NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2025689074|gb|QTU91093|]
View 

succinate dehydrogenase complex flavoprotein subunit A, partial [Lasiopodomys brandtii]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FAD_binding_2 super family cl46878
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 1-180 1.20e-100

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


The actual alignment was detected with superfamily member PTZ00139:

Pssm-ID: 481218 [Multi-domain]  Cd Length: 617  Bit Score: 302.43  E-value: 1.20e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVLKHVNG-QDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAG 79
Cdd:PTZ00139  380 GGIPTNWKTQVLTQRNGdDDKIVPGLLAAGEAACASVHGANRLGANSLLDIVVFGRAAANTVMEILKPGRPQPDLPKDAG 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQ 159
Cdd:PTZ00139  460 EASIARLDKIRHNKGDISTAQIRKRMQRTMQKHAAVFRIGESLQEGVEKIKEIYSDFKDVKIKDKSLVWNTDLIETLELE 539

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PTZ00139  540 NLLTQAKQTILSAEARKESRG 560
 
Name Accession Description Interval E-value
PTZ00139 PTZ00139
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
 1-180 1.20e-100

Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional


Pssm-ID: 240286 [Multi-domain]  Cd Length: 617  Bit Score: 302.43  E-value: 1.20e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVLKHVNG-QDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAG 79
Cdd:PTZ00139  380 GGIPTNWKTQVLTQRNGdDDKIVPGLLAAGEAACASVHGANRLGANSLLDIVVFGRAAANTVMEILKPGRPQPDLPKDAG 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQ 159
Cdd:PTZ00139  460 EASIARLDKIRHNKGDISTAQIRKRMQRTMQKHAAVFRIGESLQEGVEKIKEIYSDFKDVKIKDKSLVWNTDLIETLELE 539

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PTZ00139  540 NLLTQAKQTILSAEARKESRG 560
Succ_DH_flav_C pfam02910
Fumarate reductase flavoprotein C-term; This family contains fumarate reductases, succinate ...
 102-177 1.10e-36

Fumarate reductase flavoprotein C-term; This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.


Pssm-ID: 460743 [Multi-domain]  Cd Length: 129  Bit Score: 123.71  E-value: 1.10e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025689074 102 RLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKE 177
Cdd:pfam02910   1 RRELQKTMQDNVGVFRTEEGLKEALEKIQELRERYKNVRVTDKSKVFNTELIEALELANLLELAEATARSALARKE 76
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 1-177 2.92e-30

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 115.20  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQ-DqiVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKanAG 79
Cdd:COG0029   341 GGVATD--------LDGRtS--IPGLYAVGEVACTGVHGANRLASNSLLEGLVFGRRAAEDIAARLAESPLPPEIP--EW 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNldklrfADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFdrgmvwnTDLVETLELQ 159
Cdd:COG0029   409 DESVTD------PDEEVLIAHLRDELRRLMWDYVGIVRTAKGLERALRRLELLREEIEEYANF-------RVSRDLLELR 475

                         170
                  ....*....|....*...
gi 2025689074 160 NLMLCALQTIYGAEARKE 177
Cdd:COG0029   476 NLLLVAELIVRAALARKE 493
nadB TIGR00551
L-aspartate oxidase; L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase ...
 1-180 8.75e-17

L-aspartate oxidase; L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase complex. Quinolinate synthetase makes a precursor of the pyridine nucleotide portion of NAD. This model identifies proteins that cluster as L-aspartate oxidase (a flavoprotein difficult to separate from the set of closely related flavoprotein subunits of succinate dehydrogenase and fumarate reductase) by both UPGMA and neighbor-joining trees. The most distant protein accepted as an L-aspartate oxidase (NadB), that from Pyrococcus horikoshii, not only clusters with other NadB but is just one gene away from NadA. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273131 [Multi-domain]  Cd Length: 489  Bit Score: 76.76  E-value: 8.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQDQIvPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAescRPGDKVPSIKANAGE 80
Cdd:TIGR00551 334 GGISVD--------AFGRTTI-PGLYAIGETACTGLHGANRLASNSLLECLVFGLRAARTIS---REPPYASREYQSGVW 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  81 ESVMNLDKLRFADGSIRTSELRLsmqkSMQNHAAVFRVGSVLQEGCEKISQlygelkhlktfdrgmvWNTDLVETLELQN 160
Cdd:TIGR00551 402 DEPRSENPLDRHELQHKMSSLRS----VLWNHAGIVRLEWSLREALRKLVE----------------IQDEVDERMELSN 461

