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Conserved domains on  [gi|2044897326|ref|WP_213541011|]
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MULTISPECIES: YidC/Oxa1 family membrane protein insertase [Vescimonas]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 10002228)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins, such as mitochondrial inner membrane protein OXA1/OXA1L and bacterial membrane protein insertase YidC

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
7-279 7.54e-56

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 181.47  E-value: 7.54e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   7 YYICVPFAWLTRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYA 86
Cdd:COG0706     7 GFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  87 REGVNPMSGCLWSFIPFPILIALYAIIRtplryfmslstSVIEeigtlagtlgyeasnntydqiylakFIHEhwesfagk 166
Cdd:COG0706    87 EEGVNPLGGCLPMLIQMPIFIALYRVLR-----------NSIE-------------------------LRHA-------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 167 fdglvdlnySFLGMDLASQPSTLlsqfpgggwpvwgILLLPVISAAAQLVMSIITMrtnSTEGAGSAKTMMYLMPLMTLW 246
Cdd:COG0706   123 ---------PFLGIPDLSAPDPY-------------YIFLPILMGVTMFLQQKLNP---APAQDPQQKKMMYIMPLMFLF 177

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2044897326 247 MGYMLPAALCIYWIANTVFSLIQEVTLNKYFNK 279
Cdd:COG0706   178 FFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDK 210
 
Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
7-279 7.54e-56

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 181.47  E-value: 7.54e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   7 YYICVPFAWLTRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYA 86
Cdd:COG0706     7 GFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  87 REGVNPMSGCLWSFIPFPILIALYAIIRtplryfmslstSVIEeigtlagtlgyeasnntydqiylakFIHEhwesfagk 166
Cdd:COG0706    87 EEGVNPLGGCLPMLIQMPIFIALYRVLR-----------NSIE-------------------------LRHA-------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 167 fdglvdlnySFLGMDLASQPSTLlsqfpgggwpvwgILLLPVISAAAQLVMSIITMrtnSTEGAGSAKTMMYLMPLMTLW 246
Cdd:COG0706   123 ---------PFLGIPDLSAPDPY-------------YIFLPILMGVTMFLQQKLNP---APAQDPQQKKMMYIMPLMFLF 177

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2044897326 247 MGYMLPAALCIYWIANTVFSLIQEVTLNKYFNK 279
Cdd:COG0706   178 FFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDK 210
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 28-275 9.87e-53

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 172.56  E-value: 9.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  28 GLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPILI 107
Cdd:cd20070     1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 108 ALYAIIRTPlryfmslstsvIEEIGTlagtlgyeasnntydqiylakfihehwesfagkfdglvdlnySFLGM--DLaSQ 185
Cdd:cd20070    81 ALYQVLRNS-----------IELRGA------------------------------------------PFLWWilDL-SA 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 186 PSTllsqfpgggwpvwgILLLPVISAAAQLVMSIITMrTNSTEGAGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVF 265
Cdd:cd20070   107 PDP--------------YYILPILMGVTMFLQQKLTP-TPTDDQAPQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVSNLF 171

                         250
                  ....*....|
gi 2044897326 266 SLIQEVTLNK 275
Cdd:cd20070   172 SIIQQLIINK 181
60KD_IMP pfam02096
60Kd inner membrane protein;
27-275 1.17e-48

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 162.26  E-value: 1.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  27 YGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPIL 106
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 107 IALYAIIRtplryfmslstsvieeigtlagtlgyeasnntydqiYLAKFIHEHWEsfagkfdglvdlnysFLGMDLASQP 186
Cdd:pfam02096  81 IALYRVLR------------------------------------NSIELRHAPFF---------------LWIADLSAPD 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 187 STLLSQfpgggwpvwgILLLPVISAAAQLVMSIITMRTNSTEGAgSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVFS 266
Cdd:pfam02096 110 PISILH----------YYILPILMGVTMFLQQKLTPAPQDQPPQ-MKMMMLYFMPLMFLFFFLNFPAGLVLYWVVSNLLS 178


                  ....*....
gi 2044897326 267 LIQEVTLNK 275
Cdd:pfam02096 179 IGQQLIINR 187
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 26-269 2.02e-46

