    61 NIGTREAAFTYAISAAGVVHAIARACREGNLSTCGCsreRRPKDLPRD--WLWGGCGDNIEYGYKFAKEFIDarereTNY 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  93 RNGKDVLARV--NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIdnnhaNRK 170
Cdd:cd19337   139 PRHSRELARVlmNLHNNEAGRRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKL-----NRR 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 171 TAHKRRSTKmsvvaNKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPC 244
Cdd:cd19337   214 GTLLRRRNS-----RFNKPTKDDLVYLDDSPDYCERNPKtgSLGTKGRECNKTSSgtdgCELLCCGRGYNTKKVEVVERC 288

                         250       260
                  ....*....|....*....|....*
gi 2054268674 245 KCEVVWCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19337   289 HCKFHWCCEVKCKTCEKIVDVHICK 313
WNT1 smart00097
found in Wnt-1;
23-269 1.26e-75

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 232.21  E-value: 1.26e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674   23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLAR 101
Cdd:smart00097  61 GTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRKRGRaGGRGWKWGGCSDNIDFGIRFSREFVD-ARERGKDARAL 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  102 VNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTKms 181
Cdd:smart00097 140 MNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNSTFK-- 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  182 vvankmPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVVWCCQFR 255
Cdd:smart00097 218 ------PPTETDLVYLESSPDFCEKNPKtgSLGTQGRQCNKTSKgldgCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVK 291

                          250
                   ....*....|....
gi 2054268674  256 CQQCLIDEEIHSCK 269
Cdd:smart00097 292 CKQCRETVEKHTCK 305
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 23-269 1.03e-70

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 219.95  E-value: 1.03e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLARV 102
Cdd:cd19335    67 ASRESAFVHAIASAGVAHAVTRACAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFAD-ARENRPDARSAM 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 103 NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYensqqveiDNNHANRKTAHKRRSTKMSV 182
Cdd:cd19335   146 NRHNNEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKY--------DSASEMVVERHRESRGWVET 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 183 VANK----MPPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCC 252
Cdd:cd19335   218 LRPKyklfKPPTERDLIYYEESPNFCEPnpETGSFGTRGRECNVTShgidGCDLLCCGRGYNTRTEKRTEKCHCIFVWCC 297

                         250
                  ....*....|....*..
gi 2054268674 253 QFRCQQCLIDEEIHSCK 269
Cdd:cd19335   298 YVSCQECIRVYDVHTCK 314
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 25-269 1.07e-70

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 219.90  E-value: 1.07e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEA---WRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLAR 101
Cdd:cd19334    71 REAAFVYAISSAGVVHAITRACSKGELLNCACDPTKRGKGRDSkgeFDWGGCSDNVKYGINFARKFVDARERRVRDARAL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 102 VNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANrktahkrrstKMS 181
Cdd:cd19334   151 MNLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTN----------LLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 182 VVANKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQFR 255
Cdd:cd19334   221 ANKGHKKPTRSDLVYFESSPDYCVPNPEtgSLGTAGRVCNKTStgtdGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVK 300

                         250
                  ....*....|....
gi 2054268674 256 CQQCLIDEEIHSCK 269
Cdd:cd19334   301 CKTCTETVDVHTCK 314
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 23-269 4.79e-69

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 215.62  E-value: 4.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKN--LQNEEAWRWGGCGDNIKFGLKFTRRFLkRAKRNGKDVLA 100
Cdd:cd19339    64 GSREAAFTYAITSAGVAYAITQACSQGNLSDCGCDKSKKgyGKSDEGWKWGGCSADVKYGLRFSRKFV-DAREVKRNARS 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 101 RVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVE-IDNNHANRKTAHKRRSTK 179
Cdd:cd19339   143 LMNLHNNEAGRKAVEENLKLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEpVRGRRRRRPTFLKLKISR 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 180 msvvaNKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQ 253
Cdd:cd19339   223 -----KYKKPRPRDLVYLEKSPNYCEKDPLtgSLGTVGRRCNRTStgtdGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCY 297

