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Conserved domains on  [gi|2028832719|gb|QUB40202|]
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galactokinase [Prevotella veroralis]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 520.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRVEFKVDDPE 82
Cdd:COG0153     2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  83 -GPRATWARFIYGMVQEFKALGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATEHK 161
Cdd:COG0153    82 pGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF-GLGLDPVELAKIGQRAENE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 162 YIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKhfpd 241
Cdd:COG0153   161 FVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGV---- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 242 kkfETLRDANWEELEAVKAEV-SAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDYL 320
Cdd:COG0153   237 ---KSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2028832719 321 NDVAKE-NGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:COG0153   314 VELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 520.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRVEFKVDDPE 82
Cdd:COG0153     2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  83 -GPRATWARFIYGMVQEFKALGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATEHK 161
Cdd:COG0153    82 pGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF-GLGLDPVELAKIGQRAENE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 162 YIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKhfpd 241
Cdd:COG0153   161 FVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGV---- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 242 kkfETLRDANWEELEAVKAEV-SAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDYL 320
Cdd:COG0153   237 ---KSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2028832719 321 NDVAKE-NGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:COG0153   314 VELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05322 PRK05322
galactokinase; Provisional
 1-385 1.52e-114

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 338.76  E-value: 1.52e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   1 MDIEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYS--IDLKDRVEFKV 78
Cdd:PRK05322    1 MMKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSanFEDLGIIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  79 DDPEGPRA-TWARFIYGMVQEFKALGVDV-KGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQ 156
Cdd:PRK05322   81 DDLSFDKEdDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLF-NLDLDRLELVKLGQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 157 ATEHKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALG 236
Cdd:PRK05322  160 KTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 237 KHFPDKkfeTLRDANWEELEAVKAEVSAE-DYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCE 315
Cdd:PRK05322  240 KKLDIK---SLGELTEEEFDEYSYLIKDEtLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2028832719 316 ELDYLNDVA-KENGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:PRK05322  317 ELDTLVEAAwKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 3-381 6.44e-99

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 299.05  E-value: 6.44e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRV-EFKVDDP 81
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFaERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  82 --EGPRATWARFIYGMVQEFKALGVDV-KGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQAT 158
Cdd:TIGR00131  81 ldGSEVSDWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMG-HLPLDSKQILLRIQVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 159 EHKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKh 238
Cdd:TIGR00131 160 ENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 239 fpdKKFETLRD---ANWEELEAVKAEVSAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCE 315
Cdd:TIGR00131 239 ---TDKGALRDfmnEYFARYIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCP 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2028832719 316 ELDYLNDVAKE-NGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEG 381
Cdd:TIGR00131 316 EIDELVCSAALvNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPG 382
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 8-57 4.99e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 82.50  E-value: 4.99e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2028832719   8 SRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRP 57
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
3-385 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 520.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRVEFKVDDPE 82
Cdd:COG0153     2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  83 -GPRATWARFIYGMVQEFKALGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATEHK 161
Cdd:COG0153    82 pGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLF-GLGLDPVELAKIGQRAENE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 162 YIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKhfpd 241
Cdd:COG0153   161 FVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILGV---- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 242 kkfETLRDANWEELEAVKAEV-SAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDYL 320
Cdd:COG0153   237 ---KSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2028832719 321 NDVAKE-NGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:COG0153   314 VELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05322 PRK05322
galactokinase; Provisional
 1-385 1.52e-114

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 338.76  E-value: 1.52e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   1 MDIEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYS--IDLKDRVEFKV 78
Cdd:PRK05322    1 MMKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSanFEDLGIIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  79 DDPEGPRA-TWARFIYGMVQEFKALGVDV-KGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQ 156
Cdd:PRK05322   81 DDLSFDKEdDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLF-NLDLDRLELVKLGQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 157 ATEHKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALG 236
Cdd:PRK05322  160 KTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 237 KHFPDKkfeTLRDANWEELEAVKAEVSAE-DYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCE 315
Cdd:PRK05322  240 KKLDIK---SLGELTEEEFDEYSYLIKDEtLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2028832719 316 ELDYLNDVA-KENGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:PRK05322  317 ELDTLVEAAwKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 24-385 1.25e-107

