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Conserved domains on  [gi|20139238|sp|Q9NY93|]
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RecName: Full=Probable ATP-dependent RNA helicase DDX56; AltName: Full=ATP-dependent 61 kDa nucleolar RNA helicase; AltName: Full=DEAD box protein 21; AltName: Full=DEAD box protein 56

Protein Classification

DDX56/DBP9 family DEAD/DEAH box RNA helicase( domain architecture ID 13028929)

DDX56/DBP9 family DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of RNA, similar to fungal ATP-dependent RNA helicase DBP9 (DEAD box protein 9) that is involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
14-220 4.53e-121

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 354.58  E-value: 4.53e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpVVEQAVRGLVLVPTKE 93
Cdd:cd17961   1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES-GEEQGTRALILVPTRE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17961  80 LAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLS 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd17961 160 YGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
231-389 1.40e-36

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 132.25  E-value: 1.40e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 231 LQQFQVVCEtEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYD 310
Cdd:cd18787   1 IKQLYVVVE-EEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 311 CVIATDaevlgapvkgkrrgrgpkgdkasdpeaGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:cd18787  80 VLVATD---------------------------VAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
 
Name Accession Description Interval E-value
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
14-220 4.53e-121

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 354.58  E-value: 4.53e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpVVEQAVRGLVLVPTKE 93
Cdd:cd17961   1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES-GEEQGTRALILVPTRE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17961  80 LAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLS 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd17961 160 YGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
9-404 1.28e-106

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 325.56  E-value: 1.28e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveqavRGLVL 88
Cdd:COG0513   4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAP------QALIL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:COG0513  78 APTRELALQVAEELRKLAKYL--GLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDL-SGVETLVLDEA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPgPDQLQQFQVVCEtEEDKFLLL 248
Cdd:COG0513 155 DRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENAT-AETIEQRYYLVD-KRDKLELL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 249 YALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATD-Aevlgapvkgk 327
Cdd:COG0513 233 RRLLRDEDP-ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDvA---------- 301
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20139238 328 rrgrgpkgdkasdpeagvARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELL 404
Cdd:COG0513 302 ------------------ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLI 360
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
9-401 1.22e-65

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 219.81  E-value: 1.22e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLH--RKATGPvveqaVRGL 86
Cdd:PRK11192   3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfpRRKSGP-----PRIL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   87 VLVPTKELARQAQSMIQQLATYCARDvrVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVD 166
Cdd:PRK11192  78 ILTPTRELAMQVADQARELAKHTHLD--IATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCR-AVETLILD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  167 EADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFN-EDVQALKELILHNPVTLklqESQLPGPDQ--LQQFQVVCETEED 243
Cdd:PRK11192 155 EADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEV---EAEPSRRERkkIHQWYYRADDLEH 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  244 KFLLLYALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgap 323
Cdd:PRK11192 232 KTALLCHLLKQPEV-TRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDV------ 304
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238  324 vkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK11192 305 ---------------------AARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
31-207 1.17e-45

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 157.79  E-value: 1.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    31 TLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgpvveqAVRGLVLVPTKELARQaqsMIQQLATYCA 110
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN-------GPQALVLAPTRELAEQ---IYEELKKLGK 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   111 -RDVRVANVSAAEDSVSQRAVLmEKPDVVVGTPSRILSHLQQDslKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPR 189
Cdd:pfam00270  71 gLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPK 147
                         170
                  ....*....|....*...
gi 20139238   190 IYQAFLMSATFNEDVQAL 207
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
22-227 7.52e-40

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 143.79  E-value: 7.52e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238     22 VTDLGWSRPTLIQEKAIPLALEG-KDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQS 100
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG--------RVLVLVPTRELAEQWAE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    101 MIQQLATYCaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEEL 180
Cdd:smart00487  73 ELKKLGPSL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSN-VDLVILDEAHRLLDGGFGDQL 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 20139238    181 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPG 227
Cdd:smart00487 151 EKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEP 197
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
231-389 1.40e-36

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 132.25  E-value: 1.40e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 231 LQQFQVVCEtEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYD 310
Cdd:cd18787   1 IKQLYVVVE-EEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 311 CVIATDaevlgapvkgkrrgrgpkgdkasdpeaGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:cd18787  80 VLVATD---------------------------VAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
259-380 3.31e-18

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 80.33  E-value: 3.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   259 GKSLLFVNTLERSYrLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdka 338
Cdd:pfam00271  16 GKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDV--------------------- 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20139238   339 sdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:pfam00271  74 ------AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
273-380 7.01e-16

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 72.63  E-value: 7.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    273 RLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFH 352
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDV---------------------------AERGLDLP 54
                           90       100
                   ....*....|....*....|....*...
gi 20139238    353 HVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:smart00490  55 GVDLVIIYDLPWSPASYIQRIGRAGRAG 82
 
Name Accession Description Interval E-value
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
14-220 4.53e-121

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 354.58  E-value: 4.53e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpVVEQAVRGLVLVPTKE 93
Cdd:cd17961   1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES-GEEQGTRALILVPTRE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17961  80 LAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLS 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd17961 160 YGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
9-404 1.28e-106

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 325.56  E-value: 1.28e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveqavRGLVL 88
Cdd:COG0513   4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAP------QALIL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:COG0513  78 APTRELALQVAEELRKLAKYL--GLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDL-SGVETLVLDEA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPgPDQLQQFQVVCEtEEDKFLLL 248
Cdd:COG0513 155 DRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENAT-AETIEQRYYLVD-KRDKLELL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 249 YALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATD-Aevlgapvkgk 327
Cdd:COG0513 233 RRLLRDEDP-ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDvA---------- 301
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20139238 328 rrgrgpkgdkasdpeagvARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELL 404
Cdd:COG0513 302 ------------------ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLI 360
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
18-219 1.17e-68

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 219.62  E-value: 1.17e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveQAVRGLVLVPTKELARQ 97
Cdd:cd00268   1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKG---RGPQALVLAPTRELAMQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  98 AQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFE 177
Cdd:cd00268  78 IAEVARKLGKGT--GLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDL-SNVKYLVLDEADRMLDMGFE 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 20139238 178 EELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd00268 155 EDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
9-401 1.22e-65

