|
Name |
Accession |
Description |
Interval |
E-value |
| TIR super family |
cl23801 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
694-844 |
3.34e-28 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
The actual alignment was detected with superfamily member pfam01582:
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 111.30 E-value: 3.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 694 YDAYFCFS-SKDFEWAQNALLKHLDahyssRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 772
Cdd:pfam01582 1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 773 FRYAQSRSLsDLKSILIVVVVGSLSQYQL-------MRHETIRGFLQKQQYLRWPEDL------------QDVGWFLDKL 833
Cdd:pfam01582 76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154
|
170
....*....|.
gi 20140822 834 SGCILKEEKGK 844
Cdd:pfam01582 155 AYDISNKLNGT 165
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
308-582 |
5.09e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 81.13 E-value: 5.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 308 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTL 387
Cdd:COG4886 19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 388 QTLDLRDNalKAIGFIPSIQMVLLGGNKLVHLPHI--HFTA-NFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 464
Cdd:COG4886 99 TELDLSGN--EELSNLTNLESLDLSGNQLTDLPEElaNLTNlKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 465 KAAhtPSENPSLEQLFLTENMLQ-LAwetglcwDVFQGLSRLQILYLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLS 543
Cdd:COG4886 175 PEE--LGNLTNLKELDLSNNQITdLP-------EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 20140822 544 P-GSLPaNLEILDISRNQLLC-PDPALFSSLRVLDITHNEF 582
Cdd:COG4886 245 ElGNLT-NLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQL 284
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
85-132 |
1.75e-07 |
|
Leucine rich repeat;
:
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.75e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 20140822 85 LTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGL 132
Cdd:pfam13855 14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
84-319 |
2.74e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.78 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 84 NLTIGPGAFRNLPNLRILDLGQSQIEVLNrDAFQGLPHLLELRLFSCGLSSAvlsdGYFRNLYSLARLDLSGNQIHSLrl 163
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDL-- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 164 hSSFRELNSLSDVNFAFNQIFTICedelepLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDI 243
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 244 TRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLN 319
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PCC super family |
cl28216 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
555-633 |
6.71e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
The actual alignment was detected with superfamily member TIGR00864:
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.00 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 555 DISRNQLLCPDPALFS---SLRVLDITHNEFVCNCELSTFISWLNQTNVTLFgSPADVYCMYPNSLLGGSLYNIS--TED 629
Cdd:TIGR00864 1 DISNNKISTIEEGICAnlcNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR-QPEAALCAGPGALAGQPLLGIPllDSG 79
|
....
gi 20140822 630 CDEE 633
Cdd:TIGR00864 80 CDEE 83
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
694-844 |
3.34e-28 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 111.30 E-value: 3.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 694 YDAYFCFS-SKDFEWAQNALLKHLDahyssRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 772
Cdd:pfam01582 1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 773 FRYAQSRSLsDLKSILIVVVVGSLSQYQL-------MRHETIRGFLQKQQYLRWPEDL------------QDVGWFLDKL 833
Cdd:pfam01582 76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154
|
170
....*....|.
