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Conserved domains on  [gi|2038301653|ref|XP_041431468|]
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microtubule-associated protein tau isoform X1 [Xenopus laevis]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 527-556 1.78e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 1.78e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 527 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 556
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 558-587 1.78e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 1.78e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 558 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 587
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 589-618 4.04e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 4.04e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 589 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 618
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 504-525 9.71e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 9.71e-08
                          10        20
                  ....*....|....*....|..
gi 2038301653 504 DLKNVRSKIGSTDNIRHQPGGG 525
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 184-523 7.29e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 7.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  184 EGCEMRQDDEDEEELSPVEQPQTNGTGTDPIFLEDNKHEQKEIEEPYVDIPASSfsVGQTRPRASVSVYQVEIDANIPIN 263
Cdd:PHA03307    59 AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPPASPPPSPAPDLSE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  264 GKEAESEDVGIADTTEEKLKSPRKRVPAHGSGIPVSRVPVPKAhEQEKHETDSQEKGAQISTKHPPAKHPSRLHTVPHKS 343
Cdd:PHA03307   137 MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP-EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISA 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  344 PSSSTLKSPSSPAASSVRSSQRTSLGTVGQ----------------LGITTRLHRAKEDGGPESATAkLTASRNTPTASR 407
Cdd:PHA03307   216 SASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpaPITLPTRIWEASGWNGPSSRP-GPASSSSSPRER 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  408 IPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRAESKSGERSGYSSPGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPA 487
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2038301653  488 SAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 523
Cdd:PHA03307   371 PSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 34-228 4.60e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653   34 ESSQESVIRLPSAAHGDDAASVQEELANGeavrSQVRAQIPEGTTEAAvGHSPSQQDHAAGNAEEIALLATAGQEREPDT 113
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGE----TEAEGTEDEGEIETG-EEGEEVEDEGEGEAEGKHEVETEGDRKETEH 766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  114 MAAAVKVTAHAEDYGITE-EADGESQADKAAISSGVVESALEEDYYKESNGKDVNLEICEEDTEGWEEQ---VDEGCEMR 189
Cdd:TIGR00927  767 EGETEAEGKEDEDEGEIQaGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQelnAENQGEAK 846

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2038301653  190 QDDEDEEelspveqpqtNGTGTDPIFLEDNKHEQKEIEE 228
Cdd:TIGR00927  847 QDEKGVD----------GGGGSDGGDSEEEEEEEEEEEE 875
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 527-556 1.78e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 1.78e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 527 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 556
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 558-587 1.78e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 1.78e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 558 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 587
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 589-618 4.04e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 4.04e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 589 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 618
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 504-525 9.71e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 9.71e-08
                          10        20
                  ....*....|....*....|..
gi 2038301653 504 DLKNVRSKIGSTDNIRHQPGGG 525
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 184-523 7.29e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 7.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  184 EGCEMRQDDEDEEELSPVEQPQTNGTGTDPIFLEDNKHEQKEIEEPYVDIPASSfsVGQTRPRASVSVYQVEIDANIPIN 263
Cdd:PHA03307    59 AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPPASPPPSPAPDLSE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  264 GKEAESEDVGIADTTEEKLKSPRKRVPAHGSGIPVSRVPVPKAhEQEKHETDSQEKGAQISTKHPPAKHPSRLHTVPHKS 343
Cdd:PHA03307   137 MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP-EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISA 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  344 PSSSTLKSPSSPAASSVRSSQRTSLGTVGQ----------------LGITTRLHRAKEDGGPESATAkLTASRNTPTASR 407
Cdd:PHA03307   216 SASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpaPITLPTRIWEASGWNGPSSRP-GPASSSSSPRER 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  408 IPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRAESKSGERSGYSSPGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPA 487
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2038301653  488 SAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 523
Cdd:PHA03307   371 PSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 34-228 4.60e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653   34 ESSQESVIRLPSAAHGDDAASVQEELANGeavrSQVRAQIPEGTTEAAvGHSPSQQDHAAGNAEEIALLATAGQEREPDT 113
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGE----TEAEGTEDEGEIETG-EEGEEVEDEGEGEAEGKHEVETEGDRKETEH 766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  114 MAAAVKVTAHAEDYGITE-EADGESQADKAAISSGVVESALEEDYYKESNGKDVNLEICEEDTEGWEEQ---VDEGCEMR 189
Cdd:TIGR00927  767 EGETEAEGKEDEDEGEIQaGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQelnAENQGEAK 846

