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Conserved domains on  [gi|2048238002|ref|WP_214833231|]
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MULTISPECIES: type I methionyl aminopeptidase [Exiguobacterium]

Protein Classification

M24 family metallopeptidase( domain architecture ID 320)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP_MetAP super family cl00279
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 7-245 1.51e-115

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


The actual alignment was detected with superfamily member PRK12896:

Pssm-ID: 469704 [Multi-domain]  Cd Length: 255  Bit Score: 331.03  E-value: 1.51e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:PRK12896   17 EKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPGPRVIKDGDL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGtPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:PRK12896   97 VNIDVSAYLDGYHGDTGITFAVG-PVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSVVRDLTGHG 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPETISNYYSREENDILKEGQVIAVETFISTQDEiVYQSEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PRK12896  176 VGRSLHEEPSVILTYTDPLPNRLLRPGMTLAVEPFLNLGAK-DAETLDDGWTVVTPDKSLSAQFEHTVVVTRDGPEILT 253
 
Name Accession Description Interval E-value
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 7-245 1.51e-115

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 331.03  E-value: 1.51e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:PRK12896   17 EKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPGPRVIKDGDL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGtPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:PRK12896   97 VNIDVSAYLDGYHGDTGITFAVG-PVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSVVRDLTGHG 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPETISNYYSREENDILKEGQVIAVETFISTQDEiVYQSEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PRK12896  176 VGRSLHEEPSVILTYTDPLPNRLLRPGMTLAVEPFLNLGAK-DAETLDDGWTVVTPDKSLSAQFEHTVVVTRDGPEILT 253
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-245 4.71e-107

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 309.24  E-value: 4.71e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:COG0024    10 EKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSDRVLKDGDI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:COG0024    90 VNIDVGAILDGYHGDSARTFVVGEV-SPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGHG 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFISTQDEIVYQsEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:COG0024   169 IGREMHEEPQ-VPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKV-LDDGWTVVTKDGSLSAQFEHTVAVTEDGPEILT 245
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 7-245 4.71e-101

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 293.63  E-value: 4.71e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:cd01086     2 EGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGDI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:cd01086    82 VNIDVGVELDGYHGDSARTFIVGEV-SEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFISTQDEIVYQsEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:cd01086   161 IGRKFHEEPQ-IPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVT-LPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 7-245 3.73e-89

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 263.82  E-value: 3.73e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:TIGR00500  10 EKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPDKKVLKDGDI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:TIGR00500  90 VNIDVGVIYDGYHGDTAKTFLVGKI-SPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGHG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFIST-QDEIVYQSeeDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:TIGR00500 169 IGRKFHEEPQ-IPNYGKKFTNVRLKEGMVFTIEPMVNTgTEEITTAA--DGWTVKTKDGSLSAQFEHTIVITDNGPEILT 245
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 7-238 9.86e-47

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 154.32  E-value: 9.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASapitMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGAR----GPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSA-VKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGF-TVIRNLAG 164
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKP-SPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLG 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2048238002 165 HGLGRTLHGEPETISNYYSReendILKEGQVIAVETFIstqdeivyqSEEDGWSlftpnnslVSQFEHTVVVTK 238
Cdd:pfam00557 156 HGIGLEVHEGPYISRGGDDR----VLEPGMVFTIEPGI---------YFIPGWG--------GVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 7-245 1.51e-115

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 331.03  E-value: 1.51e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:PRK12896   17 EKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIPGPRVIKDGDL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGtPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:PRK12896   97 VNIDVSAYLDGYHGDTGITFAVG-PVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYSVVRDLTGHG 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPETISNYYSREENDILKEGQVIAVETFISTQDEiVYQSEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PRK12896  176 VGRSLHEEPSVILTYTDPLPNRLLRPGMTLAVEPFLNLGAK-DAETLDDGWTVVTPDKSLSAQFEHTVVVTRDGPEILT 253
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
7-245 4.71e-107