gi 20140822 834 SGCILKEEKGK 844
Cdd:pfam01582 155 AYDISNKLNGT 165
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
693-828 |
2.75e-26 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 105.10 E-value: 2.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 693 RYDAYFCFSSKDfeWAQNALLKHLdahYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 772
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHL---LEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 773 FRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKqQYLRWPEDLQDVGW 828
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
308-582 |
5.09e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 81.13 E-value: 5.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 308 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTL 387
Cdd:COG4886 19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 388 QTLDLRDNalKAIGFIPSIQMVLLGGNKLVHLPHI--HFTA-NFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 464
Cdd:COG4886 99 TELDLSGN--EELSNLTNLESLDLSGNQLTDLPEElaNLTNlKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 465 KAAhtPSENPSLEQLFLTENMLQ-LAwetglcwDVFQGLSRLQILYLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLS 543
Cdd:COG4886 175 PEE--LGNLTNLKELDLSNNQITdLP-------EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 20140822 544 P-GSLPaNLEILDISRNQLLC-PDPALFSSLRVLDITHNEF 582
Cdd:COG4886 245 ElGNLT-NLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQL 284
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
383-583 |
6.60e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 6.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 383 LLKTLQTLDLRDNALKAI-GFIP-SIQMVLLGGNKLVHLP-HIHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQ 458
Cdd:PRK15370 218 LQGNIKTLYANSNQLTSIpATLPdTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPE-----NLPEeLRYLSVYD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 459 NRLSSCkAAHTPSenpSLEQLFLTENMLQLAWETglcwdvfqgLS-RLQILYLSNNYLNFLPPGIfndLVALRMLSLSAN 537
Cdd:PRK15370 293 NSIRTL-PAHLPS---GITHLNVQSNSLTALPET---------LPpGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 20140822 538 KLTVLsPGSLPANLEILDISRNQLLCPDPALFSSLRVLDITHNEFV 583
Cdd:PRK15370 357 QITVL-PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLV 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
294-349 |
8.48e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 8.48e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 294 LDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLL 349
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
85-132 |
1.75e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.75e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 20140822 85 LTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGL 132
Cdd:pfam13855 14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
84-319 |
2.74e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.78 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 84 NLTIGPGAFRNLPNLRILDLGQSQIEVLNrDAFQGLPHLLELRLFSCGLSSAvlsdGYFRNLYSLARLDLSGNQIHSLrl 163
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDL-- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 164 hSSFRELNSLSDVNFAFNQIFTICedelepLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDI 243
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 244 TRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLN 319
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
339-581 |
8.46e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 339 LQVLNLSYNLLGELynsnfyGLPRVAYVdlqrnhigiIQDQtfrllKTLQTLDLRDNALKAIG-FIPSIQMVLLGGNKLV 417
Cdd:cd00116 25 LQVLRLEGNTLGEE------AAKALASA---------LRPQ-----PSLKELCLSLNETGRIPrGLQSLLQGLTKGCGLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 418 HLPhiHFTANFLELSENRLENlsdlyfLLRVPQLQFLILNQNRLSSCKAAHT----PSENPSLEQLFLTENMLqlawETG 493
Cdd:cd00116 85 ELD--LSDNALGPDGCGVLES------LLRSSSLQELKLNNNGLGDRGLRLLakglKDLPPALEKLVLGRNRL----EGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 494 LCWD---VFQGLSRLQILYLSNNylNFLPPGI------FNDLVALRMLSLSANKLTVLSPGSL------PANLEILDISR 558
Cdd:cd00116 153 SCEAlakALRANRDLKELNLANN--GIGDAGIralaegLKANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGD 230
|
250 260 270
....*....|....*....|....*....|.
gi 20140822 559 NQL-------LCPD-PALFSSLRVLDITHNE 581
Cdd:cd00116 231 NNLtdagaaaLASAlLSPNISLLTLSLSCND 261
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
555-633 |
6.71e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.00 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 555 DISRNQLLCPDPALFS---SLRVLDITHNEFVCNCELSTFISWLNQTNVTLFgSPADVYCMYPNSLLGGSLYNIS--TED 629
Cdd:TIGR00864 1 DISNNKISTIEEGICAnlcNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR-QPEAALCAGPGALAGQPLLGIPllDSG 79
|
....
gi 20140822 630 CDEE 633
Cdd:TIGR00864 80 CDEE 83
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
92-181 |
1.58e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 92 FRNLPNLRILDLGQSQIEVLNrdAFQGLPHLLELRL------------FSCGLSSAVL--------------SDGYFRNL 145
Cdd:cd21340 64 LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIenqrlppgekltFDPRSLAALSnslrvlnisgnnidSLEPLAPL 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 20140822 146 YSLARLDLSGNQIHSLR-LHSSFRELNSLSDVNFAFN 181
Cdd:cd21340 142 RNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGN 178
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
694-844 |
3.34e-28 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 111.30 E-value: 3.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 694 YDAYFCFS-SKDFEWAQNALLKHLDahyssRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 772
Cdd:pfam01582 1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 773 FRYAQSRSLsDLKSILIVVVVGSLSQYQL-------MRHETIRGFLQKQQYLRWPEDL------------QDVGWFLDKL 833
Cdd:pfam01582 76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154
|
170
....*....|.