                         250
                  ....*....|....*.
gi 2054268674 254 FRCQQCLIDEEIHSCK 269
Cdd:cd19339   298 VKCNTCSERTEEYTCK 313
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 16-268 8.78e-69

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 214.46  E-value: 8.78e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  16 LKKREHLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKN-LQNEEAWRWGGCGDNIKFGLKFTRRFLKrAKRN 94
Cdd:cd19340    42 SQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSKKgSKGGEGWTWGGCSDNVKFGERVSKKFLD-SLET 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  95 GKDVLARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNhanrktahK 174
Cdd:cd19340   121 GQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENG--------G 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 175 RRSTKMSVVANKMPPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKDRN----------CNSICCGRGYNV--QTKTV 240
Cdd:cd19340   193 LRETNGSRAIKLLNIKKNDLVYLEKSPNYCRAnvTLGWPGTLGRQCSRDKKesvsrwerksCRRLCRACGLKVrkKVVEV 272

                         250       260
                  ....*....|....*....|....*...
gi 2054268674 241 SRPCKCEVVWCCQFRCQQCLIDEEIHSC 268
Cdd:cd19340   273 TSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 23-268 5.22e-68

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 212.98  E-value: 5.22e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFTRRFLKRAKRnGKDVLARV 102
Cdd:cd19333    60 GCRETAFIYAITSAAVTHSVARACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEK-GRDLRYLM 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 103 NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTKMSV 182
Cdd:cd19333   139 NLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLLEPE 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 183 VANKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKAREC----IKDRNCNSICCGRGYNVQTKTVSRPCKCEVVWCCQFRC 256
Cdd:cd19333   219 NPNHKPPTSKDLVYFEESPNFCEKNPKlgTLGTRGRECnatsIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKC 298

                         250
                  ....*....|..
gi 2054268674 257 QQCLIDEEIHSC 268
Cdd:cd19333   299 ENCTRTRTVHTC 310
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 23-269 5.53e-64

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 202.55  E-value: 5.53e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEAWRWGGCGDNIKFGLKFTRRFLK-RAKRNGKDVLAR 101
Cdd:cd19336    63 GTREAAFVHAISSAGVAHAVTRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVDaRERRKGRASSSR 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 102 V--NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDnnhanrktahKRRSTK 179
Cdd:cd19336   143 AlmNLHNNEAGRKAIEKNMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQK----------RIGSRP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 180 MSVVANKM--PPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVVWC 251
Cdd:cd19336   213 VLVPKNPQfkPHTDADLVYLDSSPDFCEPdpKTGSLGTHGRVCNKTSKaidgCDLLCCGRGYVTRTEEVVERCSCKFHWC 292

                         250
                  ....*....|....*...
gi 2054268674 252 CQFRCQQCLIDEEIHSCK 269
Cdd:cd19336   293 CYVKCKTCRREVEVHTCR 310
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 25-269 6.01e-56

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 182.06  E-value: 6.01e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEA---WRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLAR 101
Cdd:cd19345    71 RESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKERKGKDARAL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 102 VNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTkms 181
Cdd:cd19345   151 MNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHFKK--- 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 182 vvankmpPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQFR 255
Cdd:cd19345   228 -------PTKNDLVYFENSPDYCVRDRDagSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVR 300

                         250
                  ....*....|....
gi 2054268674 256 CQQCLIDEEIHSCK 269
Cdd:cd19345   301 CKDCHQQVDVHTCK 314
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 18-269 1.49e-54

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 178.71  E-value: 1.49e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  18 KREHLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ--NEEAWRWGGCGDNIKFGLKFTRRFL--KRAKR 93
Cdd:cd19349    64 KELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQynQEEGWKWGGCSADIRYGIGFSKVFVdaREIKQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  94 NGKDVLarvNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAH 173
Cdd:cd19349   144 NARTLM---NLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTF 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 174 KRRSTKMSVvankMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIK----DRNCNSICCGRGYNVQTKTVSRPCKCE 247
Cdd:cd19349   221 LKIKKPLSY----RKPMDTDLVYIEKSPNYCEEDPVtgSVGTQGRMCNKtaqqNNGCDLMCCGRGYNTHQYSRVWQCNCK 296