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 309.24  E-value: 4.71e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:COG0024    10 EKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSDRVLKDGDI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:COG0024    90 VNIDVGAILDGYHGDSARTFVVGEV-SPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGHG 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFISTQDEIVYQsEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:COG0024   169 IGREMHEEPQ-VPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKV-LDDGWTVVTKDGSLSAQFEHTVAVTEDGPEILT 245
PRK05716 PRK05716
methionine aminopeptidase; Validated
 5-245 1.35e-101

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 295.50  E-value: 1.35e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   5 DYDALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDG 84
Cdd:PRK05716   10 EIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIPSDKVLKEG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  85 DVVNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAG 164
Cdd:PRK05716   90 DIVNIDVTVIKDGYHGDTSRTFGVGEI-SPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFSVVREYCG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 165 HGLGRTLHGEPEtISNYYSREENDILKEGQVIAVETFISTQDEIVYQsEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVL 244
Cdd:PRK05716  169 HGIGRKFHEEPQ-IPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKT-LKDGWTVVTKDGSLSAQYEHTVAVTEDGPEIL 246


                  .
gi 2048238002 245 T 245
Cdd:PRK05716  247 T 247
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 7-245 4.71e-101

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 293.63  E-value: 4.71e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:cd01086     2 EGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGDI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:cd01086    82 VNIDVGVELDGYHGDSARTFIVGEV-SEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFISTQDEIVYQsEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:cd01086   161 IGRKFHEEPQ-IPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVT-LPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 7-245 3.73e-89

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 263.82  E-value: 3.73e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:TIGR00500  10 EKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPDKKVLKDGDI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:TIGR00500  90 VNIDVGVIYDGYHGDTAKTFLVGKI-SPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGHG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 167 LGRTLHGEPEtISNYYSREENDILKEGQVIAVETFIST-QDEIVYQSeeDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:TIGR00500 169 IGRKFHEEPQ-IPNYGKKFTNVRLKEGMVFTIEPMVNTgTEEITTAA--DGWTVKTKDGSLSAQFEHTIVITDNGPEILT 245
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 9-245 3.67e-49

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 166.17  E-value: 3.67e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   9 LREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDVVN 88
Cdd:PLN03158  146 MRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVN 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  89 VDVSAVKDGYYADTGRTVIAGTPKSAKhERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHGLG 168
Cdd:PLN03158  226 VDVTVYYKGCHGDLNETFFVGNVDEAS-RQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIG 304

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 169 RTLHGEPeTISNYYSREENDILKEGQVIAVETFISTQdeiVYQSE--EDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PLN03158  305 ELFHCAP-NIPHYARNKAVGVMKAGQVFTIEPMINAG---VWRDRmwPDGWTAVTADGKRSAQFEHTLLVTETGVEVLT 379
PRK12318 PRK12318
methionyl aminopeptidase;
7-245 1.12e-47

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 159.60  E-value: 1.12e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYE--FPGYTCISINEVAAHGIPGELVIQDG 84
Cdd:PRK12318   50 EKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGIPNDIPLKNG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  85 DVVNVDVSAVKDGYYADTGRTVIAGTPKSAKhERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAG 164
Cdd:PRK12318  130 DIMNIDVSCIVDGYYGDCSRMVMIGEVSEIK-KKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGFSVVDQFVG 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 165 HGLGRTLHGEPEtISNYysREENDI-LKEGQVIAVETFISTQDEIVYQSEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEV 243
Cdd:PRK12318  209 HGVGIKFHENPY-VPHH--RNSSKIpLAPGMIFTIEPMINVGKKEGVIDPINHWEARTCDNQPSAQWEHTILITETGYEI 285


                  ..
gi 2048238002 244 LT 245
Cdd:PRK12318  286 LT 287
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 7-238 9.86e-47

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 154.32  E-value: 9.86e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASapitMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGAR----GPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSA-VKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGF-TVIRNLAG 164
Cdd:pfam00557  77 VLIDVGAeYDGGYCSDITRTFVVGKP-SPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLgEYFPHGLG 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2048238002 165 HGLGRTLHGEPETISNYYSReendILKEGQVIAVETFIstqdeivyqSEEDGWSlftpnnslVSQFEHTVVVTK 238
Cdd:pfam00557 156 HGIGLEVHEGPYISRGGDDR----VLEPGMVFTIEPGI---------YFIPGWG--------GVRIEDTVLVTE 208
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 6-245 7.72e-46

