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Conserved domains on  [gi|20150315]
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Chain A, AQUAPORIN 1

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-229 1.38e-97

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 285.37  E-value: 1.38e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315     4 EFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNqttgAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL----AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    84 GLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRR 163
Cdd:pfam00230  77 ALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRR 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20150315   164 RDLGGS-GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIY 229
Cdd:pfam00230 157 NGSLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-229 1.38e-97

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 285.37  E-value: 1.38e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315     4 EFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNqttgAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL----AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    84 GLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRR 163
Cdd:pfam00230  77 ALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRR 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20150315   164 RDLGGS-GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIY 229
Cdd:pfam00230 157 NGSLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-229 4.86e-80

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 240.28  E-value: 4.86e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    16 AEFLAMILFIFISIGSALGFhYPIKSNQTTGAvQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLR 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGV-NVAGAYGAVGG-GQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    96 AIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALA-PGVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSGPLA 173
Cdd:TIGR00861  79 VPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20150315   174 IGFSVALGHLLAIDYTGCGINPARSFGSSVITH--NFQDHWIFWVGPFIGAALAVLIY 229
Cdd:TIGR00861 159 IGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-232 2.17e-79

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 239.08  E-value: 2.17e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  12 RAVVAEFLAMILFIFISIGSALGFhypiksNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 91
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAV------KLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  92 SVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNA---------LAPGVNSGQGLGIEIIGTLQLVLCVLATTDRR 162
Cdd:cd00333  75 PLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20150315 163 RR-DLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHN---FQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:cd00333 155 NGpPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-234 3.72e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 172.23  E-value: 3.72e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  10 FWRAVVAEFLAMILFIFISIGSALGFHypiKSNQTTGAVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSC 89
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLA---GTKGGIGWLG----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  90 QISVLRAIMYIIAQCVGAIVATAILSGITSSLP---DNSLGLNAL-----APGVNSGQGLGIEIIGTLQLVLCVLATTDr 161
Cdd:COG0580  75 RFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFdatEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITD- 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20150315 162 RRRDLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVI------THNFQDHWIFWVGPFIGAALAVLIYDFILA 234
Cdd:COG0580 154 KRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-232 3.56e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 3.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATlaqSVG-HISGAHLNPAVTLGLLLSCQ 90
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAV---SVGaNISGGHVNPAVTFGAFIGGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   91 ISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLnalAPGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGS 169
Cdd:PLN00027  98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSL---SSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20150315  170 GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:PLN00027 175 APIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-229 1.38e-97

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 285.37  E-value: 1.38e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315     4 EFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNqttgAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTL 83
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSL----AVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    84 GLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRR 163
Cdd:pfam00230  77 ALLVGRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRR 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20150315   164 RDLGGS-GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIY 229
Cdd:pfam00230 157 NGSLGTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-229 4.86e-80

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 240.28  E-value: 4.86e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    16 AEFLAMILFIFISIGSALGFhYPIKSNQTTGAvQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLR 95
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGV-NVAGAYGAVGG-GQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    96 AIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALA-PGVNSGQGLGIEIIGTLQLVLCVLATTD-RRRRDLGGSGPLA 173
Cdd:TIGR00861  79 VPVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20150315   174 IGFSVALGHLLAIDYTGCGINPARSFGSSVITH--NFQDHWIFWVGPFIGAALAVLIY 229
Cdd:TIGR00861 159 IGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-232 2.17e-79

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 239.08  E-value: 2.17e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  12 RAVVAEFLAMILFIFISIGSALGFhypiksNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 91
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAV------KLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  92 SVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNA---------LAPGVNSGQGLGIEIIGTLQLVLCVLATTDRR 162
Cdd:cd00333  75 PLIRVIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDP 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20150315 163 RR-DLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHN---FQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:cd00333 155 NGpPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-234 3.72e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 172.23  E-value: 3.72e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  10 FWRAVVAEFLAMILFIFISIGSALGFHypiKSNQTTGAVQdnvkVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSC 89
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLA---GTKGGIGWLG----IALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  90 QISVLRAIMYIIAQCVGAIVATAILSGITSSLP---DNSLGLNAL-----APGVNSGQGLGIEIIGTLQLVLCVLATTDr 161
Cdd:COG0580  75 RFPWKDVLPYIIAQLLGAFLGAALVYLIYGGHFdatEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITD- 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20150315 162 RRRDLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVI------THNFQDHWIFWVGPFIGAALAVLIYDFILA 234
Cdd:COG0580 154 KRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 12-232 3.56e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 3.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATlaqSVG-HISGAHLNPAVTLGLLLSCQ 90
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKLTDNGSTTPAGLVAAALAHAFALFVAV---SVGaNISGGHVNPAVTFGAFIGGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   91 ISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLnalAPGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLGGS 169
Cdd:PLN00027  98 ITLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSL---SSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20150315  170 GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:PLN00027 175 APIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-229 3.70e-43

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 147.39  E-value: 3.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSALGFhypikSNQTTGAVQDN---VKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLS 88
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAF-----AKLTSDAALDPaglVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   89 CQISVLRAIMYIIAQCVGAIVATAILSGITSSlpdNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATT-DRRRRDLG 167
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNG---ESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAaDPKKGSLG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20150315  168 GSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIY 229
Cdd:PLN00166 171 TIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 54-237 3.22e-37

