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Conserved domains on  [gi|2032650139|ref|XP_041255153|]
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laminin subunit alpha-1 [Onychostruthus taczanowskii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 24-276 7.63e-97

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


:

Pssm-ID: 214532  Cd Length: 238  Bit Score: 312.76  E-value: 7.63e-97
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139    24 QGQPRGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPlrnaQCRVCDSHsaNPKEQHPISSAIDGTN----N 99
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDAR--NPRRSHPAENLTDGNNpnnpT 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   100 WWQSPSIQNGRQYhwVTITLDLRQVFQVAYVIIKAAnAPRPGNWILERSIDGTEFRPWQYYAisdTECLTRYNITPRIGP 179
Cdd:smart00136   75 WWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   180 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SQKLLEFTSARYIRLRLQRIRTLNADLMTLShndpkel 257
Cdd:smart00136  149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220

                           250
                    ....*....|....*....
gi 2032650139   258 dPIVTRRYYYSIKDISVGG 276
Cdd:smart00136  221 -PEVTRRYYYAISDIAVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
1226-1368 8.08e-49

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 170.91  E-value: 8.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1226 YWKLPEQFQGDQLMAYGGKLRYTVAFYALDGFGTSNFEPQILMKGGHTSKLVIYADIPSPENGVRTDKEVEMKEDSWKYF 1305
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032650139 1306 NSVsdePVLRSDFMSVLSNVEYILIKAAYGQGLQQSRIANISMEIAVkfeEMHLGRPlAHLVE 1368
Cdd:pfam00052   81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAV---PGGSGPP-ASWVE 136
Laminin_II super family cl05515
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2024-2158 2.08e-42

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06009:

Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 152.64  E-value: 2.08e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2024 VKELAVSANTSAVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQASLLLDRLKPLKM 2103
Cdd:pfam06009    1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2104 LEEN---LNRNLSEIKELISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLN 2158
Cdd:pfam06009   81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
Laminin_B pfam00052
Laminin B (Domain IV);
576-715 1.26e-39

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 144.72  E-value: 1.26e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  576 YWSAPEAYLGNKLTAFSGDLKYTVSYDIPMESVDSdiVSSVDVIIQGNGQILSTR-AAGLSLQPYEEYSNSVRLVSDNFi 654
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL--NSEPDVILEGNGLRLSYSsPDQPPPDPGQEQTYSVRLHEENW- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  655 EFNTKKAIDREMLMTVLANVTHLLIRANYNIAKKAVyRLDSVTLDTASANVIDLsSAPDVE 715
Cdd:pfam00052   78 RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSGP-PASWVE 136
Laminin_G_1 pfam00054
Laminin G domain;
2767-2895 1.66e-38

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 141.30  E-value: 1.66e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2767 RTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAVVSDGKWHTVKTEYVKRKGTIIVDGQELVAVNA 2846
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2847 LGDG-STLDVEGKLYVGGLPLDYIPKNLGNVTHSIPACIGSMTINGKQLD 2895
Cdd:pfam00054   82 PLGAtTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2320-2476 2.92e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 2.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2320 SFHFDGSGY-SVVEKALRSTVTQILISFSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTENRYNNG 2398
Cdd:cd00110      1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2399 TWYKISFNRNKKQGILTVmDAYNLnyketkqGESPGVASDLNRSDKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEI 2476
Cdd:cd00110     81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_I super family cl26988
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1584-1834 6.49e-38

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06008:

Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 144.48  E-value: 6.49e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1584 LSVN-LTGIDRVPYGILSELENATQHLKRSIVPREDPTYSLDTTKENLLNLSGGIDYLHEETTRFLKKAQQLDTMTQKTR 1662
Cdd:pfam06008    2 LSLNsLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1663 NKSQELTGFIDTVHTTIKVLAEVALSLNETlglDLPLSNAASQSLQDDISALLDALRKKDFVQQHHNATTVLKAAEKLLT 1742
Cdd:pfam06008   82 GHAKELAEAIKNLIDNIKEINEKVATLGEN---DFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1743 QVQKEYFKPQQELAELKRNASQFLSKQSSRLQDAQDLVNEALTNINEIRRLFPLISSNLAELNDKKLKIKEGEEISTMLI 1822
Cdd:pfam06008  159 RIQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETL 238

                          250
                   ....*....|..
gi 2032650139 1823 KEGKVLLNDAAA 1834
Cdd:pfam06008  239 KTARDSLDAANL 250
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2915-3068 4.52e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 129.46  E-value: 4.52e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2915 GTFFDGSGFAALVREGYKvRSDVNISLEFRTTAVHGVLLGVSSA-KVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtn 2993
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--- 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2994 sLCDGKWHKLQANKSKHHISLIIDGNLVHTDNPYVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:cd00110     77 -LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
2154-2293 7.56e-33

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 125.14  E-value: 7.56e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2154 TLTLNVKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDFQIDNNKWHRIHATRFGKTGTLSIeem 2233
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--- 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2234 nsDQKPsPKSGTSLGTASILDVNksTLMFIGGLGGQIKKSPAVKVTHFKGCLGEASLNGK 2293
Cdd:smart00282   78 --DGGN-RVSGESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2501-2665 1.92e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 1.92e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2501 SVSIMNNGYIELVPKSL-SPESELMATFATKNSSGIILAGLSrglekrqrrQAHLPFFSIMLIDGHLAVHVNAGdrasTR 2579
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGS---------QNGGDFLALELEDGRLVLRYDLG----SG 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2580 KVVLQSANgTYSDGQEHSVILIRNKRIITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCI 2659
Cdd:cd00110     68 SLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD-GPLYLGGLPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2032650139 2660 SNLIFN 2665
Cdd:cd00110    146 RDLKVN 151
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1052-1100 4.75e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 4.75e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139 1052 CNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGYRDYPDCVACDC 1100
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1516-1554 4.87e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.76  E-value: 4.87e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2032650139 1516 PCQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
959-1003 6.59e-12

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 62.33  E-value: 6.59e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   959 CNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFYAFQDGGC 1003
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1411-1457 1.38e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1411 CQCNNH---SETCDPDTGKCLdCRDNTVGDHCSACAPGYYGKVTGSANDC 1457
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1098-1155 1.92e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.92e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 1098 CDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANSALGC 1155
Cdd:pfam00053    1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 909-957 1.97e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 1.97e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  909 ACACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGL-LTGLGCV 957
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 749-797 3.40e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 3.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  749 PCKCNGHAT---ECD-IHGVCFaCQHNTTGPFCDQCLPGFYGNPSQGtsEDCQ 797
Cdd:cd00055      1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG--GGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 405-464 4.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 4.00e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  405 CDCDPFGSLSSVCVKdehhsdsqrgtWPGQCQCREGYAGEKCDRCAFGYRGYPNCLRCNC 464
Cdd:pfam00053    1 CDCNPHGSLSDTCDP-----------ETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 856-908 5.08e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.06  E-value: 5.08e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  856 PCECNGNVNPQeeGHCDPFTGQCLkCLGNTAGHHCEKCADGYYGDAVIDKNCR 908
Cdd:cd00055      1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 462-508 9.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 9.00e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139  462 CNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNLQERNPQGC 508
Cdd:pfam00053    1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1005-1050 2.33e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.44  E-value: 2.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1005 PCDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLSPK-LGCK 1050
Cdd:cd00055      1 PCDCnghGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 799-854 3.19e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.27  E-value: 3.19e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032650139  799 CACPLSSSAnnfSPTCQLseEGGiVCDkCLPGYTGSQCERCANGYYGNPLMAGQSC 854
Cdd:pfam00053    1 CDCNPHGSL---SDTCDP--ETG-QCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1460-1514 4.28e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.28e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 1460 CACPraNPASFSPTCVLkgvHDYHCDaCLPGYEGQYCERCSPGYYGAPRLPGGSC 1514
Cdd:pfam00053    1 CDCN--PHGSLSDTCDP---ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 278-325 1.63e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  278 CICYGHA---RSCplDEITkkLQCQCEHNTCGESCNKCCPGYHQKPWRPGT 325
Cdd:cd00055      2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
717-740 4.41e-03

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 4.41e-03
                            10        20
                    ....*....|....*....|....
gi 2032650139   717 CECPQGYTGLSCESCLPGYYRVDG 740
Cdd:smart00180   20 CECKPNVTGRRCDRCAPGYYGDGP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1369-1390 5.49e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 5.49e-03
                           10        20
                   ....*....|....*....|..
gi 2032650139 1369 QCRCPAGYTGLSCQSCAPGYYR 1390
Cdd:cd00055     20 QCECKPNTTGRRCDRCAPGYYG 41
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 24-276 7.63e-97

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 312.76  E-value: 7.63e-97
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139    24 QGQPRGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPlrnaQCRVCDSHsaNPKEQHPISSAIDGTN----N 99
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDAR--NPRRSHPAENLTDGNNpnnpT 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   100 WWQSPSIQNGRQYhwVTITLDLRQVFQVAYVIIKAAnAPRPGNWILERSIDGTEFRPWQYYAisdTECLTRYNITPRIGP 179
Cdd:smart00136   75 WWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   180 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SQKLLEFTSARYIRLRLQRIRTLNADLMTLShndpkel 257
Cdd:smart00136  149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220

