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Conserved domains on  [gi|2024431671|ref|XP_040511639|]
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adenomatous polyposis coli protein isoform X3 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1063 2.81e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.50  E-value: 2.81e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  773 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  853 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 931
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  932 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1010
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671 1011 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1063
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2709-2882 5.66e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.66e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2709 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2788
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2789 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2868
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431671 2869 SPKRHSGSYLVTSV 2882
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2261-2606 3.65e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.56  E-value: 3.65e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2261 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2339
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2340 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2419
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2420 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2493
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2494 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2571
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431671 2572 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2606
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1080-1179 1.62e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.62e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1080 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1159
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431671 1160 GSTLGINQKVNQSLCQVDDY 1179
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1792-1883 8.17e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 8.17e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1792 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1869
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431671 1870 KLPNNEERVRGSFT 1883
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 434-507 5.35e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.35e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431671  434 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1328-1414 5.74e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 5.74e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1328 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1406
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431671 1407 PSKSGAQT 1414
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1917-1984 4.51e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.51e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431671 1917 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1984
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1708-1761 1.08e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431671 1708 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1761
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.90e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.05e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431671  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1683-1706 1.94e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.94e-07
                           10        20
                   ....*....|....*....|....
gi 2024431671 1683 DMPRVYCVEGTPINFSTATSLSDL 1706
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 2.47e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.47e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431671   690 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 730
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2071-2090 4.27e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|
gi 2024431671 2071 DSEDDLLQECISSAMPKKKK 2090
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 553-594 5.32e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431671   553 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 594
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 381-433 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671   381 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 433
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1762-1783 2.49e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.49e-03
                           10        20
                   ....*....|....*....|..
gi 2024431671 1762 DKTEEGDILAECINSAMPKGKS 1783
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-772 2.50e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.50e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  732 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 772
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1417-1439 4.49e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|....
gi 2024431671 1417 SPPEHY-VQETPLMFSRCTSVSSL 1439
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 500-551 5.02e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.02e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671   500 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 551
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1302-1319 8.34e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.34e-03
                           10
                   ....*....|....*...
gi 2024431671 1302 ETIQTYCVEDTPICFSRC 1319
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1063 2.81e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.50  E-value: 2.81e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  773 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  853 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 931
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  932 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1010
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671 1011 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1063
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2709-2882 5.66e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.66e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2709 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2788
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2789 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2868
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431671 2869 SPKRHSGSYLVTSV 2882
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2261-2606 3.65e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.56  E-value: 3.65e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2261 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2339
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2340 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2419
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2420 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2493
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2494 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2571
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431671 2572 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2606
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1080-1179 1.62e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.62e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1080 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1159
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431671 1160 GSTLGINQKVNQSLCQVDDY 1179
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1792-1883 8.17e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 8.17e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1792 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1869
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431671 1870 KLPNNEERVRGSFT 1883
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 434-507 5.35e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.35e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431671  434 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1328-1414 5.74e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 5.74e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1328 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1406
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431671 1407 PSKSGAQT 1414
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1917-1984 4.51e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.51e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431671 1917 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1984
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1708-1761 1.08e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431671 1708 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1761
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.90e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.05e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431671  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1683-1706 1.94e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.94e-07
                           10        20
                   ....*....|....*....|....
gi 2024431671 1683 DMPRVYCVEGTPINFSTATSLSDL 1706
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 2.47e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.47e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431671   690 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 730
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 3.23e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.23e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  690 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 730
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2071-2090 4.27e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|
gi 2024431671 2071 DSEDDLLQECISSAMPKKKK 2090
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 553-594 5.32e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431671   553 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 594
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 553-593 6.12e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.12e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  553 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 593
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 381-433 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671   381 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 433
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2289-2602 2.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2289 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2366
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2367 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2446
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2447 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESAsfesLSPSRPDSPTRSQLQTPVLSPS 2526
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFA----LPPDQPERPPQPQAPPPPQPQP 2921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2527 LPDMSLSTHSTAQTSGWRKLPPNLSPSVEYDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSKHSSSL 2596
Cdd:PHA03247  2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTGHSL 3001