                         250       260
                  ....*....|....*....|..
gi 2054268674 248 VVWCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19349   297 FHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 25-269 1.51e-53

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 175.88  E-value: 1.51e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQNEEA---WRWGGCGDNIKFGLKFTRRFLKRAKRNGKDVLAR 101
Cdd:cd19346    71 REAAFVYAISSAGVVYAITRACSQGELKSCSCDPHKRGRSHDErgeFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARAL 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 102 VNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKrrstkms 181
Cdd:cd19346   151 MNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANK------- 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 182 vvaNKMPPRRMEMIHIDSSPSFC--RQSRYSEGTKARECIKDRN----CNSICCGRGYNVQTKTVSRPCKCEVVWCCQFR 255
Cdd:cd19346   224 ---NFRKATKTDLVYFENSPDYCvmDKSAGSLGTAGRVCNKSSRgtdgCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVR 300

                         250
                  ....*....|....
gi 2054268674 256 CQQCLIDEEIHSCK 269
Cdd:cd19346   301 CKECEETVDVHTCK 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 23-269 2.73e-53

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 175.17  E-value: 2.73e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDesknlqneeaWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLARV 102
Cdd:cd19355    69 GFRESAFAYAIAAAGVVHAVSNACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLD-SRETYRDIHARM 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 103 NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYensqqveidnNHANRKTAHKRRSTKMSv 182
Cdd:cd19355   138 RLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRF----------YVATLIKPHNRNTGQLE- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 183 vANKMPPRRM----EMIHIDSSPSFCRQSRYSE--GTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCC 252
Cdd:cd19355   207 -PGHAPHRRRasinDLVYFEKSPDFCEREPRLDsaGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCC 285

                         250
                  ....*....|....*..
gi 2054268674 253 QFRCQQCLIDEEIHSCK 269
Cdd:cd19355   286 YVVCEECRITEWVSVCK 302
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 21-269 2.41e-52

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 172.94  E-value: 2.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  21 HLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDES---KNLQNEeaWRWGGCGDNIKFGLKFTRRFLKRAKR---- 93
Cdd:cd19347    61 QIGSRETAFTYAISAAGVVNAVSRACREGELSTCGCSRAarpKDLPRD--WLWGGCGDNLEYGYRFAKEFVDARERekiy 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  94 -NGKDVLARV--NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNnhanrk 170
Cdd:cd19347   139 qKGSYESARTlmNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNS------ 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 171 tahkrRSTKMSVVANKMPPRRMEMIHIDSSPSFC--RQSRYSEGTKARECIKDRN----CNSICCGRGYNvQTKTVSRP- 243
Cdd:cd19347   213 -----RGKLVQVNSRFNPPTTLDLVYIDPSPDYCvrNESTGSLGTQGRLCNKTSEgmdgCELMCCGRGYD-QFKTVQTEr 286

                         250       260
                  ....*....|....*....|....*.
gi 2054268674 244 CKCEVVWCCQFRCQQCLIDEEIHSCK 269
Cdd:cd19347   287 CHCKFHWCCYVKCKKCTEIVDQFVCK 312
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 22-269 6.20e-52

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 172.12  E-value: 6.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  22 LGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKN--LQNEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVL 99
Cdd:cd19350    68 VGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVD-AREIKKNAR 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 100 ARVNRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTK 179
Cdd:cd19350   147 RLMNLHNNEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTFLKIKKR 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 180 MSvvanKMPPRRMEMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQ 253
Cdd:cd19350   227 RS----YQKPMETDLVYIERSPNYCEEDAAtgSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCF 302

                         250
                  ....*....|....*.
gi 2054268674 254 FRCQQCLIDEEIHSCK 269
Cdd:cd19350   303 VKCNTCSERTEVFTCK 318
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 25-259 1.29e-51