                           250
                    ....*....|....*....
gi 2032650139   258 dPIVTRRYYYSIKDISVGG 276
Cdd:smart00136  221 -PEVTRRYYYAISDIAVGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
30-276 3.36e-86

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 281.78  E-value: 3.36e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   30 LFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRplrnaQCRVCDSHsaNPKEQHPISSAIDGTNN----WWQSPS 105
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGGK-----KCFICDSR--DPHNSHPPSNLTDSNNGtnetWWQSET 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  106 IQngRQYHWVTITLDLRQVFQVAYVIIKAAnAPRPGNWILERSID-GTEFRPWQYYAisdTECLTRYNITPRigPPTYKR 184
Cdd:pfam00055   74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  185 DDEVICTSYYSRLVPLEHGEIHTSLINGRPSA--DDPSQKLLEFTSARYIRLRLQRIRTLNADLMTlshndpkelDPIVT 262
Cdd:pfam00055  146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLGDELLD---------DPSVL 216

                          250
                   ....*....|....
gi 2032650139  263 RRYYYSIKDISVGG 276
Cdd:pfam00055  217 RKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
1226-1368 8.08e-49

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 170.91  E-value: 8.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1226 YWKLPEQFQGDQLMAYGGKLRYTVAFYALDGFGTSNFEPQILMKGGHTSKLVIYADIPSPENGVRTDKEVEMKEDSWKYF 1305
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032650139 1306 NSVsdePVLRSDFMSVLSNVEYILIKAAYGQGLQQSRIANISMEIAVkfeEMHLGRPlAHLVE 1368
Cdd:pfam00052   81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAV---PGGSGPP-ASWVE 136
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2024-2158 2.08e-42

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 152.64  E-value: 2.08e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2024 VKELAVSANTSAVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQASLLLDRLKPLKM 2103
Cdd:pfam06009    1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2104 LEEN---LNRNLSEIKELISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLN 2158
Cdd:pfam06009   81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
LamB smart00281
Laminin B domain;
1223-1352 4.09e-40

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 145.87  E-value: 4.09e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1223 ETFYWKLPEQFQGDQLMAYGGKLRYTVAFYALDGfGTSNFEPQILMKGGHTSKLVIYADIPSPENGVRTdkEVEMKEDSW 1302
Cdd:smart00281    3 EPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRG-GTHVSAPDVILEGNGLRISHPAEGPPLPDELTTV--EVRFREENW 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1303 KYFNSvsdEPVLRSDFMSVLSNVEYILIKAAYGQGLQQSRIANISMEIAV 1352
Cdd:smart00281   80 QYYGG---RPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAV 126
Laminin_B pfam00052
Laminin B (Domain IV);
576-715 1.26e-39

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 144.72  E-value: 1.26e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  576 YWSAPEAYLGNKLTAFSGDLKYTVSYDIPMESVDSdiVSSVDVIIQGNGQILSTR-AAGLSLQPYEEYSNSVRLVSDNFi 654
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL--NSEPDVILEGNGLRLSYSsPDQPPPDPGQEQTYSVRLHEENW- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  655 EFNTKKAIDREMLMTVLANVTHLLIRANYNIAKKAVyRLDSVTLDTASANVIDLsSAPDVE 715
Cdd:pfam00052   78 RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSGP-PASWVE 136
Laminin_G_1 pfam00054
Laminin G domain;
2767-2895 1.66e-38

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 141.30  E-value: 1.66e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2767 RTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAVVSDGKWHTVKTEYVKRKGTIIVDGQELVAVNA 2846
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2847 LGDG-STLDVEGKLYVGGLPLDYIPKNLGNVTHSIPACIGSMTINGKQLD 2895
Cdd:pfam00054   82 PLGAtTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2320-2476 2.92e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 2.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2320 SFHFDGSGY-SVVEKALRSTVTQILISFSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTENRYNNG 2398
Cdd:cd00110      1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2399 TWYKISFNRNKKQGILTVmDAYNLnyketkqGESPGVASDLNRSDKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEI 2476
Cdd:cd00110     81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1584-1834 6.49e-38

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 144.48  E-value: 6.49e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1584 LSVN-LTGIDRVPYGILSELENATQHLKRSIVPREDPTYSLDTTKENLLNLSGGIDYLHEETTRFLKKAQQLDTMTQKTR 1662
Cdd:pfam06008    2 LSLNsLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1663 NKSQELTGFIDTVHTTIKVLAEVALSLNETlglDLPLSNAASQSLQDDISALLDALRKKDFVQQHHNATTVLKAAEKLLT 1742
Cdd:pfam06008   82 GHAKELAEAIKNLIDNIKEINEKVATLGEN---DFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1743 QVQKEYFKPQQELAELKRNASQFLSKQSSRLQDAQDLVNEALTNINEIRRLFPLISSNLAELNDKKLKIKEGEEISTMLI 1822
Cdd:pfam06008  159 RIQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETL 238

                          250
                   ....*....|..
gi 2032650139 1823 KEGKVLLNDAAA 1834
Cdd:pfam06008  239 KTARDSLDAANL 250
LamG smart00282
Laminin G domain;
2341-2478 4.57e-35

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 131.31  E-value: 4.57e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2341 QILISFSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTE-NRYNNGTWYKISFNRNKKQGILTVmda 2419
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSV--- 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139  2420 ynlNYKETKQGESPGVASDLNRsdKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEISR 2478
Cdd:smart00282   78 ---DGGNRVSGESPGGLTILNL--DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2915-3068 4.52e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 129.46  E-value: 4.52e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2915 GTFFDGSGFAALVREGYKvRSDVNISLEFRTTAVHGVLLGVSSA-KVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtn 2993
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--- 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2994 sLCDGKWHKLQANKSKHHISLIIDGNLVHTDNPYVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:cd00110     77 -LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamB smart00281
Laminin B domain;
575-702 1.05e-33

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 127.38  E-value: 1.05e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   575 YYWSAPEAYLGNKLTAFSGDLKYTVSYDIPmesVDSDIVSSVDVIIQGNGQILSTRAAGlSLQPYEEYSNSVRLVSDNFI 654
Cdd:smart00281    5 VYWVAPEQFLGDKVTSYGGKLRYTLSFDGR---RGGTHVSAPDVILEGNGLRISHPAEG-PPLPDELTTVEVRFREENWQ 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 2032650139   655 EFNtKKAIDREMLMTVLANVTHLLIRANYNiAKKAVYRLDSVTLDTAS 702
Cdd:smart00281   81 YYG-GRPVTREDLMMVLANLTAILIRATYS-QQMAGSRLSDVSLEVAV 126
LamG smart00282
Laminin G domain;
2154-2293 7.56e-33

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 125.14  E-value: 7.56e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2154 TLTLNVKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDFQIDNNKWHRIHATRFGKTGTLSIeem 2233
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--- 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2234 nsDQKPsPKSGTSLGTASILDVNksTLMFIGGLGGQIKKSPAVKVTHFKGCLGEASLNGK 2293
Cdd:smart00282   78 --DGGN-RVSGESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2938-3068 2.43e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 120.91  E-value: 2.43e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2938 NISLEFRTTAVHGVLLGVSSA-KVDAIGLEIVHGKVLFHVNNGAGRITASYEPrgtNSLCDGKWHKLQANKSKHHISLII 3016
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  3017 DG-NLVHTDNPyVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:smart00282   78 DGgNRVSGESP-GGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2743-2890 8.06e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.22  E-value: 8.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2743 KGSHLTLLFNQSAVRKKLSVQLNLRTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAVVSDGKWHT 2822
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2823 VKTEYVKRKGTIIVDGQELVAVNALGDGSTLDVEGKLYVGGLPLDYIPKnLGNVTHSIPACIGSMTIN 2890
Cdd:cd00110     85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2761-2892 8.17e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 8.17e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2761 SVQLNLRTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAV-VSDGKWHTVKTEYVKRKGTIIVDGQ 2839
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  2840 ELVAVNALGDGSTLDVEGKLYVGGLPLDYIPKNLgNVTHSIPACIGSMTINGK 2892
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2142-2291 4.70e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.90  E-value: 4.70e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2142 AYQPQISSTNYNTLTLNVKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDfQIDNNKWHRIHATR 2221
Cdd:cd00110     11 RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVER 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2222 FGKTGTLSIEEMNSDQKPSPKSGTSLgtasildvNKSTLMFIGGLGGQIKKSPAVKVTHFKGCLGEASLN 2291
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGGSALL--------NLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
2159-2296 1.51e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 115.49  E-value: 1.51e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2159 VKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDfQIDNNKWHRIHATRFGKTGTLSIeemnsDQK 2238
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTLSV-----DGE 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139 2239 PSPKSGTSLGTASILDVNksTLMFIGGLGGQI-KKSPAVKVTHFKGCLGEASLNGKSVG 2296
Cdd:pfam00054   75 ARPTGESPLGATTDLDVD--GPLYVGGLPSLGvKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
2346-2478 2.04e-28

