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MULTISPECIES: precorrin-6Y C5,15-methyltransferase (decarboxylating) subunit CbiT [Clostridium]

Protein Classification

precorrin-6Y C5,15-methyltransferase (decarboxylating) subunit CbiT( domain architecture ID 11454932)

precorrin-6Y C5,15-methyltransferase (decarboxylating) subunit CbiT catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 4-191 6.86e-58

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 186.91  E-value: 6.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   4 IKDSEFIRGNCPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS 83
Cdd:COG2242   218 LPDEAFERDKGPITKREVRALTLAKLALRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVP 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  84 NINLTKGDAREVLDkyieeGL-RFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKADIS 162
Cdd:COG2242   298 NVEVVEGEAPEALA-----DLpDPDAVFIGGSGGNLPEILEACWARLRPGGRLVANAVTLETLALALEALAELGYGGELV 372

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2050473897 163 MVNISKNK--GESYMMIANNPIYIVKCVRKE 191
Cdd:COG2242   373 QVQVSRLKplGGGTGFRPANPVTIISAEKPE 403
 
Name Accession Description Interval E-value
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 4-191 6.86e-58

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 186.91  E-value: 6.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   4 IKDSEFIRGNCPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS 83
Cdd:COG2242   218 LPDEAFERDKGPITKREVRALTLAKLALRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVP 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  84 NINLTKGDAREVLDkyieeGL-RFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKADIS 162
Cdd:COG2242   298 NVEVVEGEAPEALA-----DLpDPDAVFIGGSGGNLPEILEACWARLRPGGRLVANAVTLETLALALEALAELGYGGELV 372

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2050473897 163 MVNISKNK--GESYMMIANNPIYIVKCVRKE 191
Cdd:COG2242   373 QVQVSRLKplGGGTGFRPANPVTIISAEKPE 403
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
5-192 5.94e-42

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 139.37  E-value: 5.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   5 KDSEFIRG-NCPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS 83
Cdd:PRK08287    2 KDELFLRGeKVPMTKEEVRALALSKLELHRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  84 NINLTKGDARevldkyIEEGLRFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKaDISM 163
Cdd:PRK08287   82 NIDIIPGEAP------IELPGKADAIFIGGSGGNLTAIIDWSLAHLHPGGRLVLTFILLENLHSALAHLEKCGVS-ELDC 154

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2050473897 164 VNISKNK----GESYMMIANNPIYIVKCVRKED 192
Cdd:PRK08287  155 VQLQVSSltplGAGHYFKPNNPTFIISCQKEEN 187
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 15-141 2.36e-29

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 105.10  E-value: 2.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  15 PMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDARE 94
Cdd:TIGR02469   1 GMTKREVRALTLAKLRLRPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVSNIVIVEGDAPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2050473897  95 VLDKYIEEglrFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFIT 141
Cdd:TIGR02469  81 APEALLPD---PDAVFVGGSGGLLQEILEAVERRLRPGGRIVLNAIT 124
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-142 7.76e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 7.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  36 KVLDIGSGTGTISVQAAKlAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDkyiEEGLRFDSIF----I 111
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP---EADESFDVIIsdppL 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2050473897 112 GGSGGGLENIIEKSNVLLKDNGVIVMNFITL 142
Cdd:cd02440    77 HHLVEDLARFLEEARRLLKPGGVLVLTLVLA 107
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 31-169 1.31e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.95  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  31 LNNDSKVLDIGSGTGTISVQAA-KLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKYieEGLRFDSI 109
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELL--EDDKFDVV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2050473897 110 FIGGSGGGLEN---IIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKADISMVNISKN 169
Cdd:pfam13847  79 ISNCVLNHIPDpdkVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKK 141
 
Name Accession Description Interval E-value
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 4-191 6.86e-58

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 186.91  E-value: 6.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   4 IKDSEFIRGNCPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS 83
Cdd:COG2242   218 LPDEAFERDKGPITKREVRALTLAKLALRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVP 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  84 NINLTKGDAREVLDkyieeGL-RFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKADIS 162
Cdd:COG2242   298 NVEVVEGEAPEALA-----DLpDPDAVFIGGSGGNLPEILEACWARLRPGGRLVANAVTLETLALALEALAELGYGGELV 372

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2050473897 163 MVNISKNK--GESYMMIANNPIYIVKCVRKE 191
Cdd:COG2242   373 QVQVSRLKplGGGTGFRPANPVTIISAEKPE 403
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
5-192 5.94e-42