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 131.24  E-value: 3.22e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   54 VSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALA- 132
Cdd:PRK05420  39 VALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFAs 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  133 -------PGVNS-GQGLGIEIIGTLQLVLCVLATTDRRRRdlGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVI 204
Cdd:PRK05420 119 ngygehsPGGYSlLAALVCEVVLTAFFLLVILGATDKRAP--AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALF 196

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 20150315  205 THNF--QDHWIFWVGPFIGAALAVLIYDFILAPRS 237
Cdd:PRK05420 197 VGGWalEQLWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-242 7.42e-31

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 115.39  E-value: 7.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATLAQSvgHISGAHLNPAVTLGLLLSCQI 91
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAA--NISGGHVNPAVTFGMAVGGHI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   92 SVLRAIMYIIAQCVGAIVATAIL--SGITSSLPDNSLGLNALAPGVNSGQGlgieiIGTLQLVLCVLATTDRRRRDLGGS 169
Cdd:PLN00167 101 SVPTAMFYWISQMLASVMACLFLkvTTVGQHVPTYKIAEEMTGFGASVLEG-----VLTFGLVYTVYAAGDPRRGLLGAI 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20150315  170 GPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTD 242
Cdd:PLN00167 176 GPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFPTQDDRGS 248
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 8-235 1.78e-25

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 102.13  E-value: 1.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315    8 KLFWRAVVAEFLAMILFIFISIGSALGFHypiksnqTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLL 87
Cdd:PTZ00016  47 RPNVREYVAEFLGTFVLLFFGEGVVATTH-------TVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   88 SCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNS--------------LGLNALAPGVNSGQGLGIEIIGTLQLVL 153
Cdd:PTZ00016 120 FGKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKDHgipelpwetmangfAGVFATYPREGNFYAIFSELILTAILLL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  154 CVLATTDRRRRDLGGSGPLAIGFSV-ALGHLLAIDyTGCGINPARSF----------GSSVITHNFQDHWIFWVGPFIGA 222
Cdd:PTZ00016 200 VILAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLgprlfsailwGSEVFTKDNYYFWVPLVAPFVGA 278

                        250
                 ....*....|...
gi 20150315  223 ALAVLIYDFILAP 235
Cdd:PTZ00016 279 VLGMFLYDKFIPP 291
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 54-232 3.38e-24

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 98.44  E-value: 3.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   54 VSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLnalAP 133
Cdd:PLN00182  78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLMFNVTPEAFFGT---TP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  134 GVNSGQGLGIEIIGT--LQLVLCVLATTDRRRRDLGGsgpLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDH 211
Cdd:PLN00182 155 TDSSGQALVAEIIISflLMFVISGVATDSRAVGELAG---IAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI 231

                        170       180
                 ....*....|....*....|.
gi 20150315  212 WIFWVGPFIGAALAVLIYDFI 232
Cdd:PLN00182 232 WVYIVGPFVGIIAGGFVYNLI 252
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 12-232 5.15e-24

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 97.62  E-value: 5.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSalgfhypIKSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 91
Cdd:PLN00183  46 RMVLAEMVGTFILMFCVCGI-------IASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHF 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   92 SVLRAIMYIIAQCVGAIVATAILSGITSSLPDnslgLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDrRRRDLGGSGP 171
Cdd:PLN00183 119 PWSKVPLYITAQTVGSVLATYVGVSVYGVKAD----LMTTKPAQGCSSAFWVEFIATFIVMFLAASLTS-QPQSLGHLSG 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20150315  172 LAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:PLN00183 194 FVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00026 PLN00026
aquaporin NIP; Provisional
 12-229 1.46e-22

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 94.16  E-value: 1.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   12 RAVVAEFLAMILFIFISIGSALgfhypikSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQI 91
Cdd:PLN00026  72 RKLGAEFVGTFILIFAATAGPI-------VNQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHF 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   92 SVLRAIMYIIAQCVGAIVATAILSGITSslPDNSLGLNAlaPGVNSGQGLGIEIIGTLQLVLCV--LATTDRRRRDLGGs 169
Cdd:PLN00026 145 PWKHVPAYIAAQVSASICASFALKGVFH--PFMSGGVTV--PSVSTGQAFALEFIITFNLLFVVtaVATDTRAVGELAG- 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315  170 gpLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIY 229
Cdd:PLN00026 220 --IAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTY 277
PLN00184 PLN00184
aquaporin NIP1; Provisional
 10-232 8.06e-21

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 89.31  E-value: 8.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   10 FWRAVVAEFLAMILFIFISIGSalgfhypIKSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSC 89
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCAS-------VVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20150315   90 QISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNAL----APGVNSGQGLGIEIIGTLQLVLCV--LATTDRRR 163
Cdd:PLN00184 126 RFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVfigsSPVGSDLQAFVMEFIVTFYLMFIIsgVATDNRAI 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20150315  164 RDLGGsgpLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFI 232
Cdd:PLN00184 206 GELAG---LAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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