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Conserved domains on  [gi|2033921780|dbj|GIS83744|]
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MAG: hypothetical protein CM1200mP16_00440 [Nitrospina sp.]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1-299 1.20e-74

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 232.81  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAEVAreTNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKr 80
Cdd:cd14953    30 VDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAA--AQFNTPSGVAVDAAGNLYVADTGNHRIRKITPD- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKKMFAGDGGpATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDdKPAEEA 160
Cdd:cd14953   107 GVVSTLAGTGTAGFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNHRIRKITPDGVVTTVAGTGGAGYAGD-GPATAA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 161 SIYGATSLKLNNKGEMFLISPSGFVslIRMIDEKGVMRKVLDTVTPKYLDSiekskykgkvQTGELATITHFSDFAFDKK 240
Cdd:cd14953   185 QFNNPTGVAVDAAGNLYVADRGNHR--IRKITPDGVVTTVAGTGTAGFSGD----------GGATAAQLNNPTGVAVDAA 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 241 GNLFISDRLNHQIRKVDPKGVITTIAGTGeSGYYGDGGPAKEAAFRDPSALATDKEGNL 299
Cdd:cd14953   253 GNLYVADSGNHRIRKITPAGVVTTVAGGG-AGFSGDGGPATSAQFNNPTGVAVDAAGNL 310
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1-299 1.20e-74

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 232.81  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAEVAreTNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKr 80
Cdd:cd14953    30 VDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAA--AQFNTPSGVAVDAAGNLYVADTGNHRIRKITPD- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKKMFAGDGGpATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDdKPAEEA 160
Cdd:cd14953   107 GVVSTLAGTGTAGFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNHRIRKITPDGVVTTVAGTGGAGYAGD-GPATAA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 161 SIYGATSLKLNNKGEMFLISPSGFVslIRMIDEKGVMRKVLDTVTPKYLDSiekskykgkvQTGELATITHFSDFAFDKK 240
Cdd:cd14953   185 QFNNPTGVAVDAAGNLYVADRGNHR--IRKITPDGVVTTVAGTGTAGFSGD----------GGATAAQLNNPTGVAVDAA 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 241 GNLFISDRLNHQIRKVDPKGVITTIAGTGeSGYYGDGGPAKEAAFRDPSALATDKEGNL 299
Cdd:cd14953   253 GNLYVADSGNHRIRKITPAGVVTTVAGGG-AGFSGDGGPATSAQFNNPTGVAVDAAGNL 310
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
52-299 6.44e-20

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 87.77  E-value: 6.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIAGNGkkmfagdggpatgatLSFPHGIAVDKNDNVLVSDKGNYRIR 131
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG---------------GSGPHGIAVDPDGNLWFTDNGNNRIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 132 KISP-DGTIQTIAGngirgnigddkPAEEASIYGATslklnnkgemflISPSGFVsLIRMIDEKGVMRkvLDTVTpkyld 210
Cdd:COG4257    84 RIDPkTGEITTFAL-----------PGGGSNPHGIA------------FDPDGNL-WFTDQGGNRIGR--LDPAT----- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 211 siekskykGKVQTGELATITHF-SDFAFDKKGNLFISDRLNHQIRKVDPK-GVITTIAGtgesgyygdggpakEAAFRDP 288
Cdd:COG4257   133 --------GEVTEFPLPTGGAGpYGIAVDPDGNLWVTDFGANAIGRIDPDtGTLTEYAL--------------PTPGAGP 190

                         250
                  ....*....|.
gi 2033921780 289 SALATDKEGNL 299
Cdd:COG4257   191 RGLAVDPDGNL 201
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 5-300 2.77e-19

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 89.14  E-value: 2.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780    5 GTLYIADRNNNRIRSVDSQG-MITTIAGTGQQDY-NGDAEVAretNLYLPFGVALKPDGSLL-VIDRSHYRIRSVDLKRG 81
Cdd:PLN02919   580 NRLFISDSNHNRIVVTDLDGnFIVQIGSTGEEGLrDGSFEDA---TFNRPQGLAYNAKKNLLyVADTENHALREIDFVNE 656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   82 SIKTIAGNGKKMFAGDGGPA-TGATLSFPHGIAVD-KNDNVLVSDKGNYRIRKIS-PDGTIQTIAGNGIRGNIGDDKP-- 156
Cdd:PLN02919   657 TVRTLAGNGTKGSDYQGGKKgTSQVLNSPWDVCFEpVNEKVYIAMAGQHQIWEYNiSDGVTRVFSGDGYERNLNGSSGts 736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  157 ---AEEASIYGATSLKlnnkgEMFLI-SPSgfvSLIRMIDEKGVMRKVLDTVTPKYLDSIekSKYKGKVQTGELATITHF 232
Cdd:PLN02919   737 tsfAQPSGISLSPDLK-----ELYIAdSES---SSIRALDLKTGGSRLLAGGDPTFSDNL--FKFGDHDGVGSEVLLQHP 806

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780  233 SDFAFDKKGNLFISDRLNHQIRKVDP-KGVITTIAGTGESGYygDGGPAKEAAFRDPSALATDKEGNLI 300
Cdd:PLN02919   807 LGVLCAKDGQIYVADSYNHKIKKLDPaTKRVTTLAGTGKAGF--KDGKALKAQLSEPAGLALGENGRLF 873
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 5-144 6.06e-06

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 47.27  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   5 GTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAEVARETNLYL----------PFGVALKPDGSLLV-------ID 67
Cdd:NF033206  148 GTLYVADAGANALLRVDADGKVSTVAVLPPRPVTIPAGPPPGLPLPDcpvgypaqavPTGVAVGPDGALYVseltgfpFP 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  68 RSHYRIRSVDLkRGSIKTIAgngkkmfagDGgpATGATlsfphGIAVDKNDNVLV---SDKGNY------RIRKISPDGT 138
Cdd:NF033206  228 PGRARVYRVDP-GGAPTVYA---------TG--FTGLT-----DLAFDPDGNLYVlelAGGGLLkgdptgSLIRIAPDGT 290


                  ....*.
gi 2033921780 139 IQTIAG 144
Cdd:NF033206  291 RTTLLD 296
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 2-139 9.20e-06

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 46.10  E-value: 9.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGMITtiagtgqqdYNGDAEVAR-ETNLYLPFGVALKPDGSLL-VIDRSHYRIRSVDLk 79
Cdd:pfam08450  94 DPDGRFWFGTMGDDEAPGGDPGALYR---------LDPDGKLTRvLDGLTISNGLAWSPDGRTLyFADSPARKIWAYDY- 163

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  80 rgSIKTIAGNGKKMFAgDGGPATGAtlsfPHGIAVDKNDNVLVSDKGNYRIRKISPDGTI 139
Cdd:pfam08450 164 --DLDGGLISNRRVFA-DFKPGLGR----PDGMAVDAEGNVWVARWGGGKVVRFDPDGKL 216
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 52-146 7.61e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 37.64  E-value: 7.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLV----IDRSHYRIRSVDLKRGSIKTIAGNGKK--MFAGDGGPATGATLSFPHGIAVDKNDN--VLVS 123
Cdd:NF033206   10 PRGLAFGPDGRLYVaeagTGGCPSPSPLCYGNTGAVSRITPDGKKtrVVTGLPSLALGEGAAGPADVAFDGDGTyyVLTG 89

                          90       100
                  ....*....|....*....|....
gi 2033921780 124 DKGNYRIRKISPD-GTIQTIAGNG 146
Cdd:NF033206   90 LGGDPATRDGGPLlGTLLKVDLGT 113
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1-299 1.20e-74