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 139.37  E-value: 5.94e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   5 KDSEFIRG-NCPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS 83
Cdd:PRK08287    2 KDELFLRGeKVPMTKEEVRALALSKLELHRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  84 NINLTKGDARevldkyIEEGLRFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKaDISM 163
Cdd:PRK08287   82 NIDIIPGEAP------IELPGKADAIFIGGSGGNLTAIIDWSLAHLHPGGRLVLTFILLENLHSALAHLEKCGVS-ELDC 154

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2050473897 164 VNISKNK----GESYMMIANNPIYIVKCVRKED 192
Cdd:PRK08287  155 VQLQVSSltplGAGHYFKPNNPTFIISCQKEEN 187
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 4-185 2.37e-41

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 138.39  E-value: 2.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897   4 IKDSEFIRGN-CPMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKL-AKDGLVYSIEKDDDAFLVSKKNIEKFN 81
Cdd:PRK00377   10 IPDEEFERDEeIPMTKEEIRALALSKLRLRKGDMILDIGCGTGSVTVEASLLvGETGKVYAVDKDEKAINLTRRNAEKFG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  82 C-SNINLTKGDAREVLDKYIEEglrFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKAD 160
Cdd:PRK00377   90 VlNNIVLIKGEAPEILFTINEK---FDRIFIGGGSEKLKEIISASWEIIKKGGRIVIDAILLETVNNALSALENIGFNLE 166

                         170       180
                  ....*....|....*....|....*..
gi 2050473897 161 ISMVNISK--NKGESYMMIANNPIYIV 185
Cdd:PRK00377  167 ITEVIIAKgmKTKVGTAMMTRNPIFII 193
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 15-141 2.36e-29

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 105.10  E-value: 2.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  15 PMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDARE 94
Cdd:TIGR02469   1 GMTKREVRALTLAKLRLRPGDVLWDIGAGTGSVTIEAARLVPNGRVYAIERNPEALDLIERNLRRFGVSNIVIVEGDAPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2050473897  95 VLDKYIEEglrFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMNFIT 141
Cdd:TIGR02469  81 APEALLPD---PDAVFVGGSGGLLQEILEAVERRLRPGGRIVLNAIT 124
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
15-184 2.26e-16

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 73.49  E-value: 2.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  15 PMTKEDVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDARE 94
Cdd:PRK07402   22 PLTKREVRLLLISQLRLEPDSVLWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEGSAPE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  95 VLDKYIE-------EGLRfdsifiggsggGLENIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKEL---NYKADISMV 164
Cdd:PRK07402  102 CLAQLAPapdrvciEGGR-----------PIKEILQAVWQYLKPGGRLVATASSLEGLYAISEGLAQLqarNIEVVQAAV 170

                         170       180
                  ....*....|....*....|
gi 2050473897 165 NISKNKGESYMMIANNPIYI 184
Cdd:PRK07402  171 NRLETRGFSQVFAAVDPIFI 190
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 36-136 7.97e-12

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 60.58  E-value: 7.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  36 KVLDIGSGTG--TISVqAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDAREVLDKYIEEglRFDSIFIG 112
Cdd:COG4122    19 RILEIGTGTGysTLWL-ARALPDDGRLTTIEIDPERAAIARENFARAGLADrIRLILGDALEVLPRLADG--PFDLVFID 95

                          90       100
                  ....*....|....*....|....
gi 2050473897 113 GSGGGLENIIEKSNVLLKDNGVIV 136
Cdd:COG4122    96 ADKSNYPDYLELALPLLRPGGLIV 119
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-142 7.76e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.67  E-value: 7.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  36 KVLDIGSGTGTISVQAAKlAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDkyiEEGLRFDSIF----I 111
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPP---EADESFDVIIsdppL 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2050473897 112 GGSGGGLENIIEKSNVLLKDNGVIVMNFITL 142
Cdd:cd02440    77 HHLVEDLARFLEEARRLLKPGGVLVLTLVLA 107
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 28-166 3.25e-10