                         170       180
                  ....*....|....*....|
gi 2025689074 161 LMLCALQTIYGAEARKEITG 180
Cdd:TIGR00551 462 LKLVAKLVTISALKREESRG 481
 
Name Accession Description Interval E-value
PTZ00139 PTZ00139
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
 1-180 1.20e-100

Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional


Pssm-ID: 240286 [Multi-domain]  Cd Length: 617  Bit Score: 302.43  E-value: 1.20e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVLKHVNG-QDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAG 79
Cdd:PTZ00139  380 GGIPTNWKTQVLTQRNGdDDKIVPGLLAAGEAACASVHGANRLGANSLLDIVVFGRAAANTVMEILKPGRPQPDLPKDAG 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQ 159
Cdd:PTZ00139  460 EASIARLDKIRHNKGDISTAQIRKRMQRTMQKHAAVFRIGESLQEGVEKIKEIYSDFKDVKIKDKSLVWNTDLIETLELE 539

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PTZ00139  540 NLLTQAKQTILSAEARKESRG 560
PLN00128 PLN00128
Succinate dehydrogenase [ubiquinone] flavoprotein subunit
 1-180 5.06e-85

Succinate dehydrogenase [ubiquinone] flavoprotein subunit


Pssm-ID: 177739 [Multi-domain]  Cd Length: 635  Bit Score: 262.49  E-value: 5.06e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVL-KHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAG 79
Cdd:PLN00128  401 GGIPTNYHGEVVtIKGDDPDAVVPGLMAAGEAACASVHGANRLGANSLLDIVVFGRACANRVAEIAKPGEKQKPLPKDAG 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQ 159
Cdd:PLN00128  481 EKTIAWLDKLRNANGSLPTSKIRLNMQRVMQNNAAVFRTQETLEEGCKLIDEAWDSFHDVKVTDRSLIWNSDLIETLELE 560

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PLN00128  561 NLLINACITMHSAEARKESRG 581
sdhA PRK05945
succinate dehydrogenase/fumarate reductase flavoprotein subunit;
1-180 5.11e-41

succinate dehydrogenase/fumarate reductase flavoprotein subunit;


Pssm-ID: 180319 [Multi-domain]  Cd Length: 575  Bit Score: 145.26  E-value: 5.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVLKHVngqDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRpGDKVPSI-KANAG 79
Cdd:PRK05945  352 GGIPVNTDGRVRRSA---DGLVEGFFAAGECACVSVHGANRLGSNSLLECVVYGRRTGAAIAEYVQ-GRKLPEVdEQRYL 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQ 159
Cdd:PRK05945  428 KEAKQRIQALLDQSGTYRINQLRQQFQDCMTDHCGVFRTEEIMQEGLEKIQQLKQQYEQIYLDDKGKCWNTELIEALELR 507

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PRK05945  508 SLMVVGEIILTSALNRQESRG 528
Succ_DH_flav_C pfam02910
Fumarate reductase flavoprotein C-term; This family contains fumarate reductases, succinate ...
 102-177 1.10e-36

Fumarate reductase flavoprotein C-term; This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.


Pssm-ID: 460743 [Multi-domain]  Cd Length: 129  Bit Score: 123.71  E-value: 1.10e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025689074 102 RLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKE 177
Cdd:pfam02910   1 RRELQKTMQDNVGVFRTEEGLKEALEKIQELRERYKNVRVTDKSKVFNTELIEALELANLLELAEATARSALARKE 76
sdhA PRK06069
succinate dehydrogenase/fumarate reductase flavoprotein subunit;
1-180 3.88e-36

succinate dehydrogenase/fumarate reductase flavoprotein subunit;


Pssm-ID: 235689 [Multi-domain]  Cd Length: 577  Bit Score: 131.72  E-value: 3.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVLKHvngQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESC--RPGDKVPSIKANA 78
Cdd:PRK06069  353 GGIHTDVYGRVLTA---DGEWVRGLWAAGEAAAVSVHGANRLGSNSTAECLVWGRIAGEQAAEYAlkRPAPSSPVEKLAE 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  79 GEESVMnLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLEL 158
Cdd:PRK06069  430 KEEKRI-FDKLLKKEGGEPSYEIRRELNDIMDKNFGIFRDESGLAEALKKIKKLRERYKNVRIEDKSRIYNTDLKDALEL 508