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 219.81  E-value: 1.22e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLH--RKATGPvveqaVRGL 86
Cdd:PRK11192   3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfpRRKSGP-----PRIL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   87 VLVPTKELARQAQSMIQQLATYCARDvrVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVD 166
Cdd:PRK11192  78 ILTPTRELAMQVADQARELAKHTHLD--IATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCR-AVETLILD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  167 EADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFN-EDVQALKELILHNPVTLklqESQLPGPDQ--LQQFQVVCETEED 243
Cdd:PRK11192 155 EADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEV---EAEPSRRERkkIHQWYYRADDLEH 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  244 KFLLLYALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgap 323
Cdd:PRK11192 232 KTALLCHLLKQPEV-TRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDV------ 304
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238  324 vkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK11192 305 ---------------------AARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
18-216 8.51e-62

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 201.71  E-value: 8.51e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveqAVRGLVLVPTKELARQ 97
Cdd:cd17947   1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKA----ATRVLVLVPTRELAMQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  98 AQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD-SLKLrDSLELLVVDEADLLFSFGF 176
Cdd:cd17947  77 CFSVLQQLAQFT--DITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSpSFDL-DSIEILVLDEADRMLEEGF 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 20139238 177 EEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17947 154 ADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
9-407 3.40e-58

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 200.41  E-value: 3.40e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgpvveqAVRGLVL 88
Cdd:PRK11776   6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRF-------RVQALVL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   89 VPTKELARQAQSMIQQLATYcARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:PRK11776  79 CPTRELADQVAKEIRRLARF-IPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDL-DALNTLVLDEA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQlpgpDQLQQFQVVCETEEDKFLLL 248
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH----DLPAIEQRFYEVSPDERLPA 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  249 YALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkr 328
Cdd:PRK11776 233 LQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDV----------- 301
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238  329 rgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGE 407
Cdd:PRK11776 302 ----------------AARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRK 364
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
9-219 6.53e-58

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 191.76  E-value: 6.53e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveQAVRGLVL 88
Cdd:cd17954   2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENP-------QRFFALVL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCArdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD---SLKlrdSLELLVV 165
Cdd:cd17954  75 APTRELAQQISEQFEALGSSIG--LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTkgfSLK---SLKFLVM 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 20139238 166 DEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17954 150 DEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
8-219 2.30e-56

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 187.90  E-value: 2.30e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrKATGPVVeqAVRGLV 87
Cdd:cd17959   2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKL---KAHSPTV--GARALI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  88 LVPTKELARQAQSMIQQLAtyCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDE 167
Cdd:cd17959  77 LSPTRELALQTLKVTKELG--KFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLS-SVEYVVFDE 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 20139238 168 ADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17959 154 ADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
7-407 3.10e-52

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 184.63  E-value: 3.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgPVVEQAVRGL 86
Cdd:PRK10590   1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPH-AKGRRPVRAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   87 VLVPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVD 166
Cdd:PRK10590  80 ILTPTRELAAQIGENVRDYSKYL--NIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKL-DQVEILVLD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  167 EADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGpDQLQQFqvVCETEEDKFL 246
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTAS-EQVTQH--VHFVDKKRKR 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  247 LLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkg 326
Cdd:PRK10590 234 ELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDI--------- 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  327 krrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSG 406
Cdd:PRK10590 305 ------------------AARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKK 366

                 .
gi 20139238  407 E 407
Cdd:PRK10590 367 E 367
PTZ00424 PTZ00424
helicase 45; Provisional
9-401 3.76e-49

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 174.63  E-value: 3.76e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveQAVRGLVL 88
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDL-------NACQALIL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   89 VPTKELARQAQSMIQQLATYCarDVR----VANVSAAEDSvsqrAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLV 164
Cdd:PTZ00424 103 APTRELAQQIQKVVLALGDYL--KVRchacVGGTVVRDDI----NKLKAGVHMVVGTPGRVYDMIDKRHLRV-DDLKLFI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  165 VDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL--KLQESQLPGpdqLQQFQVVCETEE 242
Cdd:PTZ00424 176 LDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRIlvKKDELTLEG---IRQFYVAVEKEE 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  243 DKFLLLYALLKLSLIRgKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlga 322
Cdd:PTZ00424 253 WKFDTLCDLYETLTIT-QAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDL----- 326
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238  323 pvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PTZ00424 327 ----------------------LARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIE 383
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
8-404 9.81e-48

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 172.79  E-value: 9.81e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatgPVVEQAVRG-- 85
Cdd:PRK01297  88 RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQT----PPPKERYMGep 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   86 --LVLVPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEK-PDVVVGTPSRILSHLQQDSLKLrDSLEL 162
Cdd:PRK01297 164 raLIIAPTRELVVQIAKDAAALTKYT--GLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHL-DMVEV 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  163 LVVDEADLLFSFGFEEELKSLLCHLPRI--YQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVceT 240
Cdd:PRK01297 241 MVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAV--A 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  241 EEDKFLLLYALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevl 320
Cdd:PRK01297 319 GSDKYKLLYNLVTQNPW-ERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDV--- 394
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  321 gapvkgkrrgrgpkgdkasdpeAGvaRGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKI 400
Cdd:PRK01297 395 ----------------------AG--RGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEI 450

                 ....
gi 20139238  401 EELL 404
Cdd:PRK01297 451 EELL 454
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
18-218 2.26e-47

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 163.53  E-value: 2.26e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQ-LLLHRKATGpvveqaVRGLVLVPTKELAR 96
Cdd:cd17957   1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQkLGKPRKKKG------LRALILAPTRELAS 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  97 QAQSMIQQLATycARDVRVANVS-AAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFSFG 175
Cdd:cd17957  75 QIYRELLKLSK--GTGLRIVLLSkSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLS-SVEYLVLDEADKLFEPG 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 20139238 176 FEEELKSLL--CHLPRIyQAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17957 152 FREQTDEILaaCTNPNL-QRSLFSATIPSEVEELARSVMKDPIRI 195
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
9-401 3.17e-46

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 171.57  E-value: 3.17e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatGPVVeQAVRGLVL 88
Cdd:PRK11634   8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL------DPEL-KAPQILVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   89 VPTKELARQAQSMIQQLATYcARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:PRK11634  81 APTRELAVQVAEAMTDFSKH-MRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDL-SKLSGLVLDEA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKflll 248
Cdd:PRK11634 159 DEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNE---- 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  249 yallklSLIR-------GKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlg 321
Cdd:PRK11634 235 ------ALVRfleaedfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDV---- 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  322 apvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK11634 305 -----------------------AARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIE 361
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
9-216 5.62e-46

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 160.16  E-value: 5.62e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatgPVVEQAVRGLVL 88
Cdd:cd17940   1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-------DPKKDVIQALIL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:cd17940  74 VPTRELALQTSQVCKELGKHM--GVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADL-SHCKTLVLDEA 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17940 151 DKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
31-207 1.17e-45

