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Conserved domains on  [gi|2029300722|ref|NP_001381506|]
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carnosine synthase 1 isoform 3 [Homo sapiens]

Protein Classification

acetyl-CoA carboxylase biotin carboxylase subunit family protein( domain architecture ID 11418417)

acetyl-CoA carboxylase biotin carboxylase subunit family protein similar to Bacillus subtilis alanine--anticapsin ligase that is part of the bacABCDEFG operon responsible for the biosynthesis of bacilysin, an irreversible inactivator of the glutaminase domain of glucosamine synthetase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 543-817 9.34e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 150.79  E-value: 9.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 543 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 622
Cdd:COG0439     3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 623 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 702
Cdd:COG0439    73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 703 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 781
Cdd:COG0439   145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2029300722 782 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 817
Cdd:COG0439   224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 543-817 9.34e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 150.79  E-value: 9.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 543 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 622
Cdd:COG0439     3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 623 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 702
Cdd:COG0439    73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 703 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 781
Cdd:COG0439   145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2029300722 782 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 817
Cdd:COG0439   224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
PRK02186 PRK02186
argininosuccinate lyase; Provisional
 506-906 1.16e-21

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 101.08  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 506 ARDYGLQLHLVESDPNH--FASQLVQTFIHFDMtehRRDEENARLLAELVRARGLkldgcFSYWDDCLVLTALLCQELGL 583
Cdd:PRK02186   23 ALLRGFTPYFLTANRGKypFLDAIRVVTISADT---SDPDRIHRFVSSLDGVAGI-----MSSSEYFIEVASEVARRLGL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 584 PCSSPAAMRLAKQKsLTQLHLLHHHGPPwpAPSLHAvpccpLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQ 663
Cdd:PRK02186   95 PAANTEAIRTCRDK-KRLARTLRDHGID--VPRTHA-----LALRAVALDALDGLTYPVVVKPRMGSGSVGVRLCASVAE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 664 CHEHFSRITRDLqgeadhpgiglgwGNAMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAP 743
Cdd:PRK02186  167 AAAHCAALRRAG-------------TRAALVQAYVEGDEYSVETLTVARGHQVLGITRKHLGPPPHFVEIGHDFPAPLSA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 744 EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRPALPTRP 823
Cdd:PRK02186  234 PQRERIVRTVLRALDAVGYAFGPAHTELRVRGDTVVIIEINPRLAGGMIPVLLEEAFGVDLLDHVIDLHLGVAAFADPTA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 824 RARGHLVGVMCLVSQHLQALSstASRETLQALHDRGLLRLNLLEEALVP-GEYEEPYCSVACAGPSPTEARLRLLGLCQG 902
Cdd:PRK02186  314 KRYGAIRFVLPARSGVLRGLL--FLPDDIAARPELRFHPLKQPGDALRLeGDFRDRIAAVVCAGDHRDSVAAAAERAVAG 391


                  ....
gi 2029300722 903 LGID 906
Cdd:PRK02186  392 LSID 395
ATPgrasp_Ter pfam15632
ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to ...
 691-824 2.15e-13

ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434824 [Multi-domain]  Cd Length: 131  Bit Score: 68.02  E-value: 2.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 691 AMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFtetaacmptglapEQEAQMVQAAFRCCLGCGLlDGVFNVE 770
Cdd:pfam15632   4 PLLVMEYLPGPEYSVDCLAGHGELIAAVPRRKGDGGIQTL-------------EDDPELIEAARRLAEAFGL-DGLFNVQ 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2029300722 771 LKLTGAGPRLIEINPRM-GGFYLrdwiLELYGVDLLLAAVMVACGLRPALPTRPR 824
Cdd:pfam15632  70 FRYDGDGPKLLEINPRMsGGIGY----SCLAGVNLPYLALKLLLGLETPDPVEPR 120
 
Name Accession Description Interval E-value
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 543-817 9.34e-41