                   ....*.
gi 2024431671 2597 PRVSTW 2602
Cdd:PHA03247  3002 SRVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1762-1783 2.49e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.49e-03
                           10        20
                   ....*....|....*....|..
gi 2024431671 1762 DKTEEGDILAECINSAMPKGKS 1783
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-772 2.50e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.50e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  732 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 772
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1417-1439 4.49e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|....
gi 2024431671 1417 SPPEHY-VQETPLMFSRCTSVSSL 1439
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 500-551 5.02e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.02e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671   500 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 551
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1302-1319 8.34e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.34e-03
                           10
                   ....*....|....*...
gi 2024431671 1302 ETIQTYCVEDTPICFSRC 1319
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1063 2.81e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.50  E-value: 2.81e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  773 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  853 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 931
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  932 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 1010
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671 1011 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1063
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2709-2882 5.66e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.66e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2709 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2788
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2789 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2868
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431671 2869 SPKRHSGSYLVTSV 2882
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2261-2606 3.65e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.56  E-value: 3.65e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2261 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2339
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2340 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2419
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2420 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2493
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2494 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2571
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431671 2572 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2606
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1080-1179 1.62e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.62e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1080 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1159
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431671 1160 GSTLGINQKVNQSLCQVDDY 1179
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1792-1883 8.17e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 8.17e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1792 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1869
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431671 1870 KLPNNEERVRGSFT 1883
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 434-507 5.35e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.35e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431671  434 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1328-1414 5.74e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.61  E-value: 5.74e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 1328 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1406
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431671 1407 PSKSGAQT 1414
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1917-1984 4.51e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.51e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431671 1917 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1984
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1708-1761 1.08e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431671 1708 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1761
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.90e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.90e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.05e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431671  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1683-1706 1.94e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.94e-07
                           10        20
                   ....*....|....*....|....
gi 2024431671 1683 DMPRVYCVEGTPINFSTATSLSDL 1706
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 2.47e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.47e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431671   690 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 730
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 3.23e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.23e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  690 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 730
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2071-2090 4.27e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 4.27e-05
                           10        20
                   ....*....|....*....|
gi 2024431671 2071 DSEDDLLQECISSAMPKKKK 2090
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 553-594 5.32e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.32e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431671   553 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 594
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 553-593 6.12e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.12e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  553 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 593
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 381-433 1.59e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.59e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431671   381 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 433
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2289-2602 2.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2289 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2366
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2367 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2446
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2447 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESAsfesLSPSRPDSPTRSQLQTPVLSPS 2526
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFA----LPPDQPERPPQPQAPPPPQPQP 2921

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2527 LPDMSLSTHSTAQTSGWRKLPPNLSPSVEYDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSKHSSSL 2596
Cdd:PHA03247  2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTGHSL 3001


                   ....*.
gi 2024431671 2597 PRVSTW 2602
Cdd:PHA03247  3002 SRVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1762-1783 2.49e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.57  E-value: 2.49e-03
                           10        20
                   ....*....|....*....|..
gi 2024431671 1762 DKTEEGDILAECINSAMPKGKS 1783
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-772 2.50e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.50e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431671  732 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 772
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2296-2604 2.90e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2296 SKSPSEGQSSASSPRGVKSSvKPEPA--------PV-TRQLSGLNQGGSSKGPS--RSGSRDSTPSRPQQQP------LS 2358
Cdd:PTZ00449   540 SDEPKEGGKPGETKEGEVGK-KPGPAkehkpskiPTlSKKPEFPKDPKHPKDPEepKKPKRPRSAQRPTRPKspklpeLL 618

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2359 RPLQSPGR-NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNT-SSIPRSES 2436
Cdd:PTZ00449   619 DIPKSPKRpESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETkTTVVLDES 698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2437 ASKGLNQILGSGASNKKTD-------LSRMSSAKSSGSESDRSERP-------VLVRQSTFIKEAPSPTLRRKL------ 2496
Cdd:PTZ00449   699 FESILKETLPETPGTPFTTprplppkLPRDEEFPFEPIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDIlaeefk 778

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431671 2497 EESASFESLSPS----RPDSPTRSQLQTPVLSPSLP-------DMSLSThSTAQTSGWRKL------PPNLSPSVEYDGR 2559
Cdd:PTZ00449   779 EEDIHAETGEPDeamkRPDSPSEHEDKPPGDHPSLPkkrhrldGLALST-TDLESDAGRIAkdasgkIVKLKRSKSFDDL 857

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2024431671 2560 PAKRhdIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRR 2604
Cdd:PTZ00449   858 TTVE--EAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVRR 900
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1417-1439 4.49e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|....
gi 2024431671 1417 SPPEHY-VQETPLMFSRCTSVSSL 1439
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 500-551 5.02e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.02e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431671   500 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 551
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1302-1319 8.34e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.34e-03
                           10
                   ....*....|....*...
gi 2024431671 1302 ETIQTYCVEDTPICFSRC 1319
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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