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Conserved domains on  [gi|2052572007|ref|WP_216055033|]
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tryptophan halogenase family protein [Psychrosphaera sp. F3M07]

Protein Classification

tryptophan halogenase family protein( domain architecture ID 10521725)

tryptophan halogenase family protein such as Pseudomonas fluorescens flavin-dependent tryptophan halogenase PrnA that catalyzes the chlorination of tryptophan to yield chlorotryptophan

EC:  1.14.19.-
Gene Ontology:  GO:0016491|GO:0000166
PubMed:  17260957|19501593

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Trp_halogenase pfam04820
Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form ...
7-462 0e+00

Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.


:

Pssm-ID: 398475 [Multi-domain]  Cd Length: 457  Bit Score: 610.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007   7 RIVIAGGGTAGWMTAAMMSKVLPKSVEITLVESEAIGIVGVGEATIPPIQTFNQYLGIDEKAFLKETNGSIKLAIKFENW 86
Cdd:pfam04820   1 KIVIVGGGTAGWMAAAALARALKGGLDVTLVESEEIGTVGVGEATIPSIRTFNRMLGIDEAEFLRATQATFKLGIRFEDW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007  87 RTEGESYYHTFGSPGANMGFSSFQHYWLRAKkELGLNASLWDFDLNYLCCEQNKFNKINSN--NPIHQMPYAYHFDSGLY 164
Cdd:pfam04820  81 GRRGERYIHPFGVTGHPIDGVPFHHYWLRLR-ARGFAGPLDDYCLPAVAALAGKFSPPPKDprSGLSGLSYAYHFDAALY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 165 GQFLRRYSEKQGVKRVEGIIQHVKQNPNSrFIEGLQLEDGRQIEADFFVDCTGTRGLLLQQTLGVQYQDWSHWLPADSAI 244
Cdd:pfam04820 160 ARFLRRNAEARGVTRVEGKVVDVQLDADG-FVTSLRLEDGREVEADLFIDCSGFRGLLIEQALKTGYEDWSDWLPCDRAL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 245 AVATEELDIIPPYTRSIAQNVGWQWQIPLTHRTGNGIVYSSSYCSDDDAMETLTDNLPSKMLGTPRKLSFKTGKVEKQWH 324
Cdd:pfam04820 239 AVQCESVGPPEPYTRATAHDAGWRWRIPLQHRLGNGYVYSSAHADDDEALAELLANLGGIPLAEPRLIRFTTGRRKQAWV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 325 KNVVAIGLASGFLEPLESTSIYLIQSAVVRLMKMFSTQGHYDSVINAFNRESDIEIETIRDFIILHYNLNERTDSDFWRD 404
Cdd:pfam04820 319 KNVVALGLASGFLEPLESTSIHLIQSALRRLLALFPDGGFDPAAIAEYNRRIAREYERIRDFIILHYKATKRDDTPFWRD 398
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2052572007 405 MRDLTLPPRLAQKIELFRDSGAIFNDQYDIFLDASWLQVMLGQGVTPASYHPSIDGMS 462
Cdd:pfam04820 399 CRTMEIPDSLAEKIELFRGRGRVFRGDDELFNESSWIAVLAGQGIVPRRYDPLADAVP 456
 
Name Accession Description Interval E-value
Trp_halogenase pfam04820
Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form ...
7-462 0e+00

Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.