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 157.79  E-value: 1.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    31 TLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgpvveqAVRGLVLVPTKELARQaqsMIQQLATYCA 110
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN-------GPQALVLAPTRELAEQ---IYEELKKLGK 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   111 -RDVRVANVSAAEDSVSQRAVLmEKPDVVVGTPSRILSHLQQDslKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPR 189
Cdd:pfam00270  71 gLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPK 147
                         170
                  ....*....|....*...
gi 20139238   190 IYQAFLMSATFNEDVQAL 207
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
9-216 4.34e-44

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 155.17  E-value: 4.34e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLllhrkatgpvveqaVRGLVL 88
Cdd:cd17938   1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQI--------------VVALIL 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCAR-DVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDE 167
Cdd:cd17938  67 EPSRELAEQTYNCIENFKKYLDNpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLS-SVRFFVLDE 145
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 168 ADLLFSFGFEEELKSLLCHLPRI------YQAFLMSATF-NEDVQALKELILHNPV 216
Cdd:cd17938 146 ADRLLSQGNLETINRIYNRIPKItsdgkrLQVIVCSATLhSFEVKKLADKIMHFPT 201
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
9-216 5.42e-44

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 154.69  E-value: 5.42e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkATGPVveqAVRGLVL 88
Cdd:cd17955   1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL----SEDPY---GIFALVL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATycARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD-----SLKLrdsLELL 163
Cdd:cd17955  74 TPTRELAYQIAEQFRALGA--PLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddttkVLSR---VKFL 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 20139238 164 VVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17955 149 VLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
18-219 5.17e-43

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 151.96  E-value: 5.17e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgPVVEQAVRGLVLVPTKELARQ 97
Cdd:cd17960   1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKA--NLKKGQVGALIISPTRELATQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  98 AQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLME-KPDVVVGTPSRILSHLQ--QDSLKLRdSLELLVVDEADLLFSF 174
Cdd:cd17960  79 IYEVLQSFLEHHLPKLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEELLSrkADKVKVK-SLEVLVLDEADRLLDL 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
18-206 2.82e-40

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 145.84  E-value: 2.82e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLAL-EGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVE--QAVRGLVLVPTKEL 94
Cdd:cd17946   1 ILRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGkqKPLRALILTPTREL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  95 ARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLR--DSLELLVVDEADLLF 172
Cdd:cd17946  81 AVQVKDHLKAIAKYT--NIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLAnlKSLRFLVLDEADRML 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 20139238 173 SFGFEEELKSLLCHLP-------RIYQAFLMSATFNEDVQA 206
Cdd:cd17946 159 EKGHFAELEKILELLNkdragkkRKRQTFVFSATLTLDHQL 199
DEXDc smart00487
DEAD-like helicases superfamily;
22-227 7.52e-40

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 143.79  E-value: 7.52e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238     22 VTDLGWSRPTLIQEKAIPLALEG-KDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQS 100
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG--------RVLVLVPTRELAEQWAE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    101 MIQQLATYCaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEEL 180
Cdd:smart00487  73 ELKKLGPSL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSN-VDLVILDEAHRLLDGGFGDQL 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 20139238    181 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPG 227
Cdd:smart00487 151 EKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEP 197
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
7-401 1.43e-39

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 152.03  E-value: 1.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGL 86
Cdd:PRK04537   9 LTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDPRAL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   87 VLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLV 164
Cdd:PRK04537  89 ILAPTRELAIQ----IHKDAVKFGADlgLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  165 VDEADLLFSFGFEEELKSLLCHLPR--IYQAFLMSATFNEDVQALKELILHNPVTLkLQESQLPGPDQLQQfQVVCETEE 242
Cdd:PRK04537 165 LDEADRMFDLGFIKDIRFLLRRMPErgTRQTLLFSATLSHRVLELAYEHMNEPEKL-VVETETITAARVRQ-RIYFPADE 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  243 DKFLLLYALLKLSLiRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlga 322
Cdd:PRK04537 243 EKQTLLLGLLSRSE-GARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDV----- 316
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238  323 pvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK04537 317 ----------------------AARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIE 373
PTZ00110 PTZ00110
helicase; Provisional
9-391 6.98e-39

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 149.54  E-value: 6.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPML-----QLLLhRKATGPVVeqav 83
Cdd:PTZ00110 132 FEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIvhinaQPLL-RYGDGPIV---- 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   84 rgLVLVPTKELARQaqsmIQQLATYCARDVRVANvSAAEDSV---SQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSL 160
Cdd:PTZ00110 207 --LVLAPTRELAEQ----IREQCNKFGASSKIRN-TVAYGGVpkrGQIYALRRGVEILIACPGRLIDFLESNVTNLR-RV 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  161 ELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQAL-KELILHNPVTLKLQESQLPGPDQLQQFQVVCE 239
Cdd:PTZ00110 279 TYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLaRDLCKEEPVHVNVGSLDLTACHNIKQEVFVVE 358
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  240 TEEDKFLLLYALLKLSLIRGKSLLFVNT------LERSYRLRlfleqfSIPTCVLNGELPLRSRCHIISQFNQGFYDCVI 313
Cdd:PTZ00110 359 EHEKRGKLKMLLQRIMRDGDKILIFVETkkgadfLTKELRLD------GWPALCIHGDKKQEERTWVLNEFKTGKSPIMI 432
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238  314 ATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLP 391
Cdd:PTZ00110 433 ATDV---------------------------ASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
12-216 1.75e-38

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 139.77  E-value: 1.75e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  12 MGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatgPVVEQAVRGLVLVPT 91
Cdd:cd17939   2 MGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRI-------DTTVRETQALVLAPT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  92 KELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLL 171
Cdd:cd17939  75 RELAQQIQKVVKALGDYM--GVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRT-DKIKMFVLDEADEM 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 20139238 172 FSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17939 152 LSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
19-217 3.85e-38

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 138.96  E-value: 3.85e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  19 LQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvvEQAVRGLVLVPTKELARQA 98
Cdd:cd17941   2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTP---EDGLGALIISPTRELAMQI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  99 QSMIQQLATY----CARDVRVANVSAAEDSVSQRAVLmekpdvvVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSF 174
Cdd:cd17941  79 FEVLRKVGKYhsfsAGLIIGGKDVKEEKERINRMNIL-------VCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDM 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVT 217
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEY 194
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
9-402 1.53e-37