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 232.81  E-value: 1.20e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAEVAreTNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKr 80
Cdd:cd14953    30 VDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAA--AQFNTPSGVAVDAAGNLYVADTGNHRIRKITPD- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKKMFAGDGGpATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDdKPAEEA 160
Cdd:cd14953   107 GVVSTLAGTGTAGFSDDGG-ATAAQFNYPTGVAVDAAGNLYVADTGNHRIRKITPDGVVTTVAGTGGAGYAGD-GPATAA 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 161 SIYGATSLKLNNKGEMFLISPSGFVslIRMIDEKGVMRKVLDTVTPKYLDSiekskykgkvQTGELATITHFSDFAFDKK 240
Cdd:cd14953   185 QFNNPTGVAVDAAGNLYVADRGNHR--IRKITPDGVVTTVAGTGTAGFSGD----------GGATAAQLNNPTGVAVDAA 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 241 GNLFISDRLNHQIRKVDPKGVITTIAGTGeSGYYGDGGPAKEAAFRDPSALATDKEGNL 299
Cdd:cd14953   253 GNLYVADSGNHRIRKITPAGVVTTVAGGG-AGFSGDGGPATSAQFNNPTGVAVDAAGNL 310
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 83-299 2.53e-48

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 165.01  E-value: 2.53e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  83 IKTIAGNGKKMFAGDGGpaTGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDDKPAeeASI 162
Cdd:cd14953     1 VSTVAGSGTAGFSGGGG--TAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAA--AQF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 163 YGATSLKLNNKGEMFlISPSGfVSLIRMIDEKGVMRKVLDTVTPKYLDSIekskykgkvqTGELATITHFSDFAFDKKGN 242
Cdd:cd14953    77 NTPSGVAVDAAGNLY-VADTG-NHRIRKITPDGVVSTLAGTGTAGFSDDG----------GATAAQFNYPTGVAVDAAGN 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2033921780 243 LFISDRLNHQIRKVDPKGVITTIAGTGESGYYGDgGPAKEAAFRDPSALATDKEGNL 299
Cdd:cd14953   145 LYVADTGNHRIRKITPDGVVTTVAGTGGAGYAGD-GPATAAQFNNPTGVAVDAAGNL 200
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1-133 9.55e-42

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 147.68  E-value: 9.55e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAeVARETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKr 80
Cdd:cd14953   194 VDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFSGDG-GATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKITPA- 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2033921780  81 GSIKTIAGnGKKMFAGDGGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKI 133
Cdd:cd14953   272 GVVTTVAG-GGAGFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2-300 7.65e-34

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 125.51  E-value: 7.65e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGMITTIAGTgqqdyNGDAevarETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKRG 81
Cdd:cd05819    16 DSSGNIYVADTGNNRIQVFDPDGNFITSFGS-----FGSG----DGQFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  82 SIKTIAGNGKkmfaGDGGpatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNigddkpaeeAS 161
Cdd:cd05819    87 FLASFGGSGD----GDGE------FNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSGP---------GQ 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 162 IYGATSLKLNNKGEMFlispsgfvslirmidekgvmrkVLDTvtpkYLDSIEKSKYKGKVQTGELATITHFSDF------ 235
Cdd:cd05819   148 FNGPTGVAVDSDGNIY----------------------VADT----GNHRIQVFDPDGNFLTTFGSTGTGPGQFnyptgi 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780 236 AFDKKGNLFISDRLNHQIRKVDPKGVITTIAGTGESgyygdggpaKEAAFRDPSALATDKEGNLI 300
Cdd:cd05819   202 AVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLG---------SDGQFNRPSGLAVDSDGNLY 257
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1-256 1.06e-29

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 114.34  E-value: 1.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGM-ITTIAGTGQQDyngdaevareTNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLK 79
Cdd:cd05819    62 VDSDGNLYVADTGNHRIQKFDPDGNfLASFGGSGDGD----------GEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  80 RGSIKTIAGNGkkmfAGDGGpatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDDKPaee 159
Cdd:cd05819   132 GEFLTTFGSGG----SGPGQ------FNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNYP--- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 160 asiygaTSLKLNNKGEMFlISPSGFvSLIRMIDEKGVMRKVL--DTVTPKYLDSIekskykgkvqtgelatithfSDFAF 237
Cdd:cd05819   199 ------TGIAVDSDGNIY-VADSGN-NRVQVFDPDGAGFGGNgnFLGSDGQFNRP--------------------SGLAV 250

                         250
                  ....*....|....*....
gi 2033921780 238 DKKGNLFISDRLNHQIRKV 256
Cdd:cd05819   251 DSDGNLYVADTGNNRIQVF 269
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 38-300 2.65e-27

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 109.20  E-value: 2.65e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  38 NGDAEVARETNlylPFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIAGNGKK-MFAGDGGPATGATLSFPHGIAV-D 115
Cdd:cd14951    10 DGSFAEASFNE---PQGLALLPGNILYVADTENHALRKIDLETGTVTTLAGTGEQgRDGEGGGPGREQPLSSPWDVAWgP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 116 KNDNVLVSDKGNYRIRKISPD-GTIQTIAGNGIRGNIgDDKPAEEASiYGATS-LKLNNKGEMFlISPSGfVSLIRMID- 192
Cdd:cd14951    87 EDDILYIAMAGTHQIWAYDLDtGTCRVFAGSGNEGNR-NGPYPHEAW-FAQPSgLSLAGWGELF-VADSE-SSAIRAVSl 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 193 -EKGVMRKVLDTVTPKYL------DSIeksKYKGKVQtgelatitHFSDFAFDKKGNLFISDRLNHQIRKVDPK-GVITT 264
Cdd:cd14951   163 kDGGVKTLVGGTRVGTGLfdfgdrDGP---GAEALLQ--------HPLGVAALPDGSVYVADTYNHKIKRVDPAtGEVST 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2033921780 265 IAGTGESGYYGDggpakEAAFRDPSALATDKEGNLI 300
Cdd:cd14951   232 LAGTGKAGYKDL-----EAQFSEPSGLVVDGDGRLY 262
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 49-300 4.45e-26

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 104.71  E-value: 4.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  49 LYLPFGVALKPDGSLLVIDRSHYRIRSVDLkrgsiktiAGNGKKMFAGDGGpaTGATLSFPHGIAVDKNDNVLVSDKGNY 128
Cdd:cd05819     7 LNNPQGIAVDSSGNIYVADTGNNRIQVFDP--------DGNFITSFGSFGS--GDGQFNEPAGVAVDSDGNLYVADTGNH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 129 RIRKISPDGTIqtIAGNGIRGnigdDKPAEEASIYGATslklnnkgemflISPSGFV-------SLIRMIDEKGVMRKVL 201
Cdd:cd05819    77 RIQKFDPDGNF--LASFGGSG----DGDGEFNGPRGIA------------VDSSGNIyvadtgnHRIQKFDPDGEFLTTF 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 202 DTvtpkyldsiekskykgkvQTGELATITHFSDFAFDKKGNLFISDRLNHQIRKVDPKGviTTIAGTGESGYYGdggpak 281
Cdd:cd05819   139 GS------------------GGSGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDG--NFLTTFGSTGTGP------ 192

                         250
                  ....*....|....*....
gi 2033921780 282 eAAFRDPSALATDKEGNLI 300
Cdd:cd05819   193 -GQFNYPTGIAVDSDGNIY 210
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-299 4.62e-22

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 93.89  E-value: 4.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGqqDYNGDAEvaretnlyLPFGVALKPDGSLLVIDRSHYRIRSVDLkr 80
Cdd:cd14956    21 DADDNVYVADARNGRIQVFDKDGtFLRRFGTTG--DGPGQFG--------RPRGLAVDKDGWLYVADYWGDRIQVFTL-- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 gsiktiAGNGKKMFaGDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNgirgnigddKPAEEA 160
Cdd:cd14956    89 ------TGELQTIG-GSSGSGPG-QFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQWGG---------TGIEPG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 161 SIYGATSLKLNNKGEMFLisPSGFVSLIRMIDEKGVMRKVLDTvtpkyldsiekskyKGKvQTGELATIThfsDFAFDKK 240
Cdd:cd14956   152 SFNYPRGVAVDPDGTLYV--ADTYNDRIQVFDNDGAFLRKWGG--------------RGT-GPGQFNYPY---GIAIDPD 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 241 GNLFISDRLNHQIRKVDPKGVITTIAGTgesgyYGDGgpakEAAFRDPSALATDKEGNL 299
Cdd:cd14956   212 GNVFVADFGNNRIQKFTADGTFLTSWGS-----PGTG----PGQFKNPWGVVVDADGTV 261
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
52-299 6.44e-20

