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Conserved domains on  [gi|2015372643|gb|QTE03738|]
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MAG: nonstructural protein NS2, partial [Cygnus atratus Chaphamaparvovirus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Parvo_NS1 super family cl24009
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 160-261 3.91e-09

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


The actual alignment was detected with superfamily member pfam01057:

Pssm-ID: 474125  Cd Length: 271  Bit Score: 55.78  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015372643 160 VVDKKIPKLNCLTMHAPPSSGKNFFFDMIMAICLNYGQLgqANRNNVFAFQEAPNKRILLWNEPNYEAALTDTIKMMMGG 239
Cdd:pfam01057 105 WLSKQFGKRNTVWFYGPASTGKTNLAQAIAHAVPLYGCV--NWTNENFPFNDCPDKLLIWWEEGLMTVKVVELAKAILGG 182

                          90       100
                  ....*....|....*....|..
gi 2015372643 240 DPYNVRVKNQADLHVRRTPIIV 261
Cdd:pfam01057 183 TDVRVDQKCKGSVEIEPTPVII 204
 
Name Accession Description Interval E-value
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 160-261 3.91e-09

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 55.78  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015372643 160 VVDKKIPKLNCLTMHAPPSSGKNFFFDMIMAICLNYGQLgqANRNNVFAFQEAPNKRILLWNEPNYEAALTDTIKMMMGG 239
Cdd:pfam01057 105 WLSKQFGKRNTVWFYGPASTGKTNLAQAIAHAVPLYGCV--NWTNENFPFNDCPDKLLIWWEEGLMTVKVVELAKAILGG 182

                          90       100
                  ....*....|....*....|..
gi 2015372643 240 DPYNVRVKNQADLHVRRTPIIV 261
Cdd:pfam01057 183 TDVRVDQKCKGSVEIEPTPVII 204
COG3378 COG3378
DNA primase, phage- or plasmid-associated [Mobilome: prophages, transposons];
173-249 7.13e-03

DNA primase, phage- or plasmid-associated [Mobilome: prophages, transposons];


Pssm-ID: 442605 [Multi-domain]  Cd Length: 403  Bit Score: 37.23  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015372643 173 MHAPPSSGKNFFFDMIMAIclnygqLGQAN---------RNNVFAFQEAPNKRILLWNEPNYEAAL-TDTIKMMMGGDPY 242
Cdd:COG3378   148 LYGPGGNGKSTFLNLLTAL------LGKDNassasletlTENRFDLARLKGKRLNIASELEEGYRLdESLLKALTGGDPI 221


                  ....*..
gi 2015372643 243 NVRVKNQ 249
Cdd:COG3378   222 TARRKYK 228
 
Name Accession Description Interval E-value
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 160-261 3.91e-09

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 55.78  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015372643 160 VVDKKIPKLNCLTMHAPPSSGKNFFFDMIMAICLNYGQLgqANRNNVFAFQEAPNKRILLWNEPNYEAALTDTIKMMMGG 239
Cdd:pfam01057 105 WLSKQFGKRNTVWFYGPASTGKTNLAQAIAHAVPLYGCV--NWTNENFPFNDCPDKLLIWWEEGLMTVKVVELAKAILGG 182

                          90       100
                  ....*....|....*....|..
gi 2015372643 240 DPYNVRVKNQADLHVRRTPIIV 261
Cdd:pfam01057 183 TDVRVDQKCKGSVEIEPTPVII 204
COG3378 COG3378
DNA primase, phage- or plasmid-associated [Mobilome: prophages, transposons];
173-249 7.13e-03

DNA primase, phage- or plasmid-associated [Mobilome: prophages, transposons];


Pssm-ID: 442605 [Multi-domain]  Cd Length: 403  Bit Score: 37.23  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2015372643 173 MHAPPSSGKNFFFDMIMAIclnygqLGQAN---------RNNVFAFQEAPNKRILLWNEPNYEAAL-TDTIKMMMGGDPY 242
Cdd:COG3378   148 LYGPGGNGKSTFLNLLTAL------LGKDNassasletlTENRFDLARLKGKRLNIASELEEGYRLdESLLKALTGGDPI 221


                  ....*..
gi 2015372643 243 NVRVKNQ 249
Cdd:COG3378   222 TARRKYK 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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