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Conserved domains on  [gi|2031382080|gb|QUO23410|]
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glycosyltransferase [Clostridiaceae bacterium Marseille-Q4143]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135280)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-180 9.71e-42

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 142.71  E-value: 9.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV---IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDA 76
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVLEEGYdyeIIVVDDGSTDGTAEIARELAArvprvrVIRLSRNFGKGAAVRAGFKAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  77 EVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTyfTENKRPFH-NFGNSLVRGTINKLFHTEIKDIMTGYRAF 155
Cdd:cd04179    81 DIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRG--GGAGMPLLrRLGSRLFNFLIRLLLGVRISDTQSGFRLF 158

                         170       180
                  ....*....|....*....|....*..
gi 2031382080 156 SYQFVKTF--PVLSKGFEIETEMTIHA 180
Cdd:cd04179   159 RREVLEALlsLLESNGFEFGLELLVGA 185
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-180 9.71e-42

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 142.71  E-value: 9.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV---IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDA 76
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVLEEGYdyeIIVVDDGSTDGTAEIARELAArvprvrVIRLSRNFGKGAAVRAGFKAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  77 EVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTyfTENKRPFH-NFGNSLVRGTINKLFHTEIKDIMTGYRAF 155
Cdd:cd04179    81 DIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRG--GGAGMPLLrRLGSRLFNFLIRLLLGVRISDTQSGFRLF 158

                         170       180
                  ....*....|....*....|....*..
gi 2031382080 156 SYQFVKTF--PVLSKGFEIETEMTIHA 180
Cdd:cd04179   159 RREVLEALlsLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-206 7.91e-35

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 125.58  E-value: 7.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   1 MDKIAVLIPCYNEEKTVEKVVRDFRQVLPEAV-IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFRE 73
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDFeIIVVDDGSTDGTAEILRELAAkdprirVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  74 IDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRlsstYFTENKRPFHNFGNSLVrgTINKLFhTEIKDIMTGYR 153
Cdd:COG0463    81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR----LIREGESDLRRLGSRLF--NLVRLL-TNLPDSTSGFR 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2031382080 154 AFSYQFVKTFPvLSKGFEIETEMtIHAADKNMQVDNVVIEYRDRpegsESKLN 206
Cdd:COG0463   154 LFRREVLEELG-FDEGFLEDTEL-LRALRHGFRIAEVPVRYRAG----ESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-156 1.59e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 72.81  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV-IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDAEV 78
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFeIIVVDDGSTDGTVEIAEEYAKkdprvrVIRLPENRGKAGARNAGLRAATGDY 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2031382080  79 YIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTYFTENKRPFHNFGNSLVRGTINKLF-HTEIKDIMTGYRAFS 156
Cdd:pfam00535  82 IAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLlGLNLPFLIGGFALYR 160
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 3-85 1.91e-09

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 57.62  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRDFRQVLPEAV---IYVYDNNSSDRTVELAEKAGAVV--------RHEYLQGKGNVirrMF 71
Cdd:PRK13915   32 TVSVVLPALNEEETVGKVVDSIRPLLMEPLvdeLIVIDSGSTDATAERAAAAGARVvsreeilpELPPRPGKGEA---LW 108

                          90
                  ....*....|....
gi 2031382080  72 REIDAevyimTDGD 85
Cdd:PRK13915  109 RSLAA-----TTGD 117
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-180 9.71e-42

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 142.71  E-value: 9.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV---IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDA 76
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAVLEEGYdyeIIVVDDGSTDGTAEIARELAArvprvrVIRLSRNFGKGAAVRAGFKAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  77 EVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTyfTENKRPFH-NFGNSLVRGTINKLFHTEIKDIMTGYRAF 155
Cdd:cd04179    81 DIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRG--GGAGMPLLrRLGSRLFNFLIRLLLGVRISDTQSGFRLF 158

                         170       180
                  ....*....|....*....|....*..
gi 2031382080 156 SYQFVKTF--PVLSKGFEIETEMTIHA 180
Cdd:cd04179   159 RREVLEALlsLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-206 7.91e-35

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 125.58  E-value: 7.91e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   1 MDKIAVLIPCYNEEKTVEKVVRDFRQVLPEAV-IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFRE 73
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDFeIIVVDDGSTDGTAEILRELAAkdprirVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  74 IDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRlsstYFTENKRPFHNFGNSLVrgTINKLFhTEIKDIMTGYR 153
Cdd:COG0463    81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSR----LIREGESDLRRLGSRLF--NLVRLL-TNLPDSTSGFR 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2031382080 154 AFSYQFVKTFPvLSKGFEIETEMtIHAADKNMQVDNVVIEYRDRpegsESKLN 206
Cdd:COG0463   154 LFRREVLEELG-FDEGFLEDTEL-LRALRHGFRIAEVPVRYRAG----ESKLN 200
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-206 9.57e-18

