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Conserved domains on  [gi|2029597923|ref|XP_016678830|]
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caffeoylshikimate esterase [Gossypium hirsutum]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 6-299 9.03e-108

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02385:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 349  Bit Score: 317.85  E-value: 9.03e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   6 PPENVKYDEEFFTNSQGSKLFTCKWIPIKDEPKALIFIFHGYAMECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDG 85
Cdd:PLN02385   55 PPSGIKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHG 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  86 YVENFDDIVNDCNDHFSKICEKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIADDMKPPAAVTTLLQ 165
Cdd:PLN02385  135 YIPSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 166 GLSWVIPTWKSFNiTKDIIEIGFKEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVT 245
Cdd:PLN02385  215 LLANLLPKAKLVP-QKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVT 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029597923 246 DQQVSIELFKVASSTDKTIKLYPGMWHALLCGEPLENTEIVFADIIRWLEERTK 299
Cdd:PLN02385  294 DPSVSKFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSHST 347
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 6-299 9.03e-108

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 317.85  E-value: 9.03e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   6 PPENVKYDEEFFTNSQGSKLFTCKWIPIKDEPKALIFIFHGYAMECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDG 85
Cdd:PLN02385   55 PPSGIKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHG 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  86 YVENFDDIVNDCNDHFSKICEKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIADDMKPPAAVTTLLQ 165
Cdd:PLN02385  135 YIPSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 166 GLSWVIPTWKSFNiTKDIIEIGFKEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVT 245
Cdd:PLN02385  215 LLANLLPKAKLVP-QKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVT 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029597923 246 DQQVSIELFKVASSTDKTIKLYPGMWHALLCGEPLENTEIVFADIIRWLEERTK 299
Cdd:PLN02385  294 DPSVSKFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSHST 347
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 35-279 5.81e-75

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 230.18  E-value: 5.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  35 DEPKALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVENFDDIVNDCNDHFSKIceKEENKRKK 114
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 115 RYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIaDDMKPPAAVTTLLQGLSWVIPTWK-SFNITKDIIeigFKEPRV 193
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLRvPNNLLPDSL---SRDPEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 194 REEIRKSEYCyKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVSIELFKVASSTDKTIKLYPGMWHA 273
Cdd:pfam12146 154 VAAYAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHE 232


                  ....*.
gi 2029597923 274 LLcGEP 279
Cdd:pfam12146 233 LL-NEP 237
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
11-296 9.36e-37

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 131.28  E-value: 9.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  11 KYDEEFFTNSQGSKLFTCKWIPiKDEPKALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVENF 90
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRP-AGSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  91 DDIVNDCnDHFSKICEKEENKRkkRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPmckiADDMKPPAAVTTllqglSWV 170
Cdd:COG2267    80 DDYVDDL-RAALDALRARPGLP--VVLLGHSMGGLIALLYAARYPDRVAGLVLLAP----AYRADPLLGPSA-----RWL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 171 IptwksfnitkdiieigfkeprvreeirkseycykgpprmrtacellrvSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVS 250
Cdd:COG2267   148 R------------------------------------------------ALRLAEALARIDVPVLVLHGGADRVVPPEAA 179

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2029597923 251 IELFKvASSTDKTIKLYPGMWHALLcGEPleNTEIVFADIIRWLEE 296
Cdd:COG2267   180 RRLAA-RLSPDVELVLLPGARHELL-NEP--AREEVLAAILAWLER 221
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 61-295 1.16e-12

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 67.50  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  61 RLVKEGYAVYGMDYQGHGKSSGLD---GYVENFDDIVNDCNDHFSKI-----CEKE----------ENKRKKR---YLLG 119
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGLQnlrGHINCFDDLVYDVIQYMNRIndsiiLENEtksddesydiVNTKENRlpmYIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 120 ESMGGAVILL---LHRKKPEYWD-----GAVLVAPMCKIA-----DDMKPPAAVTTLLQGLSWVIPTwksFNITKdiiEI 186
Cdd:TIGR01607 149 LSMGGNIALRlleLLGKSNENNDklnikGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPT---FRISK---KI 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 187 GF-KEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEV--TLPFIVLHGEDDKVTDQQVSIELFKVASSTDKT 263
Cdd:TIGR01607 223 RYeKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKE 302

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2029597923 264 IKLYPGMWHaLLCGEPleNTEIVFADIIRWLE 295
Cdd:TIGR01607 303 LHTLEDMDH-VITIEP--GNEEVLKKIIEWIS 331
 
