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Conserved domains on  [gi|2029076369|ref|XP_040900041|]
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Krueppel-like factor 10 [Toxotes jaculatrix]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 17-372 8.60e-110

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 325.40  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  17 MGAGDMEAVEALMSMTKHWKTRSFRLGHFRPLTPSSDCSEDDSGPPGSAVPQDSPLCMTPPYSPPHCEAAHPPSAATLHQ 96
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  97 PAvsgsstWQPTEETQLHTHTAASQQRFQCTSVIRHTADGQHCCCSVHPDSkedrlthvhtrdckrdlnsedelntrdse 176
Cdd:cd21572    81 PA------AQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPSS----------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 177 kmiimqsdfraatpqkhlsatlpnvakdgqtqislsgpddkpdtPQSVSSVPAVVNGVSPVPVHHQILPVSSLSTTAVQK 256
Cdd:cd21572   126 --------------------------------------------PSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAA 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 257 PVtssesqrqhqlpatsaittvhtpqqqqhkqqhPLLQPQTQAGSSTQVILLGGEVAKGPIMLLVPQPAVPTLYIQPALV 336
Cdd:cd21572   162 QA--------------------------------PLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLV 209

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2029076369 337 RSGGTKLPAIAPAPGRTSPQQRQSPLQPELSRVRSH 372
Cdd:cd21572   210 TPGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-415 1.29e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*...
gi 2029076369 388 HLKAHMRTHTGEKPFKCKweGCERRFAR 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
370-455 5.63e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 370 RSHVCPREDCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCTM--CLSRFM 442
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2029076369 443 RSDHLAKHARRHL 455
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 17-372 8.60e-110

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 325.40  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  17 MGAGDMEAVEALMSMTKHWKTRSFRLGHFRPLTPSSDCSEDDSGPPGSAVPQDSPLCMTPPYSPPHCEAAHPPSAATLHQ 96
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  97 PAvsgsstWQPTEETQLHTHTAASQQRFQCTSVIRHTADGQHCCCSVHPDSkedrlthvhtrdckrdlnsedelntrdse 176
Cdd:cd21572    81 PA------AQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPSS----------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 177 kmiimqsdfraatpqkhlsatlpnvakdgqtqislsgpddkpdtPQSVSSVPAVVNGVSPVPVHHQILPVSSLSTTAVQK 256
Cdd:cd21572   126 --------------------------------------------PSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAA 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 257 PVtssesqrqhqlpatsaittvhtpqqqqhkqqhPLLQPQTQAGSSTQVILLGGEVAKGPIMLLVPQPAVPTLYIQPALV 336
Cdd:cd21572   162 QA--------------------------------PLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLV 209

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2029076369 337 RSGGTKLPAIAPAPGRTSPQQRQSPLQPELSRVRSH 372
Cdd:cd21572   210 TPGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-415 1.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*...
gi 2029076369 388 HLKAHMRTHTGEKPFKCKweGCERRFAR 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
354-439 3.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 354 SPQQRQSPLQPELSRVRSHVCPRedCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRFARSDELSRHRRTHTGEKKFV 433
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93


                  ....*.
gi 2029076369 434 CTMCLS 439
Cdd:COG5048    94 NSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
370-455 5.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 370 RSHVCPREDCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCTM--CLSRFM 442
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2029076369 443 RSDHLAKHARRHL 455
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 17-372 8.60e-110

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 325.40  E-value: 8.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  17 MGAGDMEAVEALMSMTKHWKTRSFRLGHFRPLTPSSDCSEDDSGPPGSAVPQDSPLCMTPPYSPPHCEAAHPPSAATLHQ 96
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAATLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  97 PAvsgsstWQPTEETQLHTHTAASQQRFQCTSVIRHTADGQHCCCSVHPDSkedrlthvhtrdckrdlnsedelntrdse 176
Cdd:cd21572    81 PA------AQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCPSS----------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 177 kmiimqsdfraatpqkhlsatlpnvakdgqtqislsgpddkpdtPQSVSSVPAVVNGVSPVPVHHQILPVSSLSTTAVQK 256
Cdd:cd21572   126 --------------------------------------------PSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAA 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 257 PVtssesqrqhqlpatsaittvhtpqqqqhkqqhPLLQPQTQAGSSTQVILLGGEVAKGPIMLLVPQPAVPTLYIQPALV 336
Cdd:cd21572   162 QA--------------------------------PLPQPQQQAASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLV 209

