NCBI Conserved Domain Search

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 222.80 E-value: 1.72e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 191 WGDIAEGVRVEVLNTDQNLTTKVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTI 270
Cdd:cd20120     1 WGDIAEGVRVEVPNTDCNLPTKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTI 80

                          90       100
                  ....*....|....*....|..
gi 2017835283 271 QHKYSNWKAFLVKRLTGAKTLP 292
Cdd:cd20120    81 QHKYTNWKAFLVKRLTGAKTLP 102

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 204.25 E-value: 1.31e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDGSEAADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKlP 485
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVLANGYLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYKK-P 79

                          90
                  ....*....|.
gi 2017835283 486 FKWFDYLRETG 496
Cdd:cd20126    80 FKWFDYLRETG 90

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 198.26 E-value: 2.27e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 294 DFAQKVSESMQYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHRF 373
Cdd:cd20123     1 DFSQKVSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESEDGTDDFWCHMYSPLIHHIGWSRSIGHRF 80


                  ....*
gi 2017835283 374 KRSDI 378
Cdd:cd20123    81 KRSDI 85

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 179.80 E-value: 2.56e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDGSEAADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80

                          90
                  ....*....|.
gi 2017835283 486 FKWFDYLRETG 496
Cdd:cd20099    81 FDWEEYLEETG 91

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 174.55 E-value: 3.50e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 191 WGDIAEGVRVEVLNTD--QNLTTKVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQ 268
Cdd:cd20119     1 WDNITVGMKVEVENTDtdLIEDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPR 80

                          90       100
                  ....*....|....*....|....
gi 2017835283 269 TIQHKYSNWKAFLVKRLTGAKTLP 292
Cdd:cd20119    81 TIEHKYSDWKEFLVKRLTGARTLP 104

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 170.93 E-value: 2.44e-51

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20129     1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 170.42 E-value: 1.22e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDGSEA-ADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKL 484
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVLRFGYLMIRIDSYEPdASGSDWFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                          90       100
                  ....*....|....*....|....*..
gi 2017835283 485 PFKWFDYLRETGSIAAPVKLFNKEVPN 511
Cdd:cd20125    81 TFTWEGYLRQTGATAAPQHLFHRIIPD 107

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 168.24 E-value: 2.41e-50

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20100     1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 162.69 E-value: 5.15e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDGSEAADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVLLDGYLMIGIDGGPSTDGSDWFCYHASSHAIFPVGFCQKNDIELTPPKGYDAQT 80

                          90
                  ....*....|.
gi 2017835283 486 FKWFDYLRETG 496
Cdd:cd20127    81 FNWENYLEKTK 91

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 160.78 E-value: 4.78e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 191 WGDIAEGVRVEVLNTDQNLTTKVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTI 270
Cdd:cd20121     1 WEDVMEGMKVEVLNTDAVLPSRVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTI 80

                          90       100
                  ....*....|....*....|..
gi 2017835283 271 QHKYSNWKAFLVKRLTGAKTLP 292
Cdd:cd20121    81 HAKFTDWRGYLMKRLVGSRTIP 102

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 158.18 E-value: 3.48e-46

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283  490 DYLRETGSIAAPVKLFNKEV--PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLY 567
Cdd:smart00561   2 DYLEETGARAAPVELFKQPVdsPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDIF 81

                           90
                   ....*....|....*
gi 2017835283  568 PVGWCQLTGYQLQPP 582
Cdd:smart00561  82 PVGWCEKNGHPLQPP 96

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 153.61 E-value: 9.33e-45

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20130     2 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 153.62 E-value: 1.74e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 191 WGDIAEGVRVEVLNTDQNLTT---KVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20097     1 WEKVKIGVKVEVANRDDDKPTdnvKVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPP 80

                          90       100
                  ....*....|....*....|....*
gi 2017835283 268 QTIQHKYSNWKAFLVKRLTGAKTLP 292
Cdd:cd20097    81 KSIEDKENDWKEYIMKRLHGKRTIP 105

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 143.93 E-value: 3.14e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 294 DFAQKVSESMQY-PFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHR 372
Cdd:cd20098     1 DFHEKVLESLKStPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHK 80


                  ..
gi 2017835283 373 FK 374
Cdd:cd20098    81 IR 82

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 142.67 E-value: 1.01e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 294 DFAQKVSESMQYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESeDKTDDFWCHMYSPLIHPIGWSRSIGHRF 373
Cdd:cd20124     1 DFHIKMAESMKYPFRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDG-DSDDDFWCHMWSPLIHPVGWSRRVGHSI 79


                  ....
gi 2017835283 374 KRSD 377
Cdd:cd20124    80 KMSD 83

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 129.67 E-value: 6.27e-36

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 511 NHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20102     1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 124.55 E-value: 2.10e-34

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 518 MKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 123.61 E-value: 5.78e-34

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20128     1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 117.74 E-value: 1.46e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283  376 SDILKKNEShFNAPSHLFIKVkdVDQNSEWFKEGMKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSeaaDGSDWFCY 455
Cdd:smart00561   1 EDYLEETGA-RAAPVELFKQP--VDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVK-GYRLLLHFDGW---DDKYDFWC 73

                           90       100
                   ....*....|....*....|...
gi 2017835283  456 HALSPSIFPVGFCEINKIELTPP 478
Cdd:smart00561  74 HADSPDIFPVGWCEKNGHPLQPP 96

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 116.97 E-value: 2.64e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283  284 RLTGAKTLPADFAQKVSESMQYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPI 363
Cdd:smart00561   5 EETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDK-YDFWCHADSPDIFPV 83

                           90
                   ....*....|.
gi 2017835283  364 GWSRSIGHRFK 374
Cdd:smart00561  84 GWCEKNGHPLQ 94