                         170       180
                  ....*....|....*....|..
gi 2025689074 159 QNLMLCALQTIYGAEARKEITG 180
Cdd:PRK06069  509 DGMLDLAEVVAIGALLRTESRG 530
PRK09231 PRK09231
fumarate reductase flavoprotein subunit; Validated
 1-180 2.41e-33

fumarate reductase flavoprotein subunit; Validated


Pssm-ID: 236421 [Multi-domain]  Cd Length: 582  Bit Score: 123.98  E-value: 2.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQDQIvPGLYACGEAACASVHGANRLGANSLLDLVVFGRAC---ALSIAESCRPGDKvPSIKAN 77
Cdd:PRK09231  359 GGIETD--------QNCETRI-KGLFAVGECSSVGLHGANRLGSNSLAELVVFGRVAgeqAAERAATAGPGNE-AALDAQ 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  78 AgEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLE 157
Cdd:PRK09231  429 A-ADVEQRLKALVNQEGGENWAKIRDEMGLSMEEGCGIYRTPELMQKTIDKLAELKERFKRVRITDTSSVFNTDLLYTIE 507

                         170       180
                  ....*....|....*....|...
gi 2025689074 158 LQNLMLCALQTIYGAEARKEITG 180
Cdd:PRK09231  508 LGYGLDVAECMAHSALARKESRG 530
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 1-177 2.92e-30

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 115.20  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQ-DqiVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKanAG 79
Cdd:COG0029   341 GGVATD--------LDGRtS--IPGLYAVGEVACTGVHGANRLASNSLLEGLVFGRRAAEDIAARLAESPLPPEIP--EW 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNldklrfADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFdrgmvwnTDLVETLELQ 159
Cdd:COG0029   409 DESVTD------PDEEVLIAHLRDELRRLMWDYVGIVRTAKGLERALRRLELLREEIEEYANF-------RVSRDLLELR 475

                         170
                  ....*....|....*...
gi 2025689074 160 NLMLCALQTIYGAEARKE 177
Cdd:COG0029   476 NLLLVAELIVRAALARKE 493
PRK08626 PRK08626
fumarate reductase flavoprotein subunit; Provisional
 1-180 2.41e-26

fumarate reductase flavoprotein subunit; Provisional


Pssm-ID: 181507 [Multi-domain]  Cd Length: 657  Bit Score: 104.67  E-value: 2.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQV--LKhvngqdqivpGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIK--A 76
Cdd:PRK08626  373 GGIRTNPTGESygLK----------GLFSAGEAACWDMHGFNRLGGNSLAETVVAGMIVGKYVADFCLGNELEIDTAlvE 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  77 NAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETL 156
Cdd:PRK08626  443 KFVKKQQDRIDELIAGEGKENVFEIKNEMQEIMMEKVGIFRNGPELEKAVKELQELLERSKNIGLKSKKRGANPELEEAL 522

                         170       180
                  ....*....|....*....|....
gi 2025689074 157 ELQNLMLCALQTIYGAEARKEITG 180
Cdd:PRK08626  523 RVPRMLKLALCVAYGALARTESRG 546
sdhA PRK06452
succinate dehydrogenase flavoprotein subunit; Reviewed
 7-180 1.16e-24

succinate dehydrogenase flavoprotein subunit; Reviewed


Pssm-ID: 180567 [Multi-domain]  Cd Length: 566  Bit Score: 99.58  E-value: 1.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   7 YKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANA-GEESVMN 85
Cdd:PRK06452  345 YMGGIDVDIDGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVVQFLKSNPGNPTSNYEKeAEKVVDD 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  86 LDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQNLMLCA 165
Cdd:PRK06452  425 AYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYVTDKSKVYNTEFFNALELRNMLDLA 504

                         170
                  ....*....|....*
gi 2025689074 166 LQTIYGAEARKEITG 180
Cdd:PRK06452  505 LVIAKSALERKESRG 519
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 1-66 1.71e-23

