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Conserved domains on  [gi|20143946|ref|NP_612191|]
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potassium channel subfamily K member 10 isoform 3 [Homo sapiens]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 153-211 7.46e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.77  E-value: 7.46e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 20143946   153 NSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQL 211
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 249-328 1.77e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143946   249 CIVFVTIPAVIFKYIEG---WTALESIYFVVVTLTTVGFGDFVAGGNAGinyrewyKPLVWFWILVGLAYFAAVLSMIGD 325
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVLGR 74


                  ...
gi 20143946   326 WLR 328
Cdd:pfam07885  75 FLT 77
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 153-211 7.46e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.77  E-value: 7.46e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 20143946   153 NSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQL 211
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 249-328 1.77e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143946   249 CIVFVTIPAVIFKYIEG---WTALESIYFVVVTLTTVGFGDFVAGGNAGinyrewyKPLVWFWILVGLAYFAAVLSMIGD 325
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVLGR 74


                  ...
gi 20143946   326 WLR 328
Cdd:pfam07885  75 FLT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
158-200 1.00e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.55  E-value: 1.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 20143946  158 DLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLF 200
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVF 210
2a38 TIGR00933
potassium uptake protein, TrkH family; The proteins of the Trk family are derived from ...
 202-289 7.52e-03

potassium uptake protein, TrkH family; The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273349  Cd Length: 391  Bit Score: 38.79  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143946   202 FLLAGIGdqlGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILagcIVFVTIPAVIF---KYIEGWTAL-ESIYFVVV 277
Cdd:TIGR00933 169 IILGGLG---FTVHYDVYLHLRKRVFKSLSLDTKVRLFVTFLLLA---IGFILFLLLERgntLYSYSFGALlLSAFFQSS 242

                          90
                  ....*....|....
gi 20143946   278 TLTTVGFG--DFVA 289
Cdd:TIGR00933 243 TLRTAGFStiDFAA 256
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 153-211 7.46e-19

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 80.77  E-value: 7.46e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 20143946   153 NSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQL 211
Cdd:pfam07885  18 EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 249-328 1.77e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143946   249 CIVFVTIPAVIFKYIEG---WTALESIYFVVVTLTTVGFGDFVAGGNAGinyrewyKPLVWFWILVGLAYFAAVLSMIGD 325
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPLTDAG-------RLFTIFYILIGIPLFAIFLAVLGR 74


                  ...
gi 20143946   326 WLR 328
Cdd:pfam07885  75 FLT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
158-200 1.00e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.55  E-value: 1.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 20143946  158 DLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLF 200
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVF 210
2a38 TIGR00933
potassium uptake protein, TrkH family; The proteins of the Trk family are derived from ...
 202-289 7.52e-03

potassium uptake protein, TrkH family; The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273349  Cd Length: 391  Bit Score: 38.79  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143946   202 FLLAGIGdqlGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILagcIVFVTIPAVIF---KYIEGWTAL-ESIYFVVV 277
Cdd:TIGR00933 169 IILGGLG---FTVHYDVYLHLRKRVFKSLSLDTKVRLFVTFLLLA---IGFILFLLLERgntLYSYSFGALlLSAFFQSS 242

                          90
                  ....*....|....
gi 20143946   278 TLTTVGFG--DFVA 289
Cdd:TIGR00933 243 TLRTAGFStiDFAA 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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