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 87.77  E-value: 6.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIAGNGkkmfagdggpatgatLSFPHGIAVDKNDNVLVSDKGNYRIR 131
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG---------------GSGPHGIAVDPDGNLWFTDNGNNRIG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 132 KISP-DGTIQTIAGngirgnigddkPAEEASIYGATslklnnkgemflISPSGFVsLIRMIDEKGVMRkvLDTVTpkyld 210
Cdd:COG4257    84 RIDPkTGEITTFAL-----------PGGGSNPHGIA------------FDPDGNL-WFTDQGGNRIGR--LDPAT----- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 211 siekskykGKVQTGELATITHF-SDFAFDKKGNLFISDRLNHQIRKVDPK-GVITTIAGtgesgyygdggpakEAAFRDP 288
Cdd:COG4257   133 --------GEVTEFPLPTGGAGpYGIAVDPDGNLWVTDFGANAIGRIDPDtGTLTEYAL--------------PTPGAGP 190

                         250
                  ....*....|.
gi 2033921780 289 SALATDKEGNL 299
Cdd:COG4257   191 RGLAVDPDGNL 201
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2-266 1.61e-19

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 86.61  E-value: 1.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVD-SQGMITTIAGTGQQDYngdaevaretnlylPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:COG4257    67 DPDGNLWFTDNGNNRIGRIDpKTGEITTFALPGGGSN--------------PHGIAFDPDGNLWFTDQGGNRIGRLDPAT 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGngkkmfagdggPATGAtlsFPHGIAVDKNDNVLVSDKGNYRIRKISPD-GTIQTIAGngirgnigddkPAEE 159
Cdd:COG4257   133 GEVTEFPL-----------PTGGA---GPYGIAVDPDGNLWVTDFGANAIGRIDPDtGTLTEYAL-----------PTPG 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 160 ASIYGATslklnnkgemflISPSGFV-------SLIRMIDEKgvmrkvldtvtpkyldsiekskyKGKVQTGELATITHF 232
Cdd:COG4257   188 AGPRGLA------------VDPDGNLwvadtgsGRIGRFDPK-----------------------TGTVTEYPLPGGGAR 232

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2033921780 233 -SDFAFDKKGNLFISDRLNHQIRKVDPKGVITTIA 266
Cdd:COG4257   233 pYGVAVDGDGRVWFAESGANRIVRFDPDTELTEYV 267
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-299 1.87e-19

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 86.61  E-value: 1.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQgmittiagtgqqdyNGDAEVARETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:COG4257    24 VDPDGAVWFTDQGGGRIGRLDPA--------------TGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKKmfagdggpatgatlSFPHGIAVDKNDNVLVSDKGNYRIRKISPD-GTIQTIAGngirgnigddkPAEE 159
Cdd:COG4257    90 GEITTFALPGGG--------------SNPHGIAFDPDGNLWFTDQGGNRIGRLDPAtGEVTEFPL-----------PTGG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 160 ASIYGatsLKLNNKGEMFLISPSGfvSLIRMIDekgvmrkvldtvtpkyldsiekskykgkVQTGELATITHFSDF---- 235
Cdd:COG4257   145 AGPYG---IAVDPDGNLWVTDFGA--NAIGRID----------------------------PDTGTLTEYALPTPGagpr 191

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2033921780 236 --AFDKKGNLFISDRLNHQIRKVDPK-GVITTIAGTGESGyygdggpakeaafrDPSALATDKEGNL 299
Cdd:COG4257   192 glAVDPDGNLWVADTGSGRIGRFDPKtGTVTEYPLPGGGA--------------RPYGVAVDGDGRV 244
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 5-300 2.77e-19

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 89.14  E-value: 2.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780    5 GTLYIADRNNNRIRSVDSQG-MITTIAGTGQQDY-NGDAEVAretNLYLPFGVALKPDGSLL-VIDRSHYRIRSVDLKRG 81
Cdd:PLN02919   580 NRLFISDSNHNRIVVTDLDGnFIVQIGSTGEEGLrDGSFEDA---TFNRPQGLAYNAKKNLLyVADTENHALREIDFVNE 656

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   82 SIKTIAGNGKKMFAGDGGPA-TGATLSFPHGIAVD-KNDNVLVSDKGNYRIRKIS-PDGTIQTIAGNGIRGNIGDDKP-- 156
Cdd:PLN02919   657 TVRTLAGNGTKGSDYQGGKKgTSQVLNSPWDVCFEpVNEKVYIAMAGQHQIWEYNiSDGVTRVFSGDGYERNLNGSSGts 736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  157 ---AEEASIYGATSLKlnnkgEMFLI-SPSgfvSLIRMIDEKGVMRKVLDTVTPKYLDSIekSKYKGKVQTGELATITHF 232
Cdd:PLN02919   737 tsfAQPSGISLSPDLK-----ELYIAdSES---SSIRALDLKTGGSRLLAGGDPTFSDNL--FKFGDHDGVGSEVLLQHP 806

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780  233 SDFAFDKKGNLFISDRLNHQIRKVDP-KGVITTIAGTGESGYygDGGPAKEAAFRDPSALATDKEGNLI 300
Cdd:PLN02919   807 LGVLCAKDGQIYVADSYNHKIKKLDPaTKRVTTLAGTGKAGF--KDGKALKAQLSEPAGLALGENGRLF 873
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1-298 7.24e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 82.24  E-value: 7.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQG-MITT--IAGTGqqdyNGdaevaretNLYLPFGVALKPDGSLLVIDRSHYRIRSVD 77
Cdd:cd14955    23 VDSAGNVYVADTGNNRIQKFDSTGtFLTKwgSSGSG----DG--------QFYSPTGIAVDSDGNVYVADTGNHRIQKFD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  78 LKRGSIKTIAGNGkkmfAGDGGpatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIqtIAGNGIRGNiGDDKPA 157
Cdd:cd14955    91 STGTFLTKWGSSG----SGDGQ------FNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSGTF--ITKWGSFGS-GDGQFN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 158 EEASI--------YGATSlkLNNKGEMFliSPSGfvSLIRMIDEKGVmrkvldtvtpkyldsiekskykGKVQTGELATI 229
Cdd:cd14955   158 SPTGIavdsagnvYVADT--GNNRIQKF--TSTG--TFLTKWGSEGS----------------------GDGQFNAPYGI 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 230 thfsdfAFDKKGNLFISDRLNHQIRKVDPKGVITTiagtgESGYYGDGgpakEAAFRDPSALATDKEGN 298
Cdd:cd14955   210 ------AVDSAGNVYVADTGNNRIQKFDSSGTFIT-----KWGSEGSG----DGQFNSPSGIAVDSAGN 263
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 2-146 6.44e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 76.54  E-value: 6.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGdaevaretnLYLPFGVALKPDGSLLVIDRSHYRIRsvdlkrg 81
Cdd:cd14957    73 DSNGNIYVADTDNNRIQVFNSSGVYQYSIGTGGSGDGQ---------FNGPYGIAVDSNGNIYVADTGNHRIQ------- 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033921780  82 sIKTIAGNGKKMFaGDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQ-TIAGNG 146
Cdd:cd14957   137 -VFTSSGTFSYSI-GSGGTGPG-QFNGPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQyTFGSSG 199
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 5-161 1.56e-15