Name Accession Description Interval E-value
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 6-299 9.03e-108

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 317.85  E-value: 9.03e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   6 PPENVKYDEEFFTNSQGSKLFTCKWIPIKDEPKALIFIFHGYAMECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDG 85
Cdd:PLN02385   55 PPSGIKTEESYEVNSRGVEIFSKSWLPENSRPKAAVCFCHGYGDTCTFFFEGIARKIASSGYGVFAMDYPGFGLSEGLHG 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  86 YVENFDDIVNDCNDHFSKICEKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIADDMKPPAAVTTLLQ 165
Cdd:PLN02385  135 YIPSFDDLVDDVIEHYSKIKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPMCKIADDVVPPPLVLQILI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 166 GLSWVIPTWKSFNiTKDIIEIGFKEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVT 245
Cdd:PLN02385  215 LLANLLPKAKLVP-QKDLAELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVT 293

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029597923 246 DQQVSIELFKVASSTDKTIKLYPGMWHALLCGEPLENTEIVFADIIRWLEERTK 299
Cdd:PLN02385  294 DPSVSKFLYEKASSSDKKLKLYEDAYHSILEGEPDEMIFQVLDDIISWLDSHST 347
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 4-299 3.36e-101

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 300.54  E-value: 3.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   4 EHPPE------NVKYDEEFFTNSQGSKLFTCKWIPIKDE-PKALIFIFHGYAMECSITMSSTAIRLVKEGYAVYGMDYQG 76
Cdd:PLN02298   18 ETPEEeyyalkGIKGSKSFFTSPRGLSLFTRSWLPSSSSpPRALIFMVHGYGNDISWTFQSTAIFLAQMGFACFALDLEG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  77 HGKSSGLDGYVENFDDIVNDCNDHFSKICEKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIADDMKP 156
Cdd:PLN02298   98 HGRSEGLRAYVPNVDLVVEDCLSFFNSVKQREEFQGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIRP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 157 PAAVTTLLQGLSWVIPTWkSFNITKDIIEIGFKEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEVTLPFIV 236
Cdd:PLN02298  178 PWPIPQILTFVARFLPTL-AIVPTADLLEKSVKVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIV 256

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029597923 237 LHGEDDKVTDQQVSIELFKVASSTDKTIKLYPGMWHALLCGEPLENTEIVFADIIRWLEERTK 299
Cdd:PLN02298  257 LHGSADVVTDPDVSRALYEEAKSEDKTIKIYDGMMHSLLFGEPDENIEIVRRDILSWLNERCT 319
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 35-279 5.81e-75

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 230.18  E-value: 5.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  35 DEPKALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVENFDDIVNDCNDHFSKIceKEENKRKK 114
Cdd:pfam12146   1 GEPRAVVVLVHGLG-EHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKI--REEHPGLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 115 RYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIaDDMKPPAAVTTLLQGLSWVIPTWK-SFNITKDIIeigFKEPRV 193
Cdd:pfam12146  78 LFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-KPYLAPPILKLLAKLLGKLFPRLRvPNNLLPDSL---SRDPEV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 194 REEIRKSEYCyKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVSIELFKVASSTDKTIKLYPGMWHA 273
Cdd:pfam12146 154 VAAYAADPLV-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHE 232


                  ....*.
gi 2029597923 274 LLcGEP 279
Cdd:pfam12146 233 LL-NEP 237
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 1-302 1.27e-42

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 151.58  E-value: 1.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   1 MALEHPPENVKYDEEFFTNSQGSKLFTCKWIPIKDEPKALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKS 80
Cdd:PLN02652   99 VEMVEDGEGTRWATSLFYGARRNALFCRSWAPAAGEMRGILIIIHGLN-EHSGRYLHFAKQLTSCGFGVYAMDWIGHGGS 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  81 SGLDGYVENFDDIVNDCNDHFSKIceKEENKRKKRYLLGESMGGAVIL--LLHRKKPEYWDGAVLVAPMCKIADDMKPPA 158
Cdd:PLN02652  178 DGLHGYVPSLDYVVEDTEAFLEKI--RSENPGVPCFLFGHSTGGAVVLkaASYPSIEDKLEGIVLTSPALRVKPAHPIVG 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 159 AVTTLLqglSWVIPTWKSFNITKDIIEIGfKEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEVTLPFIVLH 238
Cdd:PLN02652  256 AVAPIF---SLVAPRFQFKGANKRGIPVS-RDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLH 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2029597923 239 GEDDKVTDQQVSIELFKVASSTDKTIKLYPGMWHALLCgEPlENTEIVfADIIRWLEERTKLGN 302
Cdd:PLN02652  332 GTADRVTDPLASQDLYNEAASRHKDIKLYDGFLHDLLF-EP-EREEVG-RDIIDWMEKRLDLVN 392
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
11-296 9.36e-37