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2038301653  190 QDDEDEEelspveqpqtNGTGTDPIFLEDNKHEQKEIEE 228
Cdd:TIGR00927  847 QDEKGVD----------GGGGSDGGDSEEEEEEEEEEEE 875
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 527-556 1.78e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 1.78e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 527 VQIVHKKVDLGNVQSKCGSKDNLKHVPGGG 556
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 558-587 1.78e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.18  E-value: 1.78e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 558 IQITHKPIDLTRVTSKCGSFVNIHHKPGGG 587
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 589-618 4.04e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.03  E-value: 4.04e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2038301653 589 VELKSEKLEFDKIQSKIGSLDNVTHVPGGG 618
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 504-525 9.71e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 48.18  E-value: 9.71e-08
                          10        20
                  ....*....|....*....|..
gi 2038301653 504 DLKNVRSKIGSTDNIRHQPGGG 525
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 184-523 7.29e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 7.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  184 EGCEMRQDDEDEEELSPVEQPQTNGTGTDPIFLEDNKHEQKEIEEPYVDIPASSfsVGQTRPRASVSVYQVEIDANIPIN 263
Cdd:PHA03307    59 AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPPASPPPSPAPDLSE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  264 GKEAESEDVGIADTTEEKLKSPRKRVPAHGSGIPVSRVPVPKAhEQEKHETDSQEKGAQISTKHPPAKHPSRLHTVPHKS 343
Cdd:PHA03307   137 MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP-EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISA 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  344 PSSSTLKSPSSPAASSVRSSQRTSLGTVGQ----------------LGITTRLHRAKEDGGPESATAkLTASRNTPTASR 407
Cdd:PHA03307   216 SASSPAPAPGRSAADDAGASSSDSSSSESSgcgwgpenecplprpaPITLPTRIWEASGWNGPSSRP-GPASSSSSPRER 294

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  408 IPAKTSSIPKTPPSTVRRdqrkPPSSMGKPDRAESKSGERSGYSSPGSPGTPTGRSSSQTPTNREPKKIAVIRTPPKSPA 487
Cdd:PHA03307   295 SPSPSPSSPGSGPAPSSP----RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2038301653  488 SAKSRLQPVTSPAAmPDLKNVRSKIGSTDNIRHQPG 523
Cdd:PHA03307   371 PSRAPSSPAASAGR-PTRRRARAAVAGRARRRDATG 405
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 34-228 4.60e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.83  E-value: 4.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653   34 ESSQESVIRLPSAAHGDDAASVQEELANGeavrSQVRAQIPEGTTEAAvGHSPSQQDHAAGNAEEIALLATAGQEREPDT 113
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGE----TEAEGTEDEGEIETG-EEGEEVEDEGEGEAEGKHEVETEGDRKETEH 766

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  114 MAAAVKVTAHAEDYGITE-EADGESQADKAAISSGVVESALEEDYYKESNGKDVNLEICEEDTEGWEEQ---VDEGCEMR 189
Cdd:TIGR00927  767 EGETEAEGKEDEDEGEIQaGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQelnAENQGEAK 846

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2038301653  190 QDDEDEEelspveqpqtNGTGTDPIFLEDNKHEQKEIEE 228
Cdd:TIGR00927  847 QDEKGVD----------GGGGSDGGDSEEEEEEEEEEEE 875
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
388-504 1.16e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653 388 GPESATAKLTASRNTPTASRIPAKTSSIPKTPPSTVRRDQRKPPSSMGKPDRAESKSGERSGYSSPGSPGTPTgrSSSQT 467
Cdd:PRK12323  380 APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP--APAAA 457

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2038301653 468 PTNREPKKIAVIRTPPKSPASAKSRLQPVTSPAAMPD 504
Cdd:PRK12323  458 PAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADD 494
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 383-495 2.98e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653 383 AKEDGGPESATAKLTASRNTPT----ASRIP--AKTSSIPKTPPSTVRRDQRKPPSSMGKPDRAESKSGERSGYSS--PG 454
Cdd:PTZ00449  543 PKEGGKPGETKEGEVGKKPGPAkehkPSKIPtlSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLdiPK 622

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2038301653 455 SPGTPTGRSSSQTP-------TNREPKKIAVIRTPpKSPASAKSRLQP 495
Cdd:PTZ00449  623 SPKRPESPKSPKRPpppqrpsSPERPEGPKIIKSP-KPPKSPKPPFDP 669
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-525 6.94e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  283 KSPRKRVPAHGSGIPvSRVPVPKAHEQEKHETDsqekgaqistkhPPAKHPSRLHT---VPHKSPSSSTLKSPSSPAASS 359
Cdd:PHA03247  2594 QSARPRAPVDDRGDP-RGPAPPSPLPPDTHAPD------------PPPPSPSPAANepdPHPPPTVPPPERPRDDPAPGR 2660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  360 VRSSQRT-SLGTVGQLGITTRLHR---AKEDGGPESATAKLTASRNTPtASRIPAKTSSIPKTPPSTVRRDQRKPPSSMG 435
Cdd:PHA03247  2661 VSRPRRArRLGRAAQASSPPQRPRrraARPTVGSLTSLADPPPPPPTP-EPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038301653  436 KPDRAESKSGERSGYSSPGSPGTPTGRSSSQTPtnREPKKIAVIRTPPKSPASAKSRLQPVTSPAAMPDLKNVRSKIGST 515
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPP--AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817

                          250
                   ....*....|
gi 2038301653  516 DNIRHQPGGG 525
Cdd:PHA03247  2818 LPPAASPAGP 2827
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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