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 112.41  E-value: 2.04e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2346 FSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTENRYNNGTWYKISFNRNKKQGILTVmdaynlNYK 2425
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSV------DGE 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2426 ETKQGESP-GVASDLNRsdKDPIFIGGLPRSRALRKGL-NSRMYVGCIKNLEISR 2478
Cdd:pfam00054   75 ARPTGESPlGATTDLDV--DGPLYVGGLPSLGVKKRRLaISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
2943-3072 3.32e-26

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 106.25  E-value: 3.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2943 FRTTAVHGVLL-GVSSAKVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtnsLCDGKWHKLQANKSKHHISLIIDGNLV 3021
Cdd:pfam00054    1 FRTTEPSGLLLyNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK----LNDGKWHSVELERNGRSGTLSVDGEAR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139 3022 HT-DNPYVQSTSADTNNPIYVGGYPADVKQN-CLTSKSSFRGCLRNLVLTKGQ 3072
Cdd:pfam00054   77 PTgESPLGATTDLDVDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNGKP 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2501-2665 1.92e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 1.92e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2501 SVSIMNNGYIELVPKSL-SPESELMATFATKNSSGIILAGLSrglekrqrrQAHLPFFSIMLIDGHLAVHVNAGdrasTR 2579
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGS---------QNGGDFLALELEDGRLVLRYDLG----SG 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2580 KVVLQSANgTYSDGQEHSVILIRNKRIITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCI 2659
Cdd:cd00110     68 SLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD-GPLYLGGLPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2032650139 2660 SNLIFN 2665
Cdd:cd00110    146 RDLKVN 151
LamG smart00282
Laminin G domain;
2526-2667 1.32e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 95.87  E-value: 1.32e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2526 TFATKNSSGIILAGLSRGlekrqrrqaHLPFFSIMLIDGHLAVHVNAGDRastrKVVLQSANGTYSDGQEHSVILIRNKR 2605
Cdd:smart00282    5 SFRTTSPNGLLLYAGSKG---------GGDYLALELRDGRLVLRYDLGSG----PARLTSDPTPLNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2032650139  2606 IITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCISNLIFNKE 2667
Cdd:smart00282   72 SVTLSVDGGNRVSGESPGGLTILNLD-GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2527-2667 2.45e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 2.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2527 FATKNSSGIIL-AGLSRGlekrqrrqahlPFFSIMLIDGHLAVHVNAGDRastrKVVLQSANGTYSDGQEHSVILIRNKR 2605
Cdd:pfam02210    1 FRTRQPNGLLLyAGGGGS-----------DFLALELVNGRLVLRYDLGSG----PESLLSSGKNLNDGQWHSVRVERNGN 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2032650139 2606 IITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCISNLIFNKE 2667
Cdd:pfam02210   66 TLTLSVDGQTVVSSLPPGESLLLNLN-GPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1052-1100 4.75e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 4.75e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139 1052 CNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGYRDYPDCVACDC 1100
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1516-1554 4.87e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.76  E-value: 4.87e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2032650139 1516 PCQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
959-1003 6.59e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 62.33  E-value: 6.59e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   959 CNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFYAFQDGGC 1003
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1517-1554 7.52e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 7.52e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2032650139 1517 CQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1411-1457 1.38e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1411 CQCNNH---SETCDPDTGKCLdCRDNTVGDHCSACAPGYYGKVTGSANDC 1457
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 959-1006 1.55e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139  959 CNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFYAFQDGGCTPC 1006
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1098-1155 1.92e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.92e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 1098 CDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANSALGC 1155
Cdd:pfam00053    1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 909-957 1.97e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 1.97e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  909 ACACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGL-LTGLGCV 957
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1517-1554 2.42e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.79  E-value: 2.42e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2032650139  1517 CQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 910-956 2.48e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.83  E-value: 2.48e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2032650139  910 CACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGLLTGLGC 956
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 749-797 3.40e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 3.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  749 PCKCNGHAT---ECD-IHGVCFaCQHNTTGPFCDQCLPGFYGNPSQGtsEDCQ 797
Cdd:cd00055      1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG--GGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
910-956 3.68e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.40  E-value: 3.68e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2032650139   910 CACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGlLTGLGC 956
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 405-464 4.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 4.00e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  405 CDCDPFGSLSSVCVKdehhsdsqrgtWPGQCQCREGYAGEKCDRCAFGYRGYPNCLRCNC 464
Cdd:pfam00053    1 CDCNPHGSLSDTCDP-----------ETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 856-908 5.08e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.06  E-value: 5.08e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  856 PCECNGNVNPQeeGHCDPFTGQCLkCLGNTAGHHCEKCADGYYGDAVIDKNCR 908
Cdd:cd00055      1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 462-508 9.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 9.00e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139  462 CNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNLQERNPQGC 508
Cdd:pfam00053    1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 958-1004 9.88e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 9.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  958 PCNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFY--AFQDGGCT 1004
Cdd:cd00055      1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYglPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1051-1094 1.63e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 1.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2032650139 1051 ACNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGYRDYPD 1094
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1410-1448 2.22e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.13  E-value: 2.22e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2032650139 1410 PCQCNNH---SETCDPDTGKCLdCRDNTVGDHCSACAPGYYG 1448
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1052-1095 3.52e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 57.32  E-value: 3.52e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139  1052 CNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGY--RDYPDC 1095
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYygDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 857-901 8.21e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 8.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2032650139  857 CECNGNVNPQeeGHCDPFTGQCLkCLGNTAGHHCEKCADGYYGDA 901
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1098-1151 1.44e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 1.44e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2032650139  1098 CDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANS 1151
Cdd:smart00180    1 CDCDPGGSASGTCD---------PDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1005-1050 2.33e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.44  E-value: 2.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1005 PCDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLSPK-LGCK 1050
Cdd:cd00055      1 PCDCnghGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1411-1457 2.59e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 2.59e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1411 CQCN---NHSETCDPDTGKCLdCRDNTVGDHCSACAPGYYGKvtgSANDC 1457
Cdd:smart00180    1 CDCDpggSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD---GPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 404-457 3.06e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 3.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2032650139  404 PCDCDPFGSLSSVCVKDEhhsdsqrgtwpGQCQCREGYAGEKCDRCAFGYRGYP 457
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGT-----------GQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1006-1049 8.14e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 8.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2032650139  1006 CDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLSPKlGC 1049
Cdd:smart00180    1 CDCdpgGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP-GC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
405-457 9.43e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 9.43e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139   405 CDCDPFGSLSSVCVKDEhhsdsqrgtwpGQCQCREGYAGEKCDRCAFGYRGYP 457
Cdd:smart00180    1 CDCDPGGSASGTCDPDT-----------GQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 750-789 1.26e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.26e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2032650139  750 CKCNGHAT---ECDIH-GVCFaCQHNTTGPFCDQCLPGFYGNPS 789
Cdd:pfam00053    1 CDCNPHGSlsdTCDPEtGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1097-1156 1.44e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 1.44e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1097 ACDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANsALGCT 1156
Cdd:cd00055      1 PCDCNGHGSLSGQCD---------PGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
462-508 2.19e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 2.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2032650139   462 CNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNlqeRNPQGC 508
Cdd:smart00180    1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 461-509 2.97e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 2.97e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  461 RCNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNLQERnPQGCT 509
Cdd:cd00055      1 PCDCNGHGSLSGqcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
857-900 4.26e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.54  E-value: 4.26e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   857 CECN--GNVNPQeeghCDPFTGQCLkCLGNTAGHHCEKCADGYYGD 900
Cdd:smart00180    1 CDCDpgGSASGT----CDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1006-1049 1.08e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139 1006 CDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLS--PKLGC 1049
Cdd:pfam00053    1 CDCnphGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 799-854 3.19e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.27  E-value: 3.19e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032650139  799 CACPLSSSAnnfSPTCQLseEGGiVCDkCLPGYTGSQCERCANGYYGNPLMAGQSC 854
Cdd:pfam00053    1 CDCNPHGSL---SDTCDP--ETG-QCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
750-791 3.86e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   750 CKCN--GHATE-CD-IHGVCFaCQHNTTGPFCDQCLPGFYGNPSQG 791
Cdd:smart00180    1 CDCDpgGSASGtCDpDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1460-1514 4.28e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.28e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 1460 CACPraNPASFSPTCVLkgvHDYHCDaCLPGYEGQYCERCSPGYYGAPRLPGGSC 1514
Cdd:pfam00053    1 CDCN--PHGSLSDTCDP---ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 278-325 1.63e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  278 CICYGHA---RSCplDEITkkLQCQCEHNTCGESCNKCCPGYHQKPWRPGT 325
Cdd:cd00055      2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1459-1515 3.25e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032650139 1459 PCACPRAnpASFSPTCVlkgVHDYHCDaCLPGYEGQYCERCSPGYYGAPRLPGGsCR 1515
Cdd:cd00055      1 PCDCNGH--GSLSGQCD---PGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG-CQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 798-854 7.78e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 7.78e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032650139  798 PCACPLSSSANnfsPTCqlsEEGGIVCDkCLPGYTGSQCERCANGYYGNPLmAGQSC 854
Cdd:cd00055      1 PCDCNGHGSLS---GQC---DPGTGQCE-CKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1587-1830 3.80e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.63  E-value: 3.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1587 NLTGIDRVPYGILSELENATQHLKRSIvprEDPTYSLDTTKENLlnlsggidylhEETTRFLK-KAQQLDTMTQKTRNKS 1665
Cdd:TIGR04523  444 DLTNQDSVKELIIKNLDNTRESLETQL---KVLSRSINKIKQNL-----------EQKQKELKsKEKELKKLNEEKKELE 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1666 QEltgfidtvhttIKVLAEVALSLNETLGldlPLSNAASQsLQDDISALLDALRKKDFVqqhhnattvlKAAEKLLTQVQ 1745
Cdd:TIGR04523  510 EK-----------VKDLTKKISSLKEKIE---KLESEKKE-KESKISDLEDELNKDDFE----------LKKENLEKEID 564