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 320.02  E-value: 1.25e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  24 SPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPngTDTVMCYSIDLKDRVEFKVDDPEgPRATWARFIYGMVQEFKALG 103
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEK--SEKFIFYSENFNEEKTFELDKLE-KLNSWADYIKGVIWVLEKRG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 104 VDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATEHKYIGVNCGIMDQFASVFGKEGKL 183
Cdd:PRK03817   82 YEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAY-NLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKKDHA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 184 MRLDCRSSEFEYFPFdPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKhfpdkkfETLRDANWEELEavkaEVS 263
Cdd:PRK03817  161 IFLDTMTLEYEYVPF-PEDYEILVFDTGVKRELASSEYNERRQECEEALKILGK-------KSSKEVTEEDLS----KLP 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 264 AEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDYLNDVAKENGVTGSRIMGGGFGGCT 343
Cdd:PRK03817  229 PLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSA 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2028832719 344 INLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:PRK03817  309 IALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
PRK05101 PRK05101
galactokinase; Provisional
 3-385 7.45e-104

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 311.47  E-value: 7.45e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKD-RVEFKVDDP 81
Cdd:PRK05101    4 KQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNqQDEFSLDAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  82 EGPRAT--WARFIYGMVQEFKALGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATE 159
Cdd:PRK05101   84 IVPHPEqqWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLY-HLPLSGAEIALNGQEAE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 160 HKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFdPKGYKLVLVNSKVKHELAGSPYNDRRKSCEnvVAAlgKHF 239
Cdd:PRK05101  163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM-PEGVAVVIINSNVKRGLVDSEYNTRRQQCE--TAA--RFF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 240 PDKkfeTLRDANWEELEAVKAEVSAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDY 319
Cdd:PRK05101  238 GVK---ALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDT 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 320 LNDVAK----ENGvtGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEGSHKV 385
Cdd:PRK05101  315 LVEIVKavigDQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 3-381 6.44e-99

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 299.05  E-value: 6.44e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   3 IEFVRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRV-EFKVDDP 81
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFaERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  82 --EGPRATWARFIYGMVQEFKALGVDV-KGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQAT 158
Cdd:TIGR00131  81 ldGSEVSDWANYFKGVLHVAQERFNSFpLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMG-HLPLDSKQILLRIQVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 159 EHKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKGYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGKh 238
Cdd:TIGR00131 160 ENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 239 fpdKKFETLRD---ANWEELEAVKAEVSAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCE 315
Cdd:TIGR00131 239 ---TDKGALRDfmnEYFARYIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCP 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2028832719 316 ELDYLNDVAKE-NGVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYGHKPEIYPVIISEG 381
Cdd:TIGR00131 316 EIDELVCSAALvNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPG 382
PRK00555 PRK00555
galactokinase; Provisional
 22-377 1.31e-74

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 235.91  E-value: 1.31e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  22 YFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRVEFKVDDPEGPRATWARFIYGMVQEFKA 101
Cdd:PRK00555    5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSARIPLDTTPGQVTGWAAYAAGVIWALRG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 102 LGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLfADNKVSKWDIALAGQATEHKYIGVNCGIMDQFASVFGKEG 181
Cdd:PRK00555   85 AGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAA-TGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGAPK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 182 KLMRLDCRSSEFEYFPFDPK--GYKLVLVNSKVKHELAGSPYNDRRKSCENVVAALGkhfpdkkFETLRDANWEELEAVK 259
Cdd:PRK00555  164 TALLIDFRDLTVRPVAFDPDaaGVVLLLMDSRARHRHAGGEYAARRASCERAAADLG-------VSSLRAVQDRGLAALG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 260 AEVSAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYETHYGLSKEYEVSCEELDYLNDVAKENGVTGSRIMGGGF 339
Cdd:PRK00555  237 AIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGF 316