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 76.08  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   5 GTLYIADRNNNRIRSVD-SQGMITTIAGTGQQ--DYNGDAEvARETNL---------------------------YLP-- 52
Cdd:cd14951    30 NILYVADTENHALRKIDlETGTVTTLAGTGEQgrDGEGGGP-GREQPLsspwdvawgpeddilyiamagthqiwaYDLdt 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  53 ------------------------F----GVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIAG---NGKKMFA-GD-GG 99
Cdd:cd14951   109 gtcrvfagsgnegnrngpypheawFaqpsGLSLAGWGELFVADSESSAIRAVSLKDGGVKTLVGgtrVGTGLFDfGDrDG 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2033921780 100 PATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPD-GTIQTIAGNGIRGNIGDDKPAEEAS 161
Cdd:cd14951   189 PGAEALLQHPLGVAALPDGSVYVADTYNHKIKRVDPAtGEVSTLAGTGKAGYKDLEAQFSEPS 251
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1-299 5.66e-15

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 73.84  E-value: 5.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDyNGDaevaretnLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:cd14957    25 VDSAGNIYVADTGNNRIQVFTSSGVYSYSIGSGGTG-SGQ--------FNSPYGIAVDSNGNIYVADTDNNRIQVFNSSG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGkkmfaGDGGPatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDDKPaeea 160
Cdd:cd14957    96 VYQYSIGTGG-----SGDGQ-----FNGPYGIAVDSNGNIYVADTGNHRIQVFTSSGTFSYSIGSGGTGPGQFNGP---- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 161 siygaTSLKLNNKGEMFLISPSGfvSLIRMIDEKGVmrkvldtvtpkYLDSIEKSkykgKVQTGELATIThfsDFAFDKK 240
Cdd:cd14957   162 -----QGIAVDSDGNIYVADTGN--HRIQVFTSSGT-----------FQYTFGSS----GSGPGQFSDPY---GIAVDSD 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780 241 GNLFISDRLNHQIRKVDPKGVitTIAGTGESGYYGDGgpakeaaFRDPSALATDKEGNL 299
Cdd:cd14957   217 GNIYVADTGNHRIQVFTSSGA--YQYSIGTSGSGNGQ-------FNYPYGIAVDNDGKI 266
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 1-134 1.31e-14

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 73.07  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIrsvdsqgmittiagtgqQDYNGDAEVARETNLYL---PFGVALKPDGSLLVIDRSHYRIRSVD 77
Cdd:cd14958   183 LDEDGRVYVADRENGRI-----------------QVFDADGKFLTEWTNPElgrPYALAIDPDGLLYVVDGPPRLNRSLP 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2033921780  78 LKRGSIKTIAGNGKKMFAGDGGPATGatLSFPHGIAVDKNDNVLVSDKGNYRIRKIS 134
Cdd:cd14958   246 VRGFVIRIGKGLILGRFGPGGKAPGQ--FQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-143 2.40e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 71.97  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQ-GMITTIAGTGQQDYngdaevaretnlylPFGVALKPDGSLLVIDRSHYRIRSVDLK 79
Cdd:COG4257   152 VDPDGNLWVTDFGANAIGRIDPDtGTLTEYALPTPGAG--------------PRGLAVDPDGNLWVADTGSGRIGRFDPK 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2033921780  80 RGSIKTIAgngkkmfagdggpaTGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIA 143
Cdd:COG4257   218 TGTVTEYP--------------LPGGGARPYGVAVDGDGRVWFAESGANRIVRFDPDTELTEYV 267
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 2-138 6.98e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 70.65  E-value: 6.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGqqdyNGDAEvaretnLYLPFGVALKPDGSLLVIDRSHYRIrsvdlkr 80
Cdd:cd14954    32 DKDGRIIVADRSNNRVQVFDPDGkFLRKFGSYG----SRDGQ------FDRPAGVAVNSRGRIIVADKDNHRI------- 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2033921780  81 gSIKTIAGNGKKMFaGDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGT 138
Cdd:cd14954    95 -QVFDLNGRFLLKF-GERGTKNG-QFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDGQ 149
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1-138 2.48e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 69.23  E-value: 2.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGQqdyngdaevaRETNLYLPFGVALKPDGSLLVIDRSHYRIRsvdlk 79
Cdd:cd14956   114 VDADGNLYVADFGNQRIQKFDPDGsFLRQWGGTGI----------EPGSFNYPRGVAVDPDGTLYVADTYNDRIQ----- 178

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  80 rgsIKTIAGNGKKMFagdGGPATG-ATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGT 138
Cdd:cd14956   179 ---VFDNDGAFLRKW---GGRGTGpGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTADGT 232
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 2-135 9.30e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 67.60  E-value: 9.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGqqdyNGDAEvaretnLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:cd14955   165 DSAGNVYVADTGNNRIQKFTSTGtFLTKWGSEG----SGDGQ------FNAPYGIAVDSAGNVYVADTGNNRIQKFDSSG 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780  81 GSIKTIAGNGKkmfaGDGgpatgaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISP 135
Cdd:cd14955   235 TFITKWGSEGS----GDG------QFNSPSGIAVDSAGNVYVADSGNNRIQKFAP 279
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 2-142 3.90e-12

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 66.06  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVD-SQGMITTIAGT----------GQQDynGDAEVARetnLYLPFGVALKPDGSLLVIDRSH 70
Cdd:cd14951   142 AGWGELFVADSESSAIRAVSlKDGGVKTLVGGtrvgtglfdfGDRD--GPGAEAL---LQHPLGVAALPDGSVYVADTYN 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033921780  71 YRIRSVDLKRGSIKTIAGNGKkmfagDGGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTI 142
Cdd:cd14951   217 HKIKRVDPATGEVSTLAGTGK-----AGYKDLEAQFSEPSGLVVDGDGRLYVADTNNHRIRRLDLPTEALEV 283
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1-141 4.53e-12

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 64.92  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDsqgmittiAGTGQQdyngdaEVARETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDlkr 80
Cdd:cd14952   101 VDAAGNVYVADTGNNRVLKLA--------AGSNTQ------TVLPFTGLSNPDGVAVDGAGNVYVTDTGNNRVLKLA--- 163

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780  81 gsiktiagngkkmfAGDGGPA----TGatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQT 141
Cdd:cd14952   164 --------------AGSTTQTvlpfTG--LNSPSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPT 212
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 52-299 4.55e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 65.29  E-value: 4.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIAGNGKkmfaGDGGpatgatLSFPHGIAVDKNDNVLVSDKGNYRIR 131
Cdd:cd14955    18 PSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWGSSGS----GDGQ------FYSPTGIAVDSDGNVYVADTGNHRIQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 132 KISPDGTIQTIAGNgirgnigddkpaeeasiYGAtslklnnkGEMFLISPSGFvslirmidekgvmrkvldtvtpkylds 211
Cdd:cd14955    88 KFDSTGTFLTKWGS-----------------SGS--------GDGQFNSPSGI--------------------------- 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 212 iekskykgkvqtgelatithfsdfAFDKKGNLFISDRLNHQIRKVDPKGV-ITTIAGTGesgyYGDGgpakeaAFRDPSA 290
Cdd:cd14955   116 ------------------------AVDSAGNVYVTDSGNNRIQKFDSSGTfITKWGSFG----SGDG------QFNSPTG 161


                  ....*....
gi 2033921780 291 LATDKEGNL 299
Cdd:cd14955   162 IAVDSAGNV 170
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-133 5.20e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 65.38  E-value: 5.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGQQDYNgdaevaretnLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:cd14956   162 DPDGTLYVADTYNDRIQVFDNDGaFLRKWGGRGTGPGQ----------FNYPYGIAIDPDGNVFVADFGNNRIQKFTADG 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2033921780  81 GSIKTIAGNGkkmfagdGGPATGATlsfPHGIAVDKNDNVLVSDKGNYRIRKI 133
Cdd:cd14956   232 TFLTSWGSPG-------TGPGQFKN---PWGVVVDADGTVYVADSNNNRVQRF 274
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 2-156 5.44e-12