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 131.28  E-value: 9.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  11 KYDEEFFTNSQGSKLFTCKWIPiKDEPKALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVENF 90
Cdd:COG2267     2 TRRLVTLPTRDGLRLRGRRWRP-AGSPRGTVVLVHGLG-EHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  91 DDIVNDCnDHFSKICEKEENKRkkRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPmckiADDMKPPAAVTTllqglSWV 170
Cdd:COG2267    80 DDYVDDL-RAALDALRARPGLP--VVLLGHSMGGLIALLYAARYPDRVAGLVLLAP----AYRADPLLGPSA-----RWL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 171 IptwksfnitkdiieigfkeprvreeirkseycykgpprmrtacellrvSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVS 250
Cdd:COG2267   148 R------------------------------------------------ALRLAEALARIDVPVLVLHGGADRVVPPEAA 179

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2029597923 251 IELFKvASSTDKTIKLYPGMWHALLcGEPleNTEIVFADIIRWLEE 296
Cdd:COG2267   180 RRLAA-RLSPDVELVLLPGARHELL-NEP--AREEVLAAILAWLER 221
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
37-299 6.21e-27

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 106.18  E-value: 6.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  37 PKALIFIfHGYamecsitMSSTAI------RLVKEGYAVYGMDYQGHGkSSGLDGYVENFDDIVNDCNDHF---SKICEk 107
Cdd:COG1647    15 RKGVLLL-HGF-------TGSPAEmrplaeALAKAGYTVYAPRLPGHG-TSPEDLLKTTWEDWLEDVEEAYeilKAGYD- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 108 eenkrkKRYLLGESMGGAVILLLHRKKPEYwDGAVLVAPMCKIADDMKPPAAVttllqgLSWVIPTWKsfnitkdiieig 187
Cdd:COG1647    85 ------KVIVIGLSMGGLLALLLAARYPDV-AGLVLLSPALKIDDPSAPLLPL------LKYLARSLR------------ 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 188 fKEPRVREEIRKSEYCYKGPPrMRTACELLRVSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVSIELFKVASSTDKTIKLY 267
Cdd:COG1647   140 -GIGSDIEDPEVAEYAYDRTP-LRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWL 217

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2029597923 268 PGMWHALLCGeplENTEIVFADIIRWLEERTK 299
Cdd:COG1647   218 EDSGHVITLD---KDREEVAEEILDFLERLAA 246
PHA02857 PHA02857
monoglyceride lipase; Provisional
 16-300 1.74e-25

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 103.04  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  16 FFTNSQGSKLFTCKWIPIKdEPKALIFIFHGyAMECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVENFDDIVN 95
Cdd:PHA02857    4 CMFNLDNDYIYCKYWKPIT-YPKALVFISHG-AGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  96 DCNDHFSKIceKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKiADDMKPPAAVTTLLQGLswVIPTWK 175
Cdd:PHA02857   82 DVVQHVVTI--KSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVN-AEAVPRLNLLAAKLMGI--FYPNKI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 176 SFNITKDIIEIGFKE-------PRVREEIRKSEYCYkgpprmrtacELLRVSYDIEQRLNEVTLPFIVLHGEDDKVTDQQ 248
Cdd:PHA02857  157 VGKLCPESVSRDMDEvykyqydPLVNHEKIKAGFAS----------QVLKATNKVRKIIPKIKTPILILQGTNNEISDVS 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2029597923 249 VSIELFKVASStDKTIKLYPGMWHALLcGEPLENTEIVFADIIRWLEERTKL 300
Cdd:PHA02857  227 GAYYFMQHANC-NREIKIYEGAKHHLH-KETDEVKKSVMKEIETWIFNRVKV 276
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 5-296 1.49e-18