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 156.10  E-value: 2.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  26 SYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPI 105
Cdd:TIGR03592   1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 106 LIALYAIIRTplryfmslstsVIEeigtlagtlgyeasnntydqiylakFIHEHWesfagkfdglvdlnysFLGMDLaSQ 185
Cdd:TIGR03592  81 FIALYQVLLR-----------SIE-------------------------LRHAPF----------------LWIIDL-SS 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 186 PSTllsqfpgggwpvwgILLLPVISAAAQLVMSIITMRTNSTEgaGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVF 265
Cdd:TIGR03592 108 PDP--------------YYILPILMGVTMFLQQKLSPKGPPDP--AQQKMMMYFMPLMFLFFFLSFPAGLVLYWVVSNLF 171


                  ....
gi 2044897326 266 SLIQ 269
Cdd:TIGR03592 172 TIIQ 175
PRK01318 PRK01318
membrane protein insertase; Provisional
 5-296 1.79e-40

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 149.25  E-value: 1.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   5 IGYYICVPFAWLTRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADL 84
Cdd:PRK01318  301 WLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMEL 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  85 YAREGVNPMSGCLWSFIPFPILIALYaiirtplRYFMSLstsvIEeigtLAGtlgyeasnntydqiylakfihehwESFA 164
Cdd:PRK01318  381 YKKEKVNPLGGCLPILIQIPIFFALY-------KVLLVS----IE----LRH------------------------APFI 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 165 GKFDglvdlnysflgmDLASQ-PSTllsqfpgggwpVWGILLLPVISAAAQlvmsIITMRTNSTEGAGSAKTMMYLMPLM 243
Cdd:PRK01318  422 GWIH------------DLSAPdPYF-----------ILHIGLLPILMGITM----FLQQKLNPTPTDPMQAKIMKFMPLI 474

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2044897326 244 TLWMGYMLPAALCIYWIANTVFSLIQEVTLNKYFNKildreetEKEKAAREKR 296
Cdd:PRK01318  475 FTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEK-------KKLLAANKKK 520
 
Name Accession Description Interval E-value
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
7-279 7.54e-56

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 181.47  E-value: 7.54e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   7 YYICVPFAWLTRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYA 86
Cdd:COG0706     7 GFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  87 REGVNPMSGCLWSFIPFPILIALYAIIRtplryfmslstSVIEeigtlagtlgyeasnntydqiylakFIHEhwesfagk 166
Cdd:COG0706    87 EEGVNPLGGCLPMLIQMPIFIALYRVLR-----------NSIE-------------------------LRHA-------- 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 167 fdglvdlnySFLGMDLASQPSTLlsqfpgggwpvwgILLLPVISAAAQLVMSIITMrtnSTEGAGSAKTMMYLMPLMTLW 246
Cdd:COG0706   123 ---------PFLGIPDLSAPDPY-------------YIFLPILMGVTMFLQQKLNP---APAQDPQQKKMMYIMPLMFLF 177

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2044897326 247 MGYMLPAALCIYWIANTVFSLIQEVTLNKYFNK 279
Cdd:COG0706   178 FFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDK 210
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 28-275 9.87e-53

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 172.56  E-value: 9.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  28 GLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPILI 107
Cdd:cd20070     1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 108 ALYAIIRTPlryfmslstsvIEEIGTlagtlgyeasnntydqiylakfihehwesfagkfdglvdlnySFLGM--DLaSQ 185
Cdd:cd20070    81 ALYQVLRNS-----------IELRGA------------------------------------------PFLWWilDL-SA 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 186 PSTllsqfpgggwpvwgILLLPVISAAAQLVMSIITMrTNSTEGAGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVF 265
Cdd:cd20070   107 PDP--------------YYILPILMGVTMFLQQKLTP-TPTDDQAPQQKMMMYFMPVMFTFIFLSFPSGLVLYWLVSNLF 171

                         250
                  ....*....|
gi 2044897326 266 SLIQEVTLNK 275
Cdd:cd20070   172 SIIQQLIINK 181
60KD_IMP pfam02096
60Kd inner membrane protein;
27-275 1.17e-48

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 162.26  E-value: 1.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  27 YGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPIL 106
Cdd:pfam02096   1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 107 IALYAIIRtplryfmslstsvieeigtlagtlgyeasnntydqiYLAKFIHEHWEsfagkfdglvdlnysFLGMDLASQP 186
Cdd:pfam02096  81 IALYRVLR------------------------------------NSIELRHAPFF---------------LWIADLSAPD 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 187 STLLSQfpgggwpvwgILLLPVISAAAQLVMSIITMRTNSTEGAgSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVFS 266
Cdd:pfam02096 110 PISILH----------YYILPILMGVTMFLQQKLTPAPQDQPPQ-MKMMMLYFMPLMFLFFFLNFPAGLVLYWVVSNLLS 178