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 65.26  E-value: 5.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGqqdyngdaevARETNLYLPFGVALKPDGSLLVIDRSHYRIrsvdlkr 80
Cdd:cd14954   126 DSEGRIYVSDTRNHRVQVFDSDGqFIRKFGFEG----------AGPGQLDSPRGVAVNPDGNIVVSDFNNHRL------- 188

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2033921780  81 gsiKTIAGNGKKMFA-GDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDDKP 156
Cdd:cd14954   189 ---QVFDPDGQFLRFfGSEGSGNG-QFKRPRGVAVDDEGNIIVADSGNHRVQVFSPDGEFLCSFGTEGNGEGQFDRP 261
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 2-141 2.94e-11

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 62.61  E-value: 2.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIrsvdsqgmITTIAGTGQQdyngdaEVARETNLYLPFGVALKPDGSLLVIDRSHYRIrsVDLKRG 81
Cdd:cd14952    18 DAAGNVYVADSGNNRV--------LKLAAGSTTQ------TVLPFTGLYQPQGVAVDAAGTVYVTDFGNNRV--LKLAAG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  82 SIKTIAGngkkmfagdggPATGatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQT 141
Cdd:cd14952    82 STTQTVL-----------PFTG--LNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSNTQT 128
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-130 3.76e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 62.69  E-value: 3.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGtgqqdyngdaEVARETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKR 80
Cdd:cd14963   156 DEDGNIYVADSGNGRIQVFDKNGkFIKELNG----------SPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQG 225

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKkmfaGDGgpatgaTLSFPHGIAVDKNDNVLVSDKGNYRI 130
Cdd:cd14963   226 KELFTFGGRGK----DDG------QFNLPNGLFIDDDGRLYVTDRENNRV 265
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 3-135 5.14e-11

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 63.72  E-value: 5.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780    3 DQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYN------GDAE-VARETNLYLPFGVALKPDGSLLVIDRSHYRIRS 75
Cdd:PLN02919   750 DLKELYIADSESSSIRALDLKTGGSRLLAGGDPTFSdnlfkfGDHDgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKK 829

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   76 VDLKRGSIKTIAGNGKKMFagDGGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISP 135
Cdd:PLN02919   830 LDPATKRVTTLAGTGKAGF--KDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDL 887
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 2-131 6.56e-11

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 61.90  E-value: 6.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTIAGTGQQDYNgdaevaretnLYLPFGVALKPDGSLLVIDRSHYRIrsvdlkr 80
Cdd:cd14957   167 DSDGNIYVADTGNHRIQVFTSSGtFQYTFGSSGSGPGQ----------FSDPYGIAVDSDGNIYVADTGNHRI------- 229

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2033921780  81 gSIKTIAGNGKKMFAGDGGPATGatLSFPHGIAVDKNDNVLVSDKGNYRIR 131
Cdd:cd14957   230 -QVFTSSGAYQYSIGTSGSGNGQ--FNYPYGIAVDNDGKIYVADSNNNRIQ 277
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 49-298 1.58e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 60.74  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  49 LYLPFGVALKPDGSLLVIDRSHYRIrSVDLKRGSIKTIAGNGkkmfagDGGPATGatlSFPHGIAVDKNDNVLVSDKGNY 128
Cdd:cd14957    17 FNTPRGIAVDSAGNIYVADTGNNRI-QVFTSSGVYSYSIGSG------GTGSGQF---NSPYGIAVDSNGNIYVADTDNN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 129 RIRKISPDGTIQTIAGNGIRGNIGDDKPAEEAsiygatslkLNNKGEMFLISPSGFVslIRMIDEKGVmrkvldtvtpkY 208
Cdd:cd14957    87 RIQVFNSSGVYQYSIGTGGSGDGQFNGPYGIA---------VDSNGNIYVADTGNHR--IQVFTSSGT-----------F 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 209 LDSIekskykGKVQTGElatiTHFS---DFAFDKKGNLFISDRLNHQIRKVDPKGV-ITTIAGTGEsgyyGDGGpakeaa 284
Cdd:cd14957   145 SYSI------GSGGTGP----GQFNgpqGIAVDSDGNIYVADTGNHRIQVFTSSGTfQYTFGSSGS----GPGQ------ 204

                         250
                  ....*....|....
gi 2033921780 285 FRDPSALATDKEGN 298
Cdd:cd14957   205 FSDPYGIAVDSDGN 218
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
101-299 3.19e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.03  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 101 ATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISP-DGTIQTIAgngirgnigddkPAEEASIYGatsLKLNNKGEMFLI 179
Cdd:COG4257    11 PVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPaTGEFTEYP------------LGGGSGPHG---IAVDPDGNLWFT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 180 SPSGfvSLIRMIDEKgvmrkvldtvtpkyldsiekskykgkvqTGELATI------THFSDFAFDKKGNLFISDRLNHQI 253
Cdd:COG4257    76 DNGN--NRIGRIDPK----------------------------TGEITTFalpgggSNPHGIAFDPDGNLWFTDQGGNRI 125

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2033921780 254 RKVDPK-GVITTIAgtgesgyygdgGPAKEAafrDPSALATDKEGNL 299
Cdd:COG4257   126 GRLDPAtGEVTEFP-----------LPTGGA---GPYGIAVDPDGNL 158
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 49-300 4.34e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 59.48  E-value: 4.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  49 LYLPFGVALKPDGSLLVIDRSHYRIRsvdlkrgsIKTIAGNGKKMFaGDGGPATGAtLSFPHGIAVDKNDNVLVSDKGNY 128
Cdd:cd14954    23 LCRPWGVAVDKDGRIIVADRSNNRVQ--------VFDPDGKFLRKF-GSYGSRDGQ-FDRPAGVAVNSRGRIIVADKDNH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 129 RIRKISPDGTIQTIAGNGIRGNIGDDKPA-----EEASIYgaTSLKLNNKGEMFliSPSGfvSLIRMIDEKGVMRKVLDt 203
Cdd:cd14954    93 RIQVFDLNGRFLLKFGERGTKNGQFNYPWgvavdSEGRIY--VSDTRNHRVQVF--DSDG--QFIRKFGFEGAGPGQLD- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 204 vTPKYLdsiekskykgkvqtgelatithfsdfAFDKKGNLFISDRLNHQIRKVDPKGVitTIAGTGESGyYGDGgpakea 283
Cdd:cd14954   166 -SPRGV--------------------------AVNPDGNIVVSDFNNHRLQVFDPDGQ--FLRFFGSEG-SGNG------ 209

                         250
                  ....*....|....*..
gi 2033921780 284 AFRDPSALATDKEGNLI 300
Cdd:cd14954   210 QFKRPRGVAVDDEGNII 226
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 88-299 7.97e-10

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 59.13  E-value: 7.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  88 GNGKKMFAgDGGPATgATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPD-GTIQTIAGNGIRGNIGD-DKPAEEASiyga 165
Cdd:cd14951     2 GSGERGLK-DGSFAE-ASFNEPQGLALLPGNILYVADTENHALRKIDLEtGTVTTLAGTGEQGRDGEgGGPGREQP---- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 166 tslkLNnkgemfliSPsgfvslirmidekgvmrkvLDTVtpkyldsiekskykgkvqtgelatithfsdfAFDKKGNLFI 245
Cdd:cd14951    76 ----LS--------SP-------------------WDVA-------------------------------WGPEDDILYI 93