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 170.59  E-value: 1.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLARVN 103
Cdd:cd19352    54 RETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQlGGQGWLWGGCSDNVGFGEAISKQFVD-ALETGQDARAAMN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 104 RHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNNHANRKTAHKRRSTKMSVV 183
Cdd:cd19352   133 LHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSI 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 184 ANKmpprrmEMIHIDSSPSFCRQSRY--SEGTKARECIK---------DRNCNSIC--CGRGYNVQTKTVSRPCKCEVVW 250
Cdd:cd19352   213 SKK------ELVHLEDSPDYCLENKTlgLLGTEGRECLKrgkalskweKRSCRRLCgdCGLAVEERRAEMVSSCNCKFHW 286


                  ....*....
gi 2054268674 251 CCQFRCQQC 259
Cdd:cd19352   287 CCAVKCEQC 295
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 25-268 1.32e-49

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 165.46  E-value: 1.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  25 KETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQ-NEEAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLARVN 103
Cdd:cd19351    53 RETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRNGRtGGRGWIWGGCSDNVEFGERISKQFVD-ALETGQDARALMN 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 104 RHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDNnhaNRKTAHKRRSTKMSVV 183
Cdd:cd19351   132 LHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADFREIGNYLKVKHDQALKLEMDK---RRMRAGNSADNRGAIA 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 184 ANKMPPRRMEMIHIDSSPSFCRQ--SRYSEGTKARECIKD---------RNCNSICCGRGYNVQTK--TVSRPCKCEVVW 250
Cdd:cd19351   209 EAFGSVAETELIYLEDSPDYCTKnaSLGLQGTEGRECLQSgknlsqwerRSCRRLCTECGLRVEERrtEVVSSCNCKFHW 288

                         250
                  ....*....|....*...
gi 2054268674 251 CCQFRCQQCLIDEEIHSC 268
Cdd:cd19351   289 CCTVKCEQCRQVVTKHYC 306
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 21-259 1.95e-49

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 165.15  E-value: 1.95e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  21 HLGFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCDESKNLQN-EEAWRWGGCGDNIKFGLKFTRRFLKRAKRN----- 94
Cdd:cd19348    61 QIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDlPRDWLWGGCGDNVEYGYRFAKEFVDAREREknypk 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  95 GKDVLARV--NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYENSQQVEIDnnhanrkta 172
Cdd:cd19348   141 GSEEHARTlmNLQNNEAGRRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRIN--------- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 173 hkrRSTKMSVVANKM-PPRRMEMIHIDSSPSFC--RQSRYSEGTKARECIKDRN----CNSICCGRGYNvQTKTVS-RPC 244
Cdd:cd19348   212 ---RKGKLELVNSRFnPPTAEDLVYIDPSPDYClrNETTGSLGTQGRLCNKTSEgmdgCELMCCGRGYD-QFKTVQvERC 287

                         250
                  ....*....|....*
gi 2054268674 245 KCEVVWCCQFRCQQC 259
Cdd:cd19348   288 HCKFHWCCYVKCKKC 302
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 23-269 8.70e-47

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 158.13  E-value: 8.70e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674  23 GFKETSFLYAVSSAGLVHSISRGCSTGRLDRCTCdesknlqneeAWRWGGCGDNIKFGLKFTRRFLKrAKRNGKDVLARV 102
Cdd:cd19356    69 GFRESAFSFSLLAAGVMHSVATACSLGKLRGCGC----------EWEWGGCSHDIEFGEKFSRDFLD-SRESPRDIQARM 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 103 NRHNSHLGIKVVKNHVETKCKCHGVSGSCTVQTCWRQLSPFNIIGEILKNKYEnsqqveidnnHANRKTAHKRRStkmSV 182
Cdd:cd19356   138 RIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQ----------RAIFINSHNKNS---GV 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054268674 183 VANKMPPRRM--EMIHIDSSPSFCRQSRY--SEGTKARECIKDR----NCNSICCGRGYNVQTKTVSRPCKCEVVWCCQF 254
Cdd:cd19356   205 FLPRLRPRRLarELVYFEKSPDFCERDPAvdSPGTQGRICNKTSpgmdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYV 284

                         250
                  ....*....|....*
gi 2054268674 255 RCQQCLIDEEIHSCK 269
Cdd:cd19356   285 LCEECRVTEWVNVCK 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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