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 143.57  E-value: 1.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQ-LLLHRKATGPVVEQAvRGLV 87
Cdd:PRK04837  10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHyLLSHPAPEDRKVNQP-RALI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   88 LVPTKELARQAQSMIQQLATYCArdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDE 167
Cdd:PRK04837  89 MAPTRELAVQIHADAEPLAQATG--LKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINL-GAIQVVVLDE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  168 ADLLFSFGFEEELKSLLCHLPRIYQ--AFLMSATFNEDVQALKELILHNPVTLKLQESQLPG------------PDQLQQ 233
Cdd:PRK04837 166 ADRMFDLGFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGhrikeelfypsnEEKMRL 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  234 FQVVCETEEDKflllyallklslirgKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVI 313
Cdd:PRK04837 246 LQTLIEEEWPD---------------RAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILV 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  314 ATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTE 393
Cdd:PRK04837 311 ATDV---------------------------AARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEY 363

                 ....*....
gi 20139238  394 QFHLGKIEE 402
Cdd:PRK04837 364 ALNLPAIET 372
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
18-216 3.03e-37

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 136.39  E-value: 3.03e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKA----TGPVveqavrGLVLVPTKE 93
Cdd:cd17952   1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRElekgEGPI------AVIVAPTRE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  94 LARQAQSMIQQLATYcaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFS 173
Cdd:cd17952  75 LAQQIYLEAKKFGKA--YNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQ-RVTYLVLDEADRMFD 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17952 152 MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPI 194
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
22-219 3.63e-37

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 136.56  E-value: 3.63e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  22 VTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLL------HRkatgpvvEQAVRGLVLVPTKELA 95
Cdd:cd17949   6 KSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLsleprvDR-------SDGTLALVLVPTRELA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  96 RQAQSMIQQLaTYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQ-DSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd17949  79 LQIYEVLEKL-LKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDV-SNLRWLVLDEADRLLDM 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 175 GFEEELKSLLCHL-------------PRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17949 157 GFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
14-212 5.67e-37

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 136.17  E-value: 5.67e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALE-GKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVveQAVRGLVLVPTK 92
Cdd:cd17964   1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRR--SGVSALIISPTR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  93 ELARQAQSMIQQLaTYCARDVRVAN-VSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLR-DSLELLVVDEADL 170
Cdd:cd17964  79 ELALQIAAEAKKL-LQGLRKLRVQSaVGGTSRRAELNRLRRGRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADR 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 20139238 171 LFSFGFEEELKSLLCHLPRIY----QAFLMSATFNEDVQALKELIL 212
Cdd:cd17964 158 LLDMGFRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTL 203
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
231-389 1.40e-36

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 132.25  E-value: 1.40e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 231 LQQFQVVCEtEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYD 310
Cdd:cd18787   1 IKQLYVVVE-EEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 311 CVIATDaevlgapvkgkrrgrgpkgdkasdpeaGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:cd18787  80 VLVATD---------------------------VAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
14-219 1.29e-34

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 129.23  E-value: 1.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQLL-LHRKATgpvveQAvrgLVLVP 90
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVdPTLKSP-----QA---LCLAP 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  91 TKELARQAQSMIQQLATYCarDVRVA------NVSAAEDSVSQravlmekpdVVVGTPSRILSHLQQDSLKLRdSLELLV 164
Cdd:cd17963  73 TRELARQIGEVVEKMGKFT--GVKVAlavpgnDVPRGKKITAQ---------IVIGTPGTVLDWLKKRQLDLK-KIKILV 140
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 165 VDEAD-LLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17963 141 LDEADvMLDTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
19-215 1.65e-33

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 126.32  E-value: 1.65e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  19 LQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLL-----LHRKATGpvveqavrGLVLVPTKE 93
Cdd:cd17942   2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLyklkfKPRNGTG--------VIIISPTRE 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRavLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17942  74 LALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEK--LGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILE 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNP 215
Cdd:cd17942 152 IGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
18-218 4.55e-33

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 125.51  E-value: 4.55e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR-KATGPVVEQAVRGLVLVPTKELAR 96
Cdd:cd17945   1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLpPLDEETKDDGPYALILAPTRELAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  97 QAQSMIQQLATYcaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFSFGF 176
Cdd:cd17945  81 QIEEETQKFAKP--LGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLN-QCTYVVLDEADRMIDMGF 157
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20139238 177 EEELKSLLCHLP-------------------RIY-QAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17945 158 EPQVTKILDAMPvsnkkpdteeaeklaasgkHRYrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
9-216 5.31e-33

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 124.87  E-value: 5.31e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatgpvvEQAVRGLVL 88
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTS-------LKATQALVL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATYCArdvrvANVSAAEDSVSQRA---VLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVV 165
Cdd:cd18046  74 APTRELAQQIQKVVMALGDYMG-----IKCHACIGGTSVRDdaqKLQAGPHIVVGTPGRVFDMINRRYLRT-DYIKMFVL 147
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 20139238 166 DEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
11-216 7.82e-32

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 122.49  E-value: 7.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  11 HMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRK----ATGPVveqavrGL 86
Cdd:cd17953  16 QCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRpvkpGEGPI------GL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  87 VLVPTKELARQAQSMIQQLATycARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD--SLELLV 164
Cdd:cd17953  90 IMAPTRELALQIYVECKKFSK--ALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVTNlrRVTYVV 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 20139238 165 VDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17953 168 LDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
7-389 1.01e-31

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 128.37  E-value: 1.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGL 86
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRNPLAM 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   87 VLVPTKELARQAQSMIQQLATycARDVRVANVSAAeDSVSQRAVLMEKP-DVVVGTPSRILSHLQQDSLKLrDSLELLVV 165
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGK--GLPFKTALVVGG-DAMPQQLYRIQQGvELIVGTPGRLIDLLSKHDIEL-DNVSVLVL 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  166 DEADLLFSFGFEEELKSLLCHLPRIyQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGpDQLQQFQVVCETEEDKF 245
Cdd:PLN00206 277 DEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPN-KAVKQLAIWVETKQKKQ 354
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  246 LLLYALLKLSLIRGKSLLFVNTlersyRL--RLFLEQFSIPTCV----LNGELPLRSRCHIISQFNQGFYDCVIATDaeV 319
Cdd:PLN00206 355 KLFDILKSKQHFKPPAVVFVSS-----RLgaDLLANAITVVTGLkalsIHGEKSMKERREVMKSFLVGEVPVIVATG--V 427
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  320 LGapvkgkrrgrgpkgdkasdpeagvaRGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:PLN00206 428 LG-------------------------RGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
9-214 1.38e-31