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 116.61 E-value: 3.35e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 194 IAEGVRVEVLNTDqnlTTKVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHK 273
Cdd:cd20093     4 FKPGMKLEVPNKN---NPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                          90
                  ....*....|....
gi 2017835283 274 YSNWKAFLVKRLTG 287
Cdd:cd20093    81 ELDWAEFLIKELTG 94

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 114.68 E-value: 8.18e-31

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20103     1 PPHGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 111.09 E-value: 2.80e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 294 DFAQKVSESMQYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHRF 373
Cdd:cd20122     1 NFHNKVNESLRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNL 80


                  ...
gi 2017835283 374 KRS 376
Cdd:cd20122    81 AAS 83

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 108.37 E-value: 2.06e-28

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20137     1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 106.46 E-value: 1.54e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 509 VPNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20134     1 PPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP 74

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 104.62 E-value: 4.11e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 507 KEVPNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20138     2 KVKPPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQPP 77

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 105.43 E-value: 4.70e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20101     4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPP 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 104.70 E-value: 5.50e-27

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20136     5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAP 73

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 104.65 E-value: 6.75e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGID-GSEAADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKL 484
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVEIDdLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80

                          90
                  ....*....|..
gi 2017835283 485 PFKWFDYLRETG 496
Cdd:cd20095    81 EFDWDSYLKLCG 92

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 103.36 E-value: 7.67e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 410 MKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSeaaDGSDWFCYHALSPSIFPVGFCEINKIELTPPR 479
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGW---DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 103.89 E-value: 1.49e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVlaEGY-LMIGIDG-SEAADgsdwFCYHALSPSIFPVGFCEINKIELTPPRGYTK 483
Cdd:cd20101     6 FKVGMKLEGIDPKHPSLFCVLSVAEV--RGYrLRLHFDGySECYD----FWVNADSPDIFPVGWCEKTGHKLQPPKGYTS 79

                          90       100
                  ....*....|....*....|..
gi 2017835283 484 LPFKWFDYLRETGSIAAPVKLF 505
Cdd:cd20101    80 ETFSWSAYLKLTKAQAAPKHLF 101

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 102.33 E-value: 1.89e-26

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDE-YDQWVDCESPDLYPVGWCQ 573
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSrYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 102.96 E-value: 2.79e-26

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 513 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPPaPQSKD 588
Cdd:cd20135     5 GFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTP-PGYKD 79

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 101.21 E-value: 1.16e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 197 GVRVEVLNTDQNLTtkvFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSN 276
Cdd:cd20112     7 GMKLEVANKSNPDT---YWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEKYTD 83

                          90
                  ....*....|.
gi 2017835283 277 WKAFLVKRLTG 287
Cdd:cd20112    84 WTEFLIHDLTG 94

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 100.78 E-value: 1.35e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSEaaDGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20102     4 FRVGMKLEAVDRKNPSLICVATVTDVI-GNRFLVHFDGWD--DSYDYWC-DPDSPYIHPVGWCEENGKTLQPPKGYSPGN 79

                          90
                  ....*....|.
gi 2017835283 486 FKWFDYLRETG 496
Cdd:cd20102    80 FSWDKYLEETN 90

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 101.06 E-value: 1.37e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 194 IAEGVRVEV-LNTDQNlttkVFWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQH 272
Cdd:cd20111     4 FSPGMKLEVaVRTDPN----TYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRD 79

                          90
                  ....*....|....*
gi 2017835283 273 KYSNWKAFLVKRLTG 287
Cdd:cd20111    80 KLSDWEEFLAQTLTG 94

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 99.62 E-value: 2.13e-25

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGW-EDEYDQWVDCESPDLYPVGWCQLTGYQLQPPAP 584
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEkKLSPNIIVDVESTDIFPVGWCESNGYPLVTPRK 72

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 98.79 E-value: 4.84e-25

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20139     5 PPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVP 77

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 96.66 E-value: 2.48e-24

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 96.53 E-value: 5.13e-24

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20132     4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 94.47 E-value: 3.21e-23

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20133     4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPP 74

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 90.00 E-value: 9.42e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283  176 AAPVSCFRHA--PMGNCwgdIAEGVRVEVLNTdQNLTTkvFWIAVIVKLAGYNVLLRYEGFENDVtmDFWCNICSNDVHP 253
Cdd:smart00561  11 AAPVELFKQPvdSPPNG---FKVGMKLEAVDP-RNPSL--ICVATVVEVKGYRLLLHFDGWDDKY--DFWCHADSPDIFP 82

                           90
                   ....*....|....
gi 2017835283  254 VGWCASSGKPLVPP 267
Cdd:smart00561  83 VGWCEKNGHPLQPP 96

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 88.28 E-value: 1.86e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 513 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20110     5 LFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGHPLQPP 74

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 88.40 E-value: 2.41e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20109     2 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 88.40 E-value: 4.83e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20131    12 NGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPP 82

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 84.49 E-value: 3.07e-20

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 311 MRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDS-YDFWCHADSPDIHPVGWCEKNGHPLQ 63

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 84.23 E-value: 3.39e-20

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSR 367
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 84.61 E-value: 4.36e-20

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 511 NHgFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20108     4 NF-FKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 83.70 E-value: 1.51e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDGSEA-ADGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKL 484
Cdd:cd20116     3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPeASENSMLC-HADSLGILPVQWCLKNGVNLTPPKGYSGQ 81

                          90
                  ....*....|..
gi 2017835283 485 PFKWFDYLRETG 496
Cdd:cd20116    82 DFDWADYQKQCG 93

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 83.12 E-value: 2.89e-19

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017835283 506 NKEVPNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20091     2 SPIPPVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPP 78

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 84.28 E-value: 3.10e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 486 FKWFDYLRETGSIAAPVKLFNKEV--PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCES 563
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYtpPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                          90
                  ....*....|....*....
gi 2017835283 564 PDLYPVGWCQLTGYQLQPP 582
Cdd:cd20105    82 SEIQPIGNCEKNGGMLQPP 100