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 154.72  E-value: 7.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   6 YDALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASApitmyeFPgyTCISINEVAAHGIPG---ELVIQ 82
Cdd:cd01088     1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPA------FP--VNLSINECAAHYTPNagdDTVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  83 DGDVVNVDVSAVKDGYYADTGRTViagtPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNL 162
Cdd:cd01088    73 EGDVVKLDFGAHVDGYIADSAFTV----DFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 163 AGHGLGR-TLHGEPeTISNYYSReENDILKEGQVIAVETFIST---------------------------QDEIVYQSEE 214
Cdd:cd01088   149 TGHSIERyRLHAGK-SIPNVKGG-EGTRLEEGDVYAIEPFATTgkgyvhdgpecsiymlnrdkplrlpraRKLLDVIYEN 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2048238002 215 DGWSLFTP---------------------------------NNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:cd01088   227 FGTLPFARrwldrlgetkllmalknlckagivypypvlkeiSGGYVAQFEHTIIVREDGKEVTT 290
PRK12897 PRK12897
type I methionyl aminopeptidase;
7-245 5.03e-39

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 135.93  E-value: 5.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYTCISINEVAAHGIPGELVIQDGDV 86
Cdd:PRK12897   11 DLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFPADVPLTEGDI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTpKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHG 166
Cdd:PRK12897   91 VTIDMVVNLNGGLSDSAWTYRVGK-VSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVARDFTGHG 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2048238002 167 LGRTLHGEPeTISNYYSREENDILKEGQVIAVETFISTQDEIVyQSEEDGWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PRK12897  170 IGKEIHEEP-AIFHFGKQGQGPELQEGMVITIEPIVNVGMRYS-KVDLNGWTARTMDGKLSAQYEHTIAITKDGPIILT 246
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 7-241 4.63e-37

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 129.50  E-value: 4.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAasapitmyEFPGYTCISINEVAA--HGIPGELVIQDG 84
Cdd:cd01066     2 ARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG--------YPAGPTIVGSGARTAlpHYRPDDRRLQEG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  85 DVVNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFT-VIRNLA 163
Cdd:cd01066    74 DLVLVDLGGVYDGYHADLTRTFVIGEP-SDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGpNFGHRT 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2048238002 164 GHGLGRTLHGEPetisnYYSREENDILKEGQVIAVETFIstqdeivYQSEEDGWslftpnnslvsQFEHTVVVTKDGY 241
Cdd:cd01066   153 GHGIGLEIHEPP-----VLKAGDDTVLEPGMVFAVEPGL-------YLPGGGGV-----------RIEDTVLVTEDGP 207
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
3-249 7.13e-33

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 121.08  E-value: 7.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   3 DYDYDALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAasapitmyEFPGYTCIsineVAA-------HGI 75
Cdd:COG0006    76 PEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGA--------EGPSFDTI----VASgenaaipHYT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  76 PGELVIQDGDVVNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNG 155
Cdd:COG0006   144 PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEP-SDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 156 FTviRNLA---GHGLGRTLHGEPetisnYYSREENDILKEGQVIAVETFIstqdeivYQSEEDGWSLftpnnslvsqfEH 232
Cdd:COG0006   223 YG--EYFPhgtGHGVGLDVHEGP-----QISPGNDRPLEPGMVFTIEPGI-------YIPGIGGVRI-----------ED 277

                         250
                  ....*....|....*..
gi 2048238002 233 TVVVTKDGYEVLTGTFR 249
Cdd:COG0006   278 TVLVTEDGAEVLTRLPR 294
PRK07281 PRK07281
methionyl aminopeptidase;
7-245 4.22e-27