                  ....*....
gi 2044897326 267 LIQEVTLNK 275
Cdd:pfam02096 179 IGQQLIINR 187
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 26-269 2.02e-46

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 156.10  E-value: 2.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  26 SYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPI 105
Cdd:TIGR03592   1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 106 LIALYAIIRTplryfmslstsVIEeigtlagtlgyeasnntydqiylakFIHEHWesfagkfdglvdlnysFLGMDLaSQ 185
Cdd:TIGR03592  81 FIALYQVLLR-----------SIE-------------------------LRHAPF----------------LWIIDL-SS 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 186 PSTllsqfpgggwpvwgILLLPVISAAAQLVMSIITMRTNSTEgaGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVF 265
Cdd:TIGR03592 108 PDP--------------YYILPILMGVTMFLQQKLSPKGPPDP--AQQKMMMYFMPLMFLFFFLSFPAGLVLYWVVSNLF 171


                  ....
gi 2044897326 266 SLIQ 269
Cdd:TIGR03592 172 TIIQ 175
PRK01318 PRK01318
membrane protein insertase; Provisional
 5-296 1.79e-40

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 149.25  E-value: 1.79e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   5 IGYYICVPFAWLTRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADL 84
Cdd:PRK01318  301 WLWFITKPLFWLLDFLHSFVGNWGWAIILLTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMEL 380

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  85 YAREGVNPMSGCLWSFIPFPILIALYaiirtplRYFMSLstsvIEeigtLAGtlgyeasnntydqiylakfihehwESFA 164
Cdd:PRK01318  381 YKKEKVNPLGGCLPILIQIPIFFALY-------KVLLVS----IE----LRH------------------------APFI 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 165 GKFDglvdlnysflgmDLASQ-PSTllsqfpgggwpVWGILLLPVISAAAQlvmsIITMRTNSTEGAGSAKTMMYLMPLM 243
Cdd:PRK01318  422 GWIH------------DLSAPdPYF-----------ILHIGLLPILMGITM----FLQQKLNPTPTDPMQAKIMKFMPLI 474

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2044897326 244 TLWMGYMLPAALCIYWIANTVFSLIQEVTLNKYFNKildreetEKEKAAREKR 296
Cdd:PRK01318  475 FTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEK-------KKLLAANKKK 520
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 26-275 1.46e-39

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 139.88  E-value: 1.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  26 SYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPI 105
Cdd:PRK00145   30 SYGIAIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLGGCLPLLIQWPI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 106 LIALYAIirtplryFMSLStsvieeigtlagtlgyeasnntydqiylakfihehwesfagKFDGLvdlnySFLGM-DLAS 184
Cdd:PRK00145  110 LIALYYV-------FNNLT-----------------------------------------GINGV-----SFLWIkDLAK 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 185 QPSTllsqfpgggwpvwgiLLLPVISAAAQLVMSIITMRTNSTEgAGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTV 264
Cdd:PRK00145  137 PDIT---------------WILPILSGATTYLSGYLMTKADSSQ-AGQMKTMNIGMSIFMGVMSWKFKSALVLYWVIGNL 200

                         250
                  ....*....|.
gi 2044897326 265 FSLIQEVTLNK 275
Cdd:PRK00145  201 IQIIQTYFIKK 211
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
 26-298 2.59e-26

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 106.69  E-value: 2.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  26 SYGLALILFTLVVKLVIL-PFqLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMADLYAREGVNPMSGCLWSFIPFP 104
Cdd:PRK03449   31 AWALSVMFLVFTLRALLYkPF-VRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEMQKLQKEHGFNPILGCLPMLAQIP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 105 ILIALYAIIRTPLRyfmslstsvieeIGTLAGTLGYEASNNTYDQIYLakFIHEHWESFagkfdglvdLNYSFLGMDLA- 183
Cdd:PRK03449  110 VFLGLFHVLRSFNR------------TGTGFGQLGMSVEENRNTPNYV--FSAEDVQSF---------LDARLFGAPLSa 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 184 --SQPSTLLSQFpgGGWPVWGILL----LPVISAAAQLVMSIITMRTNSTEGAGSAKT------MMYLMPLMTLWMGYML 251
Cdd:PRK03449  167 yiTMPRSGLDAF--VDFTRTNIILvgvpLMIIAGVATHFNSRASVARQSAEAAANPQTammnklALWVFPLGVLVGGPFL 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2044897326 252 PAALCIYWIANTVFSLIQEVTLnkyFNKIlDREETEKEKAAREKRYA 298
Cdd:PRK03449  245 PLAILLYWVSNNIWTFGQQHYV---FGKI-DKEEEAKKQAKAERRAA 287
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
 3-270 2.98e-24