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2028832719 340 GGCTINLVKDDLYETFIENVTEKFNAKyGHKPeiyPVI 377
Cdd:PRK00555  317 GGCVIALVPADRAEDVADTVRRAAVTA-GYPE---PAV 350
PTZ00290 PTZ00290
galactokinase; Provisional
 23-382 1.18e-57

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 195.04  E-value: 1.18e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  23 FSPGRINLIGEHTDYNGGFVFPGAVDKG---IMAEVRpNGTDTVMCYSIDLKDRveFKVDDPEGPR--ATWARFIYG-MV 96
Cdd:PTZ00290   41 FAPGRVNFIGEHVDYMGGYVCPAAVLEGchiLVGRVK-HFCDHKLRFATETDEH--FVLDHLGGAKhnKAWTTFVRGaAT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  97 QEFKALGV-----DVKGFNIAFAGDVPLGAGMSSSAAmescFGCALndLFADNKV----------------------SKW 149
Cdd:PTZ00290  118 LRLNRLGVaidapSLQGVCMVVHGTLPMGAGMSASAS----FGVAL--LNAINTVvtrrykgcptspgrrysilppmSKE 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 150 D-IALAGQA--TEHKYIGVNCGIMDQFASVFGKEGKLMRLDCRSSEFEYFPFDP---KGYKLVLVNSKVKHELAGSP--- 220
Cdd:PTZ00290  192 ElIELAKQArrIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMTPllgDGACFLLIDSMIKHDLLGGTagm 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 221 YNDRRKSCENVVAALGKH--------FPD-----KKFETLRDANwEELEAVKAEVSAEDYQRAHFVLGEKDRVL---AVC 284
Cdd:PTZ00290  272 YNTVRSDQEGAQKKIGKHryrgkpftFSDlvrnpKKYTFDGDVV-AFMESCKPLMTPGEFERGTYNIMEQIRTLefiKLN 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 285 DALVAGDYE----TVGQKMYETHYGLSKEYEVSCEELDYLND-VAKENGVTGSRIMGGGFGGCTINLVKDDLYETFIENV 359
Cdd:PTZ00290  351 DPELPLSREerfrKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHV 430

                         410       420
                  ....*....|....*....|...
gi 2028832719 360 TEKFNAKYGHKPEIYPVIISEGS 382
Cdd:PTZ00290  431 REKFKARFGVENDVYPVVAGDGA 453
PLN02865 PLN02865
galactokinase
 24-383 4.17e-45

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 160.74  E-value: 4.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  24 SPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVMCYSIDLKDRVEFKVDDPEGPRAT----------WARFIY 93
Cdd:PLN02865   35 SPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEVRFRVDEIQHPIANvssdskeesnWGDYAR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  94 GMVQEFKALGVDVKGFNIAFAGDVP--LGAGMSSSAAMESCFGCAL---NDLfadnKVSKWDIALAGQATEHKYIGVNCG 168
Cdd:PLN02865  115 GAVYALQSRGHALSQGITGYISGSEglDSSGLSSSAAVGVAYLLALenaNNL----TVSPEDNIELDRLIENEYLGLRNG 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 169 IMDQFASVFGKEGKLMRLDCRSSEFEYFPFDPKG------YKLVLVNSKVKHELAGSP-YNDRRKSCENVVAAL----GK 237
Cdd:PLN02865  191 ILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALTNKPgYNLRVSECQEAARFLleasGN 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 238 hfpDKKFETLRDANWEELEAVKAEVSAEDYQRAHFVLGEKDRVLAVCDALVAGDYETVGQKMYEThyGLS--KEYEVSCE 315
Cdd:PLN02865  271 ---DELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISAS--GLSsiENYECGCE 345

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2028832719 316 ELDYLNDVAKEN-GVTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFNAKYghkPEIY-------PVIISEGSH 383
Cdd:PLN02865  346 PLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEKAQ---PELAsningdkPVLICEAGD 418
PLN02521 PLN02521
galactokinase
 6-382 3.93e-43

