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Conserved domains on  [gi|2052112511|ref|XP_041873431|]
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interleukin-22 receptor subunit alpha-2 isoform X2 [Corvus kubaryi]

Protein Classification

Tissue_fac and Interfer-bind domain-containing protein( domain architecture ID 10471435)

Tissue_fac and Interfer-bind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 3-120 1.07e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.38  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511   3 RIMLSFLCLLMHLLQIETTSLLVlenqdlqdsiKPQKVEFHSLNFNTTLHWQPGWAREaRDALYFVQYKVYGQSTWQNKD 82
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLP----------APQNVTFQSTNFKNILTWEPGPNSP-PDVVYTVQYKIYGSGDWKNVP 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2052112511  83 DCWGIPSRVCDLTHETSDIQEPYYGRVRATLAGVYSSW 120
Cdd:pfam01108  70 NCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-236 2.96e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 79.69  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511 132 TMVGPPMVTVVHSNKSIIVKLQAPQspykRKRGSKITMTNYY-DLLYQVFIINNllDEQHRVLVYEGKDKVIKIQDLRPG 210
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPE----TREGKNLSLRDLYgSLQYRVSYWKN--SSNGEKKNTTSTNSFVVLSDLEPG 74

                          90       100
                  ....*....|....*....|....*.
gi 2052112511 211 VSYCIVAKTYVPMLDRSSAYSSRQCT 236
Cdd:pfam09294  75 TTYCVSVQAFSPLDNKSSQRSPPQCI 100
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 3-120 1.07e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.38  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511   3 RIMLSFLCLLMHLLQIETTSLLVlenqdlqdsiKPQKVEFHSLNFNTTLHWQPGWAREaRDALYFVQYKVYGQSTWQNKD 82
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLP----------APQNVTFQSTNFKNILTWEPGPNSP-PDVVYTVQYKIYGSGDWKNVP 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2052112511  83 DCWGIPSRVCDLTHETSDIQEPYYGRVRATLAGVYSSW 120
Cdd:pfam01108  70 NCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-236 2.96e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 79.69  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511 132 TMVGPPMVTVVHSNKSIIVKLQAPQspykRKRGSKITMTNYY-DLLYQVFIINNllDEQHRVLVYEGKDKVIKIQDLRPG 210
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPE----TREGKNLSLRDLYgSLQYRVSYWKN--SSNGEKKNTTSTNSFVVLSDLEPG 74

                          90       100
                  ....*....|....*....|....*.
gi 2052112511 211 VSYCIVAKTYVPMLDRSSAYSSRQCT 236
Cdd:pfam09294  75 TTYCVSVQAFSPLDNKSSQRSPPQCI 100
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 3-120 1.07e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.38  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511   3 RIMLSFLCLLMHLLQIETTSLLVlenqdlqdsiKPQKVEFHSLNFNTTLHWQPGWAREaRDALYFVQYKVYGQSTWQNKD 82
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLP----------APQNVTFQSTNFKNILTWEPGPNSP-PDVVYTVQYKIYGSGDWKNVP 69

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2052112511  83 DCWGIPSRVCDLTHETSDIQEPYYGRVRATLAGVYSSW 120
Cdd:pfam01108  70 NCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 132-236 2.96e-19

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 79.69  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052112511 132 TMVGPPMVTVVHSNKSIIVKLQAPQspykRKRGSKITMTNYY-DLLYQVFIINNllDEQHRVLVYEGKDKVIKIQDLRPG 210
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPE----TREGKNLSLRDLYgSLQYRVSYWKN--SSNGEKKNTTSTNSFVVLSDLEPG 74

                          90       100
                  ....*....|....*....|....*.
gi 2052112511 211 VSYCIVAKTYVPMLDRSSAYSSRQCT 236
Cdd:pfam09294  75 TTYCVSVQAFSPLDNKSSQRSPPQCI 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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