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 101.35  E-value: 2.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   3 AQIGYYICVPFAW----LTRLFYSLTG---------SYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTR 69
Cdd:PRK01315    5 ADFGSAIMTPLYWvisgILVLFHTLLGflfgpdsglTWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  70 FANNRERQQQEMADLYAREGVNPMSGCLWSFIPFPILIALYAIIrtplryfmSLSTSVIEEIGTLAGTLgyeasnntydq 149
Cdd:PRK01315   85 YKGDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVL--------DSAASRGDGIGPINPPL----------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 150 iyLAKFIHEHwesfagkfdglvdlnysFLGMDLASQPSTLLSQFPGGGWPVWGILLlpVISAAAQLVMSIITMRTNSTEG 229
Cdd:PRK01315  146 --LESFRHAH-----------------IFGAPLAATFLQALNAGNTAVQVVAAVLI--ILMSASQFITQLQLMTKNMPPE 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2044897326 230 AGSA------KTMMYLMPLMTLWMGYMLPAALCIYWIANTVFSLIQE 270
Cdd:PRK01315  205 AKTGpmaqqqKMLLYLFPLMFLVSGIAFPVGVLFYWLTSNVWTMGQQ 251
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
8-269 5.46e-24

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 99.07  E-value: 5.46e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   8 YICVPFAWLTRLFYSLTG-SYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRF----ANNRERQQQEMA 82
Cdd:PRK02944   39 YFVYPLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYsskdQATQQKLQQEMM 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  83 DLYAREGVNPMSGCLWSFIPFPILIALY-AIIRTplryfmslstsviEEIGtlagtlgyeasnntydqiylakfihehwe 161
Cdd:PRK02944  119 QLFQKNGVNPLAGCLPIFIQMPILIAFYhAIMRT-------------SEIS----------------------------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 162 sfagkfdglvdlNYSFLGMDLASQPStllsqfpgggwpvwgILLLPVISAAAQLVMSIITMRTNSTEGAGSAkTMMYLMP 241
Cdd:PRK02944  157 ------------KHSFLWFDLGQADP---------------YYILPIVAGITTFIQQKLMMAGTAGQNPQMA-MMLWLMP 208

                         250       260
                  ....*....|....*....|....*...
gi 2044897326 242 LMTLWMGYMLPAALCIYWIANTVFSLIQ 269
Cdd:PRK02944  209 IMILIFAINFPAALSLYWVVGNIFMIAQ 236
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
 8-296 7.83e-24

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 102.95  E-value: 7.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   8 YICVPFAWL----TRLFYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANNRERQQQEMAD 83
Cdd:PRK01001  553 FITEPFAALlfiiMKFFKFLTGSWGISIILLTVFLKLLLYPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMA 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  84 LYAREGVNPMSGCLWSFIPFPILIALYAIIRTPLryfmslstsvieeigTLAGtlgyeasnntydqiylAKFIhehwesf 163
Cdd:PRK01001  633 LYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSF---------------LLRG----------------ASFI------- 674

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 164 agkfDGLVDlnysflgmDLASqPSTLLSqfpgggW--PVWGI--------LLLPVISAAAQLVMSiITMRTNSTEGAGSA 233
Cdd:PRK01001  675 ----PGWID--------NLTA-PDVLFS------WetPIWFIgnefhllpILLGVVMFAQQKISS-LKRKGPVTDQQRQQ 734

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2044897326 234 KTMMYLMPLMTLWMGYMLPAALCIYWIANTVFSLIQE-VTlnkyfNKILDREETEKEKAAREKR 296
Cdd:PRK01001  735 EAMGTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQwVT-----NKILDSKHLKNEVVPNKKK 793
PRK01622 PRK01622
membrane protein insertase YidC;
8-279 1.66e-23

