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Conserved domains on  [gi|2034024393|dbj|GIR69835|]
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MAG: hypothetical protein CM15mP74_10860 [Halieaceae bacterium]

Protein Classification

sulfurtransferase TusA family protein( domain architecture ID 2263)

sulfurtransferase TusA family protein similar to sulfurtransferase TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

CATH:  3.30.110.40
Gene Ontology:  GO:0097163
SCOP:  4003658

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SirA_YedF_YeeD super family cl00436
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 14-66 1.75e-17

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


The actual alignment was detected with superfamily member cd03423:

Pssm-ID: 444904  Cd Length: 69  Bit Score: 69.31  E-value: 1.75e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALL 66
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELL 54
 
Name Accession Description Interval E-value
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 14-66 1.75e-17

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 69.31  E-value: 1.75e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALL 66
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELL 54
PRK00299 PRK00299
sulfurtransferase TusA;
8-66 1.61e-15

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 64.66  E-value: 1.61e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2034024393  8 TEPQESIDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALL 66
Cdd:PRK00299   6 SSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELL 64
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 14-66 4.83e-10

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 50.19  E-value: 4.83e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGP--RAHASrhRSSTERDVPNFCEFLGHALL 66
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEvlEVLAD--DPGAVEDIPAWCRETGHELL 53
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 14-68 5.39e-07

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 42.17  E-value: 5.39e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALLIV 68
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEV 56
 
Name Accession Description Interval E-value
SirA cd03423
SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators ...
 14-66 1.75e-17

SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is thought to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239515  Cd Length: 69  Bit Score: 69.31  E-value: 1.75e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALL 66
Cdd:cd03423    2 LDTRGLRCPEPVMMLHKKVRKMKPGDTLLVLATDPSTTRDIPKFCTFLGHELL 54
PRK00299 PRK00299
sulfurtransferase TusA;
8-66 1.61e-15

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 64.66  E-value: 1.61e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 2034024393  8 TEPQESIDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALL 66
Cdd:PRK00299   6 SSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPSFCRFMDHELL 64
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 14-66 4.83e-10

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 50.19  E-value: 4.83e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGP--RAHASrhRSSTERDVPNFCEFLGHALL 66
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEvlEVLAD--DPGAVEDIPAWCRETGHELL 53
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 14-68 1.48e-08

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 46.39  E-value: 1.48e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALLIV 68
Cdd:cd00291    2 LDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEV 56
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 14-68 5.39e-07

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 42.17  E-value: 5.39e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 2034024393 14 IDAIGLKCPEPVMLLHAAMRMARAGPRAHASRHRSSTERDVPNFCEFLGHALLIV 68
Cdd:pfam01206  2 LDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVLEV 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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