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Conserved domains on  [gi|2038197656|ref|XP_018116765|]
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voltage-dependent calcium channel gamma-2 subunit [Xenopus laevis]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
6-197 1.13e-47

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 157.53  E-value: 1.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656   6 RGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCksksisenetskkneeVMTHSGLWRTCCLEGN-FKGMCKQidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQSCtGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656  85 EDTDYEADTAEYFLRAVrassIFPILSVILLFMGGLCIAASEFYKSrhniilsAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFKL-------AGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2038197656 165 SKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLA 197
Cdd:pfam00822 130 GNPFTPNRKYSFGYSFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
6-197 1.13e-47

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 157.53  E-value: 1.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656   6 RGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCksksisenetskkneeVMTHSGLWRTCCLEGN-FKGMCKQidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQSCtGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656  85 EDTDYEADTAEYFLRAVrassIFPILSVILLFMGGLCIAASEFYKSrhniilsAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFKL-------AGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2038197656 165 SKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLA 197
Cdd:pfam00822 130 GNPFTPNRKYSFGYSFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
6-197 1.13e-47

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 157.53  E-value: 1.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656   6 RGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCksksisenetskkneeVMTHSGLWRTCCLEGN-FKGMCKQidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQSCtGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656  85 EDTDYEADTAEYFLRAVrassIFPILSVILLFMGGLCIAASEFYKSrhniilsAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFKL-------AGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2038197656 165 SKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLA 197
Cdd:pfam00822 130 GNPFTPNRKYSFGYSFILGWVAFALAFIGGVLY 162
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 20-180 1.81e-13

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 67.83  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656  20 AFSLMTIAVGTDYWLYSRGvcksksisENETSKKNEEVMTHSGLWRTC-----------CLEgNFKGMCKQIDHFPEDTD 88
Cdd:pfam13903   3 AFALLLIAFATDYWLVLDV--------ALTGINNYTCLFAHLGLWRHCfksevdvdsdnQTR-FFGCLNQVPNPFPTFEE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038197656  89 YEADTAEYFLRAVRASSI-FPILSVILLFMGGLCIAASeFYKSRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKS 167
Cdd:pfam13903  74 EIVSFSVTSLPGLTRFVQaFAILSLVLIVCGVVCGLLA-LPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVKLVFEEY 152

                         170       180
                  ....*....|....*....|
gi 2038197656 168 DSKKNS-------YSYGWSF 180
Cdd:pfam13903 153 FRQWMPehqnnvrISFGWSF 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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