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 97.90  E-value: 1.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   8 YICVPFAWLTRLFYSLT-GSYGLALILFTLVVKLVILPF---QLKSKKSM-LRMNRMQGKVKDIQTRF--ANNRERQ--- 77
Cdd:PRK01622   40 YFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLavsQYKSQRGMqEKMAVMKPELDKIQAKLkvTKDLEKQkey 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  78 QQEMADLYAREGVNPMS-GCLWSFIPFPILIALY-AIIRTPlryfmslstsvieEIGTlagtlgyeasnntydqiylakf 155
Cdd:PRK01622  120 QKEMMELYKSGNINPLAmGCLPLLIQMPILSAFYyAIRRTE-------------EIAS---------------------- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 156 ihehwesfagkfdglvdlnYSFLGMDLASQPstllsqfpgggwpvwgiLLLPVISAAAQLVMSIITMRTNSTEGA-GSAK 234
Cdd:PRK01622  165 -------------------HSFLWFNLGHAD-----------------HILPIIAGLTYFIQMKVSQSNGTSPEQvQMLK 208

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2044897326 235 TMMYLMPLMTLWMGYMLPAALCIYWIANTVFSLIQEVTLNKYFNK 279
Cdd:PRK01622  209 IQGIMMPAMILFMSFAAPSALVLYWITGGLFLMGQTIVLRKVMER 253
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
 20-114 6.44e-22

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 95.43  E-value: 6.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  20 FYSLTGSYGLALILFTLVVKLVILPFQLKSKKSMLRMN----RMQGKVKDIQTRFANNRERQQQEMADLYaREGVNPMSG 95
Cdd:PRK02654   20 FYGIVPSYGLAIVALTLVIRFALYPLSAGSIRNMRRMKiaqpVMQKRQAEIQERYKNDPQKQQEEMGKLM-KEFGNPLAG 98

                          90
                  ....*....|....*....
gi 2044897326  96 CLWSFIPFPILIALYAIIR 114
Cdd:PRK02654   99 CLPLLVQMPILFALFATLR 117
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
 12-292 2.25e-20

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 90.84  E-value: 2.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  12 PFAWLT---RLFYSLTGSYG----LALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFAN------NRERQQ 78
Cdd:PRK02201  111 PIAQIIlsiMASQSLSELYGwstiLAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKAKIDAKYKDykkdkqMKQRKQ 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  79 QEMADLYAREGVNPMSGCLWSFIPFPILIALYAIIRTplryfmslstsvIEEIgtlagtlgyeasnntydqiylaKFIhe 158
Cdd:PRK02201  191 QEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQS------------LPSI----------------------KVT-- 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 159 hwesfagkfdglvdlnySFLGMDLASQPstlLSQFPGGGWPVWGILLLPVISAA-AQLVMSIITMRTN--------STEG 229
Cdd:PRK02201  235 -----------------TWLGIDLSATS---WQEIFAGNWIYLPILIIVVPVQAlSQLLPQILNKKKNkertlnvkEKEA 294

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2044897326 230 AGSAKTMMYLMPLMTLWMGYMLPAALCIYWIANTVFSLIQEVTLNKYFNKILDREETEKEKAA 292
Cdd:PRK02201  295 LKKQNKTQNIISIVFIFFGVIFAAGVQIYWIIGGIWTILQTLGIHYFKKRKFYKQKYEPKLRA 357
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
 8-320 5.78e-20

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 89.02  E-value: 5.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326   8 YICVPFAWLTRLFYSLTG-SYGLALILFTLVVKLVILPFQL-KSKKSML---RMNRMQGKVKDIQTRFaNNRERQQQEMA 82
Cdd:PRK02463   40 FLGAPMSYFIDYFANNLGlGFGLAIIIVTIIVRLIILPLGLyQSWKATYqseKMAYLKPVFEPINERL-KNATTQEEKMA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  83 ---DLYA--RE-GVNPMS--GCLWSFIPFPILIALYaiirTPLRYFMSLSTSvieeigtlagtlgyeasnntydqiylak 154
Cdd:PRK02463  119 aqtELMAaqREnGISMLGgiGCLPLLIQMPFFSALY----FAAQYTKGVSTS---------------------------- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 155 fihehwesfagkfdglvdlnySFLGMDLASqPStllsqfpgggwpvwgiLLLPVISAAAQLVMSIITMRTNSTEGAGSAK 234
Cdd:PRK02463  167 ---------------------TFLGIDLGS-PS----------------LVLTAIIGVLYFFQSWLSMMGVPEEQREQMK 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 235 TMMYLMPLMTLWMGYMLPAALCIYWIANTVFSLIQEVTLNKYFNKILDREETEKEKAAREKRYAKYQKQKELMAQQQMNG 314
Cdd:PRK02463  209 AMMYMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLITTYILKPRLRKQIAEEFAKNPPKAYKSPSGRKDVTPSQNQAI 288