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780 246 SDRLNHQIRKVDP-KGVITTIAGTGESGYYgDGGPAKEAAFRDPSALATDKEGNL 299
Cdd:cd14951    94 AMAGTHQIWAYDLdTGTCRVFAGSGNEGNR-NGPYPHEAWFAQPSGLSLAGWGEL 147
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-151 8.47e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 58.46  E-value: 8.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGmittiagtGQQDYNGDAEVARetNLYLPFGVALKpDGSLLVIDRSHYRIRSVDLKRG 81
Cdd:cd14963    64 DSDGNIYVADLYNGRIQVFDPDG--------KFLKYFPEKKDRV--KLISPAGLAID-DGKLYVSDVKKHKVIVFDLEGK 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2033921780  82 SIKTIAGNGKKmfAGDggpatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGT-IQTIAGNGIRGNI 151
Cdd:cd14963   133 LLLEFGKPGSE--PGE--------LSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGKfIKELNGSPDGKSG 193
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 52-299 1.20e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 58.37  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIagngkkmfagdgGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIR 131
Cdd:cd14962    14 PYGVAADGRGRIYVADTGRGAVFVFDLPNGKVFVI------------GNAGPNRFVSPIGVAIDANGNLYVSDAELGKVF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 132 KISPDGTIQTIAGNGirgnIGDDKPaeeasiygaTSLKLNNKGEMFLISPSGfVSLIRMIDEKGvmrkvldtvtpKYLDS 211
Cdd:cd14962    82 VFDRDGKFLRAIGAG----ALFKRP---------TGIAVDPAGKRLYVVDTL-AHKVKVFDLDG-----------RLLFD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 212 IEKSKYKGkvqtGELAtitHFSDFAFDKKGNLFISDRLNHQIRKVDPKGVITTIagTGESG-YYGDggpakeaaFRDPSA 290
Cdd:cd14962   137 IGKRGSGP----GEFN---LPTDLAVDRDGNLYVTDTMNFRVQIFDADGKFLRS--FGERGdGPGS--------FARPKG 199


                  ....*....
gi 2033921780 291 LATDKEGNL 299
Cdd:cd14962   200 IAVDSEGNI 208
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-150 2.41e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 57.21  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGMITTIAGTGQQdyngdaeVARetnlylPFGVALKPDGSLL-VIDRSHYRIRSVDLKR 80
Cdd:cd14962    65 DANGNLYVSDAELGKVFVFDRDGKFLRAIGAGAL-------FKR------PTGIAVDPAGKRLyVVDTLAHKVKVFDLDG 131

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  81 GSIKTIAGNGKKmfagdGGPatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNgiRGN 150
Cdd:cd14962   132 RLLFDIGKRGSG-----PGE-----FNLPTDLAVDRDGNLYVTDTMNFRVQIFDADGKFLRSFGE--RGD 189
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 2-134 3.40e-09

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 56.45  E-value: 3.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDsqgmittiAGTGQQdyngdaevaRE---TNLYLPFGVALKPDGSLLVIDRSHYRIRsvdl 78
Cdd:cd14952   144 DGAGNVYVTDTGNNRVLKLA--------AGSTTQ---------TVlpfTGLNSPSGVAVDTAGNVYVTDHGNNRVL---- 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  79 krgsiktiagngkKMFAGDGG----PATGatLSFPHGIAVDKNDNVLVSDKGNYRIRKIS 134
Cdd:cd14952   203 -------------KLAAGSTTptvlPFTG--LNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 2-142 8.02e-09

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 55.67  E-value: 8.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADrNNNRIRSVD-SQGMITTIAGTGQQDYNG--DAEVARETNLY---------------------------- 50
Cdd:COG3386    57 DPDGRLLVAD-HGRGLVRFDpADGEVTVLADEYGKPLNRpnDGVVDPDGRLYftdmgeylptgalyrvdpdgslrvladg 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  51 LPF--GVALKPDGS-LLVIDRSHYRIRSVDLKR-GSIktiaGNGKKMFAGDGGPatgatlSFPHGIAVDKNDNVLVSDKG 126
Cdd:COG3386   136 LTFpnGIAFSPDGRtLYVADTGAGRIYRFDLDAdGTL----GNRRVFADLPDGP------GGPDGLAVDADGNLWVALWG 205

                         170
                  ....*....|....*.
gi 2033921780 127 NYRIRKISPDGTIQTI 142
Cdd:COG3386   206 GGGVVRFDPDGELLGR 221
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 2-147 1.53e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 54.90  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGmittiagtgqqdynGDAEVARETNlYLPFGVALKPDGSLLVIDRSHyRIRSVDLKRG 81
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDG--------------GAVEVFAEPS-GRPNGLAFDPDGRLLVADHGR-GLVRFDPADG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780  82 SIKTIAgngkkmfagdggPATGATLSFPHGIAVDKNDNVLVSDKGNY----RIRKISPDGTIQTIAG-----NGI 147
Cdd:COG3386    80 EVTVLA------------DEYGKPLNRPNDGVVDPDGRLYFTDMGEYlptgALYRVDPDGSLRVLADgltfpNGI 142
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 1-142 1.59e-08

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 54.97  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGmittiagtGQQDYNGDAEVARETNLYlPFGVALKPDGSLLVIDrshYRIRSVdlkr 80
Cdd:cd14961    18 VTPTGRVVVADDGNKRIQVFDSDG--------NCLQQFGPKGDAGQDIRY-PLDVAVTPDGHIVVTD---AGDRSV---- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033921780  81 gsiKTIAGNGKKMFagdggpATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTI 142
Cdd:cd14961    82 ---KVFSFDGRLKL------FVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGIL 134
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 3-146 2.64e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 54.22  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   3 DQGTLYIADRNNNRIRSVDSQG-MITTIAGTGQqdyngdaevaRETNLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKRG 81
Cdd:cd14963   110 DDGKLYVSDVKKHKVIVFDLEGkLLLEFGKPGS----------EPGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGK 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033921780  82 SIKTIAGngkkmfagdgGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGT-IQTIAGNG 146
Cdd:cd14963   180 FIKELNG----------SPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGKeLFTFGGRG 235
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 49-260 2.88e-08

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 54.19  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  49 LYLPFGVALKPDGSLLVIDR--------SHYRIRSVDLKRGSIKTIAgngkkMFAGDGGP--ATGATL-SFPHGIAVDKN 117
Cdd:cd14958    12 LGQVSGVAVDSLGNGVVFHRggrvwdanSFDANVYVFKGPIEEDTIL-----VFDPDGGFlrSWGAGLfYMPHGLTIDPD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 118 DNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNIGDD-----KPAEEAsiygatslklnnkgemflISPSG--FV----- 185
Cdd:cd14958    87 GNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDqthfcKPTDVA------------------VAPDGdiFVadgyc 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033921780 186 -SLIRMIDEKGvmrkvldtvtpKYLDSIEKSkykGKvQTGELAtITHfsDFAFDKKGNLFISDRLNHQIRKVDPKG 260
Cdd:cd14958   149 nSRIVKFSPDG-----------KLLKSWGEP---GS-GPGQFN-LPH--SIALDEDGRVYVADRENGRIQVFDADG 206
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 1-130 3.22e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 54.09  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQGM-ITTIAGTGQqdynGDAEVARetnlylPFGVALKPDGSLLVIDRSHYRIRSVDlk 79
Cdd:cd14954   172 VNPDGNIVVSDFNNHRLQVFDPDGQfLRFFGSEGS----GNGQFKR------PRGVAVDDEGNIIVADSGNHRVQVFS-- 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2033921780  80 rgsiktiaGNGKKMFA-GDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRI 130
Cdd:cd14954   240 --------PDGEFLCSfGTEGNGEG-QFDRPSGVAVTPDGRIVVVDRGNHRI 282
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 5-81 5.97e-08

