|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
14-220 |
4.53e-121 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 354.58 E-value: 4.53e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpVVEQAVRGLVLVPTKE 93
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES-GEEQGTRALILVPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17961 80 LAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLS 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd17961 160 YGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
9-404 |
1.28e-106 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 325.56 E-value: 1.28e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveqavRGLVL 88
Cdd:COG0513 4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAP------QALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:COG0513 78 APTRELALQVAEELRKLAKYL--GLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDL-SGVETLVLDEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPgPDQLQQFQVVCEtEEDKFLLL 248
Cdd:COG0513 155 DRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENAT-AETIEQRYYLVD-KRDKLELL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 249 YALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATD-Aevlgapvkgk 327
Cdd:COG0513 233 RRLLRDEDP-ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDvA---------- 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20139238 328 rrgrgpkgdkasdpeagvARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELL 404
Cdd:COG0513 302 ------------------ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLI 360
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
18-219 |
1.17e-68 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 219.62 E-value: 1.17e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveQAVRGLVLVPTKELARQ 97
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKG---RGPQALVLAPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 98 AQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFE 177
Cdd:cd00268 78 IAEVARKLGKGT--GLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDL-SNVKYLVLDEADRMLDMGFE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 20139238 178 EELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd00268 155 EDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
9-401 |
1.22e-65 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 219.81 E-value: 1.22e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLH--RKATGPvveqaVRGL 86
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDfpRRKSGP-----PRIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATYCARDvrVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVD 166
Cdd:PRK11192 78 ILTPTRELAMQVADQARELAKHTHLD--IATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCR-AVETLILD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 167 EADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFN-EDVQALKELILHNPVTLklqESQLPGPDQ--LQQFQVVCETEED 243
Cdd:PRK11192 155 EADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEV---EAEPSRRERkkIHQWYYRADDLEH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 244 KFLLLYALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgap 323
Cdd:PRK11192 232 KTALLCHLLKQPEV-TRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDV------ 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 324 vkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK11192 305 ---------------------AARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
18-216 |
8.51e-62 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 201.71 E-value: 8.51e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPvveqAVRGLVLVPTKELARQ 97
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKA----ATRVLVLVPTRELAMQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 98 AQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD-SLKLrDSLELLVVDEADLLFSFGF 176
Cdd:cd17947 77 CFSVLQQLAQFT--DITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSpSFDL-DSIEILVLDEADRMLEEGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 20139238 177 EEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17947 154 ADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
9-407 |
3.40e-58 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 200.41 E-value: 3.40e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgpvveqAVRGLVL 88
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRF-------RVQALVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYcARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:PRK11776 79 CPTRELADQVAKEIRRLARF-IPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDL-DALNTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQlpgpDQLQQFQVVCETEEDKFLLL 248
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH----DLPAIEQRFYEVSPDERLPA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 249 YALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkr 328
Cdd:PRK11776 233 LQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDV----------- 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 329 rgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGE 407
Cdd:PRK11776 302 ----------------AARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRK 364
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
9-219 |
6.53e-58 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 191.76 E-value: 6.53e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveQAVRGLVL 88
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENP-------QRFFALVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCArdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD---SLKlrdSLELLVV 165
Cdd:cd17954 75 APTRELAQQISEQFEALGSSIG--LKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTkgfSLK---SLKFLVM 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 20139238 166 DEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17954 150 DEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
8-219 |
2.30e-56 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 187.90 E-value: 2.30e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrKATGPVVeqAVRGLV 87
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKL---KAHSPTV--GARALI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 88 LVPTKELARQAQSMIQQLAtyCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDE 167
Cdd:cd17959 77 LSPTRELALQTLKVTKELG--KFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLS-SVEYVVFDE 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 20139238 168 ADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17959 154 ADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
7-407 |
3.10e-52 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 184.63 E-value: 3.10e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgPVVEQAVRGL 86
Cdd:PRK10590 1 MSFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPH-AKGRRPVRAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVD 166
Cdd:PRK10590 80 ILTPTRELAAQIGENVRDYSKYL--NIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKL-DQVEILVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 167 EADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGpDQLQQFqvVCETEEDKFL 246
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTAS-EQVTQH--VHFVDKKRKR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 247 LLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkg 326
Cdd:PRK10590 234 ELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDI--------- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 327 krrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSG 406
Cdd:PRK10590 305 ------------------AARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKK 366
|
.