Pssm-ID: 398475 [Multi-domain]  Cd Length: 457  Bit Score: 610.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007   7 RIVIAGGGTAGWMTAAMMSKVLPKSVEITLVESEAIGIVGVGEATIPPIQTFNQYLGIDEKAFLKETNGSIKLAIKFENW 86
Cdd:pfam04820   1 KIVIVGGGTAGWMAAAALARALKGGLDVTLVESEEIGTVGVGEATIPSIRTFNRMLGIDEAEFLRATQATFKLGIRFEDW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007  87 RTEGESYYHTFGSPGANMGFSSFQHYWLRAKkELGLNASLWDFDLNYLCCEQNKFNKINSN--NPIHQMPYAYHFDSGLY 164
Cdd:pfam04820  81 GRRGERYIHPFGVTGHPIDGVPFHHYWLRLR-ARGFAGPLDDYCLPAVAALAGKFSPPPKDprSGLSGLSYAYHFDAALY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 165 GQFLRRYSEKQGVKRVEGIIQHVKQNPNSrFIEGLQLEDGRQIEADFFVDCTGTRGLLLQQTLGVQYQDWSHWLPADSAI 244
Cdd:pfam04820 160 ARFLRRNAEARGVTRVEGKVVDVQLDADG-FVTSLRLEDGREVEADLFIDCSGFRGLLIEQALKTGYEDWSDWLPCDRAL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 245 AVATEELDIIPPYTRSIAQNVGWQWQIPLTHRTGNGIVYSSSYCSDDDAMETLTDNLPSKMLGTPRKLSFKTGKVEKQWH 324
Cdd:pfam04820 239 AVQCESVGPPEPYTRATAHDAGWRWRIPLQHRLGNGYVYSSAHADDDEALAELLANLGGIPLAEPRLIRFTTGRRKQAWV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 325 KNVVAIGLASGFLEPLESTSIYLIQSAVVRLMKMFSTQGHYDSVINAFNRESDIEIETIRDFIILHYNLNERTDSDFWRD 404
Cdd:pfam04820 319 KNVVALGLASGFLEPLESTSIHLIQSALRRLLALFPDGGFDPAAIAEYNRRIAREYERIRDFIILHYKATKRDDTPFWRD 398
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2052572007 405 MRDLTLPPRLAQKIELFRDSGAIFNDQYDIFLDASWLQVMLGQGVTPASYHPSIDGMS 462
Cdd:pfam04820 399 CRTMEIPDSLAEKIELFRGRGRVFRGDDELFNESSWIAVLAGQGIVPRRYDPLADAVP 456
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
151-351 5.00e-10

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 60.37  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 151 HQMPYAYHFDSGLYGQFLRRYSEKQGVK-----RVEGIIQHvkqnpNSRFIegLQLEDGRQIEADFFVDCTGTRGLLLQQ 225
Cdd:COG0644    75 PGRGGGYVVDRARFDRWLAEQAEEAGAEvrtgtRVTDVLRD-----DGRVV--VRTGDGEEIRADYVVDADGARSLLARK 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 226 tLGVQyqdwsHWLPADSAIAVATEELDIIPPYTRSIAQNV----------GWQWQIPLthrtGNGIVysssycsdddame 295
Cdd:COG0644   148 -LGLK-----RRSDEPQDYALAIKEHWELPPLEGVDPGAVefffgegapgGYGWVFPL----GDGRV------------- 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2052572007 296 tltdnlpskMLGTPRklsfkTGKVEKQWHKNVVAIGLASGFLEPLESTSIYL-IQSA 351
Cdd:COG0644   205 ---------SVGIPL-----GGPRPRLVGDGVLLVGDAAGFVDPLTGEGIHLaMKSG 247
 
Name Accession Description Interval E-value
Trp_halogenase pfam04820
Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form ...
7-462 0e+00

Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.


Pssm-ID: 398475 [Multi-domain]  Cd Length: 457  Bit Score: 610.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007   7 RIVIAGGGTAGWMTAAMMSKVLPKSVEITLVESEAIGIVGVGEATIPPIQTFNQYLGIDEKAFLKETNGSIKLAIKFENW 86
Cdd:pfam04820   1 KIVIVGGGTAGWMAAAALARALKGGLDVTLVESEEIGTVGVGEATIPSIRTFNRMLGIDEAEFLRATQATFKLGIRFEDW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007  87 RTEGESYYHTFGSPGANMGFSSFQHYWLRAKkELGLNASLWDFDLNYLCCEQNKFNKINSN--NPIHQMPYAYHFDSGLY 164
Cdd:pfam04820  81 GRRGERYIHPFGVTGHPIDGVPFHHYWLRLR-ARGFAGPLDDYCLPAVAALAGKFSPPPKDprSGLSGLSYAYHFDAALY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 165 GQFLRRYSEKQGVKRVEGIIQHVKQNPNSrFIEGLQLEDGRQIEADFFVDCTGTRGLLLQQTLGVQYQDWSHWLPADSAI 244
Cdd:pfam04820 160 ARFLRRNAEARGVTRVEGKVVDVQLDADG-FVTSLRLEDGREVEADLFIDCSGFRGLLIEQALKTGYEDWSDWLPCDRAL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 245 AVATEELDIIPPYTRSIAQNVGWQWQIPLTHRTGNGIVYSSSYCSDDDAMETLTDNLPSKMLGTPRKLSFKTGKVEKQWH 324
Cdd:pfam04820 239 AVQCESVGPPEPYTRATAHDAGWRWRIPLQHRLGNGYVYSSAHADDDEALAELLANLGGIPLAEPRLIRFTTGRRKQAWV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 325 KNVVAIGLASGFLEPLESTSIYLIQSAVVRLMKMFSTQGHYDSVINAFNRESDIEIETIRDFIILHYNLNERTDSDFWRD 404
Cdd:pfam04820 319 KNVVALGLASGFLEPLESTSIHLIQSALRRLLALFPDGGFDPAAIAEYNRRIAREYERIRDFIILHYKATKRDDTPFWRD 398
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2052572007 405 MRDLTLPPRLAQKIELFRDSGAIFNDQYDIFLDASWLQVMLGQGVTPASYHPSIDGMS 462
Cdd:pfam04820 399 CRTMEIPDSLAEKIELFRGRGRVFRGDDELFNESSWIAVLAGQGIVPRRYDPLADAVP 456
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
151-351 5.00e-10