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 81.38 E-value: 1.12e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 401 QNSEWFKEGMKLEAIDPLNLSAICVATIRKVlaEGYLM-IGIDG-SEAADgsdwFCYHALSPSIFPVGFCEINKIELTPP 478
Cdd:cd20133     1 QSRNGFKVGMRLEGIDPEHPSLFCVLSVAEV--QGYRLrLHFDGySECYD----FWVNADSPDIHPVGWCEKTGHKLLPP 74

                          90       100
                  ....*....|....*....|....*..
gi 2017835283 479 RGYTKLPFKWFDYLRETGSIAAPVKLF 505
Cdd:cd20133    75 KGYKDGEFNWSSYLKTCKAQAAPKNLF 101

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 80.68 E-value: 1.92e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLMIGIDG---SEAADGSdwFCYHALSPSIFPVGFCEINKIELTPPRGYT 482
Cdd:cd20115     3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDlrpEEAGAHS--FVCHRDSPGIFPVQWSLKNGLHLSPPPGYP 80

                          90
                  ....*....|....
gi 2017835283 483 KLPFKWFDYLRETG 496
Cdd:cd20115    81 GQDFDWADYLKQCG 94

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 76.14 E-value: 2.30e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSEaaDGSDWFCYHALSPSIFPVGFCE 469
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVV-GGRLLLHFDGWD--PSRYDFWCDVDSPDIHPVGWCE 61

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 76.77 E-value: 3.84e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSEaaDGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMV-DNRLLIHFDNWD--ESYDYWC-DASSPYIHPVGYCQEHGRTLTTPPGYKDPK 81

                          90
                  ....*....|..
gi 2017835283 486 -FKWFDYLRETG 496
Cdd:cd20135    82 hFSWEKYLEETN 93

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 77.34 E-value: 6.93e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 163 FSWGTYITSKNLLAAPVSCFRHA--PMGNcwgDIAEGVRVEVLNTdQNLTTKVfwIAVIVKLAGYNVLLRYEGFENdvTM 240
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSytPPVN---EFKIGMKLEAQDP-RNTTSTC--IATVVGLTGARLRLRLDGSDN--KN 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 241 DFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFLVKRLTGAKTLPADFAQK 298
Cdd:cd20105    74 DFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 75.63 E-value: 9.02e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 513 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY-DQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20118     1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPP 71

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 75.03 E-value: 1.86e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEgYLMIGIDGSeaaDGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20091    10 FKVGMKLEAQDPRNLTSTCIATVVGIQGP-RLRLRLDGS---DNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMNP 85

                          90
                  ....*....|
gi 2017835283 486 FKWFDYLRET 495
Cdd:cd20091    86 SSWPMFLQKT 95

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 74.87 E-value: 2.13e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGYLmIGIDGSEaaDGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL-VHFDNWD--DTYDYWC-DPSSPYIHPVGWCQKQGKPLTPPQDYPDPD 81

                          90
                  ....*....|..
gi 2017835283 486 -FKWFDYLRETG 496
Cdd:cd20134    82 nFSWEKYLEETG 93

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

Pssm-ID: 439080 Cd Length: 61 Bit Score: 73.44 E-value: 2.19e-16

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 194 IAEGVRVEVLNTDQNlttKVFWIAVIVKLAGYNVLLRYEGFENDVtMDFWCNICSNDVHPVGWCA 258
Cdd:cd20088     1 FKVGMKLEAVDPLNP---SEICVATVVKVVGGRLLLHFDGWDPSR-YDFWCDVDSPDIHPVGWCE 61

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 74.92 E-value: 3.02e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 393 FIKVKDVDQNSEWFKEGMKLEAIDPLNLSAICVATIRKVLaeGY-LMIGIDG-SEAADgsdwFCYHALSPSIFPVGFCEI 470
Cdd:cd20131     1 FQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVC--GYrLRLHFDGySECHD----FWVNANSPDIHPAGWFEK 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2017835283 471 NKIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLF 505
Cdd:cd20131    75 TGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLF 109

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 72.93 E-value: 3.59e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 199 RVEVLNTdQNLTTkvFWIAVIVKLAGYNVLLRYEGFENDVtmDFWCNICSNDVHPVGWCASSGKPLVPPQ 268
Cdd:pfam02820   2 KLEAVDP-LNPSL--ICVATVVKVLGGRLRLRFDGWDDSY--DFWCHADSPDIHPVGWCEKNGHPLQPPK 66

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 73.04 E-value: 4.21e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVlaEGYLM-IGIDGSeaADGSDWFCYHALSPSIFPVGFCEINKIELTPPRGY 481
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKV--VGPLLwLHLDSE--KKLSPNIIVDVESTDIFPVGWCESNGYPLVTPRKY 73

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 72.65 E-value: 1.49e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 401 QNSEWFKEGMKLEAIDPLNLSAICVATIRKVLaeGYLM-IGIDGSeaADGSDwFCYHALSPSIFPVGFCEINKIELTPPR 479
Cdd:cd20132     1 YNKNGFKVGMKLEGVDPEHQSMYCVLTVAEVC--GYRIrLHFDGY--SDCYD-FWVNADSPDIHPVGWCEKTGHKLHPPK 75

                          90       100
                  ....*....|....*....|....*.
gi 2017835283 480 GYTKLPFKWFDYLRETGSIAAPVKLF 505
Cdd:cd20132    76 GYKEEEFNWQSYLKTCKAQAAPKSLF 101

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 71.11 E-value: 5.36e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 506 NKEVPNHGFRVGMKLEAVDlmePRLV---CVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20107     2 AQNPPKNEFKIGMKLEALD---PRNVtstCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPP 78