gi 20139238 407 E 407
Cdd:PRK10590 367 E 367
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
9-401 |
3.76e-49 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 174.63 E-value: 3.76e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveQAVRGLVL 88
Cdd:PTZ00424 30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDL-------NACQALIL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCarDVR----VANVSAAEDSvsqrAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLV 164
Cdd:PTZ00424 103 APTRELAQQIQKVVLALGDYL--KVRchacVGGTVVRDDI----NKLKAGVHMVVGTPGRVYDMIDKRHLRV-DDLKLFI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 165 VDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL--KLQESQLPGpdqLQQFQVVCETEE 242
Cdd:PTZ00424 176 LDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRIlvKKDELTLEG---IRQFYVAVEKEE 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 243 DKFLLLYALLKLSLIRgKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlga 322
Cdd:PTZ00424 253 WKFDTLCDLYETLTIT-QAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDL----- 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 323 pvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PTZ00424 327 ----------------------LARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIE 383
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
8-404 |
9.81e-48 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 172.79 E-value: 9.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatgPVVEQAVRG-- 85
Cdd:PRK01297 88 RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQT----PPPKERYMGep 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 86 --LVLVPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEK-PDVVVGTPSRILSHLQQDSLKLrDSLEL 162
Cdd:PRK01297 164 raLIIAPTRELVVQIAKDAAALTKYT--GLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHL-DMVEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 163 LVVDEADLLFSFGFEEELKSLLCHLPRI--YQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVceT 240
Cdd:PRK01297 241 MVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAV--A 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 241 EEDKFLLLYALLKLSLIrGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevl 320
Cdd:PRK01297 319 GSDKYKLLYNLVTQNPW-ERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDV--- 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 321 gapvkgkrrgrgpkgdkasdpeAGvaRGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKI 400
Cdd:PRK01297 395 ----------------------AG--RGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEI 450
|
....
gi 20139238 401 EELL 404
Cdd:PRK01297 451 EELL 454
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
18-218 |
2.26e-47 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 163.53 E-value: 2.26e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQ-LLLHRKATGpvveqaVRGLVLVPTKELAR 96
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQkLGKPRKKKG------LRALILAPTRELAS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 97 QAQSMIQQLATycARDVRVANVS-AAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFSFG 175
Cdd:cd17957 75 QIYRELLKLSK--GTGLRIVLLSkSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLS-SVEYLVLDEADKLFEPG 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 20139238 176 FEEELKSLL--CHLPRIyQAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17957 152 FREQTDEILaaCTNPNL-QRSLFSATIPSEVEELARSVMKDPIRI 195
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
9-401 |
3.17e-46 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 171.57 E-value: 3.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatGPVVeQAVRGLVL 88
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL------DPEL-KAPQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYcARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:PRK11634 81 APTRELAVQVAEAMTDFSKH-MRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDL-SKLSGLVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKflll 248
Cdd:PRK11634 159 DEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNE---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 249 yallklSLIR-------GKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlg 321
Cdd:PRK11634 235 ------ALVRfleaedfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDV---- 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 322 apvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK11634 305 -----------------------AARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIE 361
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
9-216 |
5.62e-46 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 160.16 E-value: 5.62e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatgPVVEQAVRGLVL 88
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-------DPKKDVIQALIL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:cd17940 74 VPTRELALQTSQVCKELGKHM--GVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADL-SHCKTLVLDEA 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 20139238 169 DLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17940 151 DKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
31-207 |
1.17e-45 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 157.79 E-value: 1.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 31 TLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgpvveqAVRGLVLVPTKELARQaqsMIQQLATYCA 110
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN-------GPQALVLAPTRELAEQ---IYEELKKLGK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 111 -RDVRVANVSAAEDSVSQRAVLmEKPDVVVGTPSRILSHLQQDslKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPR 189
Cdd:pfam00270 71 gLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPK 147
|
170
....*....|....*...