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 95.67  E-value: 1.71e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2025689074   1 GGIPTNYKGQVLkhvNGQDQIVPGLYACGEAaCASVHGANRLGANSLLDLVVFGRACALSIAESCR 66
Cdd:COG1053   381 GGLRVDADARVL---DADGTPIPGLYAAGEA-AGSVHGANRLGGNSLGDALVFGRIAGRHAAEYAK 442
PLN02815 PLN02815
L-aspartate oxidase
 1-180 2.29e-23

L-aspartate oxidase


Pssm-ID: 215436 [Multi-domain]  Cd Length: 594  Bit Score: 95.94  E-value: 2.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVlkhvngqdqIVPGLYACGEAACASVHGANRLGANSLLDLVVFG-RACALSIAESCRPGDKVPSIKANAG 79
Cdd:PLN02815  378 GGVRTGLQGET---------NVQGLYAAGEVACTGLHGANRLASNSLLEALVFArRAVQPSIDHMARALRDVSAAAAWAR 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  80 EESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHlKTFDRGMVWNTDLVETLELQ 159
Cdd:PLN02815  449 PVAPTALADSVMDEILEWTAVVRKELQRIMWNYVGIVRSTERLETAERKLEELEAEWEA-ILFRHGWKPTMVGLEACEMR 527

                         170       180
                  ....*....|....*....|.
gi 2025689074 160 NLMLCALQTIYGAEARKEITG 180
Cdd:PLN02815  528 NLFCVAKLVVSSALARKESRG 548
sdhA PRK06263
succinate dehydrogenase flavoprotein subunit; Reviewed
 22-180 6.06e-22

succinate dehydrogenase flavoprotein subunit; Reviewed


Pssm-ID: 235758 [Multi-domain]  Cd Length: 543  Bit Score: 91.58  E-value: 6.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAAcASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDkvPSIKANAGEESVMNLDKL-RFADGSIRTSE 100
Cdd:PRK06263  361 IPGLFACGEVA-GGVHGANRLGGNALADTQVFGAIAGKSAAKNAENNE--FKKVNRSVEEDIARIKSEiKFLNGSINPYD 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074 101 LRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRgmvwnTDLVETLELQNLMLCALQTIYGAEARKEITG 180
Cdd:PRK06263  438 LIDELKKTMWDYVSIVRNEKGLKKALEEINELKEKLKDLKVNGI-----VDFNKALELENMILVAELVIKSALLRKESRG 512
sdhA PRK07803
succinate dehydrogenase flavoprotein subunit; Reviewed
 22-180 4.35e-19

succinate dehydrogenase flavoprotein subunit; Reviewed


Pssm-ID: 236101 [Multi-domain]  Cd Length: 626  Bit Score: 83.55  E-value: 4.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAAcASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESV-MNLDKLRFADGSIRTSE 100
Cdd:PRK07803  405 VPGLFAAGECA-GGMHGSNRLGGNSLSDLLVFGRRAGLGAADYVRGLGSRPAVSEEAVDAAArEALAPFERPAGAENPYT 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074 101 LRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKT-----FDRGmvWNTdlveTLELQNLMLCALQTIYGAEAR 175
Cdd:PRK07803  484 LHAELQQTMNDLVGIIRKEDEIEQALEKLAELKERAANVSVeghrqYNPG--WHL----ALDLRNMLLVSECVARAALER 557


                  ....*
gi 2025689074 176 KEITG 180
Cdd:PRK07803  558 TESRG 562
PRK09077 PRK09077
L-aspartate oxidase; Provisional
 1-177 8.39e-17

L-aspartate oxidase; Provisional


Pssm-ID: 236374 [Multi-domain]  Cd Length: 536  Bit Score: 76.88  E-value: 8.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNYKGQVlkhvngqDqiVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKA---- 76
Cdd:PRK09077  354 GGVMVDLHGRT-------D--LDGLYAIGEVSYTGLHGANRMASNSLLECLVYGRSAAEDILSRLPKAPMPPTLPAwdes 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  77 ---NAGEESVM--NLDKLRFA--D--GSIRTSElRLsmqksmqnHAAVFRVGSVLQEgcekISQLYGELKhlktfdrgmV 147
Cdd:PRK09077  425 rvtDSDEEVVIqhNWHELRLFmwDyvGIVRTTK-RL--------ERALHRIRLLQQE----IDEYYANFR---------V 482