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 121.44  E-value: 1.38e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLL---------HRKATGPVV 79
Cdd:cd17967   2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLedgppsvgrGRRKAYPSA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  80 eqavrgLVLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLr 157
Cdd:cd17967  82 ------LILAPTRELAIQ----IYEEARKFSYRsgVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISL- 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20139238 158 DSLELLVVDEADLLFSFGFEEELKSLLCH----LPRIYQAFLMSATFNEDVQALKELILHN 214
Cdd:cd17967 151 SSIKFLVLDEADRMLDMGFEPQIRKIVEHpdmpPKGERQTLMFSATFPREIQRLAADFLKN 211
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
18-215 3.08e-30

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 118.12  E-value: 3.08e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSR---------PTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqAVRGLVL 88
Cdd:cd17956   1 LLKNLQNNGITSafpvqaaviPWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVP------RLRALIV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  89 VPTKELARQAQSMIQQLATycARDVRVANVS--------AAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSL 160
Cdd:cd17956  75 VPTKELVQQVYKVFESLCK--GTGLKVVSLSgqksfkkeQKLLLVDTSGRYLSRVDILVATPGRLVDHLNSTPGFTLKHL 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20139238 161 ELLVVDEAD-------------LLFSFGFEEELK-------SLLCHLPRIYQAFLMSATFNEDVQALKELILHNP 215
Cdd:cd17956 153 RFLVIDEADrllnqsfqdwletVMKALGRPTAPDlgsfgdaNLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
18-216 4.36e-30

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 116.59  E-value: 4.36e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqaVRGLVLVPTKELARQ 97
Cdd:cd17943   1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRH-------PQVLILAPTREIAVQ 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  98 AQSMIQQLATYCAR---DVRVANVSAAEDSVSqravlMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd17943  74 IHDVFKKIGKKLEGlkcEVFIGGTPVKEDKKK-----LKGCHIAVGTPGRIKQLIELGALNV-SHVRLFVLDEADKLMEG 147
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17943 148 SFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPV 189
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
9-207 4.13e-29

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 115.83  E-value: 4.13e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVE--QAVRGL 86
Cdd:cd18052  45 FEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSevQEPQAL 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  87 VLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLV 164
Cdd:cd18052 125 IVAPTRELANQ----IFLEARKFSYGtcIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISL-SKLKYLI 199
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 20139238 165 VDEADLLFSFGFEEELKSLL--CHLPR--IYQAFLMSATFNEDVQAL 207
Cdd:cd18052 200 LDEADRMLDMGFGPEIRKLVsePGMPSkeDRQTLMFSATFPEEIQRL 246
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
18-216 4.83e-29

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 113.62  E-value: 4.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPML-----QLLLhRKATGPVVeqavrgLVLVPTK 92
Cdd:cd17966   1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhinaQPPL-ERGDGPIV------LVLAPTR 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  93 ELARQAQsmiQQLATYCAR-DVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLL 171
Cdd:cd17966  74 ELAQQIQ---QEANKFGGSsRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLR-RVTYLVLDEADRM 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 20139238 172 FSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17966 150 LDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
9-216 7.45e-29

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 113.33  E-value: 7.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlllhrkatgpVVEQAVR---G 85
Cdd:cd18045   1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQ----------CLDIQVRetqA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  86 LVLVPTKELARQAQSMIQQLATYcardvrvANVSA--------AEDSVSqraVLMEKPDVVVGTPSRILSHLQQDSLKLR 157
Cdd:cd18045  71 LILSPTRELAVQIQKVLLALGDY-------MNVQChaciggtsVGDDIR---KLDYGQHIVSGTPGRVFDMIRRRSLRTR 140
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 158 dSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd18045 141 -HIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPI 198
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
26-216 1.23e-28

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 112.64  E-value: 1.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  26 GWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlllhrKATGPVveQAVRGLVLVPTKELARQAQSMIQQL 105
Cdd:cd17962   9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVII-----RCLTEH--RNPSALILTPTRELAVQIEDQAKEL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 106 ATYCARdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFEEELKSLLC 185
Cdd:cd17962  82 MKGLPP-MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVEL-DNIKIVVVDEADTMLKMGFQQQVLDILE 159
                       170       180       190
                ....*....|....*....|....*....|.
gi 20139238 186 HLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17962 160 NISHDHQTILVSATIPRGIEQLAGQLLQNPV 190
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
18-216 2.87e-27

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 108.71  E-value: 2.87e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIP-----MLQLLLHRKATGPVVeqavrgLVLVPTK 92
Cdd:cd17958   1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgfihlDLQPIPREQRNGPGV------LVLTPTR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  93 ELARQAQSMIQQlatYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRiLSHLQQDSLKLRDSLELLVVDEADLLF 172
Cdd:cd17958  75 ELALQIEAECSK---YSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGR-LNDLQMNNVINLKSITYLVLDEADRML 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 20139238 173 SFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17958 151 DMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPM 194
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
8-216 1.17e-26

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 107.43  E-value: 1.17e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHrkatgpvVEQAVRGLV 87
Cdd:cd17950   3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEP-------VDGQVSVLV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  88 LVPTKELARQAQSMIQQLATYcARDVRVA------NVSAAEDSVSQravlmEKPDVVVGTPSRILSHLQQDSLKLrDSLE 161
Cdd:cd17950  76 ICHTRELAFQISNEYERFSKY-MPNVKTAvffggvPIKKDIEVLKN-----KCPHIVVGTPGRILALVREKKLKL-SHVK 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 162 LLVVDEAD-LLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17950 149 HFVLDECDkMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
18-218 1.31e-26

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 107.04  E-value: 1.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQ-AVRGLVLVPTKELAR 96
Cdd:cd17951   1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGeGPYGLIVCPSRELAR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  97 QAQSMIQQLATYCARD----VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLF 172
Cdd:cd17951  81 QTHEVIEYYCKALQEGgypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINL-DICRYLCLDEADRMI 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 20139238 173 SFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
18-188 3.01e-25

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 103.99  E-value: 3.01e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQ 97
Cdd:cd17948   1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFNAPRGLVITPSRELAEQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  98 AQSMIQQLATYCARDVRVanVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFE 177
Cdd:cd17948  81 IGSVAQSLTEGLGLKVKV--ITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSL-EQLRHLVLDEADTLLDDSFN 157
                       170
                ....*....|.
gi 20139238 178 EELKSLLCHLP 188
Cdd:cd17948 158 EKLSHFLRRFP 168
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
27-214 7.55e-25