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 80.27  E-value: 9.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVL--PEAVIYVYDNNSSDRTVELAEKAGA-------VVRHEYLqGKGNVIRRMFREIDA 76
Cdd:cd06442     1 IIIPTYNERENIPELIERLDAALkgIDYEIIVVDDNSPDGTAEIVRELAKeyprvrlIVRPGKR-GLGSAYIEGFKAARG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  77 EVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTYFTENkRPFHN-----FGNSLVRgtinKLFHTEIKDIMTG 151
Cdd:cd06442    80 DVIVVMDADLSHPPEYIPELLEAQLEGGADLVIGSRYVEGGGVEG-WGLKRklisrGANLLAR----LLLGRKVSDPTSG 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2031382080 152 YRAFSYQFVKTF--PVLSKGFEIETEMTIHAADKNMQVDNVVIEYRDRPEGsESKLN 206
Cdd:cd06442   155 FRAYRREVLEKLidSLVSKGYKFQLELLVRARRLGYRIVEVPITFVDREHG-ESKLG 210
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-98 1.25e-17

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 81.71  E-value: 1.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRD-FRQVLPEAV--IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFRE 73
Cdd:COG1215    30 RVSVIIPAYNEEAVIEETLRSlLAQDYPKEKleVIVVDDGSTDETAEIARELAAeyprvrVIERPENGGKAAALNAGLKA 109

                          90       100
                  ....*....|....*....|....*
gi 2031382080  74 IDAEVYIMTDGDDTYPAEFAREMVD 98
Cdd:COG1215   110 ARGDIVVFLDADTVLDPDWLRRLVA 134
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-156 1.59e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 72.81  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV-IYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDAEV 78
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFeIIVVDDGSTDGTVEIAEEYAKkdprvrVIRLPENRGKAGARNAGLRAATGDY 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2031382080  79 YIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTYFTENKRPFHNFGNSLVRGTINKLF-HTEIKDIMTGYRAFS 156
Cdd:pfam00535  82 IAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLlGLNLPFLIGGFALYR 160
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 6-201 3.35e-15

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 72.99  E-value: 3.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAV-----IYVYDNNSSDRTVE----LAEKAGAVVRHEYL---QGKGNVIRRMFRE 73
Cdd:cd04188     1 VVIPAYNEEKRLPPTLEEAVEYLEERPsfsyeIIVVDDGSKDGTAEvarkLARKNPALIRVLTLpknRGKGGAVRAGMLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  74 IDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSSTYFTENKRPFH-NFG----NSLVRgtinKLFHTEIKDI 148
Cdd:cd04188    81 ARGDYILFADADLATPFEELEKLEEALKTSGYDIAIGSRAHLASAAVVKRSWLrNLLgrgfNFLVR----LLLGLGIKDT 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2031382080 149 MTGYRAFSYQFV-KTFPVLS-KGFEIETEMTIHAADKNMQVDNVVIEYRDRPeGS 201
Cdd:cd04188   157 QCGFKLFTRDAArRLFPRLHlERWAFDVELLVLARRLGYPIEEVPVRWVEIP-GS 210
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-110 7.85e-12

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 62.52  E-value: 7.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDF-RQVLPEAVIYVYDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREIDAEV 78
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLlAQTYPNFEVIVVDDGSTDGTLEILEEYAKkdprviRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2031382080  79 YIMTDGDDTYPAEFAREMVDKVLHHQSDMVVG 110
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVG 112
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 6-110 1.59e-11

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 61.86  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDF-RQVLPEAVIYVYDNNSSDRTVELAEKAGA-------VVRHEYLQGKGNVIRRMFREIDAE 77
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLlALDYPKLEVIVVDDGSTDDTLEILEELAAlyirrvlVVRDKENGGKAGALNAGLRHAKGD 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2031382080  78 VYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVG 110
Cdd:cd06423    81 IVVVLDADTILEPDALKRLVVPFFADPKVGAVQ 113
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 3-110 5.17e-11

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 61.83  E-value: 5.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRDFRQVLP--EAV-IYVYDNNSSDRTVELAEKAGA----VVRHEYLQGKGNVIRRMFREID 75
Cdd:cd06439    30 TVTIIIPAYNEEAVIEAKLENLLALDYprDRLeIIVVSDGSTDGTAEIAREYADkgvkLLRFPERRGKAAALNRALALAT 109

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2031382080  76 AEVYIMTDGDdtypAEFAREMVDKVLHHQSDMVVG 110
Cdd:cd06439   110 GEIVVFTDAN----ALLDPDALRLLVRHFADPSVG 140
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 3-85 1.91e-09