gi 20139238 190 IYQAFLMSATFNEDVQAL 207
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
9-216 |
4.34e-44 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 155.17 E-value: 4.34e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLllhrkatgpvveqaVRGLVL 88
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQI--------------VVALIL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCAR-DVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDE 167
Cdd:cd17938 67 EPSRELAEQTYNCIENFKKYLDNpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLS-SVRFFVLDE 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 168 ADLLFSFGFEEELKSLLCHLPRI------YQAFLMSATF-NEDVQALKELILHNPV 216
Cdd:cd17938 146 ADRLLSQGNLETINRIYNRIPKItsdgkrLQVIVCSATLhSFEVKKLADKIMHFPT 201
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
9-216 |
5.42e-44 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 154.69 E-value: 5.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkATGPVveqAVRGLVL 88
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL----SEDPY---GIFALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATycARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQD-----SLKLrdsLELL 163
Cdd:cd17955 74 TPTRELAYQIAEQFRALGA--PLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddttkVLSR---VKFL 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 20139238 164 VVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17955 149 VLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
18-219 |
5.17e-43 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 151.96 E-value: 5.17e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKAtgPVVEQAVRGLVLVPTKELARQ 97
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKA--NLKKGQVGALIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 98 AQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLME-KPDVVVGTPSRILSHLQ--QDSLKLRdSLELLVVDEADLLFSF 174
Cdd:cd17960 79 IYEVLQSFLEHHLPKLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEELLSrkADKVKVK-SLEVLVLDEADRLLDL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
18-206 |
2.82e-40 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 145.84 E-value: 2.82e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLAL-EGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVE--QAVRGLVLVPTKEL 94
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGkqKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 95 ARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLR--DSLELLVVDEADLLF 172
Cdd:cd17946 81 AVQVKDHLKAIAKYT--NIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLAnlKSLRFLVLDEADRML 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 20139238 173 SFGFEEELKSLLCHLP-------RIYQAFLMSATFNEDVQA 206
Cdd:cd17946 159 EKGHFAELEKILELLNkdragkkRKRQTFVFSATLTLDHQL 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
22-227 |
7.52e-40 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 143.79 E-value: 7.52e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 22 VTDLGWSRPTLIQEKAIPLALEG-KDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQS 100
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGG--------RVLVLVPTRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 101 MIQQLATYCaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEEL 180
Cdd:smart00487 73 ELKKLGPSL-GLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSN-VDLVILDEAHRLLDGGFGDQL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 20139238 181 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPG 227
Cdd:smart00487 151 EKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
7-401 |
1.43e-39 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 152.03 E-value: 1.43e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGL 86
Cdd:PRK04537 9 LTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDPRAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLV 164
Cdd:PRK04537 89 ILAPTRELAIQ----IHKDAVKFGADlgLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 165 VDEADLLFSFGFEEELKSLLCHLPR--IYQAFLMSATFNEDVQALKELILHNPVTLkLQESQLPGPDQLQQfQVVCETEE 242
Cdd:PRK04537 165 LDEADRMFDLGFIKDIRFLLRRMPErgTRQTLLFSATLSHRVLELAYEHMNEPEKL-VVETETITAARVRQ-RIYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 243 DKFLLLYALLKLSLiRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlga 322
