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Conserved domains on  [gi|2021747604|gb|QTL99652|]
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anti-sigma regulatory factor [Iocasia fonsfrigidae]

Protein Classification

ATP-binding protein( domain architecture ID 10005496)

ATP-binding protein with a histidine kinase-like ATPase domain, similar to serine/threonine-protein kinase BtrW, which phosphorylates and inactivates its specific antagonist protein BtrV and may function as a negative regulator of sigma-B activity

Gene Ontology:  GO:0005524|GO:0016787
PubMed:  16077112|12354223

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
14-140 5.41e-17

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


:

Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 71.87  E-value: 5.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  14 GDFSRGGEASSELKALLRKLGINNTIIRRAAIVTYELEMNIIIHSEGGN------IKAAVSSDEIFIYIDDEGPGIEDLE 87
Cdd:COG2172     6 ADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDpdgpveVELELDPDGLEIEVRDEGPGFDPED 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2021747604  88 KAfqPGYSTASdevremgfGAGMGLVNVKNYSDQLEIDTAPGeGTSIKVVIAI 140
Cdd:COG2172    86 LP--DPYSTLA--------EGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
14-140 5.41e-17

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 71.87  E-value: 5.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  14 GDFSRGGEASSELKALLRKLGINNTIIRRAAIVTYELEMNIIIHSEGGN------IKAAVSSDEIFIYIDDEGPGIEDLE 87
Cdd:COG2172     6 ADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDpdgpveVELELDPDGLEIEVRDEGPGFDPED 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2021747604  88 KAfqPGYSTASdevremgfGAGMGLVNVKNYSDQLEIDTAPGeGTSIKVVIAI 140
Cdd:COG2172    86 LP--DPYSTLA--------EGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 20-136 2.19e-12

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 59.69  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  20 GEASSELKALLRKLGINNTIIRRAAIVTYELEMNIIIHSEGGNI----KAAVSSDEIFIYIDDEGPGIEDLEKAFQPGYS 95
Cdd:cd16934     3 VDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVllevVAEGGRVALEILAVDQGPGIADVDEALRDGFS 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2021747604  96 TASdevremgfGAGMGLVNVKNYSDQLEIDTAPGEGTSIKV 136
Cdd:cd16934    83 TGG--------GLGLGLGGVRRLADEFDLHSAPGRGTVVVA 115
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 53-134 1.93e-11

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 57.63  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHSEGGN------IKAAVSSDEIFIYIDDEGPGIEDLEKAFQPGYSTASDEVRemgfgAGMGLVNVKNYSDQLEIDT 126
Cdd:TIGR01925  50 NAIIHGYEENcegvvyISATIEDHEVYITVRDEGIGIENLEEAREPLYTSKPELER-----SGMGFTVMENFMDDVSVDS 124


                  ....*...
gi 2021747604 127 APGEGTSI 134
Cdd:TIGR01925 125 EKEKGTKI 132
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-138 2.70e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 2.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604   53 NIIIHSEGGN---IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDeVREMGfGAGMGLVNVKNYSDQ----LE 123
Cdd:smart00387  16 NAIKYTPEGGritVTLERDGDHVEITVEDNGPGIppEDLEKIFEPFFRTDKR-SRKIG-GTGLGLSIVKKLVELhggeIS 93

                           90
                   ....*....|....*
gi 2021747604  124 IDTAPGEGTSIKVVI 138
Cdd:smart00387  94 VESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 38-138 1.85e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 46.59  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  38 TIIRRAAIVTYELEMNIIIHS-EGGNIKAAVSS-DEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEvremGFGAGMGLV 113
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLSEgGELTLTVEDNGIGIppEDLPRIFEPFSTADKRG----GGGTGLGLS 76

                          90       100
                  ....*....|....*....|....*....
gi 2021747604 114 NVKNYSDQ----LEIDTAPGEGTSIKVVI 138
Cdd:pfam02518  77 IVRKLVELlggtITVESEPGGGTTVTLTL 105
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
67-117 1.60e-06

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 46.08  E-value: 1.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2021747604  67 VSSDEIFIYIDDEGPGI--EDLEKAFQPGY--STASDevREMGfGAGMGLVNVKN 117
Cdd:PRK09470  379 VDKDGLTITVDDDGPGVpeEEREQIFRPFYrvDEARD--RESG-GTGLGLAIVEN 430
 
Name Accession Description Interval E-value
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
14-140 5.41e-17

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 71.87  E-value: 5.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  14 GDFSRGGEASSELKALLRKLGINNTIIRRAAIVTYELEMNIIIHSEGGN------IKAAVSSDEIFIYIDDEGPGIEDLE 87
Cdd:COG2172     6 ADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDpdgpveVELELDPDGLEIEVRDEGPGFDPED 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2021747604  88 KAfqPGYSTASdevremgfGAGMGLVNVKNYSDQLEIDTAPGeGTSIKVVIAI 140
Cdd:COG2172    86 LP--DPYSTLA--------EGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 20-136 2.19e-12