                         170       180       190
                  ....*....|....*....|....*....|
gi 2025689074 148 WNtDLvetLELQNLMLCALQTIYGAEARKE 177
Cdd:PRK09077  483 SN-NL---LELRNLVQVAELIVRCAMERKE 508
nadB TIGR00551
L-aspartate oxidase; L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase ...
 1-180 8.75e-17

L-aspartate oxidase; L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase complex. Quinolinate synthetase makes a precursor of the pyridine nucleotide portion of NAD. This model identifies proteins that cluster as L-aspartate oxidase (a flavoprotein difficult to separate from the set of closely related flavoprotein subunits of succinate dehydrogenase and fumarate reductase) by both UPGMA and neighbor-joining trees. The most distant protein accepted as an L-aspartate oxidase (NadB), that from Pyrococcus horikoshii, not only clusters with other NadB but is just one gene away from NadA. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273131 [Multi-domain]  Cd Length: 489  Bit Score: 76.76  E-value: 8.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQDQIvPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAescRPGDKVPSIKANAGE 80
Cdd:TIGR00551 334 GGISVD--------AFGRTTI-PGLYAIGETACTGLHGANRLASNSLLECLVFGLRAARTIS---REPPYASREYQSGVW 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  81 ESVMNLDKLRFADGSIRTSELRLsmqkSMQNHAAVFRVGSVLQEGCEKISQlygelkhlktfdrgmvWNTDLVETLELQN 160
Cdd:TIGR00551 402 DEPRSENPLDRHELQHKMSSLRS----VLWNHAGIVRLEWSLREALRKLVE----------------IQDEVDERMELSN 461

                         170       180
                  ....*....|....*....|
gi 2025689074 161 LMLCALQTIYGAEARKEITG 180
Cdd:TIGR00551 462 LKLVAKLVTISALKREESRG 481
PRK07512 PRK07512
L-aspartate oxidase; Provisional
 22-132 2.27e-16

L-aspartate oxidase; Provisional


Pssm-ID: 236036 [Multi-domain]  Cd Length: 513  Bit Score: 75.72  E-value: 2.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGdKVPSIKANAGEESVMNLDKLRfadgsirtsel 101
Cdd:PRK07512  354 LPGLWAAGEVASTGLHGANRLASNSLLEAVVFAARAAEDIAGTPAAA-AAPLSAAAAPALDPADLALLR----------- 421

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2025689074 102 rlsmqKSMQNHAAVFRVGSVLQEGCEKISQL 132
Cdd:PRK07512  422 -----PIMSRHVGVLRDADGLRRAIAALLPL 447
PRK07804 PRK07804
L-aspartate oxidase; Provisional
 22-180 5.17e-16

L-aspartate oxidase; Provisional


Pssm-ID: 236102 [Multi-domain]  Cd Length: 541  Bit Score: 74.62  E-value: 5.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESVMnldklrfadgsirTSEL 101
Cdd:PRK07804  370 VPGLYAAGEVACTGVHGANRLASNSLLEGLVVGERAGAAAAAHAAAAGRPRATPAVGPEPGLL-------------PALD 436

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2025689074 102 RLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGelkhlKTFDRGmvwntdlVETLELQNLMLCALQTIYGAEARKEITG 180
Cdd:PRK07804  437 RAELQRAMTRGAGVLRSAAGLARAADRLAAGAP-----ARVVPG-------RADWEDTNLTLVARALVAAALARTESRG 503
PRK07395 PRK07395
L-aspartate oxidase; Provisional
 1-140 3.33e-15

L-aspartate oxidase; Provisional


Pssm-ID: 236010 [Multi-domain]  Cd Length: 553  Bit Score: 72.39  E-value: 3.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074   1 GGIPTNykgqvlkhVNGQDQIvPGLYACGEAACASVHGANRLGANSLLDLVVFGRACA---LSIAESCRPGDKVPSIKAN 77
Cdd:PRK07395  348 GGVVTD--------LNNQTSI-PGLYAVGETASTGVHGANRLASNSLLECLVFAAQLAqleLPIEPPASPDLPPISFIID 418

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025689074  78 AGEESvMNLDKLRfadgsirtsELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLK 140
Cdd:PRK07395  419 ASQWK-NEQEQIQ---------RIRQELPELVWQSAGICREADTLERAIAQVEQWQQQLAALP 471
PRK08071 PRK08071
L-aspartate oxidase; Provisional
 1-61 4.91e-15