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 57.48  E-value: 3.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  28 KMDLNNDSKVLDIGSGTG--TISVqAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCS-NINLTKGDAREVldkyIEEGl 104
Cdd:COG2519    86 RLDIFPGARVLEAGTGSGalTLAL-ARAVGPEGKVYSYERREDFAEIARKNLERFGLPdNVELKLGDIREG----IDEG- 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2050473897 105 RFDSIFIggsgGGLE--NIIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYkADISMVNI 166
Cdd:COG2519   160 DVDAVFL----DMPDpwEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGF-TDIEAVET 218
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
26-110 5.51e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 50.67  E-value: 5.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  26 IWKMDLNND---SKVLDIGSGTGTISVqAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCsNINLTKGDAREvldkyIEE 102
Cdd:COG2263    35 LHLAYLRGDiegKTVLDLGCGTGMLAI-GAALLGAKKVVGVDIDPEALEIARENAERLGV-RVDFIRADVTR-----IPL 107


                  ....*...
gi 2050473897 103 GLRFDSIF 110
Cdd:COG2263   108 GGSVDTVV 115
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 31-169 1.31e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.95  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  31 LNNDSKVLDIGSGTGTISVQAA-KLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKYieEGLRFDSI 109
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELL--EDDKFDVV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2050473897 110 FIGGSGGGLEN---IIEKSNVLLKDNGVIVMNFITLNNAYKGIEKAKELNYKADISMVNISKN 169
Cdd:pfam13847  79 ISNCVLNHIPDpdkVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKK 141
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 30-137 1.44e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 49.76  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  30 DLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDAREVLDKYIEEglRFDS 108
Cdd:COG4123    34 PVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELPPG--SFDL 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2050473897 109 I------FIGGSGGG----------------LENIIEKSNVLLKDNGVIVM 137
Cdd:COG4123   112 VvsnppyFKAGSGRKspdearaiarhedaltLEDLIRAAARLLKPGGRFAL 162
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 30-107 1.49e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 50.16  E-value: 1.49e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2050473897  30 DLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDareVLDKYIEEglRFD 107
Cdd:PRK09328  105 LLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGD---WFEPLPGG--RFD 177
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 29-111 1.95e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 48.93  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTGtisVQAAKLAK-DGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLdkyiEEGLRFD 107
Cdd:COG2518    62 LDLKPGDRVLEIGTGSG---YQAAVLARlAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALGW----PEHAPFD 134


                  ....
gi 2050473897 108 SIFI 111
Cdd:COG2518   135 RIIV 138
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 29-138 2.29e-07

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 49.03  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTG-TISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDAREVLDKYIEEG--L 104
Cdd:pfam01596  39 VKLTGAKNVLEIGVFTGySALAMALALPEDGKITAIDIDPEAYEIAKKFIQKAGVAHkISFILGPALKVLEQLTQDKplP 118

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2050473897 105 RFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVMN 138
Cdd:pfam01596 119 EFDFIFIDADKSNYPNYYERLLELLKVGGLMAID 152
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
34-98 3.98e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 48.49  E-value: 3.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2050473897  34 DSKVLDIGSGTGTISVQAAKL-AKDglVYSIEKDDDAFLVSKKNIEKFNCS-NINLTKGDAREVLDK 98
Cdd:COG4076    36 GDVVLDIGTGSGLLSMLAARAgAKK--VYAVEVNPDIAAVARRIIAANGLSdRITVINADATDLDLP 100
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 34-137 5.40e-07

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 47.77  E-value: 5.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  34 DSKVLDIGSGTGTISVQA----AKLakdglVYSIEKDDDAFLVSKKNIEKFNCS-NINLTKGDAREVLDKYieEGLRFDS 108
Cdd:COG0742    42 GARVLDLFAGSGALGLEAlsrgAAS-----VVFVEKDRKAAAVIRKNLEKLGLEdRARVIRGDALRFLKRL--AGEPFDL 114

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2050473897 109 IFI------GGSGGGLENIIEKSnvLLKDNGVIVM 137
Cdd:COG0742   115 VFLdppyakGLLEKALELLAENG--LLAPGGLIVV 147
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
17-137 8.16e-07

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 47.23  E-value: 8.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  17 TKEDVR-AL-SIWKMDLNNdSKVLDIGSGTGTISVQAA-KLAKDglVYSIEKDDDAFLVSKKNIEKFNCSNINLtKGDAR 93
Cdd:pfam03602  24 TTDRVReALfNWLAPYIEG-ARVLDLFAGSGALGLEALsRGAKR--VTLVEKDKRAVQILKENLQLLGLPGAVL-VMDAL 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2050473897  94 EVLDKYIEEGLRFDSIFI-----GGSGGGLENIIEKSNvLLKDNGVIVM 137
Cdd:pfam03602 100 LALLRLAGKGPVFDIVFLdppyaKGLIEEVLDLLAEKG-WLKPNALIYV 147
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 36-107 9.84e-07