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 156.79  E-value: 3.93e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719   6 VRSRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKG-IMAEVRPNGTDTVMCYSIDLK-DRVEFKVD-DPE 82
Cdd:PLN02521   35 LKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDtIVAIRRAEGSKKLRIANVNDKyTTCTFPADpDQE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  83 GPRA--TWARFI---YGMVQEF-KALGVDVK---GFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFADNkVSKWDIAL 153
Cdd:PLN02521  115 VDLAnhKWGNYFicgYKGVFEFlKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLN-FTKKEVAQ 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 154 AGQATEhKYIGVNCGIMDQFASVFGKEGKLMRLD---CRSSEFEYfpfdPKGYKLVLVNSKV---KHELAGSPYNDRRKS 227
Cdd:PLN02521  194 FTCKCE-RHIGTQSGGMDQAISIMAQQGVAKLIDfnpVRATDVQL----PAGGTFVIANSLAesnKAVTAATNYNNRVVE 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 228 CE--NVVAA--LGKHFPD--KKFETLRDA-----------------------------NWEELEA---------VKAEVS 263
Cdd:PLN02521  269 CRlaAIVLAvkLGMSAEEaiSKVKTLSDVeglcvsfagshgssdpavavkellhegpyTAEEIEEilgesltsiFKNSPT 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 264 AED----------YQRAHFVLGEKDRVLAVCDALVAGDYET-----VGQKMYETHYGLSKEYEVSCEELDYLNDVAKENG 328
Cdd:PLN02521  349 SLAvlkaakhfklHQRAVHVYSEAKRVHAFRDTVSSSLSEEeklkkLGDLMNESHYSCSVLYECSCPELEELVKVCRDNG 428

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2028832719 329 VTGSRIMGGGFGGCTINLVKDDLYETFIENVTEKFnakygHKPEIYPVIISEGS 382
Cdd:PLN02521  429 ALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF-----YKSRIEKGVIKEED 477
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 24-347 4.65e-24

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 100.30  E-value: 4.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  24 SPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDTVmcySIDLKDRvEFKVDDPEGPRATWaRFIYGMVQEF-KAL 102
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKL---RIESPDL-GGTLDLDPLADAAL-RYIKAAIEAAlEYL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 103 GVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIA-LAGQAteHKYIGVNCGIMDQFASVFgkeG 181
Cdd:COG1577    76 GLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFY-GVELSKEELFkLALEA--EKIVHGNPSGLDTAASTY---G 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 182 KLMRLDcRSSEFEYFPFdPKGYKLVLVNSKVKHelagspyndrrkSCENVVAALGKHFpdKKFETLRDANWEELEAVkae 261
Cdd:COG1577   150 GPIYYQ-RGDRAEPLEL-PKNLPLVVGDTGVPA------------STKELVAKVRKLK--ERNPELYEAFLEEIGDL--- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 262 vsaedyqrahfvlgekdrVLAVCDALVAGDYETVGQKMYETHyGLSKEYEVSCEELDYLNDVAKENGVTGSRIMGGGFGG 341
Cdd:COG1577   211 ------------------VEEAIEALEEGDLEALGELMNENH-GLLRALGVSTPELDRLVEAARKAGALGAKLTGAGGGG 271


                  ....*.
gi 2028832719 342 CTINLV 347
Cdd:COG1577   272 CVIALA 277
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 8-57 4.99e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 82.50  E-value: 4.99e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2028832719   8 SRFIKHFDGKTGNIYFSPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRP 57
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 111-179 1.31e-13

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 65.26  E-value: 1.31e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2028832719 111 IAFAGDVPLGAGMSSSAAMESCFGCALNDLFADNkvskwdIALAGQATEHKYIGVNCGIMDQFASVFGK 179
Cdd:pfam00288   2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLP------LAKLALEAEELAGGGRGGGMDVAASLYGG 64
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 24-346 1.92e-13