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 70.42 E-value: 7.52e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLaEGYLMIGIDGSEaaDGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKlP 485
Cdd:cd20136     5 FQVGMKLEAVDRKNPSLVCVATIADIV-EDRLLVHFDNWD--DSYDYWC-DVNSPYIQPVGWCQENGRTLVAPQGYPN-P 79

                          90
                  ....*....|..
gi 2017835283 486 --FKWFDYLRET 495
Cdd:cd20136    80 ekFSWTEYLEAT 91

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 70.00 E-value: 1.03e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 513 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPPA 583
Cdd:cd20093     3 GFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDDrsADFWCDLSSGDVHPIGWCAQNGKPLQPPA 75

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 69.95 E-value: 1.25e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 510 PNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20106     6 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPP 78

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 68.82 E-value: 2.16e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIH-RLLRIHFD---GWEDEYDQWV-DCESPDLYPVGWCQLTGYQLQPPAPQSK 587
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNeYYFLVEIDdlrPEESEKITFVcHANSPGIFPVGWCAKNGLRLTPPPGYPK 79

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 66.94 E-value: 9.23e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIH-RLLRIHFDG-WEDEYDQW--VDCESPDLYPVGWCQLTGYQLQPPAP 584
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRfGYLVIGIDGpSADDGSDWfcCHASSPFIFPVGFAEKNGIELTPPRG 75

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 65.29 E-value: 3.46e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY-DQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20117     1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIpECIVHVESMDIFPVGWCETNGYPLLHP 72

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 63.81 E-value: 9.35e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIH-FDGWEDEYDQWVDCESPDLYPVGWCQLTGYQL 579
Cdd:cd20098    13 TPFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVGHKI 81

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 65.40 E-value: 1.04e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 388 APSHLFIKVKDVDQNSewFKEGMKLEAIDPLNLSAICVATIRKvLAEGYLMIGIDGSeaaDGSDWFCYHALSPSIFPVGF 467
Cdd:cd20105    16 APVHCFKQSYTPPVNE--FKIGMKLEAQDPRNTTSTCIATVVG-LTGARLRLRLDGS---DNKNDFWRLVDSSEIQPIGN 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2017835283 468 CEINKIELTPPRGYTKLPFKWFDYLRET--GSIAAPVKLFNK 507
Cdd:cd20105    90 CEKNGGMLQPPLGFRLNASSWPMFLLKTlnGAEMAPVRIFHK 131

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 63.53 E-value: 1.18e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEgYLMIGIDGSEAAdgSDWFCYHaLSPSIFPVGFCEINKIELTPP 478
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGD-EIHISFDGWRGA--FDYWCRY-DSRDIFPVGWCKKTGHPLQPP 74

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 63.41 E-value: 1.70e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 194 IAEGVRVEVLNTDQNLTTkvfWIAVIVKLAGYNVLLRYEGFENDVTMDFWCnICSND-VHPVGWCASSGKPLVPPQTI-- 270
Cdd:cd20094     4 IKVGMYLEVQDELNPYSV---WIAKVLENVGGRLLLRYDGPEDSDSPDFWL-FYLSPrLHPLGWAKSNGYTYRPPKSLek 79

                          90
                  ....*....|.
gi 2017835283 271 QHKYSNWKAFL 281
Cdd:cd20094    80 LHATEEWKAIL 90

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 62.25 E-value: 4.58e-12

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDK-TDDFWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSdSPDFWLFYLSPRLHPLGWAKSNGYTYR 72

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 61.16 E-value: 1.18e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 197 GVRVEVLNTdQNLTTKVfwIAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSN 276
Cdd:cd20091    13 GMKLEAQDP-RNLTSTC--IATVVGIQGPRLRLRLDGSDN--KNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMNPSS 87

                          90
                  ....*....|
gi 2017835283 277 WKAFLVKRLT 286
Cdd:cd20091    88 WPMFLQKTLN 97

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 61.13 E-value: 1.33e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 213 VFWIAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFLvkRLTGAKTLP 292
Cdd:cd20101    22 LFCVLSVAEVRGYRLRLHFDGYSEC--YDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSETFSWSAYL--KLTKAQAAP 97

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 61.09 E-value: 1.49e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 213 VFWIAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFLvkRLTGAKTLP 292
Cdd:cd20132    22 MYCVLTVAEVCGYRIRLHFDGYSD--CYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEEFNWQSYL--KTCKAQAAP 97

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 60.32 E-value: 2.72e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIrkvlaegylmIGIDGSE---AADGSDW---FCYHALSPSIFPVGFCEINKIELTPPR 479
Cdd:cd20106    10 FKVGMKLEARDPRNATSVCIATV----------IGITGARlrlRLDGSDNkndFWRLVDSSDIQPIGTCEKEGDMLQPPL 79

                          90
                  ....*....|....*.
gi 2017835283 480 GYTKLPFKWFDYLRET 495
Cdd:cd20106    80 GFQMNASSWPMFLLRT 95

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 59.07 E-value: 5.99e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 513 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20111     3 GFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEDRraDFWCDIMTADLHPIGWCEQNGKTLRPP 74

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 58.26 E-value: 1.13e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRII-HRLLRIHFDGWE--DEYDqWV--DCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVLaNGYLMIGIDGSEaaDGSD-WFcyHATSPSIFPVGFCEINMIELTPP 73

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 58.78 E-value: 1.13e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEgYLMIGIDGSeaaDGSDWFCYHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20107    10 FKIGMKLEALDPRNVTSTCIATVVGVLGP-RLRLRLDGS---DNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNA 85

                          90
                  ....*....|
gi 2017835283 486 FKWFDYLRET 495
Cdd:cd20107    86 SSWPMFLLKT 95