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 83.43  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923   5 HPPENVKYDEEFFTNSQGSKLFTCKWIPIKDEPK-ALIFIFHGYAmECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGL 83
Cdd:COG1073     3 PPSDKVNKEDVTFKSRDGIKLAGDLYLPAGASKKyPAVVVAHGNG-GVKEQRALYAQRLAELGFNVLAFDYRGYGESEGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  84 DGYVENFDdiVNDCNDHFSKICEKEENKRKKRYLLGESMGGAVilllhrkkpeywdgAVLVApmckiADDmKPPAAVttl 163
Cdd:COG1073    82 PREEGSPE--RRDARAAVDYLRTLPGVDPERIGLLGISLGGGY--------------ALNAA-----ATD-PRVKAV--- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 164 lqglswviptwksfnitkdIIEIGFKE-PRVREEIRKSEYCYKGP-----PRMRTAcELLRVSYDIEQRLNEVTLPFIVL 237
Cdd:COG1073   137 -------------------ILDSPFTSlEDLAAQRAKEARGAYLPgvpylPNVRLA-SLLNDEFDPLAKIEKISRPLLFI 196

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2029597923 238 HGEDDKVTDQQVSIELFKVASStDKTIKLYPGMWHALLcgePLENTEIVFADIIRWLEE 296
Cdd:COG1073   197 HGEKDEAVPFYMSEDLYEAAAE-PKELLIVPGAGHVDL---YDRPEEEYFDKLAEFFKK 251
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
17-299 1.17e-17

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 80.45  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  17 FTNSQGSKLFTckWI--PIKDEPKALIFIFHGYAMECSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGlDGYVENFDDIV 94
Cdd:COG1506     2 FKSADGTTLPG--WLylPADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAG-DWGGDEVDDVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  95 nDCNDHfskICEKEENKRKKRYLLGESMGGAVILLLHRKKPEYWDGAVLVAPMCKIADDMKPPAAVTTLLQGLSWVIPtw 174
Cdd:COG1506    79 -AAIDY---LAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDP-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 175 ksfnitkdiieigfkeprvrEEIRKseycykgpprmrtacellrvsYDIEQRLNEVTLPFIVLHGEDDKVTDQQVSIELF 254
Cdd:COG1506   153 --------------------EAYAA---------------------RSPLAYADKLKTPLLLIHGEADDRVPPEQAERLY 191

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2029597923 255 KVASSTDKTIKL--YPGMWHALLcgepLENTEIVFADIIRWLEERTK 299
Cdd:COG1506   192 EALKKAGKPVELlvYPGEGHGFS----GAGAPDYLERILDFLDRHLK 234
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 35-297 1.30e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 71.57  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  35 DEPKALIFIfHGYAmeCSITMSSTAIRLVKEGYAVYGMDYQGHGKSSGLDGYVeNFDDIVNDCNDHFskicekEENKRKK 114
Cdd:COG0596    21 PDGPPVVLL-HGLP--GSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGY-TLDDLADDLAALL------DALGLER 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 115 RYLLGESMGGAVILLLHRKKPEYWDGAVLVApmckiaddmkppaavttllqglswviptwksfnitkDIIEigfkepRVR 194
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPERVAGLVLVD------------------------------------EVLA------ALA 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 195 EEIRKSEYcykGPPRMRTACELLRvSYDIEQRLNEVTLPFIVLHGEDDKVTDQQVSIELFKVASstDKTIKLYPGMWHAL 274
Cdd:COG0596   129 EPLRRPGL---APEALAALLRALA-RTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLP--NAELVVLPGAGHFP 202

                         250       260
                  ....*....|....*....|...
gi 2029597923 275 lcgePLENTEIVFADIIRWLEER 297
Cdd:COG0596   203 ----PLEQPEAFAAALRDFLARL 221
PRK10749 PRK10749
lysophospholipase L2; Provisional
 59-150 2.65e-13

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 69.64  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  59 AIRLVKEGYAVYGMDYQGHGKSSGL-----DGYVENFDDIVNDcndhFSKICEKEENKR--KKRYLLGESMGGAVILLLH 131
Cdd:PRK10749   74 AYDLFHLGYDVLIIDHRGQGRSGRLlddphRGHVERFNDYVDD----LAAFWQQEIQPGpyRKRYALAHSMGGAILTLFL 149

                          90
                  ....*....|....*....
gi 2029597923 132 RKKPEYWDGAVLVAPMCKI 150
Cdd:PRK10749  150 QRHPGVFDAIALCAPMFGI 168
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 61-295 1.16e-12