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 47.84  E-value: 9.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2050473897  36 KVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDAREVLDkyieEGLRFD 107
Cdd:COG2890   115 RVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEPLP----GDGRFD 183
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
29-95 1.73e-06

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 46.82  E-value: 1.73e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2050473897  29 MDLNNDSKVLDIGSGTGTISVQAAKLAKDglVYSIEKDDDafLVSKKNIEKFNCSNINLTKGDAREV 95
Cdd:PRK14896   25 AEDTDGDPVLEIGPGKGALTDELAKRAKK--VYAIELDPR--LAEFLRDDEIAAGNVEIIEGDALKV 87
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 29-109 4.74e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 45.18  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLdkyieEGLRFDS 108
Cdd:COG2813    45 LPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGV-----PDGSFDL 119


                  .
gi 2050473897 109 I 109
Cdd:COG2813   120 I 120
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 30-111 5.06e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.94  E-value: 5.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  30 DLNNDSKVLDIGSGTGTISVQAAKLAKDglVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKyIEEGLRFDSI 109
Cdd:COG2265   230 DLTGGERVLDLYCGVGTFALPLARRAKK--VIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPE-LLWGGRPDVV 306


                  ..
gi 2050473897 110 FI 111
Cdd:COG2265   307 VL 308
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
29-93 7.59e-06

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 44.67  E-value: 7.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2050473897  29 MDLNNDSKVLDIGSGTGtisVQAAKLAK----DGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAR 93
Cdd:pfam01135  69 LELKPGMRVLEIGSGSG---YLTACFARmvgeVGRVVSIEHIPELVEIARRNLEKLGLENVIVVVGDGR 134
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 30-137 2.21e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.37  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  30 DLNNDSKVLDIGSGTGTISVQAAKLAKdGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDkyiEEGLRFDSI 109
Cdd:COG0500    23 RLPKGGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP---LPAESFDLV 98

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2050473897 110 FIGG-----SGGGLENIIEKSNVLLKDNGVIVM 137
Cdd:COG0500    99 VAFGvlhhlPPEEREALLRELARALKPGGVLLL 131
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 20-137 2.59e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 42.29  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  20 DVRALSIWKMDLNNDSKVLDIGSGTGTISVQAAKLakDGLVYSIEKDDDAFLVSKKNIEKFNCsNINLTKGDAREvLDky 99
Cdd:COG2226     9 DGREALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAED-LP-- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2050473897 100 IEEGlRFDSIFIggsGGGLENIIEKSNVL------LKDNGVIVM 137
Cdd:COG2226    83 FPDG-SFDLVIS---SFVLHHLPDPERALaeiarvLKPGGRLVV 122
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 30-137 4.10e-05

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 42.91  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  30 DLNNDSKVLDIGSGTG-TISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKYIEeglrFDS 108
Cdd:PRK13943   77 GLDKGMRVLEIGGGTGyNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRRLGIENVIFVCGDGYYGVPEFAP----YDV 152

                          90       100
                  ....*....|....*....|....*....
gi 2050473897 109 IFIggsGGGLENIIEKSNVLLKDNGVIVM 137
Cdd:PRK13943  153 IFV---TVGVDEVPETWFTQLKEGGRVIV 178
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 37-137 4.32e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 42.24  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  37 VLDIGSGTGTISVQAAKLAKDglVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVldKYIEEglRFDSI------- 109
Cdd:COG1041    30 VLDPFCGTGTILIEAGLLGRR--VIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDL--PLADE--SVDAIvtdppyg 103

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2050473897 110 -FIGGSGGGLENIIEKS----NVLLKDNGVIVM 137
Cdd:COG1041   104 rSSKISGEELLELYEKAleeaARVLKPGGRVVI 136
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 29-137 6.38e-05

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 41.93  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTG-TISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREvldKYIEEGlRFD 107
Cdd:PRK13942   72 LDLKEGMKVLEIGTGSGyHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKKLGYDNVEVIVGDGTL---GYEENA-PYD 147