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 54.47  E-value: 5.97e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033921780    5 GTLYIADRNNNRIRSVD-SQGMITTIAGTGQQDY-NGDAEVARetnLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKRG 81
Cdd:PLN02919   815 GQIYVADSYNHKIKKLDpATKRVTTLAGTGKAGFkDGKALKAQ---LSEPAGLALGENGRLFVADTNNSLIRYLDLNKG 890
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 52-299 9.66e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 52.29  E-value: 9.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVAlKPDGSLLVIDRSHYRIRSVDLKrgsiktiaGNGKKMFagdGGPATG-ATLSFPHGIAVDKNDNVLVSDKGNYRI 130
Cdd:cd14963    12 PMGVA-VSDGRIYVADTNNHRVQVFDYE--------GKFKKSF---GGPGTGpGEFKYPYGIAVDSDGNIYVADLYNGRI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 131 RKISPDGT-IQTIAGNGIRGNIgdDKPA----------------EEASIYGATSLKLNNKGEM-----FLISPSGFVsli 188
Cdd:cd14963    80 QVFDPDGKfLKYFPEKKDRVKL--ISPAglaiddgklyvsdvkkHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIA--- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 189 rmIDEKGVMRkVLDTVTPKYLDSIEKSKYKGKVQTGELATITHFS--DFAFDKKGNLFISDRLNHQIRKVDPKG-VITTI 265
Cdd:cd14963   155 --VDEDGNIY-VADSGNGRIQVFDKNGKFIKELNGSPDGKSGFVNprGIAVDPDGNLYVVDNLSHRVYVFDEQGkELFTF 231

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2033921780 266 AGTGEsgyyGDGgpakeaAFRDPSALATDKEGNL 299
Cdd:cd14963   232 GGRGK----DDG------QFNLPNGLFIDDDGRL 255
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 47-141 1.26e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.82  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  47 TNLYLPFGVALKPDGSLLVIDRSHYRIRsvdlkrgsiktiagngkKMFAGDGGPatgATLSF-----PHGIAVDKNDNVL 121
Cdd:cd14952     7 TGLDGPGGVAVDAAGNVYVADSGNNRVL-----------------KLAAGSTTQ---TVLPFtglyqPQGVAVDAAGTVY 66

                          90       100
                  ....*....|....*....|
gi 2033921780 122 VSDKGNYRIRKISPDGTIQT 141
Cdd:cd14952    67 VTDFGNNRVLKLAAGSTTQT 86
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 100-141 1.49e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.74  E-value: 1.49e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2033921780 100 PATGatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQT 141
Cdd:cd14952     5 PFTG--LDGPGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQT 44
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 1-255 5.19e-06

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 47.26  E-value: 5.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   1 MDDQGTLYIADRNNNRIRSVDSQG--MITTIAGTGQQDYNGDAEVARetnlylPFGVALKPDGSLLVIDrsHY---RIRS 75
Cdd:cd14958    83 IDPDGNIWVTDVGLHQVFKFDPEGklLPLLTLGERGEPGSDQTHFCK------PTDVAVAPDGDIFVAD--GYcnsRIVK 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  76 VDLkrgsiktiagNGKKMFA-GDGGPATGaTLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNGIRGNigdd 154
Cdd:cd14958   155 FSP----------DGKLLKSwGEPGSGPG-QFNLPHSIALDEDGRVYVADRENGRIQVFDADGKFLTEWTNPELGR---- 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 155 kpaeeasIYGatsLKLNNKGEMFLIspSGFVSLIRMIDEKGVMRKVLDTVtpkyldsIEKSKYKGKVQTGELATItHfsD 234
Cdd:cd14958   220 -------PYA---LAIDPDGLLYVV--DGPPRLNRSLPVRGFVIRIGKGL-------ILGRFGPGGKAPGQFQNP-H--D 277

                         250       260
                  ....*....|....*....|.
gi 2033921780 235 FAFDKKGNLFISDRLNHQIRK 255
Cdd:cd14958   278 IAVDSGGDIYVGELGPNRVQK 298
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 5-144 6.06e-06

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 47.27  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   5 GTLYIADRNNNRIRSVDSQGMITTIAGTGQQDYNGDAEVARETNLYL----------PFGVALKPDGSLLV-------ID 67
Cdd:NF033206  148 GTLYVADAGANALLRVDADGKVSTVAVLPPRPVTIPAGPPPGLPLPDcpvgypaqavPTGVAVGPDGALYVseltgfpFP 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  68 RSHYRIRSVDLkRGSIKTIAgngkkmfagDGgpATGATlsfphGIAVDKNDNVLV---SDKGNY------RIRKISPDGT 138
Cdd:NF033206  228 PGRARVYRVDP-GGAPTVYA---------TG--FTGLT-----DLAFDPDGNLYVlelAGGGLLkgdptgSLIRIAPDGT 290


                  ....*.
gi 2033921780 139 IQTIAG 144
Cdd:NF033206  291 RTTLLD 296
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-130 8.28e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.43  E-value: 8.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG-MITTI--AGTGQQDYNgdaevaretnlyLPFGVALKPDGSLLVIDRSHYRIRSVDL 78
Cdd:cd14962   109 PAGKRLYVVDTLAHKVKVFDLDGrLLFDIgkRGSGPGEFN------------LPTDLAVDRDGNLYVTDTMNFRVQIFDA 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  79 ---------KRGS-------IKTIA---------------------GNGKK-MFAGDGGPATGAtLSFPHGIAVDKNDNV 120
Cdd:cd14962   177 dgkflrsfgERGDgpgsfarPKGIAvdsegniyvvdaafdnvqifnPEGELlLTVGGPGSGPGE-FYLPSGIAIDKDDRI 255

                         170
                  ....*....|
gi 2033921780 121 LVSDKGNYRI 130
Cdd:cd14962   256 YVVDQFNRRI 265
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 2-139 9.20e-06

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 46.10  E-value: 9.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQGMITtiagtgqqdYNGDAEVAR-ETNLYLPFGVALKPDGSLL-VIDRSHYRIRSVDLk 79
Cdd:pfam08450  94 DPDGRFWFGTMGDDEAPGGDPGALYR---------LDPDGKLTRvLDGLTISNGLAWSPDGRTLyFADSPARKIWAYDY- 163

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  80 rgSIKTIAGNGKKMFAgDGGPATGAtlsfPHGIAVDKNDNVLVSDKGNYRIRKISPDGTI 139
Cdd:pfam08450 164 --DLDGGLISNRRVFA-DFKPGLGR----PDGMAVDAEGNVWVARWGGGKVVRFDPDGKL 216
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 262-300 9.40e-06

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 46.75  E-value: 9.40e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2033921780 262 ITTIAGTGESGYYGDGGPAkeAAFRDPSALATDKEGNLI 300
Cdd:cd14953     1 VSTVAGSGTAGFSGGGGTA--ARFNSPSGVAVDAAGNLY 37
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 106-132 2.45e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 40.46  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|....*..
gi 2033921780 106 LSFPHGIAVDKNDNVLVSDKGNYRIRK 132
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-133 2.46e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDsqgmittiAGTGQqdyngdaEVARETNLYLPFGVALKPDGS-LLVIDRSHYRIRSVDLKR 80
Cdd:COG3391    77 ADGRRLYVANSGSGRVSVID--------LATGK-------VVATIPVGGGPRGLAVDPDGGrLYVADSGNGRVSVIDTAT 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2033921780  81 GSIKTIAGNGKKmfagdggpatgatlsfPHGIAVDKNDN-VLVSDKGNYRIRKI 133
Cdd:COG3391   142 GKVVATIPVGAG----------------PHGIAVDPDGKrLYVANSGSNTVSVI 179
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-265 7.09e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 43.73  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  54 GVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTiagngkkmFAGDGGpatgatlsFPHGIAVDKNDNVLVSDKGNyRIRKI 133
Cdd:COG3386    12 GPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEV--------FAEPSG--------RPNGLAFDPDGRLLVADHGR-GLVRF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 134 SP-DGTIQTIAGN-GIRGNIGDD-KPAEEASIYgATSlklnnkgeMFLISPSGfvSLIRmIDEKGVMRKVLDTVT----- 205
Cdd:COG3386    75 DPaDGEVTVLADEyGKPLNRPNDgVVDPDGRLY-FTD--------MGEYLPTG--ALYR-VDPDGSLRVLADGLTfpngi 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 206 ---P--KYL---DSiekskYKGKV------QTGELATITHFSDF----------AFDKKGNLFISDRLNHQIRKVDPKGV 261
Cdd:COG3386   143 afsPdgRTLyvaDT-----GAGRIyrfdldADGTLGNRRVFADLpdgpggpdglAVDADGNLWVALWGGGGVVRFDPDGE 217


