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Conserved domains on  [gi|2022781823|ref|NP_001381103|]
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KRAB domain-containing protein 5 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.03e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 121.93  E-value: 1.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2022781823    4 LTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLGLAVSKPDLITFLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-537 1.12e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 229 NEEKPYKCKECDKAFNHRSHLTQHQIIHTGEKPYKC--KECGKAFNSSSYFTRHQRIHTGEKLYKCKACSK--CFTHSSN 304
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 305 LLVHQrIHTGEKPYKCKECGKSFKVSSALTQHERIHTGEKPYKCKEC-SKAFNCRSYLTKHQRIHTgeklykcKSCSKSF 383
Cdd:COG5048   109 SLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 384 SRSSSLIVHQRIHTGEKPYKCKECGKAFNCSSRLTQHQRIHTGEKPYICKECGkaFNCSSSLTKHQRIHTGVKlYKCKAC 463
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS-DSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 464 SKSFSHSSCLSVHQITH----------TGMKPYICKDCGISFNRSSNLRRHQ--MIHTGE--KPYKCKE--CGKLFNRCS 527
Cdd:COG5048   258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330
                  ....*....|
gi 2022781823 528 TLTRHKSIHT 537
Cdd:COG5048   338 ALKRHILLHT 347
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.03e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 121.93  E-value: 1.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2022781823    4 LTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLGLAVSKPDLITFLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.91e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.91e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2022781823   3 LLTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.57e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 9.57e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2022781823   4 LTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-537 1.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 229 NEEKPYKCKECDKAFNHRSHLTQHQIIHTGEKPYKC--KECGKAFNSSSYFTRHQRIHTGEKLYKCKACSK--CFTHSSN 304
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 305 LLVHQrIHTGEKPYKCKECGKSFKVSSALTQHERIHTGEKPYKCKEC-SKAFNCRSYLTKHQRIHTgeklykcKSCSKSF 383
Cdd:COG5048   109 SLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 384 SRSSSLIVHQRIHTGEKPYKCKECGKAFNCSSRLTQHQRIHTGEKPYICKECGkaFNCSSSLTKHQRIHTGVKlYKCKAC 463
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS-DSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 464 SKSFSHSSCLSVHQITH----------TGMKPYICKDCGISFNRSSNLRRHQ--MIHTGE--KPYKCKE--CGKLFNRCS 527
Cdd:COG5048   258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330
                  ....*....|
gi 2022781823 528 TLTRHKSIHT 537
Cdd:COG5048   338 ALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-525 2.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 500 NLRRHQMIHTGEKPYKCKECGKLFNR 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.03e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 121.93  E-value: 1.03e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2022781823    4 LTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLGLAVSKPDLITFLEQRKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.91e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 2.91e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2022781823   3 LLTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 9.57e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.52  E-value: 9.57e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2022781823   4 LTFRDVAIEFSREEWEHLDSDQKLLYGDVMLENYGNLVSL 43
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-537 1.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 229 NEEKPYKCKECDKAFNHRSHLTQHQIIHTGEKPYKC--KECGKAFNSSSYFTRHQRIHTGEKLYKCKACSK--CFTHSSN 304
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 305 LLVHQrIHTGEKPYKCKECGKSFKVSSALTQHERIHTGEKPYKCKEC-SKAFNCRSYLTKHQRIHTgeklykcKSCSKSF 383
Cdd:COG5048   109 SLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 384 SRSSSLIVHQRIHTGEKPYKCKECGKAFNCSSRLTQHQRIHTGEKPYICKECGkaFNCSSSLTKHQRIHTGVKlYKCKAC 463
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS-DSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 464 SKSFSHSSCLSVHQITH----------TGMKPYICKDCGISFNRSSNLRRHQ--MIHTGE--KPYKCKE--CGKLFNRCS 527
Cdd:COG5048   258 SESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330
                  ....*....|
gi 2022781823 528 TLTRHKSIHT 537
Cdd:COG5048   338 ALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-537 3.96e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 165 NHVHQSIFIQEKSAKCNKCIETFIQSSKHTQPQRIHIGEKSHRCN--NGEKILSKLSSLRKHKIIHNEEKPYKC-KECDK 241
Cdd:COG5048    21 KSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 242 AFNHRSHLTQHQIIHTGEKPYKCKECGKAFNSSSYFTRHQRIHTGEKLYKCKACSKCFTHSSN----------------- 304
Cdd:COG5048   101 SNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdp 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 305 -----LLVHQRIHTGEKPYKCKECGKSFKVSSALTQHERIHTGEKPYKCKECSKAFNCRSYLTKHQRIHTGEKLYKCKSC 379
Cdd:COG5048   181 ssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 380 SKSFSRSSSLIVHQRIHTGE-------KPYKCKECGKAFNCSSRLTQHQR--IHTGE--KPYICKE--CGKAFNCSSSLT 446
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 447 KHQRIHTGVKLYKCKACSKSFSHSSCL-------SVHQITHTGMKPYIC--KDCGISFNRSSNLRRHQMIHTGEKP--YK 515
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420
                  ....*....|....*....|..