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 105.70  E-value: 4.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPI----TMYEFPGYTCISINEVAAHGIPGELVIQ 82
Cdd:PRK07281   11 EAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENVLPLQIgvdgAMMDYPYATCCGLNDEVAHAFPRHYILK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  83 DGDVVNVD---------------------VSAVKD------GYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVK 135
Cdd:PRK07281   91 EGDLLKVDmvlsepldksivdvsklnfdnVEQMKKytesyrGGLADSCWAYAVGTP-SDEVKNLMDVTKEAMYRGIEQAV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 136 AGVKVNQIGKAIYADARKNGFTVIRNLAGHGLGRTLHGEPeTISNYYSREENDILKEGQVIAVETFISTQDEIVYQSEED 215
Cdd:PRK07281  170 VGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEP-MVPNYGTAGRGLRLREGMVLTIEPMINTGTWEIDTDMKT 248

                         250       260       270
                  ....*....|....*....|....*....|
gi 2048238002 216 GWSLFTPNNSLVSQFEHTVVVTKDGYEVLT 245
Cdd:PRK07281  249 GWAHKTLDGGLSCQYEHQFVITKDGPVILT 278
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 7-199 4.07e-20

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 85.25  E-value: 4.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPitmyeFPgyTCISINEVAA--HGIPGELVIQDG 84
Cdd:cd01092     2 ELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEGPS-----FD--TIVASGPNSAlpHGVPSDRKIEEG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  85 DVVNVDVSAVKDGYYADTGRTVIAGTPkSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAiyadARKngftVIRN--- 161
Cdd:cd01092    75 DLVLIDFGAIYDGYCSDITRTVAVGEP-SDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKA----ARD----VIEEagy 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2048238002 162 ------LAGHGLGRTLHGEPetisnYYSREENDILKEGQVIAVE 199
Cdd:cd01092   146 geyfihRTGHGVGLEVHEAP-----YISPGSDDVLEEGMVFTIE 184
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 10-246 3.62e-13

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 66.59  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  10 REIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAasapiTMYE----------FPgyTCISINEVAAHGIPG-- 77
Cdd:cd01089     5 KTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELG-----KVYKkekklekgiaFP--TCISVNNCVCHFSPLks 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  78 --ELVIQDGDVVNVDVSAVKDGYYADTGRTVIAG----TPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADA 151
Cdd:cd01089    78 daTYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGaeaeTPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 152 RKNGFTVIRNLAGHGLGR---TLHGEPETisnyysreeNDILKEGQVIAVETfistqdeivyqseedgwsLFTPNNSLVS 228
Cdd:cd01089   158 VDYGCTPVEGVLSHQLKRvvsSGEGKAKL---------VECVKHGLLFPYPV------------------LYEKEGEVVA 210

                         250
                  ....*....|....*...
gi 2048238002 229 QFEHTVVVTKDGYEVLTG 246
Cdd:cd01089   211 QFKLTVLLTPNGVTVLTG 228
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 59-206 2.83e-12

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 65.68  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  59 FPgyTCISINEVAAHGIP----GELVIQDGDVVNVDVSAVKDGYYADTGRTVI----AGTPKSAKHERLVEVSLTSLEAG 130
Cdd:TIGR00495  78 FP--TCISVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVvgvaQEEPVTGRKADVIAAAHLAAEAA 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 131 LSKVKAGVKVNQIGKAIYADARKNGFTVIRNLAGHGLGR-TLHGEPETISNYYSREENDI----LKEGQVIAVETFISTQ 205
Cdd:TIGR00495 156 LRLVKPGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQhVIDGEKVIISNPSDSQKKDHdtaeFEENEVYAVDILVSTG 235


                  .
gi 2048238002 206 D 206
Cdd:TIGR00495 236 E 236
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 5-214 1.17e-10