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 58.35 E-value: 1.17e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEgYLMIGIDGSEAADGSdwFCYHALSPSIFPVGFCEINKIELTPPR 479
Cdd:cd20117     3 FKENMKLEAVNPICPEEICVATVTKVKGS-YLWLQLEGSKKPIPE--CIVHVESMDIFPVGWCETNGYPLLHPR 73

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 58.40 E-value: 1.48e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 197 GVRVEVLNTdQNLTTKVfwIAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSN 276
Cdd:cd20107    13 GMKLEALDP-RNVTSTC--IATVVGVLGPRLRLRLDGSDNK--NDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMNASS 87

                          90
                  ....*....|..
gi 2017835283 277 WKAFLVKRLTGA 288
Cdd:cd20107    88 WPMFLLKTLNNA 99

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 57.55 E-value: 1.79e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRII-HRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20122    14 FRLGLNLECVDKNRISQVRVATVTKIVgKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNLAAS 83

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 58.01 E-value: 2.15e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDkTDDFWCHMYSPLIHPIGWSRSIGHRFKRSDILKKNEshF 386
Cdd:cd20132     6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSD-CYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEE--F 82


                  ....*.
gi 2017835283 387 NAPSHL 392
Cdd:cd20132    83 NWQSYL 88

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 56.52 E-value: 3.13e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20103    24 VATVADVEDYRVKLHFDGWPDI--YDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 56.55 E-value: 4.83e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 303 MQYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLrLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHRF 373
Cdd:cd20136     1 MPKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRL-LVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTL 70

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 56.72 E-value: 4.97e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 213 VFWIAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFL 281
Cdd:cd20133    22 LFCVLSVAEVQGYRLRLHFDGYSE--CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGEFNWSSYL 88

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 55.36 E-value: 6.91e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPIGWSRSIGH 371
Cdd:cd20103     5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDI-YDFWVDDDSPDIHPPGWCSKTGH 68

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 55.60 E-value: 1.08e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVlaEGYLM-IGIDGSEAAdgSDWFCYHALSPSIFPVGFCEINKIELTPP 478
Cdd:cd20118     2 FTKNMKLEAVNPRNPAEICVASITSV--KGRLLwLHLEGLQNP--VPEYIVDVESMDIFPVGWCEANGYPLTPP 71

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 55.38 E-value: 1.19e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20112     4 FQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRraDFWCDVMTADLHPVGWCTQNNKVLMPP 74

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 55.19 E-value: 1.33e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRL-LRIHFDGWEDEYDQ---WVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20116     1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHyFQVTVDDLRPEASEnsmLCHADSLGILPVQWCLKNGVNLTPP 75

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 55.23 E-value: 1.42e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLrLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIG 370
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRF-LVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQG 68

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 55.31 E-value: 1.60e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFLVKRLTG 287
Cdd:cd20106    29 IATVIGITGARLRLRLDGSDN--KNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNASSWPMFLLRTLNG 98

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 54.84 E-value: 2.29e-09

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2017835283 234 FEN-DVTMDFWCNICSNDVHPVGWCASSGKPLVPPQ 268
Cdd:cd20134    40 FDNwDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQ 75

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 54.82 E-value: 2.49e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 194 IAEGVRVEVLNTDQNLTTkvfWIAVIVKLAGYNVLLRYEGFENDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQH- 272
Cdd:cd20113     4 IGPGSRLELQDFQDSLVA---WIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRHl 80

                          90
                  ....*....|..
gi 2017835283 273 -KYSNWKAFLVK 283
Cdd:cd20113    81 kSEAEWQEILKK 92

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 54.55 E-value: 2.49e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWE--DEYDQWVDCESPDLYPVGWCQLTGYQLQPPA 583
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEdsDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPK 75

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 54.89 E-value: 2.66e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDkTDDFWCHMYSPLIHPIGWSRSIGHR-----------FKR 375
Cdd:cd20131    14 FKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSE-CHDFWVNANSPDIHPAGWFEKTGHKlqppkgykeeeFSW 92

                          90
                  ....*....|....*...
gi 2017835283 376 SDILKKNESHFnAPSHLF 393
Cdd:cd20131    93 SQYLRSTRAQA-APKHLF 109

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 54.41 E-value: 3.84e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDkTDDFWCHMYSPLIHPIGWSRSIGHRFKRSDILKKNEshF 386
Cdd:cd20133     6 FKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSE-CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGE--F 82


                  ....*.
gi 2017835283 387 NAPSHL 392
Cdd:cd20133    83 NWSSYL 88

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 54.50 E-value: 4.63e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 213 VFWIAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFLvkRLTGAKTLP 292
Cdd:cd20131    30 MYFILTVAEVCGYRLRLHFDGYSE--CHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYL--RSTRAQAAP 105

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 53.40 E-value: 5.53e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 306 PFKPSMRVEVVDKTH---LCrtrVAVVDSVIGGRLRLVYEESEDKTDdFWCHMYSPLIHPIGW 365
Cdd:cd20102     3 GFRVGMKLEAVDRKNpslIC---VATVTDVIGNRFLVHFDGWDDSYD-YWCDPDSPYIHPVGW 61

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 53.40 E-value: 5.70e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQHKYSNWKAFL 281
Cdd:cd20102    23 VATVTDVIGNRFLVHFDGWDD--SYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGNFSWDKYL 86

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 53.43 E-value: 6.87e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 304 QYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYE-ESEDKTDDFWCHMYSPLIHPIGWSRS 368
Cdd:cd20093     1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVgYEDDRSADFWCDLSSGDVHPIGWCAQ 66

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains; PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439094 [Multi-domain] Cd Length: 60 Bit Score: 51.86 E-value: 8.55e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 514 FRVGMKLEAVDLMepRLVCVATVTRI--IHRLLRIHFDGWEDEYDQWVDCESPDLYPVG 570
Cdd:cd20104     1 FKVGDRVDALDGE--GKWYEAKIVEVdeEENKVLVHYDGWSSRYDEWIDRDSERLRPLH 57