                  ....*.
gi 2044897326 315 GGRNDR 320
Cdd:PRK02463  289 ASLPKK 294
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
 28-269 4.51e-18

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 81.06  E-value: 4.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  28 GLALILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANN------RERQQQEMADLYAREGVNPMSGCLWSFI 101
Cdd:cd19751     1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 102 PFPILIALY-AIIRTPlryfmslstsvieeigtlagtlgyeasnntydQIYLAKFIHEHwesfagkfdglvdlnysflgm 180
Cdd:cd19751    81 QLPIFMAFYfAIMRTE--------------------------------EIRYHTFLWFF--------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 181 DLASQPSTLLSQFpgggwpVWGILLLPVISAAAQLVMSIITMrtnstegAGSAKTMMYLMPLMTLWMGYMLPAALCIYWI 260
Cdd:cd19751   108 DLGQPDYLYILPF------VAGITTYFQFKMTMSHQQQMQMM-------QMQMKVMLYVMPVMIIIAGLSFPSALSLYWI 174


                  ....*....
gi 2044897326 261 ANTVFSLIQ 269
Cdd:cd19751   175 ISNLFMIIQ 183
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 32-274 1.30e-16

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 77.18  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  32 ILFTLVVKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRF------ANNRERQQ--QEMADLYAREGVNPMSGCLWSFIPF 103
Cdd:cd20069     9 AATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEKLkearasGDQLEAAEarKELKELMKKHNVNPLKSLLLPLVQA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 104 PILIALYAIIRT-PLRYFMSLSTsvieeigtlAGTLgyeasnntydqiylakfihehWesfagkfdglvdlnysFlgMDL 182
Cdd:cd20069    89 PVFISFFFALRKmANLPVPSFKT---------GGLL---------------------W----------------F--TDL 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 183 ASQPSTLLsqfpgggwpvwgillLPVISAAAQL-VMSI-ITMRTNSTEGAGSAKTMMYLMPLMTLWMGYMLPAALCIYWI 260
Cdd:cd20069   121 TVPDPYYI---------------LPILTSLTFLaTIELgAETGTSGSPQSKTMKNVFRGLPVLMIPFTANFPSAVFLYWI 185

                         250
                  ....*....|....
gi 2044897326 261 ANTVFSLIQEVTLN 274
Cdd:cd20069   186 TSNLFSLAQNLLLR 199
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 33-305 5.38e-14

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 72.58  E-value: 5.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326  33 LFTLV--VKLVILPFQLKSKKSMLRMNRMQGKVKDIQTRFANN------RERQQQEmADLYAREGVNPMSGCLWSFIPFP 104
Cdd:PRK00247   36 LFGLVitVRAIIAPFTWQQYKSGRTAAHIRPKRKALREEYKGKtdeasiRELQQKQ-KDLNKEYGYNPLAGCVPALIQIP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 105 ILIALYAIIRTPLRYFMSLSTSVIEEIGTLagtlgyeasnnTYDQIylakfihehwESF-AGKFDGLVDLNYsflgmdlA 183
Cdd:PRK00247  115 VFLGLYQVLLRMARPEGGLENPVHQPIGFL-----------TSEEV----------ESFlQGRVFNVPLPAY-------V 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897326 184 SQPSTLLsQFPGGGWPVWGILLLPVISAAAQLV---MSIITMRTNSTEGAGSAKT---------MMYLMPLMTLWMGYM- 250
Cdd:PRK00247  167 SMPAEQL-AYLGTTQATVLAFVLPLFIAAAVFTainMAMSTYRSFQTNDHDSGFAvgmlkflivMAILAPIFPLSLGLTg 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2044897326 251 -LPAALCIYWIANTVFSLIQEVTLNKYFNK--ILDREETEKEKAAREKRYAKYQKQKE 305
Cdd:PRK00247  246 pFPTAIALYWVANNLWTLIQNIIMYLILERkyPLTDEFKEHHAEQRAQYREKQKEKKA 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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