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 60.88  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   5 DYDALR---EIGRIValaRDEMAKAVEPGMT----TKQLDEIGQRILEAEGAASApitmYEFPgyTCISINEVAAHGIPG 77
Cdd:PTZ00053  157 QYQDLRraaEVHRQV---RRYAQSVIKPGVKlidiCERIESKSRELIEADGLKCG----WAFP--TGCSLNHCAAHYTPN 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  78 ---ELVIQDGDVVNVDVSAVKDGYYADTGRTvIAGTPKsakHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAI------Y 148
Cdd:PTZ00053  228 tgdKTVLTYDDVCKLDFGTHVNGRIIDCAFT-VAFNPK---YDPLLQATKDATNTGIKEAGIDVRLSDIGAAIqeviesY 303

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2048238002 149 aDARKNGFTV----IRNLAGHGLGR-TLHGEpETISNYYSrEENDILKEGQVIAVETFISTQDEIVYQSEE 214
Cdd:PTZ00053  304 -EVEIKGKTYpiksIRNLNGHSIGPyIIHGG-KSVPIVKG-GENTRMEEGELFAIETFASTGRGYVNEDLE 371
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 9-246 2.04e-09

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 56.04  E-value: 2.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   9 LREIGRIVALARDEMAKAVEPGMTTKQLdeigQRILEAEGAASAPITMYefpGYTCISiNEVAA--HGIPGELVIQDGDV 86
Cdd:cd01087     4 MRKACDISAEAHRAAMKASRPGMSEYEL----EAEFEYEFRSRGARLAY---SYIVAA-GSNAAilHYVHNDQPLKDGDL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRTVIAGTPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQI---GKAIYADA-------RKNGF 156
Cdd:cd01087    76 VLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhllAHRVLAEGlkelgilKGDVD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 157 TVIRNLA---------GHGLGRTLHgepETISNYYSREENDILKEGQVIAVETFIstqdeivYQSEEDGWslftpnnslV 227
Cdd:cd01087   156 EIVESGAyakffphglGHYLGLDVH---DVGGYLRYLRRARPLEPGMVITIEPGI-------YFIPDLLD---------V 216

                         250       260
                  ....*....|....*....|....*..
gi 2048238002 228 SQF--------EHTVVVTKDGYEVLTG 246
Cdd:cd01087   217 PEYfrgggiriEDDVLVTEDGPENLTR 243
PRK09795 PRK09795
aminopeptidase; Provisional
 7-244 6.81e-08

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 52.25  E-value: 6.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLDEIGQRILEAEGAASAPITMYEFPGYtcisiNEVAAHGIPGELVIQDGDV 86
Cdd:PRK09795  134 EKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGW-----RGALPHGKASDKIVAAGEF 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  87 VNVDVSAVKDGYYADTGRT-VIAGTPKSAKHERLVEVSLTSLEAGLSKVKA---GVKVNQIGKAIYADARKNGFT-VIRN 161
Cdd:PRK09795  209 VTLDFGALYQGYCSDMTRTlLVNGEGVSAESHPLFNVYQIVLQAQLAAISAirpGVRCQQVDDAARRVITEAGYGdYFGH 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002 162 LAGHGLGRTLHGEPEtisnyYSREENDILKEGQVIAVETFIstqdeivYQSEEDGwslftpnnslvSQFEHTVVVTKDGY 241
Cdd:PRK09795  289 NTGHAIGIEVHEDPR-----FSPRDTTTLQPGMLLTVEPGI-------YLPGQGG-----------VRIEDVVLVTPQGA 345


                  ...
gi 2048238002 242 EVL 244
Cdd:PRK09795  346 EVL 348
PRK15173 PRK15173
peptidase; Provisional
 4-200 1.22e-06

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 48.56  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   4 YDYDALREIGRIVALARDEMAKAVEPGMTTKQLDEigqrileAEGAASAPITMYEFPGYTCISIN-EVAAHGIPGELVIQ 82
Cdd:PRK15173   99 WEIKRLRKSAEITEYGITEASKLIRVGCTSAELTA-------AYKAAVMSKSETHFSRFHLISVGaDFSPKLIPSNTKAC 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  83 DGDVVNVDVSAVKDGYYADTGRTVIAGTPKSAKhERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGF-TVIRN 161
Cdd:PRK15173  172 SGDLIKFDCGVDVDGYGADIARTFVVGEPPEIT-RKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNYNRG 250

