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Conserved domains on  [gi|2053620040|gb|KAG7037396|]
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WD repeat-containing protein 44, partial [Cucurbita argyrosperma subsp. argyrosperma]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-766 9.79e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 9.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 509
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 510 ekkrrGR---SSISRKSVSLENVivpetvfgLSEKPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLK 585
Cdd:COG2319   174 -----GKllaSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IFSHSDyanskfvshvyrATVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGS 664
Cdd:COG2319   241 TLTGHS------------GSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGS 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 665 YKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSq 742
Cdd:COG2319   308 DDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT- 376

                         330       340
                  ....*....|....*....|....
gi 2053620040 743 iSACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   377 -SVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-766 9.79e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 9.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 509
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 510 ekkrrGR---SSISRKSVSLENVivpetvfgLSEKPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLK 585
Cdd:COG2319   174 -----GKllaSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IFSHSDyanskfvshvyrATVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGS 664
Cdd:COG2319   241 TLTGHS------------GSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGS 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 665 YKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSq 742
Cdd:COG2319   308 DDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT- 376

                         330       340
                  ....*....|....*....|....
gi 2053620040 743 iSACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   377 -SVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 431-767 7.92e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 7.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 431 SQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTAnespeptslspnvdsHHE 510
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--------------ETGELLRTLKG---------------HTG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 511 KKRRGRSSISRK---SVSLENVIvpeTVFGL-SEKPVCSFEGHLDVVLDLSWSKSQHLLSSSM-DKTVRLWHLSSKSCLK 585
Cdd:cd00200    53 PVRDVAASADGTylaSGSSDKTI---RLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLT 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IF-SHSDyanskfvshvyraTVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVG 663
Cdd:cd00200   130 TLrGHTD-------------WVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 664 SYKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPGSSsevLITSA--DSRVRV--VDGVDLVYRFKGfrNT 739
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLG---------TLRGHENGVNSVAFSPDGY---LLASGseDGTIRVwdLRTGECVQTLSG--HT 261

                         330       340
                  ....*....|....*....|....*...
gi 2053620040 740 NSQISACLSSNGRYVISASEDSHVYIWK 767
Cdd:cd00200   262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-465 3.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.94e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2053620040  432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 465
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
432-465 2.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 465
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 542-637 5.61e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 542 PVCSFEGHLDVVLDLSWSK--SQHLLSSSMDKTVRLWHLSSKSclkiFSHSDYANSKFVSHVYRATVTCIQFNPIDdrYF 619
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHND----ESVKEIKDPQCILKGHKKKISIIDWNPMN--YY 139

                          90       100
                  ....*....|....*....|
gi 2053620040 620 I--SGSLDAKVRIWSIPDRQ 637
Cdd:PTZ00420  140 ImcSSGFDSFVNIWDIENEK 159
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-766 9.79e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 9.79e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 509
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGA-VTSVafSPD----- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 510 ekkrrGR---SSISRKSVSLENVivpetvfgLSEKPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLK 585
Cdd:COG2319   174 -----GKllaSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLR 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IFSHSDyanskfvshvyrATVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGS 664
Cdd:COG2319   241 TLTGHS------------GSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGS 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 665 YKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPgSSSEVLITSADSRVRV--VDGVDLVYRFKGFRNTNSq 742
Cdd:COG2319   308 DDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT- 376

                         330       340
                  ....*....|....*....|....
gi 2053620040 743 iSACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   377 -SVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 431-767 7.92e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 7.92e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 431 SQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTAnespeptslspnvdsHHE 510
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--------------ETGELLRTLKG---------------HTG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 511 KKRRGRSSISRK---SVSLENVIvpeTVFGL-SEKPVCSFEGHLDVVLDLSWSKSQHLLSSSM-DKTVRLWHLSSKSCLK 585
Cdd:cd00200    53 PVRDVAASADGTylaSGSSDKTI---RLWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLT 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IF-SHSDyanskfvshvyraTVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVG 663
Cdd:cd00200   130 TLrGHTD-------------WVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 664 SYKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITGFQFAPGSSsevLITSA--DSRVRV--VDGVDLVYRFKGfrNT 739
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLG---------TLRGHENGVNSVAFSPDGY---LLASGseDGTIRVwdLRTGECVQTLSG--HT 261

                         330       340
                  ....*....|....*....|....*...
gi 2053620040 740 NSQISACLSSNGRYVISASEDSHVYIWK 767
Cdd:cd00200   262 NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
432-675 1.10e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.61  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 509
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGS-VRSVafSPD----- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 510 ekkrrGR---SSISRKSVSLENVivpetvfgLSEKPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWHLSSKSCLK 585
Cdd:COG2319   258 -----GRllaSGSADGTVRLWDL--------ATGELLRTLTGHSGGVNSVAFSPdGKLLASGSDDGTVRLWDLATGKLLR 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 586 IFSHsdyanskfvshvYRATVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGS 664
Cdd:COG2319   325 TLTG------------HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVTSVAFSPDGRTLASGS 391

                         250
                  ....*....|.
gi 2053620040 665 YKGSCRLYSTS 675
Cdd:COG2319   392 ADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
539-766 1.21e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 539 SEKPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWHLSSKSCLKIFS-HSDYanskfvshvyratVTCIQFNPiDD 616
Cdd:COG2319   109 TGLLLRTLTGHTGAVRSVAFSPdGKTLASGSADGTVRLWDLATGKLLRTLTgHSGA-------------VTSVAFSP-DG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 617 RYFISGSLDAKVRIWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTSENKMQQKSEinlqnkkkkSS 695
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT---------GH 245

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2053620040 696 HKKITGFQFAPGSSSeVLITSADSRVRV--VDGVDLVYRFKGfrNTNSQISACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   246 SGSVRSVAFSPDGRL-LASGSADGTVRLwdLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
432-635 3.34e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 3.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVvesekkgellmekpEEGNLSFLLTANESPePTSL--SPNvdshh 509
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL--------------ATGELLRTLTGHSGG-VNSVafSPD----- 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 510 ekkrrGR---SSISRKSVSLENVivpetvfgLSEKPVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLK 585
Cdd:COG2319   300 -----GKllaSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLR 366

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2053620040 586 IFS-HSDyanskfvshvyraTVTCIQFNPiDDRYFISGSLDAKVRIWSIPD 635
Cdd:COG2319   367 TLTgHTG-------------AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
545-766 5.01e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 5.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 545 SFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIFS-HSDYanskfvshvyratVTCIQFNPiDDRYFISG 622
Cdd:COG2319    73 TLLGHTAAVLSVAFSpDGRLLASASADGTVRLWDLATGLLLRTLTgHTGA-------------VRSVAFSP-DGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 623 SLDAKVRIWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTSENKMQQkseinlqnkKKKSSHKKITG 701
Cdd:COG2319   139 SADGTVRLWDLATGKLLRTLTGHSgAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRS 209

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2053620040 702 FQFAPgsSSEVLIT-SADSRVRV--VDGVDLVYRFKGFRNTNSqiSACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   210 VAFSP--DGKLLASgSADGTVRLwdLATGKLLRTLTGHSGSVR--SVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 542-766 5.41e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 5.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 542 PVCSFEGHLDVVLDLSWS-KSQHLLSSSMDKTVRLWHLSSKSCLKIFS-HSD-------YANSKFV-------------- 598
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGpvrdvaaSADGTYLasgssdktirlwdl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 599 -----SHVYR---ATVTCIQFNPiDDRYFISGSLDAKVRIWSIPDRQVVDWSDLHEM-VTAACYTPDGKGALVGSYKGSC 669
Cdd:cd00200    81 etgecVRTLTghtSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 670 RLYSTSENKMQQKSEINlqnkkkkssHKKITGFQFAPgSSSEVLITSADSRVRVVD--GVDLVYRFKGFrnTNSQISACL 747
Cdd:cd00200   160 KLWDLRTGKCVATLTGH---------TGEVNSVAFSP-DGEKLLSSSSDGTIKLWDlsTGKCLGTLRGH--ENGVNSVAF 227

                         250
                  ....*....|....*....
gi 2053620040 748 SSNGRYVISASEDSHVYIW 766
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-465 3.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.94e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2053620040  432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 465
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 539-577 1.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.60e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2053620040  539 SEKPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLWH 577
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
432-465 2.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2053620040 432 QEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVW 465
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
541-576 5.08e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2053620040 541 KPVCSFEGHLDVVLDLSWSK-SQHLLSSSMDKTVRLW 576
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
615-766 9.60e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 9.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 615 DDRYFISGSLDAKVRIWSIPDRQVVDWSDLHE-MVTAACYTPDGKGALVGSYKGSCRLYSTSENKMQQkseinlqnkKKK 693
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTaAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR---------TLT 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2053620040 694 SSHKKITGFQFAPgSSSEVLITSADSRVRVVDGVD--LVYRFKGfrNTNSQISACLSSNGRYVISASEDSHVYIW 766
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATgkLLRTLTG--HSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-476 1.37e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2053620040 424 ELSALYKSQEIQAHSGSIWTIKFSLDGKYLASAGEDRIIHVWQVVESEKKGEL 476
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 603-632 2.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.35e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2053620040  603 RATVTCIQFNPiDDRYFISGSLDAKVRIWS 632
Cdd:smart00320  12 TGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 542-637 5.61e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053620040 542 PVCSFEGHLDVVLDLSWSK--SQHLLSSSMDKTVRLWHLSSKSclkiFSHSDYANSKFVSHVYRATVTCIQFNPIDdrYF 619
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHND----ESVKEIKDPQCILKGHKKKISIIDWNPMN--YY 139

                          90       100
                  ....*....|....*....|
gi 2053620040 620 I--SGSLDAKVRIWSIPDRQ 637
Cdd:PTZ00420  140 ImcSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
603-632 6.97e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.97e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2053620040 603 RATVTCIQFNPiDDRYFISGSLDAKVRIWS 632
Cdd:pfam00400  11 TGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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