Cdd:PRK04537 243 EKQTLLLGLLSRSE-GARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDV----- 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 323 pvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIE 401
Cdd:PRK04537 317 ----------------------AARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIE 373
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
9-391 |
6.98e-39 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 149.54 E-value: 6.98e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPML-----QLLLhRKATGPVVeqav 83
Cdd:PTZ00110 132 FEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIvhinaQPLL-RYGDGPIV---- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 84 rgLVLVPTKELARQaqsmIQQLATYCARDVRVANvSAAEDSV---SQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSL 160
Cdd:PTZ00110 207 --LVLAPTRELAEQ----IREQCNKFGASSKIRN-TVAYGGVpkrGQIYALRRGVEILIACPGRLIDFLESNVTNLR-RV 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 161 ELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQAL-KELILHNPVTLKLQESQLPGPDQLQQFQVVCE 239
Cdd:PTZ00110 279 TYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLaRDLCKEEPVHVNVGSLDLTACHNIKQEVFVVE 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 240 TEEDKFLLLYALLKLSLIRGKSLLFVNT------LERSYRLRlfleqfSIPTCVLNGELPLRSRCHIISQFNQGFYDCVI 313
Cdd:PTZ00110 359 EHEKRGKLKMLLQRIMRDGDKILIFVETkkgadfLTKELRLD------GWPALCIHGDKKQEERTWVLNEFKTGKSPIMI 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 314 ATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLP 391
Cdd:PTZ00110 433 ATDV---------------------------ASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
12-216 |
1.75e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 139.77 E-value: 1.75e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 12 MGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLlhrkatgPVVEQAVRGLVLVPT 91
Cdd:cd17939 2 MGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRI-------DTTVRETQALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 92 KELARQAQSMIQQLATYCarDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLL 171
Cdd:cd17939 75 RELAQQIQKVVKALGDYM--GVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRT-DKIKMFVLDEADEM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 20139238 172 FSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17939 152 LSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
19-217 |
3.85e-38 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 138.96 E-value: 3.85e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 19 LQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvvEQAVRGLVLVPTKELARQA 98
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTP---EDGLGALIISPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 99 QSMIQQLATY----CARDVRVANVSAAEDSVSQRAVLmekpdvvVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSF 174
Cdd:cd17941 79 FEVLRKVGKYhsfsAGLIIGGKDVKEEKERINRMNIL-------VCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVT 217
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEY 194
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
9-402 |
1.53e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 143.57 E-value: 1.53e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQ-LLLHRKATGPVVEQAvRGLV 87
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHyLLSHPAPEDRKVNQP-RALI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 88 LVPTKELARQAQSMIQQLATYCArdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDE 167
Cdd:PRK04837 89 MAPTRELAVQIHADAEPLAQATG--LKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINL-GAIQVVVLDE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 168 ADLLFSFGFEEELKSLLCHLPRIYQ--AFLMSATFNEDVQALKELILHNPVTLKLQESQLPG------------PDQLQQ 233
Cdd:PRK04837 166 ADRMFDLGFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGhrikeelfypsnEEKMRL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 234 FQVVCETEEDKflllyallklslirgKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVI 313
Cdd:PRK04837 246 LQTLIEEEWPD---------------RAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 314 ATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTE 393
Cdd:PRK04837 311 ATDV---------------------------AARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEY 363
|
....*....