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1746 KEyfkpQQELAELKRNASQFLSKQSSRLQDAQDLVNEALTNINEIRRLFPLISSNLAELNDKKlkiKEGEEISTML--IK 1823
Cdd:TIGR04523  565 EK----NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAK---KENEKLSSIIknIK 637


                   ....*..
gi 2032650139 1824 EGKVLLN 1830
Cdd:TIGR04523  638 SKKNKLK 644
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
799-847 6.17e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 6.17e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2032650139   799 CACPLSssaNNFSPTCqlsEEGGIVCDkCLPGYTGSQCERCANGYYGNP 847
Cdd:smart00180    1 CDCDPG---GSASGTC---DPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1460-1507 7.22e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.30  E-value: 7.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2032650139  1460 CACPRANpaSFSPTCVLKGVHdyhCDaCLPGYEGQYCERCSPGYYGAP 1507
Cdd:smart00180    1 CDCDPGG--SASGTCDPDTGQ---CE-CKPNVTGRRCDRCAPGYYGDG 42
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1965-2165 3.06e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1965 QNEAKNLKKKSDGLLFGLNGLNKKVEKIQESTNKIGNQLNDS---LLTFRA----LHNNARKRMLEVKELAVSANTS--- 2034
Cdd:COG3883     22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALqaeIDKLQAeiaeAEAEIEERREELGERARALYRSggs 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2035 -----AVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQASLLLDRLKplkmleeNLN 2109
Cdd:COG3883    102 vsyldVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA-------ELE 174

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032650139 2110 RNLSEIKELISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTAEPD 2165
Cdd:COG3883    175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1952-2158 4.47e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.17  E-value: 4.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1952 LLGKETLLlsSKFQNEAKNLKKKSDGLLFGLNGLNKKVEKIQESTNKIGNQLNDSLLTFRAL------HNNARKRMLEVK 2025
Cdd:TIGR04523  147 IKKKEKEL--EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLkkkiqkNKSLESQISELK 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2026 ELAVSANTSAVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQasllldrLKPLKMLE 2105
Cdd:TIGR04523  225 KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQ-------LNQLKSEI 297

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2106 ENLNRN-----LSEIKELISQARKQaasikvavsadrdcIRAYQPQISSTNYNTLTLN 2158
Cdd:TIGR04523  298 SDLNNQkeqdwNKELKSELKNQEKK--------------LEEIQNQISQNNKIISQLN 341
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1627-1841 6.65e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 44.67  E-value: 6.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1627 KENLLNLsggIDYLHEETTRFLKKAQQLDTMTQKTRNKSQELTGFIDTVHTTIKVLaevalsLNETLGLdlpLSNAASQS 1706
Cdd:cd22656    116 KKTIKAL---LDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDL------LTDEGGA---IARKEIKD 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1707 LQDDISALLDALRKKdfvqqhhnattvlkaAEKLLTQVQKEYFKPQQELAELKRnASQFLSKQSSRLQDAQDLVNEALTN 1786
Cdd:cd22656    184 LQKELEKLNEEYAAK---------------LKAKIDELKALIADDEAKLAAALR-LIADLTAADTDLDNLLALIGPAIPA 247

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139 1787 INEIRRLFPLISSNLAELNDkKLKIKEGEEISTMLIKEGkvlLNDA----AAVAQDVKN 1841
Cdd:cd22656    248 LEKLQGAWQAIATDLDSLKD-LLEDDISKIPAAILAKLE---LEKAiekwNELAEKADK 302
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
297-321 7.28e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 7.28e-04
                            10        20
                    ....*....|....*....|....*
gi 2032650139   297 QCQCEHNTCGESCNKCCPGYHQKPW 321
Cdd:smart00180   19 QCECKPNVTGRRCDRCAPGYYGDGP 43
TNFRSF16 cd13416
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ...
 717-922 2.92e-03

Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.


Pssm-ID: 276921 [Multi-domain]  Cd Length: 159  Bit Score: 41.13  E-value: 2.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  717 CECPQGY---TGLSCESCLPGyyrvdgilfggicqpckcnghatecdiHGVCFACQHNTTGpfCDQCLPGFYGNPSQGTS 793
Cdd:cd13416      1 EACPSGQytsSGECCEQCPPG---------------------------EGVARPCGDNQTV--CEPCLDGVTFSDVVSHT 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  794 EDCQPCA-CPLSSsannfSPTCQLSEEGGIVCdkclpgytgsqceRCANGYYGNPLMagQSCAPCEcngnVNPQEEG--- 869
Cdd:cd13416     52 EPCQPCTrCPGLM-----SMRAPCTATHDTVC-------------ECAYGYYLDEDS--GTCEPCT----VCPPGQGvvq 107

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139  870 HCDPftgqclkcLGNTAghhCEKCADGYYGDAVIDKN-CRACA-CHVNGSLSSTC 922
Cdd:cd13416    108 SCGP--------NQDTV---CEACPEGTYSDEDSSTDpCLPCTvCEDGEVELREC 151
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 1371-1536 3.69e-03

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 42.98  E-value: 3.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1371 RCPAGYTGLSCQSCA---PGYYRGKHTElsVREPHALIAPCVPCQCN----NHSETCDPDTGKCLDCRDNTVgDHCSACA 1443
Cdd:PTZ00214   378 RCSAGYLGVDGKSCSescSGDTRGVCTK--VAEGSESTEVSCRCVCKptfyNSSGTCTPCTDSCAVCKDGTP-TGCQQCS 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1444 PGY---YGKVTGSANDC-------SPCA--------------CPRANPASFSPTCVLKGVHDYHCDACLPGyegqYCERC 1499
Cdd:PTZ00214   455 PGKileFSIVSSESADCvdqcsvgSECAecgitidgsryctrCKDASTYPFNGVCIPNTQRDAYCTSTANG----ACTTC 530

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2032650139 1500 SpgyyGAPRLPGGSCRPCQCNPGGSVhgnCDG-ATGQC 1536
Cdd:PTZ00214   531 S----GAAFLMNGGCYTTEHYPGSTI---CDKqSNGKC 561
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
717-740 4.41e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 4.41e-03
                            10        20
                    ....*....|....*....|....
gi 2032650139   717 CECPQGYTGLSCESCLPGYYRVDG 740
Cdd:smart00180   20 CECKPNVTGRRCDRCAPGYYGDGP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1369-1390 5.49e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 5.49e-03
                           10        20
                   ....*....|....*....|..
gi 2032650139 1369 QCRCPAGYTGLSCQSCAPGYYR 1390
Cdd:cd00055     20 QCECKPNTTGRRCDRCAPGYYG 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 717-748 5.88e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 5.88e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2032650139  717 CECPQGYTGLSCESCLPGYYRVDGILFGgiCQ 748
Cdd:cd00055     21 CECKPNTTGRRCDRCAPGYYGLPSQGGG--CQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1369-1390 6.61e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.61e-03
                            10        20
                    ....*....|....*....|..
gi 2032650139  1369 QCRCPAGYTGLSCQSCAPGYYR 1390
Cdd:smart00180   19 QCECKPNVTGRRCDRCAPGYYG 40
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1691-1816 7.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 7.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1691 ETLGLDLPLSNAASQSLQDDISALLDALRkkdfvQQHHNATTVLKAAEKLLTQVQKEYFKPQQELAELKRNASQFlskqS 1770
Cdd:COG4913    369 AALGLPLPASAEEFAALRAEAAALLEALE-----EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI----P 439

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2032650139 1771 SRLQDAQDLVNEALtNINEIRRLFplissnLAELndkkLKIKEGEE 1816
Cdd:COG4913    440 ARLLALRDALAEAL-GLDEAELPF------VGEL----IEVRPEEE 474
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 24-276 7.63e-97

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 312.76  E-value: 7.63e-97
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139    24 QGQPRGLFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRPlrnaQCRVCDSHsaNPKEQHPISSAIDGTN----N 99
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHTEQGK----KCDYCDAR--NPRRSHPAENLTDGNNpnnpT 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   100 WWQSPSIQNGRQYhwVTITLDLRQVFQVAYVIIKAAnAPRPGNWILERSIDGTEFRPWQYYAisdTECLTRYNITPRIGP 179
Cdd:smart00136   75 WWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   180 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SQKLLEFTSARYIRLRLQRIRTLNADLMTLShndpkel 257
Cdd:smart00136  149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220

