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Conserved domains on  [gi|2026794641|gb|QTX04941|]
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iron chelate uptake ABC transporter family permease subunit [Agromyces archimandritae]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10790899)

FecCD family ABC transporter permease is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

Gene Ontology:  GO:0140359|GO:0042626|GO:0006826|GO:0043190|GO:0016020
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 29-366 2.16e-81

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 443810  Cd Length: 344  Bit Score: 251.96  E-value: 2.16e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  29 VVRIGRAAILVHPRSAIVTAALAAAAILAAAAGLAVGTLGIPLAEVPAAVLGfADDARQVRVAQGIRLPRAVTALAAGAA 108
Cdd:COG4779     8 VLRVGRVSLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLG-EGDPGASFVVLELRLPRALAALLVGAA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 109 LGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSrLVLVG 188
Cdd:COG4779    87 LGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYR-LILVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 189 IGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPV 268
Cdd:COG4779   166 IGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 269 ERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMT 348
Cdd:COG4779   246 ERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVT 325

                         330
                  ....*....|....*...
gi 2026794641 349 GIVGGLYLIWLLLPGRNR 366
Cdd:COG4779   326 GALGGPYLLWLLIRENRR 343
 
Name Accession Description Interval E-value
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 29-366 2.16e-81

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 251.96  E-value: 2.16e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  29 VVRIGRAAILVHPRSAIVTAALAAAAILAAAAGLAVGTLGIPLAEVPAAVLGfADDARQVRVAQGIRLPRAVTALAAGAA 108
Cdd:COG4779     8 VLRVGRVSLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLG-EGDPGASFVVLELRLPRALAALLVGAA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 109 LGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSrLVLVG 188
Cdd:COG4779    87 LGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYR-LILVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 189 IGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPV 268
Cdd:COG4779   166 IGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 269 ERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMT 348
Cdd:COG4779   246 ERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVT 325

                         330
                  ....*....|....*...
gi 2026794641 349 GIVGGLYLIWLLLPGRNR 366
Cdd:COG4779   326 GALGGPYLLWLLIRENRR 343
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
71-361 2.05e-57

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 189.92  E-value: 2.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  71 LAEVPAAVLGFADDARQVRVAQGiRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGD 150
Cdd:PRK10440   36 TSQVFAALMGDAPRSMTMVVTEW-RLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 151 AVQVALGAAVGGIATAGVVVLLSSRGGSMGGSrLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHA 230
Cdd:PRK10440  115 LTAIALAAMAGGIVTSLLVWLLAWRNGIDTFR-LIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKT 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 231 VPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRS 310
Cdd:PRK10440  194 SPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGT 273

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2026794641 311 AGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:PRK10440  274 ARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLI 324
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 69-361 1.74e-45

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 158.07  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  69 IPLAEVPAAVLGFADDARQVRVAQgIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFD 148
Cdd:pfam01032  17 ISPSDVFSALLGGDDSLAALIVLD-LRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILLGG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 149 G-DAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTW 227
Cdd:pfam01032  96 SlSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMGSLSGANW 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 228 EHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRL 307
Cdd:pfam01032 176 SDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIARLL 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2026794641 308 -NRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:pfam01032 256 vGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 116-360 5.31e-31

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 118.43  E-value: 5.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 116 FQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIM 195
Cdd:cd06550    18 LQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGIVLSAFF 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 196 AAVNDLLLVKGDlERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLL 275
Cdd:cd06550    98 SAGVILISLLSD-DSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 276 VALAVLLTAAATAAVGPIAFVALAAPQLVRRL-NRSAGVPVWGSAAMGALLLTIADVVTRLLpVAFQVPIGRMTGIVGGL 354
Cdd:cd06550   177 LLLVALLVVAAVALVGVILFVGLIAPHLARRLfGRSHRYLLPLSALLGAILLLLGDLLSRTL-LPSELPVGPVTALLGAP 255


                  ....*.
gi 2026794641 355 YLIWLL 360
Cdd:cd06550   256 YFLYLL 261
 
Name Accession Description Interval E-value
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 29-366 2.16e-81

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 251.96  E-value: 2.16e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  29 VVRIGRAAILVHPRSAIVTAALAAAAILAAAAGLAVGTLGIPLAEVPAAVLGfADDARQVRVAQGIRLPRAVTALAAGAA 108
Cdd:COG4779     8 VLRVGRVSLRLRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLG-EGDPGASFVVLELRLPRALAALLVGAA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 109 LGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSrLVLVG 188
Cdd:COG4779    87 LGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYR-LILVG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 189 IGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPV 268
Cdd:COG4779   166 IGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRV 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 269 ERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMT 348
Cdd:COG4779   246 ERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVT 325

                         330
                  ....*....|....*...
gi 2026794641 349 GIVGGLYLIWLLLPGRNR 366
Cdd:COG4779   326 GALGGPYLLWLLIRENRR 343
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
71-361 2.05e-57