gi 20139238 394 QFHLGKIEE 402
Cdd:PRK04837 364 ALNLPAIET 372
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
18-216 |
3.03e-37 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 136.39 E-value: 3.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKA----TGPVveqavrGLVLVPTKE 93
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRElekgEGPI------AVIVAPTRE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 94 LARQAQSMIQQLATYcaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFS 173
Cdd:cd17952 75 LAQQIYLEAKKFGKA--YNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQ-RVTYLVLDEADRMFD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17952 152 MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPI 194
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
22-219 |
3.63e-37 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 136.56 E-value: 3.63e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 22 VTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLL------HRkatgpvvEQAVRGLVLVPTKELA 95
Cdd:cd17949 6 KSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLsleprvDR-------SDGTLALVLVPTRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 96 RQAQSMIQQLaTYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQ-DSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd17949 79 LQIYEVLEKL-LKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDV-SNLRWLVLDEADRLLDM 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 175 GFEEELKSLLCHL-------------PRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17949 157 GFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
14-212 |
5.67e-37 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 136.17 E-value: 5.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALE-GKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVveQAVRGLVLVPTK 92
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRR--SGVSALIISPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 93 ELARQAQSMIQQLaTYCARDVRVAN-VSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLR-DSLELLVVDEADL 170
Cdd:cd17964 79 ELALQIAAEAKKL-LQGLRKLRVQSaVGGTSRRAELNRLRRGRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADR 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 20139238 171 LFSFGFEEELKSLLCHLPRIY----QAFLMSATFNEDVQALKELIL 212
Cdd:cd17964 158 LLDMGFRPDLEQILRHLPEKNadprQTLLFSATVPDEVQQIARLTL 203
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
231-389 |
1.40e-36 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 132.25 E-value: 1.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 231 LQQFQVVCEtEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYD 310
Cdd:cd18787 1 IKQLYVVVE-EEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVR 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 311 CVIATDaevlgapvkgkrrgrgpkgdkasdpeaGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:cd18787 80 VLVATD---------------------------VAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
14-219 |
1.29e-34 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 129.23 E-value: 1.29e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQLL-LHRKATgpvveQAvrgLVLVP 90
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVdPTLKSP-----QA---LCLAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 91 TKELARQAQSMIQQLATYCarDVRVA------NVSAAEDSVSQravlmekpdVVVGTPSRILSHLQQDSLKLRdSLELLV 164
Cdd:cd17963 73 TRELARQIGEVVEKMGKFT--GVKVAlavpgnDVPRGKKITAQ---------IVIGTPGTVLDWLKKRQLDLK-KIKILV 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 165 VDEAD-LLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd17963 141 LDEADvMLDTQGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
19-215 |
1.65e-33 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 126.32 E-value: 1.65e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 19 LQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLL-----LHRKATGpvveqavrGLVLVPTKE 93
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLyklkfKPRNGTG--------VIIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 94 LARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRavLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFS 173
Cdd:cd17942 74 LALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEK--LGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 20139238 174 FGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNP 215
Cdd:cd17942 152 IGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
18-218 |
4.55e-33 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 125.51 E-value: 4.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR-KATGPVVEQAVRGLVLVPTKELAR 96
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLpPLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 97 QAQSMIQQLATYcaRDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLLFSFGF 176
Cdd:cd17945 81 QIEEETQKFAKP--LGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLN-QCTYVVLDEADRMIDMGF 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20139238 177 EEELKSLLCHLP-------------------RIY-QAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17945 158 EPQVTKILDAMPvsnkkpdteeaeklaasgkHRYrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
9-216 |
5.31e-33 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 124.87 E-value: 5.31e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatgpvvEQAVRGLVL 88
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTS-------LKATQALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATYCArdvrvANVSAAEDSVSQRA---VLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVV 165
Cdd:cd18046 74 APTRELAQQIQKVVMALGDYMG-----IKCHACIGGTSVRDdaqKLQAGPHIVVGTPGRVFDMINRRYLRT-DYIKMFVL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 20139238 166 DEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
11-216 |
7.82e-32 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 122.49 E-value: 7.82e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 11 HMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRK----ATGPVveqavrGL 86
Cdd:cd17953 16 QCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRpvkpGEGPI------GL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATycARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD--SLELLV 164
Cdd:cd17953 90 IMAPTRELALQIYVECKKFSK--ALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVTNlrRVTYVV 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 20139238 165 VDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17953 168 LDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