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 60.37  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 151 HQMPYAYHFDSGLYGQFLRRYSEKQGVK-----RVEGIIQHvkqnpNSRFIegLQLEDGRQIEADFFVDCTGTRGLLLQQ 225
Cdd:COG0644    75 PGRGGGYVVDRARFDRWLAEQAEEAGAEvrtgtRVTDVLRD-----DGRVV--VRTGDGEEIRADYVVDADGARSLLARK 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 226 tLGVQyqdwsHWLPADSAIAVATEELDIIPPYTRSIAQNV----------GWQWQIPLthrtGNGIVysssycsdddame 295
Cdd:COG0644   148 -LGLK-----RRSDEPQDYALAIKEHWELPPLEGVDPGAVefffgegapgGYGWVFPL----GDGRV------------- 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2052572007 296 tltdnlpskMLGTPRklsfkTGKVEKQWHKNVVAIGLASGFLEPLESTSIYL-IQSA 351
Cdd:COG0644   205 ---------SVGIPL-----GGPRPRLVGDGVLLVGDAAGFVDPLTGEGIHLaMKSG 247
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
7-238 8.58e-06

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 47.63  E-value: 8.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007   7 RIVIAGGGTAGWMTAAMMSKvlpKSVEITLVE-SEAIGIVGVGEATIPPIQTFNQYLGIDEkAFLKEtngsiklaikfen 85
Cdd:COG0654     5 DVLIVGGGPAGLALALALAR---AGIRVTVVErAPPPRPDGRGIALSPRSLELLRRLGLWD-RLLAR------------- 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007  86 wrtegesyyhtfGSPGANMGFssfqHYWLRAKkelglnaSLWDFDLnylcceqnkfnkinsnnPIHQMPYAYHFDSGLYG 165
Cdd:COG0654    68 ------------GAPIRGIRV----RDGSDGR-------VLARFDA-----------------AETGLPAGLVVPRADLE 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052572007 166 QFLRRYSEKQGVK-----RVEGIIQ---HVkqnpnsrfieGLQLEDGRQIEADFFVDCTG----TRGLLLQQTLGVQYQD 233
Cdd:COG0654   108 RALLEAARALGVElrfgtEVTGLEQdadGV----------TVTLADGRTLRADLVVGADGarsaVRRLLGIGFTGRDYPQ 177

                  ....*
gi 2052572007 234 WSHWL 238
Cdd:COG0654   178 RALWA 182
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
7-37 3.55e-04

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 42.81  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2052572007   7 RIVIAGGGTAGWMTAAMMSKVLPKSVEITLV 37
Cdd:COG1252     3 RIVIVGGGFAGLEAARRLRKKLGGDAEVTLI 33
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
1-50 1.06e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 41.48  E-value: 1.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2052572007   1 MTGAINRIVIAGGGTAGWMTAAMMSKVLPKSVEITLVESEAigIVGVGEA 50
Cdd:COG4529     1 MTGARKRIAIIGGGASGTALAIHLLRRAPEPLRITLFEPRP--ELGRGVA 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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