gi 20140822 834 SGCILKEEKGK 844
Cdd:pfam01582 155 AYDISNKLNGT 165
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
693-828 |
2.75e-26 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 105.10 E-value: 2.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 693 RYDAYFCFSSKDfeWAQNALLKHLdahYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 772
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHL---LEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 773 FRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKqQYLRWPEDLQDVGW 828
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
308-582 |
5.09e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 81.13 E-value: 5.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 308 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTL 387
Cdd:COG4886 19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 388 QTLDLRDNalKAIGFIPSIQMVLLGGNKLVHLPHI--HFTA-NFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 464
Cdd:COG4886 99 TELDLSGN--EELSNLTNLESLDLSGNQLTDLPEElaNLTNlKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 465 KAAhtPSENPSLEQLFLTENMLQ-LAwetglcwDVFQGLSRLQILYLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLS 543
Cdd:COG4886 175 PEE--LGNLTNLKELDLSNNQITdLP-------EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 20140822 544 P-GSLPaNLEILDISRNQLLC-PDPALFSSLRVLDITHNEF 582
Cdd:COG4886 245 ElGNLT-NLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
305-660 |
4.77e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.44 E-value: 4.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 305 NPRLFGTLKDLKMLNLAFNKINKIGEnAFYGLDSLQVLNLSYNLLGELyNSNFYGLPRVAYVDLQRNHIGIIqDQTFRLL 384
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 385 KTLQTLDLRDNALKAIGfipsiqmvllggNKLVHLPHIhftaNFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 464
Cdd:COG4886 182 TNLKELDLSNNQITDLP------------EPLGNLTNL----EELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 465 kaahtpsenPSLEQLfltenmlqlawetglcwdvfqglSRLQILYLSNNYLNFLPPGIfnDLVALRMLSLSANKLTVLSP 544
Cdd:COG4886 244 ---------PELGNL-----------------------TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 545 GSLPANLEILDISRNQLLCPDPALFSSLRVLDITHNEFVCNCELSTFISWLNQTNVTLFGSPADVYCMYPNSLLGGSLYN 624
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
|
330 340 350
....*....|....*....|....*....|....*.
gi 20140822 625 ISTEDCDEEEAMRSLKFSLFILCTVTLTLFLVITLV 660
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
246-561 |
1.92e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.51 E-value: 1.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 246 NFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKI 325
Cdd:COG4886 5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 326 NKIGENAFYGLDSLQVLNLSYNllgelynSNFYGLPRVAYVDLQRNHIGIIqDQTFRLLKTLQTLDLRDNALKAIGfips 405
Cdd:COG4886 85 LLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 406 iqmvllggNKLVHLPHIHFtanfLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSckAAHTPSENPSLEQLFLTENM 485
Cdd:COG4886 153 --------EPLGNLTNLKS----LDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20140822 486 LQ-LAWEtglcwdvFQGLSRLQILYLSNNYLNFLPpgIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQL 561
Cdd:COG4886 217 LTdLPEP-------LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
383-583 |
6.60e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 66.26 E-value: 6.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 383 LLKTLQTLDLRDNALKAI-GFIP-SIQMVLLGGNKLVHLP-HIHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQ 458
Cdd:PRK15370 218 LQGNIKTLYANSNQLTSIpATLPdTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPE-----NLPEeLRYLSVYD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 459 NRLSSCkAAHTPSenpSLEQLFLTENMLQLAWETglcwdvfqgLS-RLQILYLSNNYLNFLPPGIfndLVALRMLSLSAN 537
Cdd:PRK15370 293 NSIRTL-PAHLPS---GITHLNVQSNSLTALPET---------LPpGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 20140822 538 KLTVLsPGSLPANLEILDISRNQLLCPDPALFSSLRVLDITHNEFV 583
Cdd:PRK15370 357 QITVL-PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLV 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
294-349 |
8.48e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 8.48e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 294 LDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLL 349
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
503-561 |
1.78e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.15 E-value: 1.78e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20140822 503 SRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSPGSL--PANLEILDISRNQL 561
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
315-373 |
8.28e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 8.28e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 20140822 315 LKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHI 373
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
474-539 |
2.10e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.10e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 474 PSLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKL 539
Cdd:pfam13855 1 PNLRSLDLSNNRL-----TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
389-580 |
2.40e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.25 E-value: 2.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 389 TLDLRDNALKAI--GFIPSIQMVLLGGNKLVHLPH-IHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQNRLSsC 464
Cdd:PRK15370 203 TLILDNNELKSLpeNLQGNIKTLYANSNQLTSIPAtLPDTIQEMELSINRITELPE-----RLPSaLQSLDLFHNKIS-C 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 465 KAAHTPSEnpsLEQLFLTENMLqlaweTGLCWDVFQGLSRLqilYLSNNYLNFLPPGIfndLVALRMLSLSANKLTVLsP 544
Cdd:PRK15370 277 LPENLPEE---LRYLSVYDNSI-----RTLPAHLPSGITHL---NVQSNSLTALPETL---PPGLKTLEAGENALTSL-P 341
|
170 180 190
....*....|....*....|....*....|....*.