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 150.79  E-value: 9.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 543 EENARLLAELVRARGLklDGCFSYWDDCLVLTALLCQELGLPCSSPAAMRLAKQKSLTQlHLLHHHGPPwpapslhAVPC 622
Cdd:COG0439     3 DAIIAAAAELARETGI--DAVLSESEFAVETAAELAEELGLPGPSPEAIRAMRDKVLMR-EALAAAGVP-------VPGF 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 623 CPLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGiglgwgnaMLLMEFVEGTE 702
Cdd:COG0439    73 ALVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGSPNGE--------VLVEEFLEGRE 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 703 HDVDLVLFGGRLLAAFVSDNGPTRlPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAG-PRLI 781
Cdd:COG0439   145 YSVEGLVRDGEVVVCSITRKHQKP-PYFVELGHEAPSPLPEELRAEIGELVARALRALGYRRGAFHTEFLLTPDGePYLI 223

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2029300722 782 EINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRP 817
Cdd:COG0439   224 EINARLGGEHIPPLTELATGVDLVREQIRLALGEPR 259
PRK02186 PRK02186
argininosuccinate lyase; Provisional
 506-906 1.16e-21

argininosuccinate lyase; Provisional


Pssm-ID: 235010 [Multi-domain]  Cd Length: 887  Bit Score: 101.08  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 506 ARDYGLQLHLVESDPNH--FASQLVQTFIHFDMtehRRDEENARLLAELVRARGLkldgcFSYWDDCLVLTALLCQELGL 583
Cdd:PRK02186   23 ALLRGFTPYFLTANRGKypFLDAIRVVTISADT---SDPDRIHRFVSSLDGVAGI-----MSSSEYFIEVASEVARRLGL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 584 PCSSPAAMRLAKQKsLTQLHLLHHHGPPwpAPSLHAvpccpLESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDAPQ 663
Cdd:PRK02186   95 PAANTEAIRTCRDK-KRLARTLRDHGID--VPRTHA-----LALRAVALDALDGLTYPVVVKPRMGSGSVGVRLCASVAE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 664 CHEHFSRITRDLqgeadhpgiglgwGNAMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAP 743
Cdd:PRK02186  167 AAAHCAALRRAG-------------TRAALVQAYVEGDEYSVETLTVARGHQVLGITRKHLGPPPHFVEIGHDFPAPLSA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 744 EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVACGLRPALPTRP 823
Cdd:PRK02186  234 PQRERIVRTVLRALDAVGYAFGPAHTELRVRGDTVVIIEINPRLAGGMIPVLLEEAFGVDLLDHVIDLHLGVAAFADPTA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 824 RARGHLVGVMCLVSQHLQALSstASRETLQALHDRGLLRLNLLEEALVP-GEYEEPYCSVACAGPSPTEARLRLLGLCQG 902
Cdd:PRK02186  314 KRYGAIRFVLPARSGVLRGLL--FLPDDIAARPELRFHPLKQPGDALRLeGDFRDRIAAVVCAGDHRDSVAAAAERAVAG 391


                  ....
gi 2029300722 903 LGID 906
Cdd:PRK02186  392 LSID 395
ATPgrasp_Ter pfam15632
ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to ...
 691-824 2.15e-13

ATP-grasp in the biosynthetic pathway with Ter operon; This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.


Pssm-ID: 434824 [Multi-domain]  Cd Length: 131  Bit Score: 68.02  E-value: 2.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 691 AMLLMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFtetaacmptglapEQEAQMVQAAFRCCLGCGLlDGVFNVE 770
Cdd:pfam15632   4 PLLVMEYLPGPEYSVDCLAGHGELIAAVPRRKGDGGIQTL-------------EDDPELIEAARRLAEAFGL-DGLFNVQ 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2029300722 771 LKLTGAGPRLIEINPRM-GGFYLrdwiLELYGVDLLLAAVMVACGLRPALPTRPR 824
Cdd:pfam15632  70 FRYDGDGPKLLEINPRMsGGIGY----SCLAGVNLPYLALKLLLGLETPDPVEPR 120
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 638-789 9.29e-09

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 55.37  E-value: 9.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 638 VPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGIGLGWGNAMLLMEFVEGTEHDVDlVLFG--GRLL 715
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFAAIREEIEQWKEMYPEAVVDGGSFLVEEYIEGEEFAVD-AYFDenGEPV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2029300722 716 AAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGAGP-RLIEINP-RMGG 789
Cdd:pfam13535  80 ILNILKHDFASSEDVSDRIYVTSASIIRETQAAFTEFLKRINALLGLKNFPVHIELRVDEDGQiIPIEVNPlRFAG 155
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 587-804 1.50e-08