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 189.92  E-value: 2.05e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  71 LAEVPAAVLGFADDARQVRVAQGiRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGD 150
Cdd:PRK10440   36 TSQVFAALMGDAPRSMTMVVTEW-RLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 151 AVQVALGAAVGGIATAGVVVLLSSRGGSMGGSrLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHA 230
Cdd:PRK10440  115 LTAIALAAMAGGIVTSLLVWLLAWRNGIDTFR-LIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKT 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 231 VPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRS 310
Cdd:PRK10440  194 SPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGT 273

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2026794641 311 AGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:PRK10440  274 ARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLI 324
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 68-364 7.19e-47

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 161.39  E-value: 7.19e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  68 GIPLAEVPAAVLGFADDARQVRVAQGIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLF 147
Cdd:COG0609     8 PISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIVLG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 148 DG-DAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDART 226
Cdd:COG0609    88 GGlSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAGAS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 227 WEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRR 306
Cdd:COG0609   168 WDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARL 247

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2026794641 307 L-NRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLLPGR 364
Cdd:COG0609   248 LvGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 69-361 1.74e-45

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 158.07  E-value: 1.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  69 IPLAEVPAAVLGFADDARQVRVAQgIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFD 148
Cdd:pfam01032  17 ISPSDVFSALLGGDDSLAALIVLD-LRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAILLGG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 149 G-DAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTW 227
Cdd:pfam01032  96 SlSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMGSLSGANW 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 228 EHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRL 307
Cdd:pfam01032 176 SDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIARLL 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2026794641 308 -NRSAGVPVWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:pfam01032 256 vGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLL 310
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
67-366 3.42e-36

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 139.20  E-value: 3.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  67 LGIPLAEVPAAVLGFADDARQVRVAQG--------IRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAAT 138
Cdd:PRK10577  361 LGLLLLLALVVALSFGRDAHGWNWLSGqlldallpLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGL 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 139 GAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDlERAVEANLWR 218
Cdd:PRK10577  441 GVVLALFLVPGAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGD-PRAAQLLTWL 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 219 SGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVAL 298
Cdd:PRK10577  520 SGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGL 599

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2026794641 299 AAPQLVRRLNRSAGVP-VWGSAAMGALLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLLPGRNR 366
Cdd:PRK10577  600 MAPHLARMLGGRRARPqLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRRR 668
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 116-360 5.31e-31

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 118.43  E-value: 5.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 116 FQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIM 195
Cdd:cd06550    18 LQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGIVLSAFF 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 196 AAVNDLLLVKGDlERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLL 275
Cdd:cd06550    98 SAGVILISLLSD-DSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 276 VALAVLLTAAATAAVGPIAFVALAAPQLVRRL-NRSAGVPVWGSAAMGALLLTIADVVTRLLpVAFQVPIGRMTGIVGGL 354
Cdd:cd06550   177 LLLVALLVVAAVALVGVILFVGLIAPHLARRLfGRSHRYLLPLSALLGAILLLLGDLLSRTL-LPSELPVGPVTALLGAP 255


                  ....*.
gi 2026794641 355 YLIWLL 360
Cdd:cd06550   256 YFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
95-361 3.59e-29

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 114.76  E-value: 3.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  95 RLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQ-VALGAAVGGIATAgvvVLLS 173
Cdd:PRK09777   51 RLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVMwLPLLAFIGGMAGL---ILLK 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 174 SRGGSMGGSRLVLVGIGVGAIMAAVNDLLLvkgdLERAVEAN---LWRSGSLDARTWEHAVPVLIAVIVLLPAIAALIRR 250
Cdd:PRK09777  128 MLAGTHQPMKLALTGVALSALWASLTDYLM----LSRPQDINnalLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRD 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 251 ANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLnrSAGVPVW---GSAAMGALLLT 327
Cdd:PRK09777  204 LDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSL--VGGRHRRllpVSALTGALLLL 281

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2026794641 328 IADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:PRK09777  282 LADLLARIIHPPLELPAGVLTAIIGAPWFFWLLV 315
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
69-367 7.16e-26

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 109.16  E-value: 7.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  69 IPLAEVPAAVLGFADDARQVRVAQGIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFD 148
Cdd:PRK10577   36 LPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 149 GDAVQVALGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDlERAVEANLWRSGSLDARTWE 228
Cdd:PRK10577  116 ALLALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNE-QYLQGLFLWGAGSLAQNDWS 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 229 HAVPVLIAVIVLLPAIAALIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLN 308
Cdd:PRK10577  195 GVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLG 274

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2026794641 309 -RSAGVPVWGSAAMGALLLTIADVVTRLL--PVAFQVPIGRMTGIVGGLYLIWLLLPGRNRA 367
Cdd:PRK10577  275 aRRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLPRLRSAQ 336
btuC PRK09535
cobalamin ABC transporter permease BtuC;
76-360 8.54e-19