gi 20140822 545 GSLPANLEILDISRNQLLCPDPALFSSLRVLDITHN 580
Cdd:PRK15370 342 ASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRN 377
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
697-793 |
3.24e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 55.40 E-value: 3.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 697 YFCFSSKDFEWAQnALLKHLDAHyssrnRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYA 776
Cdd:pfam13676 2 FISYAGEDRAWAE-WLADALEAA-----GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75
|
90
....*....|....*..
gi 20140822 777 QSRSLSDLKsiLIVVVV 793
Cdd:pfam13676 76 LADPEGRKR--LIPVRL 90
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
291-582 |
9.38e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.09 E-value: 9.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 291 VLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNL-SYNLLGELyNSNFYGLPRVAYVDLQ 369
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSNKFSGEI-PKNLGKHNNLTVLDLS 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 370 RNHI-GIIQD------QTFRLLktLQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPHIHFT----ANFLELSENRLE- 437
Cdd:PLN00113 365 TNNLtGEIPEglcssgNLFKLI--LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTklplVYFLDISNNNLQg 442
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 438 NLSDLYFllRVPQLQFLILNQNRLSSCKAAHTPSENpsLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYLNF 517
Cdd:PLN00113 443 RINSRKW--DMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSLSELMQLKLSENKLSG 513
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20140822 518 LPPGIFNDLVALRMLSLSANKLTvlspGSLPAN------LEILDISRNQLLCPDPALF---SSLRVLDITHNEF 582
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLS----GQIPASfsempvLSQLDLSQNQLSGEIPKNLgnvESLVQVNISHNHL 583
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
79-542 |
7.28e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 55.71 E-value: 7.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 79 GTQYANLTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQi 158
Cdd:COG4886 29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 159 hslrlhsSFRELNSLSDVNFAFNQIFTIcEDELEPLQgktlsffglkltklfsrvsvgwetcrnpfrgvRLETLDLSENg 238
Cdd:COG4886 108 -------ELSNLTNLESLDLSGNQLTDL-PEELANLT--------------------------------NLKELDLSNN- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 239 wtvditrnfsniiqgsQISSLilkhhimgpgfgfqnirdpdqstfaslarssvlqldlshgfifslnPRLFGTLKDLKML 318
Cdd:COG4886 147 ----------------QLTDL----------------------------------------------PEPLGNLTNLKSL 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 319 NLAFNKINKIGEnAFYGLDSLQVLNLSYNLLGELyNSNFYGLPRVAYVDLQRNHIGIIqDQTFRLLKTLQTLDLRDNALK 398
Cdd:COG4886 165 DLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 399 AIGFI---PSIQMVLLGGNKLVHLPHIHFTAN--FLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSEN 473
Cdd:COG4886 242 DLPELgnlTNLEELDLSNNQLTDLPPLANLTNlkTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20140822 474 PSLEQLFLTENMLQLAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVL 542
Cdd:COG4886 322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
402-581 |
1.06e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 55.86 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 402 FIP-SIQMVLLGGNKLVHLPHiHFTANFLELSENrlENLsdlyfLLRVPQ-----LQFLILNQNRLSSCkAAHTPSenpS 475
Cdd:PRK15370 196 CIPeQITTLILDNNELKSLPE-NLQGNIKTLYAN--SNQ-----LTSIPAtlpdtIQEMELSINRITEL-PERLPS---A 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 476 LEQLFLTENMLqlaweTGLCWDVFQGLsrlQILYLSNNYLNFLPPGIFNDLVALRMLSlsaNKLTVLsPGSLPANLEILD 555
Cdd:PRK15370 264 LQSLDLFHNKI-----SCLPENLPEEL---RYLSVYDNSIRTLPAHLPSGITHLNVQS---NSLTAL-PETLPPGLKTLE 331
|
170 180
....*....|....*....|....*.