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 59.69  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  20 GEASSELKALLRKLGINNTIIRRAAIVTYELEMNIIIHSEGGNI----KAAVSSDEIFIYIDDEGPGIEDLEKAFQPGYS 95
Cdd:cd16934     3 VDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVllevVAEGGRVALEILAVDQGPGIADVDEALRDGFS 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2021747604  96 TASdevremgfGAGMGLVNVKNYSDQLEIDTAPGEGTSIKV 136
Cdd:cd16934    83 TGG--------GLGLGLGGVRRLADEFDLHSAPGRGTVVVA 115
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 53-134 1.93e-11

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 57.63  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHSEGGN------IKAAVSSDEIFIYIDDEGPGIEDLEKAFQPGYSTASDEVRemgfgAGMGLVNVKNYSDQLEIDT 126
Cdd:TIGR01925  50 NAIIHGYEENcegvvyISATIEDHEVYITVRDEGIGIENLEEAREPLYTSKPELER-----SGMGFTVMENFMDDVSVDS 124


                  ....*...
gi 2021747604 127 APGEGTSI 134
Cdd:TIGR01925 125 EKEKGTKI 132
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 46-134 1.67e-10

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 55.24  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  46 VTYELEMNIIIHS----EGG--NIKAAVSSDEIFIYIDDEGPGIEDLEKAFQPGYSTASDEVRemgfgAGMGLVNVKNYS 119
Cdd:cd16942    42 VVSEAVTNAIIHGynndPNGivSISVIIEDGVVHLTVRDEGVGIPDIEEARQPLFTTKPELER-----SGMGFTIMENFM 116

                          90
                  ....*....|....*
gi 2021747604 120 DQLEIDTAPGEGTSI 134
Cdd:cd16942   117 DEVIVESEVNKGTTV 131
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 53-138 2.70e-10

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 2.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604   53 NIIIHSEGGN---IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDeVREMGfGAGMGLVNVKNYSDQ----LE 123
Cdd:smart00387  16 NAIKYTPEGGritVTLERDGDHVEITVEDNGPGIppEDLEKIFEPFFRTDKR-SRKIG-GTGLGLSIVKKLVELhggeIS 93

                           90
                   ....*....|....*
gi 2021747604  124 IDTAPGEGTSIKVVI 138
Cdd:smart00387  94 VESEPGGGTTFTITL 108
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
59-138 6.29e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 52.99  E-value: 6.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  59 EGGNI--KAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVREmgfGAGMGLVNVKNYSD----QLEIDTAPGE 130
Cdd:COG0642   241 EGGTVtvSVRREGDRVRISVEDTGPGIppEDLERIFEPFFRTDPSRRGG---GTGLGLAIVKRIVElhggTIEVESEPGK 317


                  ....*...
gi 2021747604 131 GTSIKVVI 138
Cdd:COG0642   318 GTTFTVTL 325
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 38-138 1.85e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 46.59  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  38 TIIRRAAIVTYELEMNIIIHS-EGGNIKAAVSS-DEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEvremGFGAGMGLV 113
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLSEgGELTLTVEDNGIGIppEDLPRIFEPFSTADKRG----GGGTGLGLS 76

                          90       100
                  ....*....|....*....|....*....
gi 2021747604 114 NVKNYSDQ----LEIDTAPGEGTSIKVVI 138
Cdd:pfam02518  77 IVRKLVELlggtITVESEPGGGTTVTLTL 105
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 63-140 2.26e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 46.26  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLV----NVKNYSDQLEIDTAPGEGTSIKV 136
Cdd:cd16943    27 IRTWAHVDQVLIEVEDTGSGIdpEILGRIFDPFFTT-----KPVGEGTGLGLSlsyrIIQKHGGTIRVASVPGGGTRFTI 101


                  ....
gi 2021747604 137 VIAI 140
Cdd:cd16943   102 ILPI 105
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 52-138 3.54e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 47.87  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  52 MNIII-------HSEGG--NIKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLVNVKNYSD 120
Cdd:COG4191   262 LNLLInaidameEGEGGriTISTRREGDYVVISVRDNGPGIppEVLERIFEPFFTT-----KPVGKGTGLGLSISYGIVE 336