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2050473897 108 SIFIGGSGGGL-ENIIEKsnvlLKDNGVIVM 137
Cdd:PRK13942  148 RIYVTAAGPDIpKPLIEQ----LKDGGIMVI 174
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-140 8.33e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.77  E-value: 8.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  31 LNNDSKVLDIGSGTGTISVQAAKLAKDglVYSIEKDDDAFLVSKKNIEKFncsNINLTKGDAREVLdkyiEEGLRFDSIF 110
Cdd:COG2227    22 LPAGGRVLDVGCGTGRLALALARRGAD--VTGVDISPEALEIARERAAEL---NVDFVQGDLEDLP----LEDGSFDLVI 92

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2050473897 111 -------IGGSGGGLENIIEksnvLLKDNGVIVMNFI 140
Cdd:COG2227    93 csevlehLPDPAALLRELAR----LLKPGGLLLLSTP 125
trmB PRK00121
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
 32-111 9.71e-05

tRNA (guanine-N(7)-)-methyltransferase; Reviewed


Pssm-ID: 234649  Cd Length: 202  Bit Score: 41.30  E-value: 9.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  32 NNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKYIEEGlRFDSIFI 111
Cdd:PRK00121   39 NDAPIHLEIGFGKGEFLVEMAKANPDINFIGIEVHEPGVGKALKKIEEEGLTNLRLLCGDAVEVLLDMFPDG-SLDRIYL 117
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 37-96 9.96e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 41.18  E-value: 9.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2050473897  37 VLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFlvskknieKFNCSNINLTK---------GDAREVL 96
Cdd:pfam02475 103 VVDMFAGIGPFSIPIAKHSKARRVYAIELNPESY--------KYLKENIKLNKvedvvkpilGDVREVI 163
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
26-137 1.13e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 41.70  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  26 IWKMDLNNDSkVLDIGSGTGTISVQAAKL-AKDglVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDarevldkyIEEG 103
Cdd:COG2264   142 LEKLLKPGKT-VLDVGCGSGILAIAAAKLgAKR--VLAVDIDPVAVEAARENAELNGVEDrIEVVLGD--------LLED 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2050473897 104 LRFDSIFIggsgggleNIIekSNVL----------LKDNGVIVM 137
Cdd:COG2264   211 GPYDLVVA--------NIL--ANPLielapdlaalLKPGGYLIL 244
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 36-111 1.25e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 41.71  E-value: 1.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2050473897  36 KVLDIGSGTGTISVQAAKL-AKDglVYSIEKDDDAFLVSKKNIE--KFNcSNINLTKGDAREVLDKYIEEGLRFDSIFI 111
Cdd:COG1092   219 RVLNLFSYTGGFSVHAAAGgAKS--VTSVDLSATALEWAKENAAlnGLD-DRHEFVQADAFDWLRELAREGERFDLIIL 294
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 12-137 1.50e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 41.10  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  12 GNCPMTKEDVRALSiwkMDLNNDSKVLDIGSGTGTISVQAAKL-AKDglVYSIEKDDDAFLVSKKNIEKFNCSNiNLTKG 90
Cdd:pfam06325 143 GTHPTTKLCLEALE---RLVKPGESVLDVGCGSGILAIAALKLgAKK--VVGVDIDPVAVRAAKENAELNGVEA-RLEVY 216

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2050473897  91 DAREVLDkyieegLRFDSIFIGGSGGGLENIIEKSNVLLKDNGVIVM 137
Cdd:pfam06325 217 LPGDLPK------EKADVVVANILADPLIELAPDIYALVKPGGYLIL 257
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
28-91 2.39e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 40.52  E-value: 2.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2050473897  28 KMDLNNDSkVLDIGSGTGTISVQAAKL-AKDglVYSIEKDDDAFLVSKKNIEKFNCS-NINLTKGD 91
Cdd:PRK00517  115 KLVLPGKT-VLDVGCGSGILAIAAAKLgAKK--VLAVDIDPQAVEAARENAELNGVElNVYLPQGD 177
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 30-95 4.51e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 39.72  E-value: 4.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2050473897  30 DLNNDSKVLDIGSGTGTISVQAAKLAKDglVYSIEKDDD--AFLvsKKNIEKFncSNINLTKGDAREV 95
Cdd:COG0030    34 GITPGDTVLEIGPGLGALTRALLERAAR--VTAVEIDRRlaAIL--RETFAAY--PNLTVIEGDALKV 95
PLN02781 PLN02781
Probable caffeoyl-CoA O-methyltransferase
 29-135 6.84e-04