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 52.50 E-value: 1.36e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLrLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIG 370
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMVDNRL-LIHFDNWDESYDYWCDASSPYIHPVGYCQEHG 68

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 51.93 E-value: 2.15e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFenDVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQH--KYSnWKAFL 281
Cdd:cd20136    24 VATIADIVEDRLLVHFDNW--DDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYPNpeKFS-WTEYL 88

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 51.10 E-value: 2.47e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 405 WFKEGMKLEAIDPLNLSAICVATIRKVLAeGYLMIGIDGSEAAdgSDWFCYHAlSPSIFPVGFCEINKIELTPP 478
Cdd:cd20108     5 FFKTGMKLEAVDRKNPHFICPATIGEVRG-SEVLVTFDGWRGA--FDYWCRYD-SRDIFPVGWCSLTGDNLQPP 74

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 51.04 E-value: 2.64e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEGyLMIGIDGSEAAdgSDWFCYHAlSPSIFPVGFCEINKIELTPP 478
Cdd:cd20109     6 FKVGMKLEAIDKKNPYLICPATIGDVKGDE-VFITFDGWRGA--FDYWCKYD-SRDIFPVGWCRLTGDVLQPP 74

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 51.89 E-value: 2.67e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 307 FKPSMRVEVVDKTH---LCrtrVAVVDSVIGGRLRLVYEE-SEDKtdDFWCHMYSPLIHPIGWSRSIGH----------- 371
Cdd:cd20101     6 FKVGMKLEGIDPKHpslFC---VLSVAEVRGYRLRLHFDGySECY--DFWVNADSPDIFPVGWCEKTGHklqppkgytse 80

                          90       100
                  ....*....|....*....|..
gi 2017835283 372 RFKRSDILKKNEShFNAPSHLF 393
Cdd:cd20101    81 TFSWSAYLKLTKA-QAAPKHLF 101

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 51.08 E-value: 2.96e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20138    28 VATVADTDDHRVKVHFDGWNNC--YDYWIDADSPDIHPAGWCAKTGHPLQPP 77

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 50.31 E-value: 4.87e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRlVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGH 371
Cdd:cd20138     9 FQKNMKLEVVDKRNPMLIRVATVADTDDHRVK-VHFDGWNNCYDYWIDADSPDIHPAGWCAKTGH 72

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 50.75 E-value: 5.35e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 304 QYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYE-ESEDKTDDFWCHMYSPLIHPIGW 365
Cdd:cd20112     1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCgYGDDRRADFWCDVMTADLHPVGW 63

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 50.05 E-value: 5.90e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 217 AVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20092    26 ATVGDVDGDEIHISFDGWRG--AFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 50.60 E-value: 6.76e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 304 QYPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEE-SEDKTDDFWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:cd20111     1 QNGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGyGEDRRADFWCDIMTADLHPIGWCEQNGKTLR 72

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 49.76 E-value: 6.78e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 403 SEWFKEGMKLEAIDPLNLSAICVATIRKVlAEGYLMIGIDGSEAAdgSDWFCYHAlSPSIFPVGFCEINKIELTPP 478
Cdd:cd20110     3 SNLFKVGMKLEAVDRKNPHLICPATVGAV-KDDQIFVTFDGWRGA--FDYWCRYD-SRDIFPVGWCARSGHPLQPP 74

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 50.38 E-value: 8.49e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPIGW 365
Cdd:cd20091    10 FKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNK-NDFWRLVDSSDIHPVGW 67

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 49.46 E-value: 1.38e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 197 GVRVEVLNTDQNLTTKVfwiAVIVKLAGYNVLLRYEGFENDvTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20122    17 GLNLECVDKNRISQVRV---ATVTKIVGKRLHLRYEGSEPD-DDGFWCHEDSPLIHPVGWAQTVGHNLAAS 83

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 49.72 E-value: 1.47e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 516 VGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDE-YDQWV---DCEspdLYPVGWCQLTGYQLQPPA 583
Cdd:cd20114     6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLEDEsHDQWLfylDTR---LRPVGWCQENNLRMEPPT 74

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 49.42 E-value: 1.65e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 234 FEN-DVTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQH-KYSNWKAFLVK 283
Cdd:cd20135    40 FDNwDESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDpKHFSWEKYLEE 91

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 49.17 E-value: 1.68e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 197 GVRVEVLNTDQNLTTKVfwiAVIVKLAGYNVLLRYEGFENDvTMDFWCNICSNDVHPVGWC 257
Cdd:cd20098    18 GMRLEVVDKMCISRTRV---AVVEEVVGGRLRLQYVDSEDD-DDDFWCHMKSPLIHPVGWS 74

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 49.20 E-value: 1.73e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIrkVLAEG-YLMIGIDGSEAADGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKL 484
Cdd:cd20093     4 FKPGMKLEVPNKNNPDTYWVATV--VMTCGpLLRLRYVGYEDDRSADFWC-DLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                          90
                  ....*....|.
gi 2017835283 485 PFKWFDYLRET 495
Cdd:cd20093    81 ELDWAEFLIKE 91

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 48.79 E-value: 2.03e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 217 AVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20108    26 ATIGEVRGSEVLVTFDGWRG--AFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 49.04 E-value: 2.78e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYE--ESEDKtDDFWCHMYSPLIHPIGWSRSIGH 371
Cdd:cd20113     4 IGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEglEGSDK-SDTWLFYLDPFLHQVGWAAQHGY 69

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 47.67 E-value: 3.34e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 217 AVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20100    23 ATVTRVVGRLLRVHFDGWDDE--FDQWVDCDSPDIYPVGWCELVGYPLQPP 71

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 47.91 E-value: 4.02e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20124    14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 48.69 E-value: 4.21e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHR-LLRIHFDGWEDEYD--QWVdC---ESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVLRFgYLMIRIDSYEPDASgsDWF-CyheSSPCIFPAGFCEVNNITLTPP 74