                           250
                    ....*....|....*....
gi 2032650139   258 dPIVTRRYYYSIKDISVGG 276
Cdd:smart00136  221 -PEVTRRYYYAISDIAVGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
30-276 3.36e-86

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 281.78  E-value: 3.36e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   30 LFPAILNLASNAHISTNATCGEKGPEMFCKLVEHVPGRplrnaQCRVCDSHsaNPKEQHPISSAIDGTNN----WWQSPS 105
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGGK-----KCFICDSR--DPHNSHPPSNLTDSNNGtnetWWQSET 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  106 IQngRQYHWVTITLDLRQVFQVAYVIIKAAnAPRPGNWILERSID-GTEFRPWQYYAisdTECLTRYNITPRigPPTYKR 184
Cdd:pfam00055   74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  185 DDEVICTSYYSRLVPLEHGEIHTSLINGRPSA--DDPSQKLLEFTSARYIRLRLQRIRTLNADLMTlshndpkelDPIVT 262
Cdd:pfam00055  146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLGDELLD---------DPSVL 216

                          250
                   ....*....|....
gi 2032650139  263 RRYYYSIKDISVGG 276
Cdd:pfam00055  217 RKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
1226-1368 8.08e-49

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 170.91  E-value: 8.08e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1226 YWKLPEQFQGDQLMAYGGKLRYTVAFYALDGFGTSNFEPQILMKGGHTSKLVIYADIPSPENGVRTDKEVEMKEDSWKYF 1305
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032650139 1306 NSVsdePVLRSDFMSVLSNVEYILIKAAYGQGLQQSRIANISMEIAVkfeEMHLGRPlAHLVE 1368
Cdd:pfam00052   81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAV---PGGSGPP-ASWVE 136
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 2024-2158 2.08e-42

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 152.64  E-value: 2.08e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2024 VKELAVSANTSAVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQASLLLDRLKPLKM 2103
Cdd:pfam06009    1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2104 LEEN---LNRNLSEIKELISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLN 2158
Cdd:pfam06009   81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
LamB smart00281
Laminin B domain;
1223-1352 4.09e-40

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 145.87  E-value: 4.09e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1223 ETFYWKLPEQFQGDQLMAYGGKLRYTVAFYALDGfGTSNFEPQILMKGGHTSKLVIYADIPSPENGVRTdkEVEMKEDSW 1302
Cdd:smart00281    3 EPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRG-GTHVSAPDVILEGNGLRISHPAEGPPLPDELTTV--EVRFREENW 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1303 KYFNSvsdEPVLRSDFMSVLSNVEYILIKAAYGQGLQQSRIANISMEIAV 1352
Cdd:smart00281   80 QYYGG---RPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAV 126
Laminin_B pfam00052
Laminin B (Domain IV);
576-715 1.26e-39

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 144.72  E-value: 1.26e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  576 YWSAPEAYLGNKLTAFSGDLKYTVSYDIPMESVDSdiVSSVDVIIQGNGQILSTR-AAGLSLQPYEEYSNSVRLVSDNFi 654
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSL--NSEPDVILEGNGLRLSYSsPDQPPPDPGQEQTYSVRLHEENW- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  655 EFNTKKAIDREMLMTVLANVTHLLIRANYNIAKKAVyRLDSVTLDTASANVIDLsSAPDVE 715
Cdd:pfam00052   78 RDSDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSGP-PASWVE 136
Laminin_G_1 pfam00054
Laminin G domain;
2767-2895 1.66e-38

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 141.30  E-value: 1.66e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2767 RTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAVVSDGKWHTVKTEYVKRKGTIIVDGQELVAVNA 2846
Cdd:pfam00054    2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2847 LGDG-STLDVEGKLYVGGLPLDYIPKNLGNVTHSIPACIGSMTINGKQLD 2895
Cdd:pfam00054   82 PLGAtTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2320-2476 2.92e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 2.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2320 SFHFDGSGY-SVVEKALRSTVTQILISFSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTENRYNNG 2398
Cdd:cd00110      1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2399 TWYKISFNRNKKQGILTVmDAYNLnyketkqGESPGVASDLNRSDKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEI 2476
Cdd:cd00110     81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1584-1834 6.49e-38

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 144.48  E-value: 6.49e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1584 LSVN-LTGIDRVPYGILSELENATQHLKRSIVPREDPTYSLDTTKENLLNLSGGIDYLHEETTRFLKKAQQLDTMTQKTR 1662
Cdd:pfam06008    2 LSLNsLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1663 NKSQELTGFIDTVHTTIKVLAEVALSLNETlglDLPLSNAASQSLQDDISALLDALRKKDFVQQHHNATTVLKAAEKLLT 1742
Cdd:pfam06008   82 GHAKELAEAIKNLIDNIKEINEKVATLGEN---DFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLS 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1743 QVQKEYFKPQQELAELKRNASQFLSKQSSRLQDAQDLVNEALTNINEIRRLFPLISSNLAELNDKKLKIKEGEEISTMLI 1822
Cdd:pfam06008  159 RIQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETL 238

                          250
                   ....*....|..
gi 2032650139 1823 KEGKVLLNDAAA 1834
Cdd:pfam06008  239 KTARDSLDAANL 250
LamG smart00282
Laminin G domain;
2341-2478 4.57e-35

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 131.31  E-value: 4.57e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2341 QILISFSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTE-NRYNNGTWYKISFNRNKKQGILTVmda 2419
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDpTPLNDGQWHRVAVERNGRSVTLSV--- 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139  2420 ynlNYKETKQGESPGVASDLNRsdKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEISR 2478
Cdd:smart00282   78 ---DGGNRVSGESPGGLTILNL--DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2915-3068 4.52e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 129.46  E-value: 4.52e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2915 GTFFDGSGFAALVREGYKvRSDVNISLEFRTTAVHGVLLGVSSA-KVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtn 2993
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--- 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2994 sLCDGKWHKLQANKSKHHISLIIDGNLVHTDNPYVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:cd00110     77 -LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
LamB smart00281
Laminin B domain;
575-702 1.05e-33

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 127.38  E-value: 1.05e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139   575 YYWSAPEAYLGNKLTAFSGDLKYTVSYDIPmesVDSDIVSSVDVIIQGNGQILSTRAAGlSLQPYEEYSNSVRLVSDNFI 654
Cdd:smart00281    5 VYWVAPEQFLGDKVTSYGGKLRYTLSFDGR---RGGTHVSAPDVILEGNGLRISHPAEG-PPLPDELTTVEVRFREENWQ 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 2032650139   655 EFNtKKAIDREMLMTVLANVTHLLIRANYNiAKKAVYRLDSVTLDTAS 702
Cdd:smart00281   81 YYG-GRPVTREDLMMVLANLTAILIRATYS-QQMAGSRLSDVSLEVAV 126
LamG smart00282
Laminin G domain;
2154-2293 7.56e-33

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 125.14  E-value: 7.56e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2154 TLTLNVKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDFQIDNNKWHRIHATRFGKTGTLSIeem 2233
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--- 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2234 nsDQKPsPKSGTSLGTASILDVNksTLMFIGGLGGQIKKSPAVKVTHFKGCLGEASLNGK 2293
Cdd:smart00282   78 --DGGN-RVSGESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2938-3068 2.43e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 120.91  E-value: 2.43e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2938 NISLEFRTTAVHGVLLGVSSA-KVDAIGLEIVHGKVLFHVNNGAGRITASYEPrgtNSLCDGKWHKLQANKSKHHISLII 3016
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  3017 DG-NLVHTDNPyVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:smart00282   78 DGgNRVSGESP-GGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2743-2890 8.06e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.22  E-value: 8.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2743 KGSHLTLLFNQSAVRKKLSVQLNLRTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAVVSDGKWHT 2822
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2823 VKTEYVKRKGTIIVDGQELVAVNALGDGSTLDVEGKLYVGGLPLDYIPKnLGNVTHSIPACIGSMTIN 2890
Cdd:cd00110     85 VSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2761-2892 8.17e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 8.17e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2761 SVQLNLRTFASTGLIYYMAHQNQVDYAALQLYAGQLHFSFDLGKGKAVALHPAV-VSDGKWHTVKTEYVKRKGTIIVDGQ 2839
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  2840 ELVAVNALGDGSTLDVEGKLYVGGLPLDYIPKNLgNVTHSIPACIGSMTINGK 2892
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2142-2291 4.70e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.90  E-value: 4.70e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2142 AYQPQISSTNYNTLTLNVKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDfQIDNNKWHRIHATR 2221
Cdd:cd00110     11 RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVER 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2222 FGKTGTLSIEEMNSDQKPSPKSGTSLgtasildvNKSTLMFIGGLGGQIKKSPAVKVTHFKGCLGEASLN 2291
Cdd:cd00110     90 NGRSVTLSVDGERVVESGSPGGSALL--------NLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_1 pfam00054
Laminin G domain;
2159-2296 1.51e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 115.49  E-value: 1.51e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2159 VKTAEPDNLLFYLGSNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDfQIDNNKWHRIHATRFGKTGTLSIeemnsDQK 2238
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTLSV-----DGE 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139 2239 PSPKSGTSLGTASILDVNksTLMFIGGLGGQI-KKSPAVKVTHFKGCLGEASLNGKSVG 2296
Cdd:pfam00054   75 ARPTGESPLGATTDLDVD--GPLYVGGLPSLGvKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
2346-2478 2.04e-28