                          90       100
                  ....*....|....*....|..
gi 2021747604 121 Q----LEIDTAPGEGTSIKVVI 138
Cdd:COG4191   337 KhggrIEVESEPGGGTTFTITL 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 63-136 9.25e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 46.49  E-value: 9.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDevremgfGAGMGLVNVKNYSD----QLEIDTAPGEGTSIKV 136
Cdd:COG5000   341 VSTRREDGRVRIEVSDNGPGIpeEVLERIFEPFFTTKPK-------GTGLGLAIVKKIVEehggTIELESRPGGGTTFTI 413
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
53-138 1.23e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 46.47  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHS-EGGNIK--AAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVREMGfGAGMGLVNVKNYSD----QLE 123
Cdd:COG5002   292 NAIKYTpEGGTITvsLREEDDQVRISVRDTGIGIpeEDLPRIFERFYRVDKSRSRETG-GTGLGLAIVKHIVEahggRIW 370

                          90
                  ....*....|....*
gi 2021747604 124 IDTAPGEGTSIKVVI 138
Cdd:COG5002   371 VESEPGKGTTFTITL 385
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
67-117 1.60e-06

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 46.08  E-value: 1.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2021747604  67 VSSDEIFIYIDDEGPGI--EDLEKAFQPGY--STASDevREMGfGAGMGLVNVKN 117
Cdd:PRK09470  379 VDKDGLTITVDDDGPGVpeEEREQIFRPFYrvDEARD--RESG-GTGLGLAIVEN 430
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
53-138 2.52e-06

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 44.90  E-value: 2.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHS-EGGNIK--AAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVREmgfGAGMGLVNVKNYSD----QLE 123
Cdd:COG2205   143 NAIKYSpPGGTITisARREGDGVRISVSDNGPGIpeEELERIFERFYRGDNSRGEG---GTGLGLAIVKRIVEahggTIW 219

                          90
                  ....*....|....*
gi 2021747604 124 IDTAPGEGTSIKVVI 138
Cdd:COG2205   220 VESEPGGGTTFTVTL 234
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 63-138 4.52e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 44.84  E-value: 4.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVRemgfgaGMGLVNVKNYSDQ----LEIDTAPGEGTSIKV 136
Cdd:COG3290   309 LSIRDDGDELVIEVEDSGPGIpeELLEKIFERGFSTKLGEGR------GLGLALVKQIVEKyggtIEVESEEGEGTVFTV 382


                  ..
gi 2021747604 137 VI 138
Cdd:COG3290   383 RL 384
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 63-112 6.50e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 42.31  E-value: 6.50e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVREMGfGAGMGL 112
Cdd:cd16949    22 LDISQDGDQWTITITDDGPGVpeDQLEQIFLPFYRVDSARDRESG-GTGLGL 72
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
52-141 3.94e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 41.88  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  52 MNIIIH-----SEGGNIKAAV---SSDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLVN--VKNYS 119
Cdd:PRK11360  506 LNILINavqaiSARGKIRIRTwqySDGQVAVSIEDNGCGIdpELLKKIFDPFFTT-----KAKGTGLGLALSQriINAHG 580

                          90       100
                  ....*....|....*....|..
gi 2021747604 120 DQLEIDTAPGEGTSIKVVIAIK 141
Cdd:PRK11360  581 GDIEVESEPGVGTTFTLYLPIN 602
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 68-136 1.02e-04

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 39.29  E-value: 1.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2021747604  68 SSDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLVNVKNYSDQ----LEIDTAPGEGTSIKV 136
Cdd:cd16919    44 PGNYVCLEVSDTGSGMpaEVLRRAFEPFFTT-----KEVGKGTGLGLSMVYGFVKQsgghLRIYSEPGVGTTVRI 113
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 63-133 1.52e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 38.81  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYID-----------DEGPGI--EDLEKAFQPGYSTASDevREMGFGAGMGLVNVKNYSDQL----EID 125
Cdd:cd16948    18 LKYSKQGGKIEIYSEtneqgvvlsikDFGIGIpeEDLPRVFDKGFTGENG--RNFQESTGMGLYLVKKLCDKLghkiDVE 95


                  ....*...
gi 2021747604 126 TAPGEGTS 133
Cdd:cd16948    96 SEVGEGTT 103
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 34-136 1.85e-04

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 39.49  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  34 GINNTIIRRAAIvtyelEMNIIIHSEGGNIkaavSSDEIFIYIddegpgiedlekaFQPGYSTAsDEVREM-GFGAGMGL 112
Cdd:cd16916    93 GIDREKIREKAI-----ERGLITADEAATL----SDDEVLNLI-------------FAPGFSTA-EQVTDVsGRGVGMDV 149

                          90       100
                  ....*....|....*....|....*.
gi 2021747604 113 V--NVKNYSDQLEIDTAPGEGTSIKV 136
Cdd:cd16916   150 VkrSIESLGGTIEVESEPGQGTTFTI 175
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 59-136 2.30e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.16  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  59 EGGNIKAAVSSDEI-FIYIDDEGPGI--EDLEKAFQPGYStaSDEVREMGFGAGMGLVN--VKNYSDQLEIDTAPGEGTS 133
Cdd:cd16940    31 QGSRVEIKLSADDGaVIRVEDNGPGIdeEELEALFERFYR--SDGQNYGGSGLGLSIVKriVELHGGQIFLGNAQGGGLE 108