Probable caffeoyl-CoA O-methyltransferase


Pssm-ID: 215417  Cd Length: 234  Bit Score: 39.03  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTG-TISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSN-INLTKGDAREVLDKYIEEGLR- 105
Cdd:PLN02781   64 VKIMNAKNTLEIGVFTGySLLTTALALPEDGRITAIDIDKEAYEVGLEFIKKAGVDHkINFIQSDALSALDQLLNNDPKp 143

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2050473897 106 -FDSIFIGGSGGGLENIIEKSNVLLKDNGVI 135
Cdd:PLN02781  144 eFDFAFVDADKPNYVHFHEQLLKLVKVGGII 174
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 36-137 8.40e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 38.64  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  36 KVLDIGSGTG-TISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNI-NLTKGDAREVLDKYIEeglrFDSIFIGG 113
Cdd:PRK13944   75 KILEVGTGSGyQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIERLGYWGVvEVYHGDGKRGLEKHAP----FDAIIVTA 150

                          90       100
                  ....*....|....*....|....
gi 2050473897 114 SGGGLENIIEKSnvlLKDNGVIVM 137
Cdd:PRK13944  151 AASTIPSALVRQ---LKDGGVLVI 171
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 36-161 8.79e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 39.07  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  36 KVLDIGSGTGTISVQAAKlAKDGLVYSIEKDDDAFLVSKKNIEKfNC--SNINLTKGDAREVLDKYIEeglRFDSIfIGG 113
Cdd:COG2520   183 RVLDMFAGVGPFSIPIAK-RSGAKVVAIDINPDAVEYLKENIRL-NKveDRVTPILGDAREVAPELEG---KADRI-IMN 256

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2050473897 114 SGGGLENIIEKSNVLLKDNGVIVMNFIT-----LNNAYKGIEK-AKELNYKADI 161
Cdd:COG2520   257 LPHSADEFLDAALRALKPGGVIHYYEIVpeedpFERAEERIEEaAEEAGYEVEI 310
PRK14968 PRK14968
putative methyltransferase; Provisional
 36-87 1.11e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.34  E-value: 1.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2050473897  36 KVLDIGSGTGTISVQAAKLAKDglVYSIEKDDDAFLVSKKNIEKFNCSNINL 87
Cdd:PRK14968   26 RVLEVGTGSGIVAIVAAKNGKK--VVGVDINPYAVECAKCNAKLNNIRNNGV 75
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
30-136 1.12e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.26  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  30 DLNNDSKVLDIGSGTGtisVQAAKLAK-DGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDARevldkyieEGLR--- 105
Cdd:PRK00312   75 ELKPGDRVLEIGTGSG---YQAAVLAHlVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGW--------KGWPaya 143

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2050473897 106 -FDSIFIGGSGGGL-ENIIEksnvLLKDNGVIV 136
Cdd:PRK00312  144 pFDRILVTAAAPEIpRALLE----QLKEGGILV 172
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-111 1.29e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 36.77  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2050473897  37 VLDIGSGTGTISVQAAKLAKdGLVYSIEKDDDAFLVSKKNIEKFNCsNINLTKGDAREvldkYIEEGLRFDSIFI 111
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAED----LPFPDGSFDLVVS 69
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 29-138 1.66e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 37.57  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2050473897  29 MDLNNDSKVLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDARE-VLDKyieeglRFD 107
Cdd:pfam05175  27 LPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSgVEDG------KFD 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2050473897 108 SI-----F---IGGSGGGLENIIEKSNVLLKDNGV--IVMN 138
Cdd:pfam05175 101 LIisnppFhagLATTYNVAQRFIADAKRHLRPGGElwIVAN 141
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 37-111 1.71e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 37.65  E-value: 1.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2050473897  37 VLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINLTKGDAREVLDKYIEEGlRFDSIFI 111
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAKANPDKNFIGIEIRVPGVAKALKKIDALGLQNLRILCGNALDVLPNYFPPG-SLQKIFI 78
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 37-87 9.53e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 34.98  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2050473897  37 VLDIGSGTGTISVQAAKLAKDGLVYSIEKDDDAFLVSKKNIEKFNCSNINL 87
Cdd:TIGR01444   2 VIDVGANIGDTSLYFARKGAEGRVIAFEPLPDAYEILEENVKLNNLPNVVL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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