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 47.94 E-value: 4.51e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEeSEDKTDDFWCHMYSPLIHPIGWSRSIGH 371
Cdd:cd20139     9 FQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFD-GWDHNYDFWVDADSPDIHPVGWCDKTGH 72

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 47.63 E-value: 5.06e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAeGYLMIGIDGSEaaDGSDWFCYHALSPSIFPVGFC 468
Cdd:cd20098    15 FKVGMRLEVVDKMCISRTRVAVVEEVVG-GRLRLQYVDSE--DDDDDFWCHMKSPLIHPVGWS 74

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 47.88 E-value: 6.25e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 517 GMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPPA 583
Cdd:cd20113     7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSdkSDTWLFYLDPFLHQVGWAAQHGYTLQPPA 75

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 46.68 E-value: 8.39e-07

                          10        20
                  ....*....|....*....|....*..
gi 2017835283 241 DFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20110    48 DYWCRYDSRDIFPVGWCARSGHPLQPP 74

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 46.51 E-value: 9.54e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 305 YPFKPSMRVEVVDkthLCRTR---VAVVDSVIGgRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHR 372
Cdd:cd20100     1 HGFKVGMKLEAVD---LMEPRlicVATVTRVVG-RLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYP 67

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 46.78 E-value: 9.87e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPPQ 268
Cdd:cd20139    28 VATIVDKDDHRIKLHFDGWDHN--YDFWVDADSPDIHPVGWCDKTGHALQVPL 78

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 46.84 E-value: 1.07e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAeGYLMIGIDGSEAADGSDWFCYHaLSPSIFPVGFCEINKIELTPPRGYTKL 484
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVG-GRLLLRYDGPEDSDSPDFWLFY-LSPRLHPLGWAKSNGYTYRPPKSLEKL 80

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 46.36 E-value: 1.09e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYeesedktdDFWCHMYS-------PLIHPIGWSRSIGH 371
Cdd:cd20137     5 FQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHF--------DGWSHGYDfwidadhPDIHPAGWCSKTGH 68

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 46.78 E-value: 1.34e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017835283 512 HGFRVGMKLEAVDLMEPRLVCVATVTRIIH-RLLRIHFDGWEDEY--DQWVDC--ESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20115     1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNeKFFLVEMDDLRPEEagAHSFVChrDSPGIFPVQWSLKNGLHLSPP 76

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 46.84 E-value: 1.48e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPIG 364
Cdd:cd20107    10 FKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNK-NDFWRLVDSTEIHPIG 66

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 45.59 E-value: 2.60e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20137    24 VASVEDVEDHRIKIHFDGWSHG--YDFWIDADHPDIHPAGWCSKTGHPLQPP 73

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 45.97 E-value: 2.72e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRI-IHRLLRIHFDGWE-DEYDQWV--DCESPDLYPVGWCQLTGYQLQPPAPQSK 587
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMIGIDGGPsTDGSDWFcyHASSHAIFPVGFCQKNDIELTPPKGYDA 78

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 44.65 E-value: 4.47e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEeSEDKTDDFWCHMYSPLIHPIGWSRSIGH 371
Cdd:cd20092     6 FKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFD-GWRGAFDYWCRYDSRDIFPVGWCKKTGH 69

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 44.54 E-value: 4.98e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017835283 217 AVIVKLAGYNVLLRYEGFEND-----VTMDfwcnicSNDVHPVGWCASSGKPLVPPQTI 270
Cdd:cd20096    21 ATITKVVGPLLWLHLDSEKKLspniiVDVE------STDIFPVGWCESNGYPLVTPRKY 73

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 44.83 E-value: 5.31e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 196 EGVRVEVLNTDQNLTTKvfwIAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPPQT 269
Cdd:cd20124    16 QGMRVEVVDKSQVSRTR---MAVVDTVIGGRLRLLYEDGDSD--DDFWCHMWSPLIHPVGWSRRVGHSIKMSDR 84

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 46.14 E-value: 5.42e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 276 NWKAFLvkRLTGAKTLPAD-FAQKVSESMQyPFKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCH 354
Cdd:cd20105     3 SWDKYL--KETGAVPAPVHcFKQSYTPPVN-EFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNK-NDFWRL 78

                          90
                  ....*....|
gi 2017835283 355 MYSPLIHPIG 364
Cdd:cd20105    79 VDSSEIQPIG 88

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 44.49 E-value: 5.63e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 217 AVIVKLAGYNVLLRYEGFENdvTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20109    26 ATIGDVKGDEVFITFDGWRG--AFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 44.45 E-value: 6.40e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017835283 393 FIKVKDVDQNSewFKEGMKLEAIDPLNLSAICVATIRKVLAeGYLMIGIDGSEAADGSDWfCyHALSPSIFPVGF 467
Cdd:cd20122     3 HNKVNESLRSR--FRLGLNLECVDKNRISQVRVATVTKIVG-KRLHLRYEGSEPDDDGFW-C-HEDSPLIHPVGW 72

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 45.13 E-value: 7.72e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 516 VGMKLEA----VDLME-PRLVCVATVTRIIHRLLRIHFDGW--EDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20119     6 VGMKVEVentdTDLIEdPTSFWIATVLKIAGYKALMRYEGFgtDDSKDFWVNLCSEDVHPVGWCATRGKPLIPP 79

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 44.56 E-value: 7.79e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 198 VRVEVLNTDQNLTTKVfwiAVIVKLAGYNVLLRYEGFEnDVTMDFWCNICSNDVHPVGWCASSG 261
Cdd:cd20123    18 MRVEVVDKTHLCRTRV---AVVESVIGGRLRLVYEESE-DGTDDFWCHMYSPLIHHIGWSRSIG 77