7-389 |
1.01e-31 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 128.37 E-value: 1.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGL 86
Cdd:PLN00206 121 LSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRNPLAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATycARDVRVANVSAAeDSVSQRAVLMEKP-DVVVGTPSRILSHLQQDSLKLrDSLELLVV 165
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGK--GLPFKTALVVGG-DAMPQQLYRIQQGvELIVGTPGRLIDLLSKHDIEL-DNVSVLVL 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 166 DEADLLFSFGFEEELKSLLCHLPRIyQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGpDQLQQFQVVCETEEDKF 245
Cdd:PLN00206 277 DEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPN-KAVKQLAIWVETKQKKQ 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 246 LLLYALLKLSLIRGKSLLFVNTlersyRL--RLFLEQFSIPTCV----LNGELPLRSRCHIISQFNQGFYDCVIATDaeV 319
Cdd:PLN00206 355 KLFDILKSKQHFKPPAVVFVSS-----RLgaDLLANAITVVTGLkalsIHGEKSMKERREVMKSFLVGEVPVIVATG--V 427
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 320 LGapvkgkrrgrgpkgdkasdpeagvaRGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFV 389
Cdd:PLN00206 428 LG-------------------------RGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
9-214 |
1.38e-31 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 121.44 E-value: 1.38e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLL---------HRKATGPVV 79
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLedgppsvgrGRRKAYPSA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 80 eqavrgLVLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLr 157
Cdd:cd17967 82 ------LILAPTRELAIQ----IYEEARKFSYRsgVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISL- 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20139238 158 DSLELLVVDEADLLFSFGFEEELKSLLCH----LPRIYQAFLMSATFNEDVQALKELILHN 214
Cdd:cd17967 151 SSIKFLVLDEADRMLDMGFEPQIRKIVEHpdmpPKGERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
18-215 |
3.08e-30 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 118.12 E-value: 3.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSR---------PTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqAVRGLVL 88
Cdd:cd17956 1 LLKNLQNNGITSafpvqaaviPWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVP------RLRALIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 89 VPTKELARQAQSMIQQLATycARDVRVANVS--------AAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSL 160
Cdd:cd17956 75 VPTKELVQQVYKVFESLCK--GTGLKVVSLSgqksfkkeQKLLLVDTSGRYLSRVDILVATPGRLVDHLNSTPGFTLKHL 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20139238 161 ELLVVDEAD-------------LLFSFGFEEELK-------SLLCHLPRIYQAFLMSATFNEDVQALKELILHNP 215
Cdd:cd17956 153 RFLVIDEADrllnqsfqdwletVMKALGRPTAPDlgsfgdaNLLERSVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
18-216 |
4.36e-30 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 116.59 E-value: 4.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqaVRGLVLVPTKELARQ 97
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRH-------PQVLILAPTREIAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 98 AQSMIQQLATYCAR---DVRVANVSAAEDSVSqravlMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd17943 74 IHDVFKKIGKKLEGlkcEVFIGGTPVKEDKKK-----LKGCHIAVGTPGRIKQLIELGALNV-SHVRLFVLDEADKLMEG 147
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 20139238 175 GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17943 148 SFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPV 189
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
9-207 |
4.13e-29 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 115.83 E-value: 4.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVE--QAVRGL 86
Cdd:cd18052 45 FEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSevQEPQAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQaqsmIQQLATYCARD--VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLV 164
Cdd:cd18052 125 IVAPTRELANQ----IFLEARKFSYGtcIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISL-SKLKYLI 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 20139238 165 VDEADLLFSFGFEEELKSLL--CHLPR--IYQAFLMSATFNEDVQAL 207
Cdd:cd18052 200 LDEADRMLDMGFGPEIRKLVsePGMPSkeDRQTLMFSATFPEEIQRL 246
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
18-216 |
4.83e-29 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 113.62 E-value: 4.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPML-----QLLLhRKATGPVVeqavrgLVLVPTK 92
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhinaQPPL-ERGDGPIV------LVLAPTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 93 ELARQAQsmiQQLATYCAR-DVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLELLVVDEADLL 171
Cdd:cd17966 74 ELAQQIQ---QEANKFGGSsRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLR-RVTYLVLDEADRM 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 20139238 172 FSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17966 150 LDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
9-216 |
7.45e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 113.33 E-value: 7.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlllhrkatgpVVEQAVR---G 85
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQ----------CLDIQVRetqA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 86 LVLVPTKELARQAQSMIQQLATYcardvrvANVSA--------AEDSVSqraVLMEKPDVVVGTPSRILSHLQQDSLKLR 157
Cdd:cd18045 71 LILSPTRELAVQIQKVLLALGDY-------MNVQChaciggtsVGDDIR---KLDYGQHIVSGTPGRVFDMIRRRSLRTR 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 158 dSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd18045 141 -HIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPI 198
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
26-216 |
1.23e-28 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 112.64 E-value: 1.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 26 GWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlllhrKATGPVveQAVRGLVLVPTKELARQAQSMIQQL 105
Cdd:cd17962 9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVII-----RCLTEH--RNPSALILTPTRELAVQIEDQAKEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 106 ATYCARdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFEEELKSLLC 185
Cdd:cd17962 82 MKGLPP-MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVEL-DNIKIVVVDEADTMLKMGFQQQVLDILE 159
|
170 180 190
....*....|....*....|....*....|.