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 67.50  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  61 RLVKEGYAVYGMDYQGHGKSSGLD---GYVENFDDIVNDCNDHFSKI-----CEKE----------ENKRKKR---YLLG 119
Cdd:TIGR01607  69 NFNKNGYSVYGLDLQGHGESDGLQnlrGHINCFDDLVYDVIQYMNRIndsiiLENEtksddesydiVNTKENRlpmYIIG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 120 ESMGGAVILL---LHRKKPEYWD-----GAVLVAPMCKIA-----DDMKPPAAVTTLLQGLSWVIPTwksFNITKdiiEI 186
Cdd:TIGR01607 149 LSMGGNIALRlleLLGKSNENNDklnikGCISLSGMISIKsvgsdDSFKFKYFYLPVMNFMSRVFPT---FRISK---KI 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 187 GF-KEPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIEQRLNEV--TLPFIVLHGEDDKVTDQQVSIELFKVASSTDKT 263
Cdd:TIGR01607 223 RYeKSPYVNDIIKFDKFRYDGGITFNLASELIKATDTLDCDIDYIpkDIPILFIHSKGDCVCSYEGTVSFYNKLSISNKE 302

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2029597923 264 IKLYPGMWHaLLCGEPleNTEIVFADIIRWLE 295
Cdd:TIGR01607 303 LHTLEDMDH-VITIEP--GNEEVLKKIIEWIS 331
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 40-253 6.46e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 58.67  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  40 LIFIFHGYAMecSITMSSTAIR-LVKEGYAVYGMDYQGHGKSSG---LDGYveNFDDIVNDcndhFSKICEKeeNKRKKR 115
Cdd:pfam00561   2 PVLLLHGLPG--SSDLWRKLAPaLARDGFRVIALDLRGFGKSSRpkaQDDY--RTDDLAED----LEYILEA--LGLEKV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 116 YLLGESMGGAVILLLHRKKPEYWDGAVLVAPmckIADDMKPPAAVTTLLQGLSWVIPTWKS-FNITKDIIEIGFK----- 189
Cdd:pfam00561  72 NLVGHSMGGLIALAYAAKYPDRVKALVLLGA---LDPPHELDEADRFILALFPGFFDGFVAdFAPNPLGRLVAKLlalll 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029597923 190 -----EPRVREEIRKSEYCYKGPPRMRTACELLRVSYDIE----QRLNEVTLPFIVLHGEDDKVTDQQVSIEL 253
Cdd:pfam00561 149 lrlrlLKALPLLNKRFPSGDYALAKSLVTGALLFIETWSTelraKFLGRLDEPTLIIWGDQDPLVPPQALEKL 221
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 61-276 1.13e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 42.46  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  61 RLVKEGYAVYGMDYQGHGKSSGLDGYVENFDDIVNDCNDHFSKicekeenkrKKRYLLGESMGGAVILLLHRKKPeywDG 140
Cdd:pfam12697  16 ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAA---------RPVVLVGHSLGGAVALAAAAAAL---VV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923 141 AVLVAPMCkIADDMKPPAAVTTLLQGLSWVIPTWKSFNITKDIIeigFKEPRVREEIRKSeycYKGPPRMRTACELLRVS 220
Cdd:pfam12697  84 GVLVAPLA-APPGLLAALLALLARLGAALAAPAWLAAESLARGF---LDDLPADAEWAAA---LARLAALLAALALLPLA 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2029597923 221 ydieqRLNEVTLPFIVLHGEDDKVTDQQVSIelfkVASSTDKTIKLYPGMWHALLC 276
Cdd:pfam12697 157 -----AWRDLPVPVLVLAEEDRLVPELAQRL----LAALAGARLVVLPGAGHLPLD 203
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
233-299 8.94e-04

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 39.86  E-value: 8.94e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2029597923 233 PFIVLHGEDDKVTDQqvSIELFK--VASSTDKTIKLYPGMWHALLCGEPLENTEIVFADIIRWLEERTK 299
Cdd:COG0657   141 PTLIVTGEADPLVDE--SEALAAalRAAGVPVELHVYPGGGHGFGLLAGLPEARAALAEIAAFLRRALA 207
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
30-170 1.92e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 39.36  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029597923  30 WIPIKDEPKALIFIFHGyaMECSIT---MSSTAIRLVKEGYAVYGMDYQGHGKSSGL------DGYVENFDDIVNDCndh 100
Cdd:COG0429    53 WSDPPAPSKPLVVLLHG--LEGSSDshyARGLARALYARGWDVVRLNFRGCGGEPNLlprlyhSGDTEDLVWVLAHL--- 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029597923 101 fskiceKEENKRKKRYLLGESMGGAVILLL---HRKKPEYWDGAVLVAPMCKIAddmkppAAVTTLLQGLSWV 170
Cdd:COG0429   128 ------RARYPYAPLYAVGFSLGGNLLLKYlgeQGDDAPPLKAAVAVSPPLDLA------ASADRLERGFNRL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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