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 112.41  E-value: 2.04e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2346 FSTFSPNGLLLYLSSNGTRDFLSLELVDGKVRVTVDLGSGPLALTTENRYNNGTWYKISFNRNKKQGILTVmdaynlNYK 2425
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSV------DGE 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2426 ETKQGESP-GVASDLNRsdKDPIFIGGLPRSRALRKGL-NSRMYVGCIKNLEISR 2478
Cdd:pfam00054   75 ARPTGESPlGATTDLDV--DGPLYVGGLPSLGVKKRRLaISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
2943-3072 3.32e-26

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 106.25  E-value: 3.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2943 FRTTAVHGVLL-GVSSAKVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtnsLCDGKWHKLQANKSKHHISLIIDGNLV 3021
Cdd:pfam00054    1 FRTTEPSGLLLyNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK----LNDGKWHSVELERNGRSGTLSVDGEAR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139 3022 HT-DNPYVQSTSADTNNPIYVGGYPADVKQN-CLTSKSSFRGCLRNLVLTKGQ 3072
Cdd:pfam00054   77 PTgESPLGATTDLDVDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNGKP 129
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2943-3068 7.02e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 7.02e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2943 FRTTAVHGVLLGVSSAKVDAIGLEIVHGKVLFHVNNGAGRITASYEPRgtnSLCDGKWHKLQANKSKHHISLIIDGNLVH 3022
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGK---NLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2032650139 3023 TDNPYVQSTSADTNNPIYVGGYPADVKQNCLTSKSSFRGCLRNLVL 3068
Cdd:pfam02210   78 SSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2346-2476 9.12e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 9.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2346 FSTFSPNGLLLYlSSNGTRDFLSLELVDGKVRVTVDLGSGPLALT-TENRYNNGTWYKISFNRNKKQGILTVmdaynlNY 2424
Cdd:pfam02210    1 FRTRQPNGLLLY-AGGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSV------DG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2032650139 2425 KETKQGESPGVASDLNrsDKDPIFIGGLPRSRALRKGLNSRMYVGCIKNLEI 2476
Cdd:pfam02210   74 QTVVSSLPPGESLLLN--LNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2501-2665 1.92e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 1.92e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2501 SVSIMNNGYIELVPKSL-SPESELMATFATKNSSGIILAGLSrglekrqrrQAHLPFFSIMLIDGHLAVHVNAGdrasTR 2579
Cdd:cd00110      1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGS---------QNGGDFLALELEDGRLVLRYDLG----SG 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2580 KVVLQSANgTYSDGQEHSVILIRNKRIITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCI 2659
Cdd:cd00110     68 SLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD-GPLYLGGLPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2032650139 2660 SNLIFN 2665
Cdd:cd00110    146 RDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2766-2892 5.11e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.80  E-value: 5.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2766 LRTFASTGLIYYmAHQNQVDYAALQLYAGQLHFSFDLGKGKAVAL-HPAVVSDGKWHTVKTEYVKRKGTIIVDGQELVAV 2844
Cdd:pfam02210    1 FRTRQPNGLLLY-AGGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2032650139 2845 NALGDGSTLDVEGKLYVGGLPLDYIPKNLGnVTHSIPACIGSMTINGK 2892
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2526-2667 1.32e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 95.87  E-value: 1.32e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  2526 TFATKNSSGIILAGLSRGlekrqrrqaHLPFFSIMLIDGHLAVHVNAGDRastrKVVLQSANGTYSDGQEHSVILIRNKR 2605
Cdd:smart00282    5 SFRTTSPNGLLLYAGSKG---------GGDYLALELRDGRLVLRYDLGSG----PARLTSDPTPLNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2032650139  2606 IITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCISNLIFNKE 2667
Cdd:smart00282   72 SVTLSVDGGNRVSGESPGGLTILNLD-GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2159-2293 8.24e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.25  E-value: 8.24e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2159 VKTAEPDNLLFYLGsNGKTDFLAVEMRRGKVALLWDLGSGPTRVEYPDFQIDNNKWHRIHATRFGKTGTLSIeemnsDQK 2238
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV-----DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2239 PsPKSGTSLGTASILDVNKStlMFIGGLGGQIKKSPAVKVTHFKGCLGEASLNGK 2293
Cdd:pfam02210   75 T-VVSSLPPGESLLLNLNGP--LYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2527-2667 2.45e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 2.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2527 FATKNSSGIIL-AGLSRGlekrqrrqahlPFFSIMLIDGHLAVHVNAGDRastrKVVLQSANGTYSDGQEHSVILIRNKR 2605
Cdd:pfam02210    1 FRTRQPNGLLLyAGGGGS-----------DFLALELVNGRLVLRYDLGSG----PESLLSSGKNLNDGQWHSVRVERNGN 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2032650139 2606 IITVQVDESKPAELRLGSAAENSPINiSNFYAGGIPAGEGILGLKLAGSFHGCISNLIFNKE 2667
Cdd:pfam02210   66 TLTLSVDGQTVVSSLPPGESLLLNLN-GPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
2527-2669 7.55e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.06  E-value: 7.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2527 FATKNSSGIIL-AGlsrglekrqrRQAHLPFFSIMLIDGHLAVHVNAGDRAstrkvVLQSANGTYSDGQEHSVILIRNKR 2605
Cdd:pfam00054    1 FRTTEPSGLLLyNG----------TQTERDFLALELRDGRLEVSYDLGSGA-----AVVRSGDKLNDGKWHSVELERNGR 65