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 103.58  E-value: 7.55e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  27 WSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatGPVV------------EQAVRGLVLVPTKEL 94
Cdd:cd18051  41 YTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQ---GPGEslpsesgyygrrKQYPLALVLAPTREL 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  95 ARQAQSMIQQLAtYCARdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd18051 118 ASQIYDEARKFA-YRSR-VRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGL-DYCKYLVLDEADRMLDM 194
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 20139238 175 GFEEELKSLL--CHLPR--IYQAFLMSATFNEDVQALKELILHN 214
Cdd:cd18051 195 GFEPQIRRIVeqDTMPPtgERQTLMFSATFPKEIQMLARDFLDN 238
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
9-225 7.77e-25

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 102.79  E-value: 7.77e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQlLLHRKATGPvveqavRGL 86
Cdd:cd18048  20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLS-RVDALKLYP------QCL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  87 VLVPTKELARQAQSMIQQLATYCArDVRVanVSAAEDSVSQRAVLMEKpDVVVGTPSRILSHLQQDSLKLRDSLELLVVD 166
Cdd:cd18048  93 CLSPTFELALQTGKVVEEMGKFCV-GIQV--IYAIRGNRPGKGTDIEA-QIVIGTPGTVLDWCFKLRLIDVTNISVFVLD 168
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 167 EADLLFSF-GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQL 225
Cdd:cd18048 169 EADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
7-220 1.03e-24

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 102.78  E-value: 1.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR----KATGPVVeqa 82
Cdd:cd18049  24 LNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQpfleRGDGPIC--- 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  83 vrgLVLVPTKELARQAQsmiQQLATYC-ARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSlE 161
Cdd:cd18049 101 ---LVLAPTRELAQQVQ---QVAAEYGrACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRC-T 173
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 162 LLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd18049 174 YLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
8-220 1.98e-22

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 97.00  E-value: 1.98e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR----KATGPVVeqav 83
Cdd:cd18050  63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQpyleRGDGPIC---- 138
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  84 rgLVLVPTKELARQaqsmIQQLATYCARDVRVAN--VSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLE 161
Cdd:cd18050 139 --LVLAPTRELAQQ----VQQVADDYGKSSRLKStcIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLR-RCT 211
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 162 LLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd18050 212 YLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
9-219 2.81e-21

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 92.09  E-value: 2.81e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQlllhrkATGPVVEQAvRGL 86
Cdd:cd18047   3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLS------QVEPANKYP-QCL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  87 VLVPTKELARQAQSMIQQLATYCArdvRVANVSAAEDSVSQRAVLMeKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVD 166
Cdd:cd18047  76 CLSPTYELALQTGKVIEQMGKFYP---ELKLAYAVRGNKLERGQKI-SEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLD 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 20139238 167 EADLLFSF-GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd18047 152 EADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
33-184 8.74e-20

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 87.60  E-value: 8.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  33 IQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLatycARD 112
Cdd:cd17944  16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIE-KLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFKDI----TRK 90
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20139238 113 VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFEEELKSLL 184
Cdd:cd17944  91 LSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDL-TKLKHVVLDEVDQMLDMGFAEQVEEIL 161
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
44-199 6.11e-19

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 83.61  E-value: 6.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  44 GKDLLARARTGSGKTAAYAIPMLQLLLhrkatgpvvEQAVRGLVLVPTKELARQAQSMIQQLATycaRDVRVANVSAAED 123
Cdd:cd00046   1 GENVLITAPTGSGKTLAALLAALLLLL---------KKGKKVLVLVPTKALALQTAERLRELFG---PGIRVAVLVGGSS 68
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 124 SVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADlLFSFGFEEELKSLLCHLPRIY---QAFLMSAT 199
Cdd:cd00046  69 AEEREKNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAH-ALLIDSRGALILDLAVRKAGLknaQVILLSAT 146
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
259-380 3.31e-18

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 80.33  E-value: 3.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   259 GKSLLFVNTLERSYrLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdka 338
Cdd:pfam00271  16 GKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDV--------------------- 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20139238   339 sdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:pfam00271  74 ------AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
13-168 2.62e-16

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 82.19  E-value: 2.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  13 GLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHrkatgpvvEQAVRGLVLVPTK 92
Cdd:COG1205  40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE--------DPGATALYLYPTK 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  93 ELAR-QAQSmIQQLATYCARDVRVANVsaaeD---SVSQRAVLMEKPDVVVGTP----SRILSHLQQDSLKLRdSLELLV 164
Cdd:COG1205 112 ALARdQLRR-LRELAEALGLGVRVATY----DgdtPPEERRWIREHPDIVLTNPdmlhYGLLPHHTRWARFFR-NLRYVV 185

                ....
gi 20139238 165 VDEA 168
Cdd:COG1205 186 IDEA 189
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
18-199 2.69e-16

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 78.57  E-value: 2.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  18 LLQAVTDLGWSRPTLIQEKAIPLALegKDLLAR------------------ARTGSGKTAAYAIPMLQLLLH-----RKA 74
Cdd:cd17965  19 LKGSNKTDEEIKPSPIQTLAIKKLL--KTLMRKvtkqtsneepklevfllaAETGSGKTLAYLAPLLDYLKRqeqepFEE 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  75 TGPVVEQA-----VRGLVLVPTKELARQAQSMIQQLATYCArdVRVANVSAA-EDSVSQRAVLMEKP-DVVVGTPSRILS 147
Cdd:cd17965  97 AEEEYESAkdtgrPRSVILVPTHELVEQVYSVLKKLSHTVK--LGIKTFSSGfGPSYQRLQLAFKGRiDILVTTPGKLAS 174
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 20139238 148 hLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSAT 199
Cdd:cd17965 175 -LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225
HELICc smart00490
helicase superfamily c-terminal domain;
273-380 7.01e-16

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 72.63  E-value: 7.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    273 RLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFH 352
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDV---------------------------AERGLDLP 54
                           90       100
                   ....*....|....*....|....*...
gi 20139238    353 HVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:smart00490  55 GVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
34-168 6.07e-12

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 64.53  E-value: 6.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQSMIQQLATYCARDV 113
Cdd:cd17923   5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGS--------RALYLYPTKALAQDQLRSLRELLEQLGLGI 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 114 RVANVSAAEDSVSQRAVLMEKPDVVVGTPSR----ILSHLQQDSLKLRdSLELLVVDEA 168
Cdd:cd17923  77 RVATYDGDTPREERRAIIRNPPRILLTNPDMlhyaLLPHHDRWARFLR-NLRYVVLDEA 134
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
33-199 1.94e-08