                  ...
gi 2021747604 134 IKV 136
Cdd:cd16940   109 AWV 111
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 63-138 2.91e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 38.38  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGIED--LEKAFQPGysTASDEVReMGFGAGMGLVN--VKNYSDQLEIDTAPGEGTSIKVVI 138
Cdd:cd16954    59 VTARQTDGGLHLIVDDDGPGVPEsqRSKIFQRG--QRLDEQR-PGQGLGLAIAKeiVEQYGGELSLSDSPLGGARFEVVF 135
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
69-138 5.36e-04

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 38.67  E-value: 5.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2021747604  69 SDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLVN--VKNYSDQLEIDTAPGEGTSIKVVI 138
Cdd:COG3852   284 RLYVRIEVIDNGPGIpeEILDRIFEPFFTT-----KEKGTGLGLAIVQkiVEQHGGTIEVESEPGKGTTFRIYL 352
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
53-138 6.10e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 38.46  E-value: 6.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHS-----EGGNI--KAAVSSDEIFIYIDDEGPGI--EDLEKAFQpgystasdEVREMGFGAGMGLVNVKN-----Y 118
Cdd:COG2972   347 NAIEHGiepkeGGGTIriSIRKEGDRLVITVEDNGVGMpeEKLEKLLE--------ELSSKGEGRGIGLRNVRErlklyY 418

                          90       100
                  ....*....|....*....|..
gi 2021747604 119 SDQ--LEIDTAPGEGTSIKVVI 138
Cdd:COG2972   419 GEEygLEIESEPGEGTTVTIRI 440
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
63-138 8.96e-04

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 37.85  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  63 IKAAVSSDEIFIYIDDEGPGIeDLE----KA-----------------------FQPGYSTAsDEVREM-GFGAGMGLV- 113
Cdd:COG0643   313 LSAYHEGGRVVIEVSDDGRGL-DLEkiraKAiekglitaeeaaalsdeelleliFAPGFSTA-EEVTDLsGRGVGMDVVk 390

                          90       100
                  ....*....|....*....|....*.
gi 2021747604 114 -NVKNYSDQLEIDTAPGEGTSIKVVI 138
Cdd:COG0643   391 tNIEALGGTIEIESEPGKGTTFTLRL 416
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 70-138 1.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.11  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2021747604  70 DEIFIYIDDEGPGI--EDLEKAFQPGYSTASDEVRemgfgaGMGLVNVKNYSDQL----EIDTAPGEGTSIKVVI 138
Cdd:cd16915    35 DDLVIEVRDTGPGIapELRDKVFERGVSTKGQGER------GIGLALVRQSVERLggsiTVESEPGGGTTFSIRI 103
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 59-141 3.94e-03

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 36.11  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  59 EGGNI---KAAVSSDEIFIYIDDEGPGI--EDLEKAFQPGYSTasdevREMGFGAGMGLVN--VKNYSDQLEIDTAPGEG 131
Cdd:COG5809   397 EGGNItieTKAEDDDKVVISVTDEGCGIpeERLKKLGEPFYTT-----KEKGTGLGLMVSYkiIEEHGGKITVESEVGKG 471

                          90
                  ....*....|
gi 2021747604 132 TSIKVVIAIK 141
Cdd:COG5809   472 TTFSITLPIK 481
PRK10547 PRK10547
chemotaxis protein CheA; Provisional
 90-138 6.30e-03

chemotaxis protein CheA; Provisional


Pssm-ID: 236712 [Multi-domain]  Cd Length: 670  Bit Score: 35.48  E-value: 6.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2021747604  90 FQPGYSTASDEVREMGFGAGMGLV--NVKNYSDQLEIDTAPGEGTSIKVVI 138
Cdd:PRK10547  471 FAPGFSTAEQVTDVSGRGVGMDVVkrNIQEMGGHVEIQSKQGKGTTIRILL 521
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
53-138 6.61e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 35.36  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021747604  53 NIIIHSEGGN--IKAAVSSDEIFIYIDDEGPGIEDlekafqpgystasdevrEMGFGAGMGLVN----VKNYSDQLEIDT 126
Cdd:COG4585   173 NALKHAGATRvtVTLEVDDGELTLTVRDDGVGFDP-----------------EAAPGGGLGLRGmrerAEALGGTLTIGS 235

                          90
                  ....*....|..
gi 2021747604 127 APGEGTSIKVVI 138
Cdd:COG4585   236 APGGGTRVRATL 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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