L-aspartate oxidase; Provisional


Pssm-ID: 236147 [Multi-domain]  Cd Length: 510  Bit Score: 71.94  E-value: 4.91e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2025689074   1 GGIPTNYKGQVlkhvngqdqIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSI 61
Cdd:PRK08071  333 GGVKTNLDGET---------SIPGLYAIGEVACTGVHGANRLASNSLLEGLVFGKRAAEHI 384
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 1-47 7.34e-15

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 71.16  E-value: 7.34e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2025689074   1 GGIPTNYKGQVLkhvNGQDQIVPGLYACGEAACASVHGANRLGANSL 47
Cdd:pfam00890 355 GGVRTDENGRVL---DADGQPIPGLYAAGEVACGGVHGANRLGGNSL 398
PRK06175 PRK06175
L-aspartate oxidase; Provisional
 25-61 4.21e-12

L-aspartate oxidase; Provisional


Pssm-ID: 180442 [Multi-domain]  Cd Length: 433  Bit Score: 63.16  E-value: 4.21e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2025689074  25 LYACGEAACASVHGANRLGANSLLDLVVFGRACALSI 61
Cdd:PRK06175  347 LYAFGEVSCTGVHGANRLASNSLLEGLVFSKRGAEKI 383
sdhA PRK08641
succinate dehydrogenase flavoprotein subunit; Reviewed
 22-180 4.75e-11

succinate dehydrogenase flavoprotein subunit; Reviewed


Pssm-ID: 236319 [Multi-domain]  Cd Length: 589  Bit Score: 60.37  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAAcASVHGANRLGANSLLDLV----VFGRACALSIAESCRPGDKVPS--IKANAGEESVMNLDKLRfADGS 95
Cdd:PRK08641  368 IPGLFAAGECD-YSYHGANRLGANSLLSAIyggmVAGPNAVEYIKGLGKSADDVSSsvFEQALKQEQEKFDNILS-MDGT 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  96 IRTSELRLSMQKSMQNHAAVFRVGSVLQEGCEKISQLYGELKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEAR 175
Cdd:PRK08641  446 ENAYVLHKELGEWMTDNVTVVRENDKLLETDEKIQELMERYKRISVNDTSRWSNQGASFTRQLWNMLELARVITIGALNR 525


                  ....*
gi 2025689074 176 KEITG 180
Cdd:PRK08641  526 NESRG 530
flavo_cyto_c TIGR01813
flavocytochrome c; This model describes a family of redox proteins related to the succinate ...
 1-55 4.97e-11

flavocytochrome c; This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport]


Pssm-ID: 273816 [Multi-domain]  Cd Length: 439  Bit Score: 60.05  E-value: 4.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2025689074   1 GGIPTNYKGQVLkhvNGQDQIVPGLYACGEAAcASVHGANRLGANSLLDLVVFGR 55
Cdd:TIGR01813 385 GGVKINTKAEVL---DANGKPIPGLFAAGEVT-GGVHGANRLGGNAIADCIVFGR 435
PRK08401 PRK08401
L-aspartate oxidase; Provisional
 22-147 8.64e-11

L-aspartate oxidase; Provisional


Pssm-ID: 236259 [Multi-domain]  Cd Length: 466  Bit Score: 59.43  E-value: 8.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESvmNLDKLRfadgsirtsel 101
Cdd:PRK08401  323 IKNLYAIGEAASNGFHGANRLASNSLLECIVSGLEVARTISRERPKLREVKEPPYHGYELG--DVDSIR----------- 389

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2025689074 102 rlsmqKSMQNHAAVFRVGSVLQEGCEKISQLYGElKHLKTFDRGMV 147
Cdd:PRK08401  390 -----EILWNHAGIVRSEESLREGLKKLEGIEAD-PRLKLLAKGVL 429
PRK06481 PRK06481
flavocytochrome c;
1-55 3.61e-09

flavocytochrome c;


Pssm-ID: 180584 [Multi-domain]  Cd Length: 506  Bit Score: 54.84  E-value: 3.61e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2025689074   1 GGIPTNYKGQVLKHvngQDQIVPGLYACGEAAcASVHGANRLGANSLLDLVVFGR 55
Cdd:PRK06481  443 GGVKINTNTEVLKK---DGSPITGLYAAGEVT-GGLHGENRIGGNSVADIIIFGR 493
sdhA PRK07573
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
22-48 1.29e-07