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 2606 IITVQVDESKPAELRLGSAAENSPINISNFYAGGIP-AGEGILGLKLAGSFHGCISNLIFNKELL 2669
Cdd:pfam00054   66 SGTLSVDGEARPTGESPLGATTDLDVDGPLYVGGLPsLGVKKRRLAISPSFDGCIRDVIVNGKPL 130
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1052-1100 4.75e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.76  E-value: 4.75e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139 1052 CNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGYRDYPDCVACDC 1100
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1516-1554 4.87e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.76  E-value: 4.87e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2032650139 1516 PCQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
959-1003 6.59e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 62.33  E-value: 6.59e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   959 CNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFYAFQDGGC 1003
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1517-1554 7.52e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 7.52e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2032650139 1517 CQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1411-1457 1.38e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 1.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1411 CQCNNH---SETCDPDTGKCLdCRDNTVGDHCSACAPGYYGKVTGSANDC 1457
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 959-1006 1.55e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.55e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139  959 CNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFYAFQDGGCTPC 1006
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1098-1155 1.92e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.22  E-value: 1.92e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 1098 CDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANSALGC 1155
Cdd:pfam00053    1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 909-957 1.97e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 1.97e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  909 ACACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGL-LTGLGCV 957
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1517-1554 2.42e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.79  E-value: 2.42e-11
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2032650139  1517 CQCNPGGSVHGNCDGATGQCPCKPGVTGQLCEECEPRH 1554
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 910-956 2.48e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.83  E-value: 2.48e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2032650139  910 CACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGLLTGLGC 956
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 749-797 3.40e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 3.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  749 PCKCNGHAT---ECD-IHGVCFaCQHNTTGPFCDQCLPGFYGNPSQGtsEDCQ 797
Cdd:cd00055      1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQG--GGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
910-956 3.68e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 60.40  E-value: 3.68e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2032650139   910 CACHVNGSLSSTCQHETGICSCKSNVIGERCDKCLNGYYGlLTGLGC 956
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 405-464 4.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 4.00e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  405 CDCDPFGSLSSVCVKdehhsdsqrgtWPGQCQCREGYAGEKCDRCAFGYRGYPNCLRCNC 464
Cdd:pfam00053    1 CDCNPHGSLSDTCDP-----------ETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 856-908 5.08e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.06  E-value: 5.08e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139  856 PCECNGNVNPQeeGHCDPFTGQCLkCLGNTAGHHCEKCADGYYGDAVIDKNCR 908
Cdd:cd00055      1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 462-508 9.00e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 9.00e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139  462 CNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNLQERNPQGC 508
Cdd:pfam00053    1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 958-1004 9.88e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 9.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  958 PCNCSQFGSVSEDCN-HHGQCHCVPGVAGEKCDRCAHGFY--AFQDGGCT 1004
Cdd:cd00055      1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYglPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1051-1094 1.63e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 1.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2032650139 1051 ACNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGYRDYPD 1094
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1410-1448 2.22e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.13  E-value: 2.22e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2032650139 1410 PCQCNNH---SETCDPDTGKCLdCRDNTVGDHCSACAPGYYG 1448
Cdd:cd00055      1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1052-1095 3.52e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 57.32  E-value: 3.52e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139  1052 CNCSSAGSANPQCDVLTGQCQCKTEFGGRDCSRCALGY--RDYPDC 1095
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYygDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 857-901 8.21e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 8.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2032650139  857 CECNGNVNPQeeGHCDPFTGQCLkCLGNTAGHHCEKCADGYYGDA 901
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1098-1151 1.44e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 1.44e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2032650139  1098 CDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANS 1151
Cdd:smart00180    1 CDCDPGGSASGTCD---------PDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1005-1050 2.33e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.44  E-value: 2.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1005 PCDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLSPK-LGCK 1050
Cdd:cd00055      1 PCDCnghGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1411-1457 2.59e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 2.59e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 2032650139  1411 CQCN---NHSETCDPDTGKCLdCRDNTVGDHCSACAPGYYGKvtgSANDC 1457
Cdd:smart00180    1 CDCDpggSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD---GPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 404-457 3.06e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.05  E-value: 3.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2032650139  404 PCDCDPFGSLSSVCVKDEhhsdsqrgtwpGQCQCREGYAGEKCDRCAFGYRGYP 457
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGT-----------GQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1006-1049 8.14e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 8.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2032650139  1006 CDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLSPKlGC 1049
Cdd:smart00180    1 CDCdpgGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP-GC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
405-457 9.43e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 9.43e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2032650139   405 CDCDPFGSLSSVCVKDEhhsdsqrgtwpGQCQCREGYAGEKCDRCAFGYRGYP 457
Cdd:smart00180    1 CDCDPGGSASGTCDPDT-----------GQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 750-789 1.26e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.26e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2032650139  750 CKCNGHAT---ECDIH-GVCFaCQHNTTGPFCDQCLPGFYGNPS 789
Cdd:pfam00053    1 CDCNPHGSlsdTCDPEtGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1097-1156 1.44e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 1.44e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1097 ACDCDLSGTKAETCNgtegvcgceEETGVCSCKENVFGLQCSECKPGTFGLSANsALGCT 1156
Cdd:cd00055      1 PCDCNGHGSLSGQCD---------PGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
462-508 2.19e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 2.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2032650139   462 CNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNlqeRNPQGC 508
Cdd:smart00180    1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 461-509 2.97e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 2.97e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  461 RCNCSLVGSINE--DPCTEPCLCKENVEGENCDLCKPGFYNLQERnPQGCT 509
Cdd:cd00055      1 PCDCNGHGSLSGqcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
857-900 4.26e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.54  E-value: 4.26e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   857 CECN--GNVNPQeeghCDPFTGQCLkCLGNTAGHHCEKCADGYYGD 900
Cdd:smart00180    1 CDCDpgGSASGT----CDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1006-1049 1.08e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2032650139 1006 CDC---AHTQNNCNADSGQCICPPHTQGQKCELCEENYWGLS--PKLGC 1049
Cdd:pfam00053    1 CDCnphGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 799-854 3.19e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 49.27  E-value: 3.19e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032650139  799 CACPLSSSAnnfSPTCQLseEGGiVCDkCLPGYTGSQCERCANGYYGNPLMAGQSC 854
Cdd:pfam00053    1 CDCNPHGSL---SDTCDP--ETG-QCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
750-791 3.86e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.85  E-value: 3.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2032650139   750 CKCN--GHATE-CD-IHGVCFaCQHNTTGPFCDQCLPGFYGNPSQG 791
Cdd:smart00180    1 CDCDpgGSASGtCDpDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1460-1514 4.28e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 4.28e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139 1460 CACPraNPASFSPTCVLkgvHDYHCDaCLPGYEGQYCERCSPGYYGAPRLPGGSC 1514
Cdd:pfam00053    1 CDCN--PHGSLSDTCDP---ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 278-325 1.63e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2032650139  278 CICYGHA---RSCplDEITkkLQCQCEHNTCGESCNKCCPGYHQKPWRPGT 325
Cdd:cd00055      2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1459-1515 3.25e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032650139 1459 PCACPRAnpASFSPTCVlkgVHDYHCDaCLPGYEGQYCERCSPGYYGAPRLPGGsCR 1515
Cdd:cd00055      1 PCDCNGH--GSLSGQCD---PGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG-CQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 798-854 7.78e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 7.78e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2032650139  798 PCACPLSSSANnfsPTCqlsEEGGIVCDkCLPGYTGSQCERCANGYYGNPLmAGQSC 854
Cdd:cd00055      1 PCDCNGHGSLS---GQC---DPGTGQCE-CKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1587-1830 3.80e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.63  E-value: 3.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1587 NLTGIDRVPYGILSELENATQHLKRSIvprEDPTYSLDTTKENLlnlsggidylhEETTRFLK-KAQQLDTMTQKTRNKS 1665
Cdd:TIGR04523  444 DLTNQDSVKELIIKNLDNTRESLETQL---KVLSRSINKIKQNL-----------EQKQKELKsKEKELKKLNEEKKELE 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1666 QEltgfidtvhttIKVLAEVALSLNETLGldlPLSNAASQsLQDDISALLDALRKKDFVqqhhnattvlKAAEKLLTQVQ 1745
Cdd:TIGR04523  510 EK-----------VKDLTKKISSLKEKIE---KLESEKKE-KESKISDLEDELNKDDFE----------LKKENLEKEID 564

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1746 KEyfkpQQELAELKRNASQFLSKQSSRLQDAQDLVNEALTNINEIRRLFPLISSNLAELNDKKlkiKEGEEISTML--IK 1823
Cdd:TIGR04523  565 EK----NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAK---KENEKLSSIIknIK 637


                   ....*..
gi 2032650139 1824 EGKVLLN 1830
Cdd:TIGR04523  638 SKKNKLK 644
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
799-847 6.17e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 6.17e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2032650139   799 CACPLSssaNNFSPTCqlsEEGGIVCDkCLPGYTGSQCERCANGYYGNP 847
Cdd:smart00180    1 CDCDPG---GSASGTC---DPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1460-1507 7.22e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.30  E-value: 7.22e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2032650139  1460 CACPRANpaSFSPTCVLKGVHdyhCDaCLPGYEGQYCERCSPGYYGAP 1507
Cdd:smart00180    1 CDCDPGG--SASGTCDPDTGQ---CE-CKPNVTGRRCDRCAPGYYGDG 42
VSP pfam03302
Giardia variant-specific surface protein;
777-1119 1.14e-04

Giardia variant-specific surface protein;


Pssm-ID: 146106 [Multi-domain]  Cd Length: 397  Bit Score: 47.27  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  777 CDQCLPGFygnpsqGTSEDCQPCacplSSSANNFSPTCQL-SEEGGIVCDKCLPGY---TGSQC----ERCANGYYGNPL 848
Cdd:pfam03302    1 CDECKPGY------ELSADKTKC----TSSAPCKTENCKAcSNDKREVCEECNSNNyltPTSQCiddcAKIGNYYYTTNA 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  849 MAGQSCAPCECNGNVNPQEEGHCD--------------PFTGQCLKCLGNTAGhHCEKCADG---YYGD----------- 900
Cdd:pfam03302   71 NNKKICKECTVANCKTCEDQGQCQacndgfyksgdacsPCHESCKTCSGGTAS-DCTECLTGkalRYGNdgtkgtcgegc 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  901 --AVIDKNCRACACHVNG-SLSSTCQHET-----GICS---------CK-SNVIGERCDKCLNGYYglltglgcvpcncS 962
Cdd:pfam03302  150 ttGTGAGACKTCGLTIDGtSYCSECATETeypqnGVCTstaaratatCKaSSVANGMCSSCANGYF-------------R 216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  963 QFGSVSEDCNHHGQCHCVPGVAGEKCDRCAHGfYAFQDGGCTPCDCAhtqnncnadsgqciCPPHTQGQKCELCEENYWG 1042
Cdd:pfam03302  217 MNGGCYETTKFPGKSVCEEANSGGTCQKEAPG-YKLNNGDLVTCSPG--------------CKTCTSNTVCTTCMDGYVK 281

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 1043 LSPKlgCKACNCSsagsanpqCDVLTGQCQcktefggrDCSRCALG-YRDYPDCVACdcdlsgTKAETCNGTEGVCGC 1119
Cdd:pfam03302  282 TSDS--CTKCDSS--------CETCTGATT--------TCKTCATGyYKSGTGCVSC------TSSESDNGITGVKGC 335
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1965-2165 3.06e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1965 QNEAKNLKKKSDGLLFGLNGLNKKVEKIQESTNKIGNQLNDS---LLTFRA----LHNNARKRMLEVKELAVSANTS--- 2034
Cdd:COG3883     22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALqaeIDKLQAeiaeAEAEIEERREELGERARALYRSggs 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2035 -----AVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQASLLLDRLKplkmleeNLN 2109
Cdd:COG3883    102 vsyldVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA-------ELE 174

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2032650139 2110 RNLSEIKELISQARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTAEPD 2165
Cdd:COG3883    175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1952-2158 4.47e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.17  E-value: 4.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1952 LLGKETLLlsSKFQNEAKNLKKKSDGLLFGLNGLNKKVEKIQESTNKIGNQLNDSLLTFRAL------HNNARKRMLEVK 2025
Cdd:TIGR04523  147 IKKKEKEL--EKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLkkkiqkNKSLESQISELK 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2026 ELAVSANTSAVVDLSHFGEFSQKLMNTSSTLSQVNDTLRKTSELIIDSSKAAHTAEKQVKEVEAQasllldrLKPLKMLE 2105
Cdd:TIGR04523  225 KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQ-------LNQLKSEI 297