gi 20139238 186 HLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17962 160 NISHDHQTILVSATIPRGIEQLAGQLLQNPV 190
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
18-216 |
2.87e-27 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 108.71 E-value: 2.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIP-----MLQLLLHRKATGPVVeqavrgLVLVPTK 92
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgfihlDLQPIPREQRNGPGV------LVLTPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 93 ELARQAQSMIQQlatYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRiLSHLQQDSLKLRDSLELLVVDEADLLF 172
Cdd:cd17958 75 ELALQIEAECSK---YSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGR-LNDLQMNNVINLKSITYLVLDEADRML 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 20139238 173 SFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17958 151 DMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPM 194
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
8-216 |
1.17e-26 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 107.43 E-value: 1.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHrkatgpvVEQAVRGLV 87
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEP-------VDGQVSVLV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 88 LVPTKELARQAQSMIQQLATYcARDVRVA------NVSAAEDSVSQravlmEKPDVVVGTPSRILSHLQQDSLKLrDSLE 161
Cdd:cd17950 76 ICHTRELAFQISNEYERFSKY-MPNVKTAvffggvPIKKDIEVLKN-----KCPHIVVGTPGRILALVREKKLKL-SHVK 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 162 LLVVDEAD-LLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPV 216
Cdd:cd17950 149 HFVLDECDkMLEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
18-218 |
1.31e-26 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 107.04 E-value: 1.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQ-AVRGLVLVPTKELAR 96
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGeGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 97 QAQSMIQQLATYCARD----VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLF 172
Cdd:cd17951 81 QTHEVIEYYCKALQEGgypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINL-DICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 20139238 173 SFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL 218
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
18-188 |
3.01e-25 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 103.99 E-value: 3.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQ 97
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 98 AQSMIQQLATYCARDVRVanVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFE 177
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKV--ITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSL-EQLRHLVLDEADTLLDDSFN 157
|
170
....*....|.
