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Conserved domains on  [gi|2020513427|ref|NP_001135973|]
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vacuolar fusion protein MON1 homolog A isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 282-382 1.07e-35

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 126.22  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 282 DLRHFLYKSKSSGLFTSP--EIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYS 359
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCFELYVLFS 80

                          90       100
                  ....*....|....*....|...
gi 2020513427 360 PLGTKASAVSAIHKLMRWIRKEE 382
Cdd:pfam19038  81 PLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 155-253 1.43e-33

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 120.41  E-value: 1.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 155 SLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNaAGFFHAHISYLePDTDLCLLLV 234
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFN-PGVLHRYISFL-GDINLCLLLL 79

                          90
                  ....*....|....*....
gi 2020513427 235 STDREDFFAVSDCRRRFQE 253
Cdd:pfam19037  80 SGDKPAFFELSLLDDRFWL 98
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 44-116 1.10e-22

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 92.27  E-value: 1.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020513427  44 GYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNL 116
Cdd:pfam19036  53 NTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 282-382 1.07e-35

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 126.22  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 282 DLRHFLYKSKSSGLFTSP--EIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYS 359
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCFELYVLFS 80

                          90       100
                  ....*....|....*....|...
gi 2020513427 360 PLGTKASAVSAIHKLMRWIRKEE 382
Cdd:pfam19038  81 PLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 155-253 1.43e-33

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 120.41  E-value: 1.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 155 SLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNaAGFFHAHISYLePDTDLCLLLV 234
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFN-PGVLHRYISFL-GDINLCLLLL 79

                          90
                  ....*....|....*....
gi 2020513427 235 STDREDFFAVSDCRRRFQE 253
Cdd:pfam19037  80 SGDKPAFFELSLLDDRFWL 98
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 44-116 1.10e-22

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 92.27  E-value: 1.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020513427  44 GYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNL 116
Cdd:pfam19036  53 NTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 282-382 1.07e-35

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 126.22  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 282 DLRHFLYKSKSSGLFTSP--EIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYS 359
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPslPTDPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCFELYVLFS 80

                          90       100
                  ....*....|....*....|...
gi 2020513427 360 PLGTKASAVSAIHKLMRWIRKEE 382
Cdd:pfam19038  81 PLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 155-253 1.43e-33

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 120.41  E-value: 1.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020513427 155 SLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNaAGFFHAHISYLePDTDLCLLLV 234
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPFKSLELWIPICLPKFN-PGVLHRYISFL-GDINLCLLLL 79

                          90
                  ....*....|....*....
gi 2020513427 235 STDREDFFAVSDCRRRFQE 253
Cdd:pfam19037  80 SGDKPAFFELSLLDDRFWL 98
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 44-116 1.10e-22

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 92.27  E-value: 1.10e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2020513427  44 GYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNL 116
Cdd:pfam19036  53 NTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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