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 57.26  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 587 SPAAMRLAKQKSLTQLhllhhhgppwpAPSLHAVPCCP---LESEADVERAVHQVPLPGVMKLEFGAGAVGVRLVEDApq 663
Cdd:COG0189    87 DPEAIRRARDKLFTLQ-----------LLARAGIPVPPtlvTRDPDDLRAFLEELGGPVVLKPLDGSGGRGVFLVEDE-- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 664 chEHFSRITRDLQGEADHPgiglgwgnaMLLMEFVEGTE-HDVDLVLFGGRLLAAF--VSDNGPTR----LPGFTETAAc 736
Cdd:COG0189   154 --DALESILEALTELGSEP---------VLVQEFIPEEDgRDIRVLVVGGEPVAAIrrIPAEGEFRtnlaRGGRAEPVE- 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2029300722 737 mptglAPEQEAQMVQAAFRCclgcgLLDGVFNVELKLTGAGPRLIEINPRMGgfyLRdWILELYGVDL 804
Cdd:COG0189   222 -----LTDEERELALRAAPA-----LGLDFAGVDLIEDDDGPLVLEVNVTPG---FR-GLERATGVDI 275
ATPgrasp_N pfam18130
ATP-grasp N-terminal domain; This is the N-terminal domain found in BL00235 present in ...
 504-584 1.75e-06

ATP-grasp N-terminal domain; This is the N-terminal domain found in BL00235 present in Bacillus licheniformis. BL00235 is a ATP-grasp superfamily protein that catalyzes the formation of an alpha-peptide bond between two L-amino acids in an ATP-dependent manner. BL00235 has a highly restricted substrate specificity: the N-terminal substrate is confined to L-methionine an L-leucine, while the C-terminal substrates include small residues such as L-alanine, L-serine, L-threonine and L-cysteine.


Pssm-ID: 407962 [Multi-domain]  Cd Length: 81  Bit Score: 46.49  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 504 EAARDYGLQLHLV----ESDPNHFASqlVQTFIHFDMTEhrrDEENA-RLLAELVRARGLklDGCFSYWDDCLVLTALLC 578
Cdd:pfam18130   2 EAARALGIDVTVVdepgEWAPGHLPA--VEEFIPLDLAD---DPDRAlEIVRALHRARPV--DGVVTFTDPFLPFVARAA 74


                  ....*.
gi 2029300722 579 QELGLP 584
Cdd:pfam18130  75 EALGLP 80
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 617-800 3.18e-06

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 50.27  E-value: 3.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 617 LHAVPCCPLESEADVERA--VHQVPLPGVMKLEFGAGAVGVRLVEDapqchehFSRITRDLQGEADhpgiglgwgnaMLL 694
Cdd:PRK12767  124 IPTPKSYLPESLEDFKAAlaKGELQFPLFVKPRDGSASIGVFKVND-------KEELEFLLEYVPN-----------LII 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 695 MEFVEGTEHDVD-LVLFGGRLLAAFVSDNGPTRlPGFTETAAcmpTGLAPEQEAQMVQAAFRccLGCgllDGVFNVELKL 773
Cdd:PRK12767  186 QEFIEGQEYTVDvLCDLNGEVISIVPRKRIEVR-AGETSKGV---TVKDPELFKLAERLAEA--LGA---RGPLNIQCFV 256

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2029300722 774 TGAGPRLIEINPRMGG-FYLR--------DWILELY 800
Cdd:PRK12767  257 TDGEPYLFEINPRFGGgYPLSymaganepDWIIRNL 292
ATP-grasp_3 pfam02655
ATP-grasp domain; No functional information or experimental verification of function is known ...
 620-789 8.43e-06

ATP-grasp domain; No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).