                  ....
gi 2033921780 262 ITTI 265
Cdd:COG3386   218 LLGR 221
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 4-280 2.58e-04

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 41.95  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   4 QGTLYIADRNNNRIRSVDSQGMITTIAGT-----GQqdyngdaevaretnLYLPFGVALKPDGSLLVIDrSHYRIRSVDL 78
Cdd:cd14960    27 SGRLVIADSNNQCVQVFSNDGQFKLRFGVrgrspGQ--------------LQRPTGVAVTLNGDIIIAD-YDNKWVSIFS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  79 KRGSIKTIAGNGKkmfagdggpatgatLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTIAGNgiRGNiGDDKPAe 158
Cdd:cd14960    92 PDGKFKSKIGAGK--------------LMGPKGVAVDRNGHIIVVDNKACCVFIFQPNGKLVTRFGS--RGN-GDRQFA- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 159 easiyGATSLKLNNKGEmflispsgfvslIRMIDEKGVMRKVLDTVtPKYLDSIeKSKYKGKVQ----TGelatithfsd 234
Cdd:cd14960   154 -----GPHFAAVNNNNE------------IIVTDFHNHSVKVFNAE-GEFLFKF-GSNGEGNGQfnapTG---------- 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2033921780 235 FAFDKKGNLFISDRLNHQIRKVDPKGVITTIAGTGESGYYGDGGPA 280
Cdd:cd14960   205 VAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSADPLYGPQGLA 250
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 48-146 3.35e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 41.88  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  48 NLYLPFGVALKPDGSLLVIDRSHYRIRSVDLKRGSIKTIaGNgkkmfAGDGGPATGatlsFPHGIAVDKNDNVLVSDKGN 127
Cdd:cd14961     9 TLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNCLQQF-GP-----KGDAGQDIR----YPLDVAVTPDGHIVVTDAGD 78

                          90
                  ....*....|....*....
gi 2033921780 128 YRIRKISPDGTIQTIAGNG 146
Cdd:cd14961    79 RSVKVFSFDGRLKLFVRKS 97
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 98-300 4.75e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.03  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  98 GGPATGATLSFPHGIAVDKNDNVLVSDKGNYRIRKIspdgtiqtiagngirgnigdDKPAEEASIYGatslklnNKGEMF 177
Cdd:cd14962     3 GEERPKEALTRPYGVAADGRGRIYVADTGRGAVFVF--------------------DLPNGKVFVIG-------NAGPNR 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 178 LISPSGFVslirmIDEKGvMRKVLDTVTPKYLDSIEKSKYKGKVqtGELATITHFSDFAFDKKGN-LFISDRLNHQIRKV 256
Cdd:cd14962    56 FVSPIGVA-----IDANG-NLYVSDAELGKVFVFDRDGKFLRAI--GAGALFKRPTGIAVDPAGKrLYVVDTLAHKVKVF 127

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2033921780 257 DPKG-VITTIagtGESGyygdGGPAKeaaFRDPSALATDKEGNLI 300
Cdd:cd14962   128 DLDGrLLFDI---GKRG----SGPGE---FNLPTDLAVDRDGNLY 162
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 109-299 5.30e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 41.11  E-value: 5.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 109 PHGIAVDKNDNVLVSDKGNYRIRKISPDGTiqTIAGNGIRGNiGDDKpaeeasiygatslklnnkgemfLISPSGFvsli 188
Cdd:cd14956    15 PRGIAVDADDNVYVADARNGRIQVFDKDGT--FLRRFGTTGD-GPGQ----------------------FGRPRGL---- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780 189 rmidekgvmrkvldtvtpkyldsiekskykgkvqtgelatithfsdfAFDKKGNLFISDRLNHQIRKVDPKGVITTIAGT 268
Cdd:cd14956    66 -----------------------------------------------AVDKDGWLYVADYWGDRIQVFTLTGELQTIGGS 98

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2033921780 269 gesgyYGDGgpakEAAFRDPSALATDKEGNL 299
Cdd:cd14956    99 -----SGSG----PGQFNAPRGVAVDADGNL 120
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 238-300 8.44e-04

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 40.71  E-value: 8.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2033921780 238 DKKGNLFISDRLNHQIRKVDPKGVITTIAGTGESGYYG-DGGPakeaaFRDPSALATDKEGNLI 300
Cdd:cd14958    84 DPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGsDQTH-----FCKPTDVAVAPDGDIF 142
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 104-174 2.08e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.18  E-value: 2.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2033921780 104 ATLSFPHGIAVDKNDNVLVSDKGNYRIRKISPDGTIQTiagngIRGNIGDDKPAeeasIYGATSLKLNNKG 174
Cdd:cd14961     8 GTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNCLQ-----QFGPKGDAGQD----IRYPLDVAVTPDG 69
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 2-79 2.54e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 38.87  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   2 DDQGTLYIADRNNNRIRSVDSQG----MITTIAGTgqqdyngdaevaretnLYLPFGVALKPDGSLLVIDRSHYRIRSVD 77
Cdd:cd14960   208 DSNGNIIVADWGNSRIQVFDSSGsflsYINTSADP----------------LYGPQGLALTSDGHVVVADSGNHCFKVYR 271


                  ..
gi 2033921780  78 LK 79
Cdd:cd14960   272 YL 273
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3-129 5.63e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780   3 DQGTLYIADRNNNRIRSVDSQGM--ITTIAgTGQQdyngdaevaretnlylPFGVALKPDGS-LLVIDRSHYRI----RS 75
Cdd:COG3391   120 DGGRLYVADSGNGRVSVIDTATGkvVATIP-VGAG----------------PHGIAVDPDGKrLYVANSGSNTVsvivSV 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2033921780  76 VDLKRGSIKtiagngkkmfagdggpATGATLSFPHGIAVDK-NDNVLVSDKGNYR 129
Cdd:COG3391   183 IDTATGKVV----------------ATIPVGGGPVGVAVSPdGRRLYVANRGSNT 221
Phytase-like pfam13449
Esterase-like activity of phytase; This is a repeated domain that carries several highly ...
 52-140 5.71e-03

Esterase-like activity of phytase; This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.


Pssm-ID: 433217 [Multi-domain]  Cd Length: 284  Bit Score: 38.03  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFG-----VALKPDGSLLVI--DRSHYRIR----SVDLKRGSIKTIAGNGK-KMFAGDGGPATGATLSfPHGIAVDKNDN 119
Cdd:pfam13449   2 PFGglsglAYDPDDGRFYAVsdDGSKNPARfytlDIDLDGDGIGGVEITGVtPLRDPDGAPFPPRGLD-PEGIAVAPDGT 80

                          90       100
                  ....*....|....*....|.
gi 2033921780 120 VLVSDKGNYRIRKISPDGTIQ 140
Cdd:pfam13449  81 FWVSSEGGPFILRFDLDGRLL 101
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 52-146 7.61e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 37.64  E-value: 7.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033921780  52 PFGVALKPDGSLLV----IDRSHYRIRSVDLKRGSIKTIAGNGKK--MFAGDGGPATGATLSFPHGIAVDKNDN--VLVS 123
Cdd:NF033206   10 PRGLAFGPDGRLYVaeagTGGCPSPSPLCYGNTGAVSRITPDGKKtrVVTGLPSLALGEGAAGPADVAFDGDGTyyVLTG 89

                          90       100
                  ....*....|....*....|....
gi 2033921780 124 DKGNYRIRKISPD-GTIQTIAGNG 146
Cdd:NF033206   90 LGGDPATRDGGPLlGTLLKVDLGT 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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