gi 2022781823 516 CKECGKLFNRCSTLTRHKSIHT 537
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-532 7.03e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 139 RRHQKTHFLHNHCKRKKCEKAFHECTNHVHQSIFIQEKSAKCNKCIETFIQSSKHTQpQRIHIGEKSHRCNNGEKILSKL 218
Cdd:COG5048    85 THHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLL-SISNLRNNPLPGNNSSSVNTPQ 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 219 SSLRKHKIIHNEEkpykckeCDKAFNHRSHLTQHQIIHTGEKPYKCKECGKaFNSSSYFTRHQRIHTGEKLYKCKACSKC 298
Cdd:COG5048   164 SNSLHPPLPANSL-------SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 299 FTHSSNLLVHQRIHTGEKPYKCKECGKSFKVSSALTQHERIHTGE-------KPYKCKECSKAFNCRSYLTKHQR--IHT 369
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHS 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 370 GEKLykckscsksfsrssslivhqrihtgeKPYKCKE--CGKAFNCSSRLTQHQRIHTGEKPYICKEC-------GKAFN 440
Cdd:COG5048   316 GESL--------------------------KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNN 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 441 CSSSLTKHQRIHTGVKLYKC--KACSKSFSHSSCLSVHQITHTGMKP--YICKDCGISFNRSSNLRRHQMIHTGEKPYKC 516
Cdd:COG5048   370 EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                         410
                  ....*....|....*.
gi 2022781823 517 kECGKLFNRCSTLTRH 532
Cdd:COG5048   450 -SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-525 2.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 500 NLRRHQMIHTGEKPYKCKECGKLFNR 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 3.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 332 ALTQHERIHTGEKPYKCKECSKAFNC 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-328 3.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.13e-04
                          10        20
                  ....*....|....*....|....*
gi 2022781823 304 NLLVHQRIHTGEKPYKCKECGKSFK 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-273 6.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 248 HLTQHQIIHTGEKPYKCKECGKAFNS 273
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
389-413 9.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.66e-04
                          10        20
                  ....*....|....*....|....*
gi 2022781823 389 LIVHQRIHTGEKPYKCKECGKAFNC 413
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 230-336 1.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2022781823 230 EEKPYKCKECDKAFNHRSHLT----QHQIIHTGEKPYKCK--ECGKAFNSSSYFTRHqRIHtgeklykcKACSKCFTHSS 303
Cdd:COG5189   314 RKLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENP 384

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2022781823 304 NLLVHQRIHTGEKPYKCKECGKSFKVSSALTQH 336
Cdd:COG5189   385 SPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-245 4.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 220 SLRKHKIIHNEEKPYKCKECDKAFNH 245
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-441 8.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 2022781823 416 RLTQHQRIHTGEKPYICKECGKAFNC 441
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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