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2032650139 2106 ENLNRN-----LSEIKELISQARKQaasikvavsadrdcIRAYQPQISSTNYNTLTLN 2158
Cdd:TIGR04523  298 SDLNNQkeqdwNKELKSELKNQEKK--------------LEEIQNQISQNNKIISQLN 341
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1627-1841 6.65e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 44.67  E-value: 6.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1627 KENLLNLsggIDYLHEETTRFLKKAQQLDTMTQKTRNKSQELTGFIDTVHTTIKVLaevalsLNETLGLdlpLSNAASQS 1706
Cdd:cd22656    116 KKTIKAL---LDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDL------LTDEGGA---IARKEIKD 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1707 LQDDISALLDALRKKdfvqqhhnattvlkaAEKLLTQVQKEYFKPQQELAELKRnASQFLSKQSSRLQDAQDLVNEALTN 1786
Cdd:cd22656    184 LQKELEKLNEEYAAK---------------LKAKIDELKALIADDEAKLAAALR-LIADLTAADTDLDNLLALIGPAIPA 247

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2032650139 1787 INEIRRLFPLISSNLAELNDkKLKIKEGEEISTMLIKEGkvlLNDA----AAVAQDVKN 1841
Cdd:cd22656    248 LEKLQGAWQAIATDLDSLKD-LLEDDISKIPAAILAKLE---LEKAiekwNELAEKADK 302
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
297-321 7.28e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 7.28e-04
                            10        20
                    ....*....|....*....|....*
gi 2032650139   297 QCQCEHNTCGESCNKCCPGYHQKPW 321
Cdd:smart00180   19 QCECKPNVTGRRCDRCAPGYYGDGP 43
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1966-2130 1.41e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.36  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1966 NEAKNLKKKSDGLlfglnglNKKVEKIQES---TNKIGNQLNDSLLTFRALHNNARKRMLEVKELavsanTSAVVDLshf 2042
Cdd:COG1340     57 EEAQELREKRDEL-------NEKVKELKEErdeLNEKLNELREELDELRKELAELNKAGGSIDKL-----RKEIERL--- 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 2043 gEFsqKLMNTSSTLSQVNDTLRKTSEL--IIDSSKAAHTAEKQVKEVEAQasllldrLKPLKMLEENLNRNLSEIKELIS 2120
Cdd:COG1340    122 -EW--RQQTEVLSPEEEKELVEKIKELekELEKAKKALEKNEKLKELRAE-------LKELRKEAEEIHKKIKELAEEAQ 191

                          170
                   ....*....|
gi 2032650139 2121 QARKQAASIK 2130
Cdd:COG1340    192 ELHEEMIELY 201
TNFRSF16 cd13416
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ...
 717-922 2.92e-03

Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.


Pssm-ID: 276921 [Multi-domain]  Cd Length: 159  Bit Score: 41.13  E-value: 2.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  717 CECPQGY---TGLSCESCLPGyyrvdgilfggicqpckcnghatecdiHGVCFACQHNTTGpfCDQCLPGFYGNPSQGTS 793
Cdd:cd13416      1 EACPSGQytsSGECCEQCPPG---------------------------EGVARPCGDNQTV--CEPCLDGVTFSDVVSHT 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  794 EDCQPCA-CPLSSsannfSPTCQLSEEGGIVCdkclpgytgsqceRCANGYYGNPLMagQSCAPCEcngnVNPQEEG--- 869
Cdd:cd13416     52 EPCQPCTrCPGLM-----SMRAPCTATHDTVC-------------ECAYGYYLDEDS--GTCEPCT----VCPPGQGvvq 107

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2032650139  870 HCDPftgqclkcLGNTAghhCEKCADGYYGDAVIDKN-CRACA-CHVNGSLSSTC 922
Cdd:cd13416    108 SCGP--------NQDTV---CEACPEGTYSDEDSSTDpCLPCTvCEDGEVELREC 151
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 1371-1536 3.69e-03

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 42.98  E-value: 3.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1371 RCPAGYTGLSCQSCA---PGYYRGKHTElsVREPHALIAPCVPCQCN----NHSETCDPDTGKCLDCRDNTVgDHCSACA 1443
Cdd:PTZ00214   378 RCSAGYLGVDGKSCSescSGDTRGVCTK--VAEGSESTEVSCRCVCKptfyNSSGTCTPCTDSCAVCKDGTP-TGCQQCS 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1444 PGY---YGKVTGSANDC-------SPCA--------------CPRANPASFSPTCVLKGVHDYHCDACLPGyegqYCERC 1499
Cdd:PTZ00214   455 PGKileFSIVSSESADCvdqcsvgSECAecgitidgsryctrCKDASTYPFNGVCIPNTQRDAYCTSTANG----ACTTC 530

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2032650139 1500 SpgyyGAPRLPGGSCRPCQCNPGGSVhgnCDG-ATGQC 1536
Cdd:PTZ00214   531 S----GAAFLMNGGCYTTEHYPGSTI---CDKqSNGKC 561
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
717-740 4.41e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 4.41e-03
                            10        20
                    ....*....|....*....|....
gi 2032650139   717 CECPQGYTGLSCESCLPGYYRVDG 740
Cdd:smart00180   20 CECKPNVTGRRCDRCAPGYYGDGP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1369-1390 5.49e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 5.49e-03
                           10        20
                   ....*....|....*....|..
gi 2032650139 1369 QCRCPAGYTGLSCQSCAPGYYR 1390
Cdd:cd00055     20 QCECKPNTTGRRCDRCAPGYYG 41
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 717-748 5.88e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.33  E-value: 5.88e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2032650139  717 CECPQGYTGLSCESCLPGYYRVDGILFGgiCQ 748
Cdd:cd00055     21 CECKPNTTGRRCDRCAPGYYGLPSQGGG--CQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1369-1390 6.61e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.61e-03
                            10        20
                    ....*....|....*....|..
gi 2032650139  1369 QCRCPAGYTGLSCQSCAPGYYR 1390
Cdd:smart00180   19 QCECKPNVTGRRCDRCAPGYYG 40
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1691-1816 7.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 7.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139 1691 ETLGLDLPLSNAASQSLQDDISALLDALRkkdfvQQHHNATTVLKAAEKLLTQVQKEYFKPQQELAELKRNASQFlskqS 1770
Cdd:COG4913    369 AALGLPLPASAEEFAALRAEAAALLEALE-----EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI----P 439

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2032650139 1771 SRLQDAQDLVNEALtNINEIRRLFplissnLAELndkkLKIKEGEE 1816
Cdd:COG4913    440 ARLLALRDALAEAL-GLDEAELPF------VGEL----IEVRPEEE 474
TNFRSF cd00185
Tumor necrosis factor receptor superfamily (TNFRSF); Members of TNFR superfamily (TNFRSF) ...
 777-858 9.85e-03

Tumor necrosis factor receptor superfamily (TNFRSF); Members of TNFR superfamily (TNFRSF) interactions with TNF superfamily (TNFSF) ligands (TNFL) control key cellular processes such as differentiation, proliferation, apoptosis, and cell growth. Dysregulation of these pathways has been shown to result in a wide range of pathological conditions, including autoimmune diseases, inflammation, cancer, and viral infection. There are 29 very diverse family members of TNFRSF reported in humans: 22 are type I transmembrane receptors (single pass with the N terminus on extracellular side of the cell membrane) and have a clear signal peptide; the remaining 7 members are either type III transmembrane receptors (single pass with the N terminus on extracellular side of the membrane but no signal sequence; TNFR13B, TNFR13C, TNFR17, and XEDAR), or attached to the membrane via a glycosylphosphatidylinositol (GPI) linker (TNFR10C), or secreted as soluble receptors (TNFR11B and TNFR6B). All TNFRs contain relatively short cysteine-rich domains (CRDs) in the ectodomain, and are involved in interaction with the TNF homology domain (THD) of their ligands. TNFRs often have multiple CRDs (between one and six), with the most frequent configurations of three or four copies; most CRDs possess three disulfide bridges, but could have between one and four. Localized or genome-wide duplication and evolution of the TNFRSF members appear to have paralleled the emergence of the adaptive immune system; teleosts (i.e. ray-finned, bony fish), which possess an immune system with B and T cells, possess primary and secondary lymphoid organs, and are capable of adaptive responses to pathogens also display several characteristics that are different from the mammalian immune system, making teleost TNFSF orthologs and paralogs of interest to better understand immune system evolution and the immunological pathways elicited to pathogens.


Pssm-ID: 276900 [Multi-domain]  Cd Length: 87  Bit Score: 37.57  E-value: 9.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032650139  777 CDQCLPGFY--GNPSQGTSEDCQPCACPLSSSANNFSPTCQLseeggivCDKCLPGY---------TGSQCERCANGYYG 845
Cdd:cd00185      2 CQRCPPGEYlsSDCTATTDTVCSPCPPGTYSESWNSLSKCLP-------CTTCGGGNqvektpctaTDNRCCTCKPGFYC 74

                           90
                   ....*....|...
gi 2032650139  846 NPLMAGQSCAPCE 858
Cdd:cd00185     75 DEGTNVEECKPCT 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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