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2048238002 162 LAGHGLGRTLHGEPetiSNYYSREENDILKEGQVIAVET 200
Cdd:PRK15173  251 HLGHGNGVFLGLEE---SPFVSTHATESFTSGMVLSLET 286
PRK14575 PRK14575
putative peptidase; Provisional
 4-200 2.02e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 48.16  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   4 YDYDALREIGRIVALARDEMAKAVEPGMTTKQLDEigqrileAEGAASAPITMYEFPGYTCISIN-EVAAHGIPGELVIQ 82
Cdd:PRK14575  182 WEIKRLRKSAEITEYGITEASKLIRVGCTSAELTA-------AYKAAVMSKSETHFSRFHLISVGaDFSPKLIPSNTKAC 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  83 DGDVVNVDVSAVKDGYYADTGRTVIAGTPKSAKhERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGF-TVIRN 161
Cdd:PRK14575  255 SGDLIKFDCGVDVDGYGADIARTFVVGEPPEIT-RKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSGLpNYNRG 333

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2048238002 162 LAGHGLGRTLHGEPetiSNYYSREENDILKEGQVIAVET 200
Cdd:PRK14575  334 HLGHGNGVFLGLEE---SPFVSTHATESFTSGMVLSLET 369
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 7-147 7.98e-05

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 43.17  E-value: 7.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   7 DALREIGRIVALARDEMAKAVEPGMTTKQLD-EIgQRILEAEGAasapitmyEFPGYTCI---SINEVAAHGIPGELVIQ 82
Cdd:PRK10879  180 AVLRRAGEISALAHTRAMEKCRPGMFEYQLEgEI-HHEFNRHGA--------RYPSYNTIvgsGENGCILHYTENESEMR 250

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2048238002  83 DGDVVNVDVSAVKDGYYADTGRTVIAGTPKSAKHERLVEVSLTSLEAGLSKVKAGVKVNQIGKAI 147
Cdd:PRK10879  251 DGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEV 315
Creatinase cd01090
Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.
 67-202 2.48e-04

Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea.


Pssm-ID: 238523 [Multi-domain]  Cd Length: 228  Bit Score: 40.98  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  67 INEVAAHGIPGELVIQDGDVVNVDVSAVKDGYYADTGRTVIAGTPKSAkHERLVEVSLTSLEAGLSKVKAGVKVNQIGKA 146
Cdd:cd01090    63 INTDGAHNPVTNRKVQRGDILSLNCFPMIAGYYTALERTLFLDEVSDA-HLKIWEANVAVHERGLELIKPGARCKDIAAE 141

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2048238002 147 IYADARKNGFTVIRNLA-GHGLGrtlhgepeTISNYYSRE-----ENDI---LKEGQVIAVETFI 202
Cdd:cd01090   142 LNEMYREHDLLRYRTFGyGHSFG--------VLSHYYGREaglelREDIdtvLEPGMVVSMEPMI 198
PRK14576 PRK14576
putative endopeptidase; Provisional
 4-200 3.13e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 38.46  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002   4 YDYDALREIGRIVALARDEMAKAVEPGMTTKQLDEigqrileAEGAASAPITMYEFPGYTCISINE-VAAHGIPGELVIQ 82
Cdd:PRK14576  181 WEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTA-------AFKAAVMSFPETNFSRFNLISVGDnFSPKIIADTTPAK 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048238002  83 DGDVVNVDVSAVKDGYYADTGRTVIAGTPKSAKhERLVEVSLTSLEAGLSKVKAGVKVNQIGKAIYADARKNGFT-VIRN 161
Cdd:PRK14576  254 VGDLIKFDCGIDVAGYGADLARTFVLGEPDKLT-QQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSGLPhYNRG 332

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2048238002 162 LAGHGLGRTLHGEPetiSNYYSREENDILKEGQVIAVET 200
Cdd:PRK14576  333 HLGHGDGVFLGLEE---VPFVSTQATETFCPGMVLSLET 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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