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Conserved domains on  [gi|2023612147|ref|NP_001381243|]
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kinetochore protein Spc24 isoform 5 [Homo sapiens]

Protein Classification

kinetochore Spc24 family protein( domain architecture ID 10550629)

kinetochore Spc24 family protein acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity

Gene Ontology:  GO:0000776|GO:0051301

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spc24 pfam08286
Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved ...
 82-163 1.78e-12

Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation


:

Pssm-ID: 429899 [Multi-domain]  Cd Length: 107  Bit Score: 60.31  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147  82 QLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVsKIEWDYECEPGMVK 161
Cdd:pfam08286   1 ELDNEKFRLAKELNDLESELERLESELAKLKEELEELEEQGVEVDEEDERSEDETVLKLKLYRSL-GIELEYDYNKALIR 79


                  ..
gi 2023612147 162 GR 163
Cdd:pfam08286  80 NK 81
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 5.27e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023612147  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
 
Name Accession Description Interval E-value
Spc24 pfam08286
Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved ...
 82-163 1.78e-12

Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation


Pssm-ID: 429899 [Multi-domain]  Cd Length: 107  Bit Score: 60.31  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147  82 QLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVsKIEWDYECEPGMVK 161
Cdd:pfam08286   1 ELDNEKFRLAKELNDLESELERLESELAKLKEELEELEEQGVEVDEEDERSEDETVLKLKLYRSL-GIELEYDYNKALIR 79


                  ..
gi 2023612147 162 GR 163
Cdd:pfam08286  80 NK 81
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 5.27e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023612147  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 35-128 1.61e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147   35 EQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLQLTRELEE---- 110
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEaeee 776

                           90
                   ....*....|....*...
gi 2023612147  111 LKEIEADLERQEKEVDED 128
Cdd:TIGR02168  777 LAEAEAEIEELEAQIEQL 794
 
Name Accession Description Interval E-value
Spc24 pfam08286
Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved ...
 82-163 1.78e-12

Spc24 subunit of Ndc80; Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation


Pssm-ID: 429899 [Multi-domain]  Cd Length: 107  Bit Score: 60.31  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147  82 QLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVsKIEWDYECEPGMVK 161
Cdd:pfam08286   1 ELDNEKFRLAKELNDLESELERLESELAKLKEELEELEEQGVEVDEEDERSEDETVLKLKLYRSL-GIELEYDYNKALIR 79


                  ..
gi 2023612147 162 GR 163
Cdd:pfam08286  80 NK 81
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-128 5.27e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147   3 AFRDIEEVSQGLLSLLGANRAEAQQRRL---LGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVE 79
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2023612147  80 LQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 23-128 1.03e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147  23 AEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEKEVA---QSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKA 99
Cdd:COG1196   265 LEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIArleERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                          90       100
                  ....*....|....*....|....*....
gi 2023612147 100 SLLQLTRELEELKEIEADLERQEKEVDED 128
Cdd:COG1196   345 ELEEAEEELEEAEAELAEAEEALLEAEAE 373
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 35-128 1.61e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147   35 EQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLQLTRELEE---- 110
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEaeee 776

                           90
                   ....*....|....*...
gi 2023612147  111 LKEIEADLERQEKEVDED 128
Cdd:TIGR02168  777 LAEAEAEIEELEAQIEQL 794
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 14-120 7.50e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 35.90  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023612147  14 LLSLLGANRAEAQQRRLlGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEE 93
Cdd:COG4942     6 LLALLLALAAAAQADAA-AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAE 84

                          90       100
                  ....*....|....*....|....*..
gi 2023612147  94 DTRLKASLLQLTRELEELKEIEADLER 120
Cdd:COG4942    85 LAELEKEIAELRAELEAQKEELAELLR 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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