gi 20140822 556 ISRNQLLCPDPALFSSLRVLDITHNE 581
Cdd:PRK15370 332 AGENALTSLPASLPPELQVLDVSKNQ 357
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
85-132 |
1.75e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.75e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 20140822 85 LTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGL 132
Cdd:pfam13855 14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
84-319 |
2.74e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.78 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 84 NLTIGPGAFRNLPNLRILDLGQSQIEVLNrDAFQGLPHLLELRLFSCGLSSAvlsdGYFRNLYSLARLDLSGNQIHSLrl 163
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDL-- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 164 hSSFRELNSLSDVNFAFNQIFTICedelepLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDI 243
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20140822 244 TRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLN 319
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
339-581 |
8.46e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 339 LQVLNLSYNLLGELynsnfyGLPRVAYVdlqrnhigiIQDQtfrllKTLQTLDLRDNALKAIG-FIPSIQMVLLGGNKLV 417
Cdd:cd00116 25 LQVLRLEGNTLGEE------AAKALASA---------LRPQ-----PSLKELCLSLNETGRIPrGLQSLLQGLTKGCGLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 418 HLPhiHFTANFLELSENRLENlsdlyfLLRVPQLQFLILNQNRLSSCKAAHT----PSENPSLEQLFLTENMLqlawETG 493
Cdd:cd00116 85 ELD--LSDNALGPDGCGVLES------LLRSSSLQELKLNNNGLGDRGLRLLakglKDLPPALEKLVLGRNRL----EGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 494 LCWD---VFQGLSRLQILYLSNNylNFLPPGI------FNDLVALRMLSLSANKLTVLSPGSL------PANLEILDISR 558
Cdd:cd00116 153 SCEAlakALRANRDLKELNLANN--GIGDAGIralaegLKANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGD 230
|
250 260 270
....*....|....*....|....*....|.
gi 20140822 559 NQL-------LCPD-PALFSSLRVLDITHNE 581
Cdd:cd00116 231 NNLtdagaaaLASAlLSPNISLLTLSLSCND 261
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
498-583 |
8.47e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 52.93 E-value: 8.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 498 VFQGLSRLQILYLSNNYLNF-LPPGIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQL---LCPDPALFSSLR 573
Cdd:PLN00113 88 AIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLsgeIPNDIGSFSSLK 167
|
90
....*....|
gi 20140822 574 VLDITHNEFV 583
Cdd:PLN00113 168 VLDLGGNVLV 177
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
491-584 |
3.60e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 50.85 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 491 ETGLCWDVFqGLSRL------QI--LYLSNNYLNFLPPGIFNDLvalRMLSLSANKLTVLsPGSLPANLEILDISRNQLL 562
Cdd:PRK15370 180 KTELRLKIL-GLTTIpacipeQIttLILDNNELKSLPENLQGNI---KTLYANSNQLTSI-PATLPDTIQEMELSINRIT 254
|
90 100
....*....|....*....|..