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 86.73  E-value: 8.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  76 AAVLGFADDARQVRVAQGIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVA 155
Cdd:PRK09535   76 ASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQ 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 156 LGAAVGGIATAGVVVLLSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKG--DLERAVeanLWRSGSLDARTW---EHA 230
Cdd:PRK09535  156 AAAFAGALVAAFGVYAIATENGRTPVATLLLAGVAVQTFLGAVISYLLLHSgeSLRRAV---YWLMGHLHGSTWsdvEVA 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 231 VPVLIAVIVLLPAIAaliRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRL--- 307
Cdd:PRK09535  233 LPVVVVGFVVLLAYA---RDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLvgp 309

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2026794641 308 NRSAGVPVwgSAAMGALLLTIADVVTRLLPVafQVPIGRMTGIVGGLYLIWLL 360
Cdd:PRK09535  310 DHRILLPT--SALAGASFLVATDTVARSGPA--EVPVGIVTAALGAPFFLYLL 358
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 94-365 3.93e-18

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 84.13  E-value: 3.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  94 IRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALGAAvgGIATAGVV--VL 171
Cdd:COG4139    54 LRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLA--AIAGALLVtlLL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 172 LSSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHAvPVLIAVIVLLPAIAALIRRA 251
Cdd:COG4139   132 LAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQL-WLLLALLPVLLWLCLQGKPL 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 252 NLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRS---AGVPvwGSAAMGALLLTI 328
Cdd:COG4139   211 NLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTdhrFLLP--ACALAGAALLLL 288

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2026794641 329 ADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLLPGRN 365
Cdd:COG4139   289 ADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRRK 325
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 94-361 5.64e-15

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 74.99  E-value: 5.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  94 IRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFDGDAVQVALG-AAVGGIATAGVVVLL 172
Cdd:PRK03784   57 LRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSlCAIAGALLITLILLR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 173 SSRGGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDLERAVEANLWRSGSLDARTWEHAvpvlIAVIVLLPAIAALIRRA- 251
Cdd:PRK03784  137 FARRHRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQS----WLMLALLPVLIWLCCQGr 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 252 --NLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRLNRS---AGVPvwGSAAMGALLL 326
Cdd:PRK03784  213 plNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTdhrVLLP--GCALAGASLL 290

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2026794641 327 TIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWLLL 361
Cdd:PRK03784  291 LLADIVARLALASAELPIGVVTATLGAPVFIWLLL 325
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
92-359 2.98e-14

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 72.81  E-value: 2.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  92 QGIRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATG-AIAQIV---LFDGDAVqvALGAAVGGIATAG 167
Cdd:PRK11228   48 QNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAmALTSALsptPFAGYSL--AFIAACGGGLSWL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 168 VVVLLSSR-GGSMGGSRLVLVGIGVGAIMAAVNDLLLVKGDlERAVEANLWRSGSLDARTWEHAVPVLIAVIVLLPAIAA 246
Cdd:PRK11228  126 LVMTAGGGwRHTHDRNRLILAGIALSALCMALTRITLLLAE-DHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 247 LIRRANLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLVRRL---NRSAGVPVwgSAAMGA 323
Cdd:PRK11228  205 LANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWigyDQRNVLPM--SMLLGA 282

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2026794641 324 LLLTIADVVTRLLPVAFQVPIGRMTGIVGGLYLIWL 359
Cdd:PRK11228  283 TLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
69-359 2.56e-13

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 70.12  E-value: 2.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641  69 IPLAEVPAAVLGFADDARQVRVAQGiRLPRAVTALAAGAALGVAGAVFQSLSRNALGSPDVIGFTTGAATGAIAQIVLFD 148
Cdd:PRK10441   35 LPASVVLEALSGTCQSADCTIVLDA-RLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 149 GDAVQVALGAAVGGIATAGVVVLLSSRGGSMGG--SRLVLVGIGVGAIMAAV-NDLLLVKGDLERAVEanLWRSGSLDAR 225
Cdd:PRK10441  114 YSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLspVRLTLAGVALAAVLEGLtSGIALLNPDVYDQLR--FWQAGSLDIR 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026794641 226 TWeHAVPVLIAVIVLLPAIAALIRRA-NLMELGDDLASQLGVPVERTRLLLVALAVLLTAAATAAVGPIAFVALAAPQLV 304
Cdd:PRK10441  192 NL-HTLKVVLIPVLIAGATALLLSRAlNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMA 270

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2026794641 305 RRL---NRSAGVPVwgSAAMGALLLTIADVVTRLLpVAFQVPIGRMTGIVGGLYLIWL 359
Cdd:PRK10441  271 RWLvgaDHRWSLPV--TLLATPALLLFADIIGRLL-VPGELRVSVVSAFIGAPVLIFL 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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