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 70.01  E-value: 1.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  24 SPGRINLIGEHTDYNGGFVFPGAVDKGIMAEVRPNGTDtvMCYSIDLKDRVEFKV-DDPEGPRATWARFIYGMVQEFKAL 102
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDG--SFIESDLGRGSLDDApDELDGLKYVLAEFLSRFSELNPPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 103 gvdvkgFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFADNkVSKWDIALAGQATEHKYIGVNCGImDQFASVFGKegk 182
Cdd:TIGR00549  79 ------LEITIESEIPPGRGLGSSAAVAVALIRALADYFGSE-LSKEELAELANEAEKIAHGKPSGI-DTATSTSGG--- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 183 lMRLDCRSSEFEYFPFDPKGYkLVLVNSKVKHelagspynDRRKSCENVvAALGKHFPDkkfetLRDANWEELEAVkaev 262
Cdd:TIGR00549 148 -PVYFEKGEGEFTKLISLDGY-FVIADTGVSG--------STKEAVARV-RQLLERFPE-----LIDSIMDAIGEL---- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 263 saedyqrahfvlgekdrVLAVCDALVAGDYETVGQKMYETHyGLSKEYEVSCEELDYLNDVAKENGVTGSRIMGGGFGGC 342
Cdd:TIGR00549 208 -----------------TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGC 269


                  ....
gi 2028832719 343 TINL 346
Cdd:TIGR00549 270 MIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 24-350 2.80e-13

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 69.70  E-value: 2.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  24 SPGRINLIGEHtdynggfvfpgAVDKGimaevrpngtDTVMCYSIDLKDRV--EFKVDD--------PEGPRATWARFIY 93
Cdd:PRK03926    6 APGKIYLFGEH-----------AVVYG----------KPAIACAIDLRTYVraEFNDDSiyiesdygKTGEKHPYVSAAI 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719  94 GMVQEFkalgVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFaDNKVSKWDIALAGQATEHKYIGVNCGImDQF 173
Cdd:PRK03926   65 EKMREE----ADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLL-GLGLSLEEIAKLGHKVELLVQGAASPT-DTY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 174 ASVFGKegklmrldcrssefeyFPFDPKGYKLvlvnskvkhelagsPYNDrrksCENVVAALGKHFPDKKFETLRDANWE 253
Cdd:PRK03926  139 VSTMGG----------------FVTIPDRKKL--------------PFPE----CGIVVGYTGSSGSTKELVANVRKLKE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 254 ELEAV---------KAEVSAEDYqrahfvlgekdrvlavcdaLVAGDYETVGQKMYETHyGLSKEYEVSCEELDYLNDVA 324
Cdd:PRK03926  185 EYPELiepilssigKISEKGEEL-------------------ILSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAA 244

                         330       340
                  ....*....|....*....|....*.
gi 2028832719 325 KENGVTGSRIMGGGFGGCTINLVKDD 350
Cdd:PRK03926  245 RTAGALGAKITGAGGGGCMVALAAPE 270
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 285-367 3.15e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 44.77  E-value: 3.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028832719 285 DALVAGDYETVGQKMYETHYGLSKE--YEVSCEELDYLNDVAKENGvTGSRIMGGGFGGCTINLVKDDLYetfIENVTEK 362
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLEPLlvVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDEDD---AEEVARA 78


                  ....*
gi 2028832719 363 FNAKY 367
Cdd:pfam08544  79 LREAG 83
PLN02451 PLN02451
homoserine kinase
 100-164 6.02e-05

homoserine kinase


Pssm-ID: 215248  Cd Length: 370  Bit Score: 44.78  E-value: 6.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2028832719 100 KALGVDVKGFNIAFAGDVPLGAGMSSSAAMESCFGCALNDLFAdNKVSKWDIALAGQATEHKYIG 164
Cdd:PLN02451  126 KLLGIRSVGLSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFG-SPLGKDDLVLAGLESEAKVSG 189
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 286-349 1.16e-04

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 43.69  E-value: 1.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2028832719 286 ALVAGDYETVGQKMYETHyGLSKEYEVSCEELDYLNDVAKENGVTGSRIMGGGFGGCTINLVKD 349
Cdd:PTZ00298  233 ALQKGNLFRVGELMNANH-DLCQKLTVSCRELDSIVQTCRTYGALGAKMSGTGRGGLVVALAAS 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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