Pssm-ID: 396979 [Multi-domain]  Cd Length: 160  Bit Score: 46.99  E-value: 8.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 620 VPCCPLESEADVEravhqvPLPGVMKLEFGAGAVGVRLVEDapqchehfsritrdlqGEADHPGIglgwgNAMLLMEFVE 699
Cdd:pfam02655  18 TPETLQAEELLRE------EKKYVVKPRDGCGGEGVRKVEN----------------GREDEAFI-----ENVLVQEFIE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 700 GTEHDVDLVLFGGRllAAFVSDNgpTRLPGFTETAACMPTGLAP---EQEAQMVQAAFRCCLGCGLLDGVFNVELKLTGA 776
Cdd:pfam02655  71 GEPLSVSLLSDGEK--ALPLSVN--RQYIDNGGSGFVYAGNVTPsrtELKEEIIELAEEVVECLPGLRGYVGVDLVLKDN 146

                         170
                  ....*....|...
gi 2029300722 777 GPRLIEINPRMGG 789
Cdd:pfam02655 147 EPYVIEVNPRITT 159
PylC COG2232
Pyrrolysine biosynthesis ligase PylC and related enzymes, ATP-grasp superfamily [Amino acid ...
 718-896 1.20e-04

Pyrrolysine biosynthesis ligase PylC and related enzymes, ATP-grasp superfamily [Amino acid transport and metabolism];


Pssm-ID: 441833 [Multi-domain]  Cd Length: 370  Bit Score: 45.30  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 718 FVSDNGPTRLPGFTE----TAACM---------PTGLAPEQEAQMVQAAFRCCLGCGLLdGVFNVELKLTGAGPRLIEIN 784
Cdd:COG2232   182 FLADGSDARVLGFNRqligPAGERpfryggnigPLALPPALAEEMRAIAEALVAALGLV-GLNGVDFILDGDGPYVLEVN 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 785 PRMGGfylrdwILELYGVDL---LLAAVMVACglRPALPTRPRARGHLVGVMCLV-SQHlqALSSTASRETLQALHDRGl 860
Cdd:COG2232   261 PRPQA------SLDLYEDATggnLFDAHLRAC--RGELPEVPRPKPRRVAAKAILyAPR--DLTIPDDLSWPPWVADIP- 329

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2029300722 861 lrlnlleealVPGEY---EEPYCSVACAGPSPTEARLRL 896
Cdd:COG2232   330 ----------APGTRiekGEPVCTVLAEGPTAEAARALL 358
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
625-830 1.83e-03

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 41.84  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 625 LESEADVERAVHQVPLPGVMK--------LEFGAGAVGVRLVEDAPQCHEHFSRITrdlqgEADHPgiglgwgnaMLLME 696
Cdd:COG3919   138 LDSADDLDALAEDLGFPVVVKpadsvgydELSFPGKKKVFYVDDREELLALLRRIA-----AAGYE---------LIVQE 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722 697 FVEGTEhDVDLVLFG-----GRLLAAFVSdngpTRL----PGFTETAACMPTGlapeqEAQMVQAAFRcclgcgLLD--- 764
Cdd:COG3919   204 YIPGDD-GEMRGLTAyvdrdGEVVATFTG----RKLrhypPAGGNSAARESVD-----DPELEEAARR------LLEalg 267

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2029300722 765 --GVFNVELKL---TGAgPRLIEINPRMGG-FYLrdwiLELYGVDLLLAAVMVACG--LRPALPTRPRARGHLV 830
Cdd:COG3919   268 yhGFANVEFKRdprDGE-YKLIEINPRFWRsLYL----ATAAGVNFPYLLYDDAVGrpLEPVPAYREGVLWRVL 336
carB PRK12815
carbamoyl phosphate synthase large subunit; Reviewed
 692-788 7.85e-03

carbamoyl phosphate synthase large subunit; Reviewed


Pssm-ID: 237215 [Multi-domain]  Cd Length: 1068  Bit Score: 39.95  E-value: 7.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029300722  692 MLLMEFVEGTEHDVDLvlfggrllaafVSDNGPTRLPGFTE------------TAACMPTGLAPEQEAQMVQAAFRCCLG 759
Cdd:PRK12815   744 ILIDQFIDGKEYEVDA-----------ISDGEDVTIPGIIEhieqagvhsgdsIAVLPPQSLSEEQQEKIRDYAIKIAKK 812

                           90       100
                   ....*....|....*....|....*....
gi 2029300722  760 CGLLdGVFNVELKLTGAGPRLIEINPRMG 788
Cdd:PRK12815   813 LGFR-GIMNIQFVLANDEIYVLEVNPRAS 840
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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