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2029076369 337 RSGGTKLPAIAPAPGRTSPQQRQSPLQPELSRVRSH 372
Cdd:cd21572   210 TPGGTKLAAIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 18-372 1.43e-85

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 262.56  E-value: 1.43e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  18 GAGDMEAVEALMSMTKHWKTRSFRLGHFRPLTPSSDCSEDDSGPPGSAVPQD-SPLCMTPPYSPPHCEAAHPPSAATLHQ 96
Cdd:cd21974     1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSlSSLCMTPPYSPPFFEASHSPSVASLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  97 PAVsgsSTWQPTEETQLHTHTAASQQRFQCTSVIRHTADgqhcccsvhpdskedrlthvhtrdckrdlnsedelntrdse 176
Cdd:cd21974    81 PSA---ASSQPPPEPESSEPPAASPQRAQATSVIRHTAD----------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 177 kmiimqsdfraatpqkhlsatlpnvakdgqtqislsgpddkpdtpqsvssvpavVNGVSPVPVHHQILPVSSLSTTAVQK 256
Cdd:cd21974   117 ------------------------------------------------------PVPVSPPPVLCQMLPVSSSSGVIVAF 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 257 PVTSSesqrqhqlpatsaittvhtpqqqqhkqqHPLLQPQTQAGSSTQVILLGGEVAKGPIMLLVPQPAVPTLYIQPALV 336
Cdd:cd21974   143 LKAPQ----------------------------QPSPQPQKPALPQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQPTVV 194

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2029076369 337 RSGGTKLPAIAPAPGRTSPQQRqSPLQPELSRVRSH 372
Cdd:cd21974   195 TPGGTKLLPIAPAPGFIPSGQS-SAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 21-350 1.60e-13

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 69.64  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  21 DMEAVEALMSMTKhWKTRSFR--LGHFRPLTPSSD-CSEDDSGPPGSAVPQD----SPLCMTPPYSPPHCEaahpPSAAT 93
Cdd:cd21584     5 DLEAVEALVCMSS-WGQRSQKgdLLKIRPLTPASDsCDSLTLHPAAPELPKDfhslSSLCMTPPHSPSFAE----PSTTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369  94 LHQPAvsgsstwqpteetqlhthtaasqqRFQCTSVIRHTADgqhcccsvhpdskedrlthvhtrdckrdlnsedelntr 173
Cdd:cd21584    80 PPPPC------------------------RAMATSVIRHTAD-------------------------------------- 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 174 dsekmiimqsdfraatpqkhlsatlpnvakdgqtqislsgpddkpdtpqSVSSVPavvngVSPVPVHHQILPVSS---LS 250
Cdd:cd21584    98 -------------------------------------------------SSPPVP-----VPSPPVLCQMIPVSGqsgMI 123

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 251 TTAVQKPVTSSESQRqhqlpatsaittvhtpqqqqhkqqhPLLqpqTQAGSSTQVILLGGEVAKGPIMLLVPQPAVP-TL 329
Cdd:cd21584   124 SAFLQPPALSAGTVK-------------------------PIL---PQTAPASQPLLVGSPVPQGTVMLVLPQASVPqPP 175

                         330       340
                  ....*....|....*....|.
gi 2029076369 330 YIQPALVRSGGTKLPAIAPAP 350
Cdd:cd21584   176 QCPQTVMTLGNTKLLPLAPAP 196
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-415 1.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.29e-04
                          10        20
                  ....*....|....*....|....*...
gi 2029076369 388 HLKAHMRTHTGEKPFKCKweGCERRFAR 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCP--ECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
354-439 3.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 354 SPQQRQSPLQPELSRVRSHVCPRedCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRFARSDELSRHRRTHTGEKKFV 433
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93


                  ....*.
gi 2029076369 434 CTMCLS 439
Cdd:COG5048    94 NSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
370-455 5.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029076369 370 RSHVCPREDCSKTYFKSSHLKAHMRTHTGEKPFKCKWEGCERRF-----ARSDELSRHRRTHTGEKKFVCTM--CLSRFM 442
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 2029076369 443 RSDHLAKHARRHL 455
Cdd:COG5048   400 RDSNLSLHIITHL 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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