gi 20140822 563 CPDPALFSSLRVLDITHNEFVC 584
Cdd:PRK15370 255 ELPERLPSALQSLDLFHNKISC 276
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
338-397 |
5.59e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 5.59e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 338 SLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNAL 397
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
429-580 |
6.33e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.16 E-value: 6.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 429 LELSENRLENLSDLYFLlrvPQLQFLILNQNRLSSCKAAHTpseNPSLEQLFLTENMLQlawetglCWDVFQGLSRLQIL 508
Cdd:cd21340 7 LYLNDKNITKIDNLSLC---KNLKVLYLYDNKITKIENLEF---LTNLTHLYLQNNQIE-------KIENLENLVNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 509 YLSNNYLNF-------------------LPPG---IFND------LVALRMLSLSANKLTVLSPGSLPANLEILDISRNQ 560
Cdd:cd21340 74 YLGGNRISVveglenltnleelhienqrLPPGeklTFDPrslaalSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQ 153
|
170 180
....*....|....*....|....*
gi 20140822 561 L-----LCPDPALFSSLRVLDITHN 580
Cdd:cd21340 154 IsdleeLLDLLSSWPSLRELDLTGN 178
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
555-633 |
6.71e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.00 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 555 DISRNQLLCPDPALFS---SLRVLDITHNEFVCNCELSTFISWLNQTNVTLFgSPADVYCMYPNSLLGGSLYNIS--TED 629
Cdd:TIGR00864 1 DISNNKISTIEEGICAnlcNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR-QPEAALCAGPGALAGQPLLGIPllDSG 79
|
....
gi 20140822 630 CDEE 633
Cdd:TIGR00864 80 CDEE 83
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
408-582 |
1.38e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.31 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 408 MVLLGGNKLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQLFLTENMLQ 487
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 488 LAWETGLCWDVFQGLSRLQIL-----------------YLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLSP--GSLP 548
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELdlsgneelsnltnleslDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEplGNLT 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 20140822 549 aNLEILDISRNQL--LCPDPALFSSLRVLDITHNEF 582
Cdd:COG4886 160 -NLKSLDLSNNQLtdLPEELGNLTNLKELDLSNNQI 194
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
361-416 |
2.93e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 2.93e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20140822 361 PRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALK-----AIGFIPSIQMVLLGGNKL 416
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlspgAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
449-515 |
3.97e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 3.97e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20140822 449 PQLQFLILNQNRLSSCKAaHTPSENPSLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYL 515
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
96-183 |
1.22e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 96 PNLRILDLGQSQIEVLNRDAFQGLPHLLELrlfscglssavlsdgyfrnlyslarlDLSGNQIHSLRLHsSFRELNSLSD 175
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL--------------------------DLSNNLLTTLSPG-AFSGLPSLRY 53
|
....*...
gi 20140822 176 VNFAFNQI 183
Cdd:pfam13855 54 LDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
92-181 |
1.58e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 92 FRNLPNLRILDLGQSQIEVLNrdAFQGLPHLLELRL------------FSCGLSSAVL--------------SDGYFRNL 145
Cdd:cd21340 64 LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIenqrlppgekltFDPRSLAALSnslrvlnisgnnidSLEPLAPL 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 20140822 146 YSLARLDLSGNQIHSLR-LHSSFRELNSLSDVNFAFN 181
Cdd:cd21340 142 RNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGN 178
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
443-584 |
3.33e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.42 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 443 YFLLRVPQLQFLILNQNRLS------SCKAAHTPsenPSLEQLFLTENMLQLAWE-TGLCWDVFQGLSRLQILYLSNNYL 515
Cdd:cd00116 17 ELLPKLLCLQVLRLEGNTLGeeaakaLASALRPQ---PSLKELCLSLNETGRIPRgLQSLLQGLTKGCGLQELDLSDNAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140822 516 NFLPPGIFNDLV--------------------------------ALRMLSLSANKLTVLS----PGSLPAN--LEILDIS 557
Cdd:cd00116 94 GPDGCGVLESLLrssslqelklnnnglgdrglrllakglkdlppALEKLVLGRNRLEGAScealAKALRANrdLKELNLA 173
|
170 180 190
....*....|....*....|....*....|....
gi 20140822 558 RNQL-------LCPDPALFSSLRVLDITHNEFVC 584
Cdd:cd00116 174 NNGIgdagiraLAEGLKANCNLEVLDLNNNGLTD 207
|
|
| |