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 57.62  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRDFRQVLPEAV---IYVYDNNSSDRTVELAEKAGAVV--------RHEYLQGKGNVirrMF 71
Cdd:PRK13915   32 TVSVVLPALNEEETVGKVVDSIRPLLMEPLvdeLIVIDSGSTDATAERAAAAGARVvsreeilpELPPRPGKGEA---LW 108

                          90
                  ....*....|....
gi 2031382080  72 REIDAevyimTDGD 85
Cdd:PRK13915  109 RSLAA-----TTGD 117
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-148 8.75e-09

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 55.32  E-value: 8.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRDFRQVLPEAVIY---VYDNNSSDRTVELAEKagavvrheyLQGKGNVIR----------- 68
Cdd:cd02525     1 FVSIIIPVRNEEKYIEELLESLLNQSYPKDLIeiiVVDGGSTDGTREIVQE---------YAAKDPRIRlidnpkriqsa 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  69 ---RMFREIDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLSStYFTENKRPFHNFGNSLVrGTINKLFHTEI 145
Cdd:cd02525    72 glnIGIRNSRGDIIIRVDAHAVYPKDYILELVEALKRTGADNVGGPMETI-GESKFQKAIAVAQSSPL-GSGGSAYRGGA 149


                  ...
gi 2031382080 146 KDI 148
Cdd:cd02525   150 VKI 152
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 6-85 2.69e-07

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 49.91  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVL---PEAVIYVYDNNSSDRTVELAEKAGAVV--RHE-YLQGKGNVIRRMFREI----- 74
Cdd:cd06438     1 ILIPAHNEEAVIGNTVRSLKAQDyprELYRIFVVADNCTDDTAQVARAAGATVleRHDpERRGKGYALDFGFRHLlnlad 80

                          90
                  ....*....|.
gi 2031382080  75 DAEVYIMTDGD 85
Cdd:cd06438    81 DPDAVVVFDAD 91
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-98 2.79e-07

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 49.99  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   1 MDKIAVLIPCYNEEKTVEKVVRDF-RQVLPEAVIYVYDNNSSDRTVELAEKAGA----VVRHEYLQGKGNVIRRMFREID 75
Cdd:COG1216     2 RPKVSVVIPTYNRPELLRRCLESLlAQTYPPFEVIVVDNGSTDGTAELLAALAFprvrVIRNPENLGFAAARNLGLRAAG 81

                          90       100
                  ....*....|....*....|...
gi 2031382080  76 AEVYIMTDGDDTYPAEFAREMVD 98
Cdd:COG1216    82 GDYLLFLDDDTVVEPDWLERLLA 104
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-60 4.84e-07

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 49.98  E-value: 4.84e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2031382080   3 KIAVLIPCYNEEKTVEKVVRDFRQVLPEavIYVYDNNSSDRTVELAEKAGA-VVRHEYL 60
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESVKWAVDE--IIVVDSGSTDRTVEIAKEYGAkVYQRWWD 57
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 6-102 5.06e-07

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 49.30  E-value: 5.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEAVIYVYDNNSSDRTVELAEKAGA-----VVRH---EYLQGKGNV-------IRRM 70
Cdd:cd06436     1 VLVPCLNEEAVIQRTLASLLRNKPNFLVLVIDDASDDDTAGIVRLAITdsrvhLLRRhlpNARTGKGDAlnaaydqIRQI 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2031382080  71 FRE--IDAE-VYIMTDGDDTYPAEFAREMVDKVLH 102
Cdd:cd06436    81 LIEegADPErVIIAVIDADGRLDPNALEAVAPYFS 115
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 4-58 8.55e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 49.11  E-value: 8.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2031382080   4 IAVLIPCYNEEKTVEKVVRDFRQVLPEAV-IYVYDNNSSDRTVELAEKAGAVVRHE 58
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLNPLPLeIIVVDGGSTDGTVAIARSAGVVVISS 56
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-150 2.84e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 47.24  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   5 AVLIPCYNEEKTVEKVVRDFR-QVLPEAVIYVYDNNSSDRTVEL----AEKAGAVVRHEYLQGKGNVIR---RMFREIDA 76
Cdd:cd04196     1 AVLMATYNGEKYLREQLDSILaQTYKNDELIISDDGSTDGTVEIikeyIDKDPFIIILIRNGKNLGVARnfeSLLQAADG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  77 EVYIMTDGDDTYPAEFAREMVDKVLHHQ------SDMVVGDRL-----SSTYFTENKRPFHNFGNSLVRGT-------IN 138
Cdd:cd04196    81 DYVFFCDQDDIWLPDKLERLLKAFLKDDkpllvySDLELVDENgnpigESFFEYQKIKPGTSFNNLLFQNVvtgctmaFN 160