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 54.19  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  33 IQEKAI-PLALEGKDLLARARTGSGKT--AAYAIpmlqLLLHRKATGPVVeqavrglVLVPTKELARQ-AQSMIQQLATY 108
Cdd:cd17921   5 IQREALrALYLSGDSVLVSAPTSSGKTliAELAI----LRALATSGGKAV-------YIAPTRALVNQkEADLRERFGPL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 109 cardvrVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLfsfGFEEE---LKSLLC 185
Cdd:cd17921  74 ------GKNVGLLTGDPSVNKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLI---GDGERgvvLELLLS 144
                       170
                ....*....|....*..
gi 20139238 186 HLPRIYQAF---LMSAT 199
Cdd:cd17921 145 RLLRINKNArfvGLSAT 161
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
34-316 6.06e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 55.42  E-value: 6.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  34 QEKAI-----PLALEGKDLLARARTGSGKT--AAYAIpmLQLLLHRKAtgpvveqavrgLVLVPTKELARQAQSMIQQLa 106
Cdd:COG1061  85 QQEALeallaALERGGGRGLVVAPTGTGKTvlALALA--AELLRGKRV-----------LVLVPRRELLEQWAEELRRF- 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 107 tycardVRVANVSAAEDSVSqravlmekPDVVVGTPSRILSHLQQDslKLRDSLELLVVDEADLLFSFGFEEelksLLCH 186
Cdd:COG1061 151 ------LGDPLAGGGKKDSD--------APITVATYQSLARRAHLD--ELGDRFGLVIIDEAHHAGAPSYRR----ILEA 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 187 LPRIYQaFLMSAT-FNEDVQALKELILHNPV---TLK-LQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRG-- 259
Cdd:COG1061 211 FPAAYR-LGLTATpFRSDGREILLFLFDGIVyeySLKeAIEDGYLAPPEYYGIRVDLTDERAEYDALSERLREALAADae 289
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20139238 260 -----------------KSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATD 316
Cdd:COG1061 290 rkdkilrellrehpddrKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVD 363
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
34-171 2.01e-07

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 53.75  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  34 QEKAIPLAL-EGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveqavRGLVLVPTKELARQ-AQSMIQQLATYcar 111
Cdd:COG1204  27 QAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALLNGG----------KALYIVPLRALASEkYREFKRDFEEL--- 93
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 112 DVRVANVSAAEDSVSQRAvlmEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLL 171
Cdd:COG1204  94 GIKVGVSTGDYDSDDEWL---GRYDILVATPEKLDSLLRNGPSWLRD-VDLVVVDEAHLI 149
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
17-219 9.75e-07

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 49.46  E-value: 9.75e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  17 RLLQAVTDLGWSRPTliQEKAIPLALEGKDLLARARTGSGKTAAYAIPmlqLLLHRKATgpvveqavrgLVLVPTKELar 96
Cdd:cd17920   2 QILKEVFGYDEFRPG--QLEAINAVLAGRDVLVVMPTGGGKSLCYQLP---ALLLDGVT----------LVVSPLISL-- 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  97 qAQSMIQQLAtycARDVRVANVSAAEDSVSQRAVLME----KPDVVVGTPSRILS-HLQQ--DSLKLRDSLELLVVDEAD 169
Cdd:cd17920  65 -MQDQVDRLQ---QLGIRAAALNSTLSPEEKREVLLRikngQYKLLYVTPERLLSpDFLEllQRLPERKRLALIVVDEAH 140
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139238 170 LLFSFGFE-----EELKSLLCHLPRIyQAFLMSATFNEDVQA--LKELILHNPVTLK 219
Cdd:cd17920 141 CVSQWGHDfrpdyLRLGRLRRALPGV-PILALTATATPEVREdiLKRLGLRNPVIFR 196
DEXHc_RLR cd18036
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ...
34-167 2.24e-06

DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350794 [Multi-domain]  Cd Length: 204  Bit Score: 48.63  E-value: 2.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvveQAVRGLVLVPTKELARQAQSmiqQLATYCARDV 113
Cdd:cd18036   7 QLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAG----EKGRVVVLVNKVPLVEQQLE---KFFKYFRKGY 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 114 RVANVSAAEDSVSQRAVLMEKPDVVVGTP----SRILSHLQQDSLKLRDsLELLVVDE 167
Cdd:cd18036  80 KVTGLSGDSSHKVSFGQIVKASDVIICTPqiliNNLLSGREEERVYLSD-FSLLIFDE 136
PRK00254 PRK00254
ski2-like helicase; Provisional
41-199 9.12e-06

ski2-like helicase; Provisional


Pssm-ID: 234702 [Multi-domain]  Cd Length: 720  Bit Score: 48.66  E-value: 9.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238   41 ALEGKDLLARARTGSGKTAAYAIPMLQLLLhrkatgpvvEQAVRGLVLVPTKELARQAqsmIQQLATYCARDVRVANVSA 120
Cdd:PRK00254  36 VLEGKNLVLAIPTASGKTLVAEIVMVNKLL---------REGGKAVYLVPLKALAEEK---YREFKDWEKLGLRVAMTTG 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238  121 AEDSVSQravLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSAT 199
Cdd:PRK00254 104 DYDSTDE---WLGKYDIIIATAEKFDSLLRHGSSWIKD-VKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSAT 178
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
53-200 2.76e-05

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 44.22  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  53 TGSGKTaayaIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQaqsMIQQLATYCARDVRVANVSAAEDSVSQRavlm 132
Cdd:cd17926  27 TGSGKT----LTALALIAYLKEL--------RTLIVVPTDALLDQ---WKERFEDFLGDSSIGLIGGGKKKDFDDA---- 87
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 133 ekpDVVVGTPSrILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHlpriYQAFLmSATF 200
Cdd:cd17926  88 ---NVVVATYQ-SLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTFSEILKELNAK----YRLGL-TATP 146
DEXHc_HFM1 cd18023
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ...
33-171 5.06e-05

DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350781 [Multi-domain]  Cd Length: 206  Bit Score: 44.65  E-value: 5.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  33 IQEKAIPLALEG-KDLLARARTGSGKTAAYAIPMLQLLlhrKATGPVVEQAVRGLVLVPTKELARqaqsmiQQLATYCAR 111
Cdd:cd18023   5 IQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLL---KERNPLPWGNRKVVYIAPIKALCS------EKYDDWKEK 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20139238 112 DVRVaNVSAAE---DSVSQRAVLMEKPDVVVGTPSRI--LSHLQQDSLKLRDSLELLVVDEADLL 171
Cdd:cd18023  76 FGPL-GLSCAEltgDTEMDDTFEIQDADIILTTPEKWdsMTRRWRDNGNLVQLVALVLIDEVHII 139
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
42-199 6.28e-05

