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Conserved domains on  [gi|2023954351|ref|WP_209792251|]
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MULTISPECIES: hypothetical protein, partial [Campylobacter]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 15-76 9.86e-16

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06439:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 251  Bit Score: 68.38  E-value: 9.86e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2023954351  15 TYIGYPFLIFLVSKmvepfRKWKVKKFDDSLDSPMVTIIIAAYNELNYLEAKIKNTLSLEYP 76
Cdd:cd06439     1 TYFGYPLLLKLLAR-----LRPKPPSLPDPAYLPTVTIIIPAYNEEAVIEAKLENLLALDYP 57
 
Name Accession Description Interval E-value
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 15-76 9.86e-16

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 68.38  E-value: 9.86e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2023954351  15 TYIGYPFLIFLVSKmvepfRKWKVKKFDDSLDSPMVTIIIAAYNELNYLEAKIKNTLSLEYP 76
Cdd:cd06439     1 TYFGYPLLLKLLAR-----LRPKPPSLPDPAYLPTVTIIIPAYNEEAVIEAKLENLLALDYP 57
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 7-76 7.64e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 38.57  E-value: 7.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023954351   7 ISIGIIAYTYIGYPFLIFLvskmvepfrkwkvKKFDDSLDSPMVTIIIAAYNELNYLEAKIKNTLSLEYP 76
Cdd:COG1215     1 LLLLLALLALLYLLLLALA-------------RRRRAPADLPRVSVIIPAYNEEAVIEETLRSLLAQDYP 57
 
Name Accession Description Interval E-value
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 15-76 9.86e-16

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 68.38  E-value: 9.86e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2023954351  15 TYIGYPFLIFLVSKmvepfRKWKVKKFDDSLDSPMVTIIIAAYNELNYLEAKIKNTLSLEYP 76
Cdd:cd06439     1 TYFGYPLLLKLLAR-----LRPKPPSLPDPAYLPTVTIIIPAYNEEAVIEAKLENLLALDYP 57
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 7-76 7.64e-05

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 38.57  E-value: 7.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023954351   7 ISIGIIAYTYIGYPFLIFLvskmvepfrkwkvKKFDDSLDSPMVTIIIAAYNELNYLEAKIKNTLSLEYP 76
Cdd:COG1215     1 LLLLLALLALLYLLLLALA-------------RRRRAPADLPRVSVIIPAYNEEAVIEETLRSLLAQDYP 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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