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 236054 [Multi-domain]  Cd Length: 640  Bit Score: 50.20  E-value: 1.29e-07
                          10        20
                  ....*....|....*....|....*..
gi 2025689074  22 VPGLYACGEAACaSVHGANRLGANSLL 48
Cdd:PRK07573  419 IPGLFVIGEANF-SDHGANRLGASALM 444
PTZ00306 PTZ00306
NADH-dependent fumarate reductase; Provisional
 24-55 3.38e-06

NADH-dependent fumarate reductase; Provisional


Pssm-ID: 140327 [Multi-domain]  Cd Length: 1167  Bit Score: 46.31  E-value: 3.38e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2025689074   24 GLYACGEAAcASVHGANRLGANSLLDLVVFGR 55
Cdd:PTZ00306   862 GLFGAGEVT-GGVHGGNRLGGNSLLECVVFGK 892
PRK12834 PRK12834
putative FAD-binding dehydrogenase; Reviewed
 1-64 2.02e-05

putative FAD-binding dehydrogenase; Reviewed


Pssm-ID: 183782 [Multi-domain]  Cd Length: 549  Bit Score: 43.73  E-value: 2.02e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2025689074   1 GGIPTNYKGQVLkhvnGQD-QIVPGLYACGEAA---CASVHGANRLGANSLLDLVVFGRACALSIAES 64
Cdd:PRK12834  486 GGLETDLDSRVL----GADgTPLPGLYAAGEAAgfgGGGVHGYNALEGTFLGGCIFSGRAAGRAAARA 549
PRK12844 PRK12844
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 1-72 7.84e-05

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 183787 [Multi-domain]  Cd Length: 557  Bit Score: 42.05  E-value: 7.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025689074   1 GGIPTNYKGQVLKHvngQDQIVPGLYACGEAAcASVHGANRLGAN-SLLDLVVFGRACALSIAEScRPGDKVP 72
Cdd:PRK12844  489 GGLLTDEHARVLRE---DGSVIPGLYATGNCT-ASVMGRTYPGAGaSIGNSFVFGYIAALHAAGA-RSADPPP 556
COG3573 COG3573
Predicted oxidoreductase [General function prediction only];
1-63 1.14e-04

Predicted oxidoreductase [General function prediction only];


Pssm-ID: 442794 [Multi-domain]  Cd Length: 551  Bit Score: 41.70  E-value: 1.14e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2025689074   1 GGIPTNYKGQVLkhvNGQDQIVPGLYACGEAA---CASVHGANRL-GanSLLDLVVF-GRACALSIAE 63
Cdd:COG3573   487 GGLQTDLDSRVL---DADGQPIPGLYAAGEAAgfgGGGVHGYRALeG--TFLGGCIFsGRAAGRAIAA 549
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 15-44 7.94e-03

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 35.91  E-value: 7.94e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025689074  15 VNGQDQIVPGLYACGEAAcASVHGANRLGA 44
Cdd:pfam01946 202 VRGTREVVPGLYVAGMEV-AEVDGAPRMGP 230
PRK06854 PRK06854
adenylyl-sulfate reductase subunit alpha;
22-177 9.02e-03

adenylyl-sulfate reductase subunit alpha;


Pssm-ID: 235879 [Multi-domain]  Cd Length: 608  Bit Score: 36.05  E-value: 9.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  22 VPGLYACGEAACASVH----GAnrlganslldlVVFGRACALSIAESCRPG-DKVPSIKANAGEESVMNLDK-----LRF 91
Cdd:PRK06854  395 VEGLFAAGDVVGGSPHkfssGS-----------FAEGRIAAKAAVRYILDNkDEKPEIDDDQIEELKKEIYApleryEEF 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025689074  92 ADGS---------IRTSELRLSMQKSMQNHAAVFRV-----GSVLQEGCEKISQLYGELKHLKTFDrgmvwNTDLVETLE 157
Cdd:PRK06854  464 KDYStdpdvnpnyISPEQLEERLQKIMDEYAGGISTnyttnEKLLEIALELLEMLEEDSEKLAARD-----LHELMRCWE 538

                         170       180
                  ....*....|....*....|
gi 2025689074 158 LQNLMLCALQTIYGAEARKE 177
Cdd:PRK06854  539 LKHRLLVAEAHIRHLLFRKE 558
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH