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Conserved domains on  [gi|2052862162|tpg|DAF43300|]
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MAG TPA: TT viral ORF2, partial [Anelloviridae sp. ctgwM5]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TT_ORF2 super family cl03800
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 16-86 6.74e-10

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


The actual alignment was detected with superfamily member pfam02957:

Pssm-ID: 251643  Cd Length: 103  Bit Score: 51.74  E-value: 6.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052862162  16 FKKPAFNNKKLQLQLVNGFVHEHDLVCCCNNPGYHVLQITATQIGQ-ELSPKQKQQIIKCLgETTTGDAEDG 86
Cdd:pfam02957   1 WRPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPAlPAAPEEPGDLAKWL-TTTGEDGGTG 71
 
Name Accession Description Interval E-value
TT_ORF2 pfam02957
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 16-86 6.74e-10

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


Pssm-ID: 251643  Cd Length: 103  Bit Score: 51.74  E-value: 6.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052862162  16 FKKPAFNNKKLQLQLVNGFVHEHDLVCCCNNPGYHVLQITATQIGQ-ELSPKQKQQIIKCLgETTTGDAEDG 86
Cdd:pfam02957   1 WRPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPAlPAAPEEPGDLAKWL-TTTGEDGGTG 71
 
Name Accession Description Interval E-value
TT_ORF2 pfam02957
TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of ...
 16-86 6.74e-10

TT viral ORF2; TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.


Pssm-ID: 251643  Cd Length: 103  Bit Score: 51.74  E-value: 6.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2052862162  16 FKKPAFNNKKLQLQLVNGFVHEHDLVCCCNNPGYHVLQITATQIGQ-ELSPKQKQQIIKCLgETTTGDAEDG 86
Cdd:pfam02957   1 WRPPRYNPKGLELQWINSIVRSHDLFCGCGDPLKHLIHPILRQLPAlPAAPEEPGDLAKWL-TTTGEDGGTG 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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