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 43.86  E-value: 6.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  42 LEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveqavRGLVLVPTKELARQAqsmIQQLATYCARDVRVANVSAA 121
Cdd:cd18028  15 LKGENLLISIPTASGKTLIAEMAMVNTLLEGG----------KALYLVPLRALASEK---YEEFKKLEEIGLKVGISTGD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 122 EDSvsqRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEELKSLLCHLPRIY---QAFLMSA 198
Cdd:cd18028  82 YDE---DDEWLGDYDIIVATYEKFDSLLRHSPSWLRD-VGVVVVDEIHLISDEERGPTLESIVARLRRLNpntQIIGLSA 157

                .
gi 20139238 199 T 199
Cdd:cd18028 158 T 158
DEXHc_dicer cd18034
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ...
45-168 6.68e-05

DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350792 [Multi-domain]  Cd Length: 200  Bit Score: 44.18  E-value: 6.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  45 KDLLARARTGSGKT--AAYAI-PMLQLLLHRKATGPVVeqavrgLVLVPTKELARQaQSMiqQLATYCarDVRVANVSAA 121
Cdd:cd18034  17 RNTIVVLPTGSGKTliAVMLIkEMGELNRKEKNPKKRA------VFLVPTVPLVAQ-QAE--AIRSHT--DLKVGEYSGE 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 20139238 122 EDSVSQRAV----LMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:cd18034  86 MGVDKWTKErwkeELEKYDVLVMTAQILLDALRHGFLSL-SDINLLIFDEC 135
ResIII pfam04851
Type III restriction enzyme, res subunit;
53-168 7.60e-05

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 43.43  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238    53 TGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRavlm 132
Cdd:pfam04851  32 TGSGKTLTAAKLIARLFKKGPIK--------KVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKDESVDDN---- 99
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 20139238   133 ekpDVVVGTPSRILSHLQQDSLKL-RDSLELLVVDEA 168
Cdd:pfam04851 100 ---KIVVTTIQSLYKALELASLELlPDFFDVIIIDEA 133
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
27-167 9.11e-05

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 45.48  E-value: 9.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  27 WSRPTLIQEKAIPLALEGKDLLARARTGSGKT-AAYAIPMLQLLLHRKATGPvvEQAVRGLVLVPTKELA-------RQA 98
Cdd:COG1201  22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAFLPALDELARRPRPGEL--PDGLRVLYISPLKALAndiernlRAP 99
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238  99 QSMIQQLATYCARDVRVAnV-----SAAEdsvsqRAVLMEK-PDVVVGTP---SRILShlQQDSLKLRDSLELLVVDE 167
Cdd:COG1201 100 LEEIGEAAGLPLPEIRVG-VrtgdtPASE-----RQRQRRRpPHILITTPeslALLLT--SPDARELLRGVRTVIVDE 169
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
347-389 2.28e-04

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 39.99  E-value: 2.28e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 20139238 347 RGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANN-PGIVLTFV 389
Cdd:cd18785  34 EGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKdEGEVILFV 77
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
44-167 2.87e-04

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 41.80  E-value: 2.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  44 GKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvveqaVRGLVLVPTKELARQAQSMIQQLATYCARDVRVAnVSAAED 123
Cdd:cd17922   1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKG------VQVLYISPLKALINDQERRLEEPLDEIDLEIPVA-VRHGDT 73
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 20139238 124 SVSQRAVLMEK-PDVVVGTP---SRILSHLQQDSLkLRDsLELLVVDE 167
Cdd:cd17922  74 SQSEKAKQLKNpPGILITTPeslELLLVNKKLREL-FAG-LRYVVVDE 119
DEXHc_TRCF cd17991
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair ...
87-183 3.17e-04

DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350749 [Multi-domain]  Cd Length: 193  Bit Score: 41.79  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  87 VLVPTKELARQ-AQSMIQQLATYcarDVRVANVSAAEDSVSQRAVLME----KPDVVVGTpSRILShlqqDSLKLRDsLE 161
Cdd:cd17991  69 VLVPTTLLAQQhYETFKERFANF---PVNVELLSRFTTAAEQREILEGlkegKVDIVIGT-HRLLS----KDVEFKN-LG 139
                        90       100
                ....*....|....*....|....
gi 20139238 162 LLVVDEADLlfsFGFE--EELKSL 183
Cdd:cd17991 140 LLIIDEEQR---FGVKqkEKLKEL 160
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
29-167 5.42e-04

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 41.25  E-value: 5.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  29 RPTLIQEKAI---------PLALegkDLLARARTGSGKTAAYAIPMLQlllhrkatgpVVEQAVRGLVLVPTKELARQaq 99
Cdd:cd17918  15 SLTKDQAQAIkdiekdlhsPEPM---DRLLSGDVGSGKTLVALGAALL----------AYKNGKQVAILVPTEILAHQ-- 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 100 sMIQQLATYCArDVRVANVSAAedsvsQRAVLMEKPDVVVGTPSRIlshlQQDSLKLrdSLELLVVDE 167
Cdd:cd17918  80 -HYEEARKFLP-FINVELVTGG-----TKAQILSGISLLVGTHALL----HLDVKFK--NLDLVIVDE 134
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
34-168 5.56e-04

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 41.47  E-value: 5.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPmlQLLLHRKATGPvveqavrGLVLVPTKELAR-QAQSMIQQLATYCARd 112
Cdd:cd18018  17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLP--ALLLRRRGPGL-------TLVVSPLIALMKdQVDALPRAIKAAALN- 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 113 vrvANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEA 168
Cdd:cd18018  87 ---SSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLRQTPPISLLVVDEA 139
DEXHc_RecG cd17992
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ...
54-167 3.73e-03

DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350750 [Multi-domain]  Cd Length: 225  Bit Score: 39.05  E-value: 3.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238  54 GSGKTAAYAIPMLQlllhrkatgpVVEQAVRGLVLVPTKELARQ-AQSMIQQLATYcarDVRVA----NVSAAEdsvsQR 128
Cdd:cd17992  76 GSGKTVVAALAMLA----------AVENGYQVALMAPTEILAEQhYDSLKKLLEPL---GIRVAlltgSTKAKE----KR 138
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 20139238 129 AVLME----KPDVVVGTpsrilsH-LQQDSLKLRDsLELLVVDE 167
Cdd:cd17992 139 EILEKiasgEIDIVIGT------HaLIQEDVEFHN-LGLVIIDE 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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