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 43.77 E-value: 1.05e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 307 FKPSMRVEVVDKTH---LCrtrVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:cd20096     1 FERGMKLEAVNPENpnqIC---VATITKVVGPLLWLHLDSEKKLSPNIIVDVESTDIFPVGWCESNGYPLV 68

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 42.99 E-value: 3.25e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKtDDFWCHMYSPLIHPIG 364
Cdd:cd20106    10 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPIG 66

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 42.51 E-value: 4.85e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDVTmDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20118    21 VASITSVKGRLLWLHLEGLQNPVP-EYIVDVESMDIFPVGWCEANGYPLTPP 71

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 42.29 E-value: 6.44e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 407 KEGMKLEAI----DPLNLSAIC--VATIRKVlaEGYLM-IGIDGSEAADGSDwFCYHALSPSIFPVGFCEINKIELTPPR 479
Cdd:cd20097     5 KIGVKVEVAnrddDKPTDNVKVywFARIIKV--AGYRVlLRYEGYDEDSSHD-FWINLCSNEIHPIGYAAENGKILVPPK 81

                          90
                  ....*....|....
gi 2017835283 480 GYTKLPFKWFDYLR 493
Cdd:cd20097    82 SIEDKENDWKEYIM 95

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 41.86 E-value: 7.31e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 196 EGVRVEVLNtdqNLTTKVFWIAVIVK-LAGYNVLLRYEGFENDVTMD--FWCNICSNDVHPVGWCASSGKPLVPPQTIQH 272
Cdd:cd20095     3 VGMKLEALH---PKNPSTICPATVTKvFNEYYFLVEIDDLRPEESEKitFVCHANSPGIFPVGWCAKNGLRLTPPPGYPK 79


                  ....*....
gi 2017835283 273 KYSNWKAFL 281
Cdd:cd20095    80 SEFDWDSYL 88

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 41.12 E-value: 8.85e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 197 GVRVEVLNTdqnLTTKVFWIAVIVKLAGYNVLLRYEGFENDvtMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20129     6 GMKLEAVDL---MEPRLVCVATVTRIIHRLLRIHFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 71

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 41.09 E-value: 1.34e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 307 FKPSMRVEVVD---KTHLCrtrVAVVDSVIGGRLRLV----YEESEDKTDDFWCHMYSPLIHPIGWSRSIG 370
Cdd:cd20095     1 FKVGMKLEALHpknPSTIC---PATVTKVFNEYYFLVeiddLRPEESEKITFVCHANSPGIFPVGWCAKNG 68

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 41.14 E-value: 1.89e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 536 VTRIIHR-----LLRihFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20097    29 FARIIKVagyrvLLR--YEGYDEDssHDFWINLCSNEIHPIGYAAENGKILVPP 80

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 40.86 E-value: 1.99e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 213 VFWIAVIVKLAGYNVLLRYEGFENDvTMDFWCNICSNDVHPVGWCASSGKPLVPPQTIQ--HKYSNWKAFLVKRLTGA 288
Cdd:cd20114    20 QYWIVRVIENVGGRLRLRYVGLEDE-SHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICdlKSASEWKEALEKSLAEA 96

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 39.97 E-value: 4.20e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017835283 406 FKEGMKLEAIDPLNLSAICVATIRKVLAEgYLMIGIDGSEAADGSDWFCyHALSPSIFPVGFCEINKIELTPPRGYTKLP 485
Cdd:cd20112     4 FQPGMKLEVANKSNPDTYWVATIITTCGQ-LLLLRYCGYGDDRRADFWC-DVMTADLHPVGWCTQNNKVLMPPDAIKEKY 81


                  ....*..
gi 2017835283 486 FKWFDYL 492
Cdd:cd20112    82 TDWTEFL 88

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 38.05 E-value: 1.22e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEeSEDKTDDFWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:cd20130     6 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFD-GWDSEYDQWVDCESPDIYPVGWCELTGYQLQ 72

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 38.68 E-value: 1.27e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017835283 516 VGMKLEAVDL---MEPRLVCVATVTRI--IHRLLRihFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20120     6 EGVRVEVPNTdcnLPTKVFWIAGIVKLagYKALLR--YEGFENDssLDFWCNICGSDIHPVGWCATSGKPLVPP 77

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 38.29 E-value: 1.47e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 516 VGMKLEAVD---LMEPRLVCVATVTRIIHRLLRIHFDGWEDE--YDQWVDCESPDLYPVGWCQLTGYQLQPP 582
Cdd:cd20121     6 EGMKVEVLNtdaVLPSRVYWIASVIQLAGYKALLRYEGFENDssHDFWCNLGTVDVHPIGWCAINSKILVPP 77

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 37.65 E-value: 1.62e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 307 FKPSMRVEVVDKTHLCRTRVAVVDSVIGGRLRLVYEESEDKTDDfWCHMYSPLIHPIGWSRSIGHRFK 374
Cdd:cd20129     3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQ-WVDCESPDLYPVGWCQLTGYQLQ 69

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 37.28 E-value: 1.95e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017835283 197 GVRVEVLNTdqnLTTKVFWIAVIVKLAGYNVLLRYEGFenDVTMDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20130     9 GMKLEAVDL---MEPRLICVATVKRVVHRLLSIHFDGW--DSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 36.86 E-value: 3.33e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2017835283 514 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQ-WVDCESPDLYPVGWCQLTGYQLQ 580
Cdd:cd20123    14 FKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESEDGTDDfWCHMYSPLIHHIGWSRSIGHRFK 81

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 36.01 E-value: 7.49e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2017835283 216 IAVIVKLAGYNVLLRYEGFENDVTmDFWCNICSNDVHPVGWCASSGKPLVPP 267
Cdd:cd20117    22 VATVTKVKGSYLWLQLEGSKKPIP-ECIVHVESMDIFPVGWCETNGYPLLHP 72