                         170
                  ....*....|..
gi 2031382080 139 KLFHTEIKDIMT 150
Cdd:cd04196   161 RELLELALPFPD 172
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 6-163 1.68e-05

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 44.78  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFRQVLPEA-----VIYVyDNNSSDRTVELAEKAGA------VVRHEYLQGKGNVIRRMFREI 74
Cdd:cd04187     1 IVVPVYNEEENLPELYERLKAVLESLgydyeIIFV-DDGSTDRTLEILRELAArdprvkVIRLSRNFGQQAALLAGLDHA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  75 DAEVYIMTDGDDTYPAEFAREMVDKvLHHQSDMVVGDRLSS--TYFtenKRPFHNFGNSLvrgtINKLFHTEIKDIMTGY 152
Cdd:cd04187    80 RGDAVITMDADLQDPPELIPEMLAK-WEEGYDVVYGVRKNRkeSWL---KRLTSKLFYRL----INKLSGVDIPDNGGDF 151

                         170
                  ....*....|.
gi 2031382080 153 RAFSYQFVKTF 163
Cdd:cd04187   152 RLMDRKVVDAL 162
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 2-114 3.15e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 44.28  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   2 DKIAVLIPCYNEEKTVEKVVRD-FRQVLPEAVIYVYDNNSSDRTVELAEKAGAVVRHEYLQ-----------GKGNVIRR 69
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAiLAQPYPPVEVVVVVNPSDAETLDVAEEIAARFPDVRLRvirnarllgptGKSRGLNH 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2031382080  70 MFREIDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGDRLS 114
Cdd:pfam13641  82 GFRAVKSDLVVLHDDDSVLHPGTLKKYVQYFDSPKVGAVGTPVFS 126
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-121 1.20e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 42.66  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   6 VLIPCYNEEKTVEKVVRDFR-QVLPEAVIYVY--DNNSSDRTVELAEKAGAvvrHEYLQ------------GKGNVIRRM 70
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSaLDYPKEKFEVIlvDDHSTDGTVQILEFAAA---KPNFQlkilnnsrvsisGKKNALTTA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2031382080  71 FREIDAEVYIMTDGDDTYPAEFAREMVDKVLHHQSDMVVGdrlSSTYFTEN 121
Cdd:cd04192    78 IKAAKGDWIVTTDADCVVPSNWLLTFVAFIQKEQIGLVAG---PVIYFKGK 125
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 4-221 1.51e-04

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 42.83  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080   4 IAVLIPCYNEE----KTVEKVVRDFRQVLPEAVIYVY-----DNNSSDRTVELAEKAGA----------VVRHEYLQGKG 64
Cdd:PTZ00260   72 LSIVIPAYNEEdrlpKMLKETIKYLESRSRKDPKFKYeiiivNDGSKDKTLKVAKDFWRqninpnidirLLSLLRNKGKG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  65 NVIRRMFREIDAEVYIMTDGDD-TYPAEFAR--EMVDKVLHHQSDMVVGDR--LSSTYFTENKRPFHNFGNSLVRGTINK 139
Cdd:PTZ00260  152 GAVRIGMLASRGKYILMVDADGaTDIDDFDKleDIMLKIEQNGLGIVFGSRnhLVDSDVVAKRKWYRNILMYGFHFIVNT 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080 140 LFHTEIKDIMTGYRAFSYQFVK-TFPVLSK---GFEIEtemTIHAADK-NMQVDNVVIEYRDRPegsESKLNTYSDGAKV 214
Cdd:PTZ00260  232 ICGTNLKDTQCGFKLFTRETARiIFPSLHLerwAFDIE---IVMIAQKlNLPIAEVPVNWTEVE---GSKLNVISASIQM 305


                  ....*..
gi 2031382080 215 LMSIAKL 221
Cdd:PTZ00260  306 ARDILLV 312
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 11-113 3.73e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 38.00  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2031382080  11 YNEEKTVEKVVRDFR-QVLPEAVIYVYDNNSSDRTVELAEKAGAVVRHEYLQGKGNV---------IRRMFREIDAEVYI 80
Cdd:cd04185     6 YNRLDLLKECLDALLaQTRPPDHIIVIDNASTDGTAEWLTSLGDLDNIVYLRLPENLggaggfyegVRRAYELGYDWIWL 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2031382080  81 MtDgDDTYPAEFARE-MVDKVLHHQSDMVVGDRL 113
Cdd:cd04185    86 M-D-DDAIPDPDALEkLLAYADKDNPQFLAPLVL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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