gi 20139238 178 EELKSLLCHLP 188
Cdd:cd17948 158 EKLSHFLRRFP 168
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
27-214 |
7.55e-25 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 103.58 E-value: 7.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 27 WSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRkatGPVV------------EQAVRGLVLVPTKEL 94
Cdd:cd18051 41 YTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQ---GPGEslpsesgyygrrKQYPLALVLAPTREL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 95 ARQAQSMIQQLAtYCARdVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSF 174
Cdd:cd18051 118 ASQIYDEARKFA-YRSR-VRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGL-DYCKYLVLDEADRMLDM 194
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 20139238 175 GFEEELKSLL--CHLPR--IYQAFLMSATFNEDVQALKELILHN 214
Cdd:cd18051 195 GFEPQIRRIVeqDTMPPtgERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
9-225 |
7.77e-25 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 102.79 E-value: 7.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQlLLHRKATGPvveqavRGL 86
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLS-RVDALKLYP------QCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATYCArDVRVanVSAAEDSVSQRAVLMEKpDVVVGTPSRILSHLQQDSLKLRDSLELLVVD 166
Cdd:cd18048 93 CLSPTFELALQTGKVVEEMGKFCV-GIQV--IYAIRGNRPGKGTDIEA-QIVIGTPGTVLDWCFKLRLIDVTNISVFVLD 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 167 EADLLFSF-GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQL 225
Cdd:cd18048 169 EADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
7-220 |
1.03e-24 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 102.78 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 7 LGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR----KATGPVVeqa 82
Cdd:cd18049 24 LNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQpfleRGDGPIC--- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 83 vrgLVLVPTKELARQAQsmiQQLATYC-ARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSlE 161
Cdd:cd18049 101 ---LVLAPTRELAQQVQ---QVAAEYGrACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRC-T 173
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 162 LLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd18049 174 YLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
8-220 |
1.98e-22 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 97.00 E-value: 1.98e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 8 GFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHR----KATGPVVeqav 83
Cdd:cd18050 63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQpyleRGDGPIC---- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 84 rgLVLVPTKELARQaqsmIQQLATYCARDVRVAN--VSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRdSLE 161
Cdd:cd18050 139 --LVLAPTRELAQQ----VQQVADDYGKSSRLKStcIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLR-RCT 211
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 162 LLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKL 220
Cdd:cd18050 212 YLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
9-219 |
2.81e-21 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 92.09 E-value: 2.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 9 FEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEG--KDLLARARTGSGKTAAYAIPMLQlllhrkATGPVVEQAvRGL 86
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLS------QVEPANKYP-QCL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQAQSMIQQLATYCArdvRVANVSAAEDSVSQRAVLMeKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVD 166
Cdd:cd18047 76 CLSPTYELALQTGKVIEQMGKFYP---ELKLAYAVRGNKLERGQKI-SEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLD 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 20139238 167 EADLLFSF-GFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLK 219
Cdd:cd18047 152 EADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
33-184 |
8.74e-20 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 87.60 E-value: 8.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 33 IQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQlLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLatycARD 112
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIE-KLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFKDI----TRK 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20139238 113 VRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEADLLFSFGFEEELKSLL 184
Cdd:cd17944 91 LSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDL-TKLKHVVLDEVDQMLDMGFAEQVEEIL 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
44-199 |
6.11e-19 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 83.61 E-value: 6.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 44 GKDLLARARTGSGKTAAYAIPMLQLLLhrkatgpvvEQAVRGLVLVPTKELARQAQSMIQQLATycaRDVRVANVSAAED 123
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLL---------KKGKKVLVLVPTKALALQTAERLRELFG---PGIRVAVLVGGSS 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 124 SVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADlLFSFGFEEELKSLLCHLPRIY---QAFLMSAT 199
Cdd:cd00046 69 AEEREKNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAH-ALLIDSRGALILDLAVRKAGLknaQVILLSAT 146
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
259-380 |
3.31e-18 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 80.33 E-value: 3.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 259 GKSLLFVNTLERSYrLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdka 338
Cdd:pfam00271 16 GKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDV--------------------- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 20139238 339 sdpeagVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:pfam00271 74 ------AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
13-168 |
2.62e-16 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 82.19 E-value: 2.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 13 GLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHrkatgpvvEQAVRGLVLVPTK 92
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE--------DPGATALYLYPTK 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 93 ELAR-QAQSmIQQLATYCARDVRVANVsaaeD---SVSQRAVLMEKPDVVVGTP----SRILSHLQQDSLKLRdSLELLV 164
Cdd:COG1205 112 ALARdQLRR-LRELAEALGLGVRVATY----DgdtPPEERRWIREHPDIVLTNPdmlhYGLLPHHTRWARFFR-NLRYVV 185
|
....
gi 20139238 165 VDEA 168
Cdd:COG1205 186 IDEA 189
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
18-199 |
2.69e-16 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 78.57 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 18 LLQAVTDLGWSRPTLIQEKAIPLALegKDLLAR------------------ARTGSGKTAAYAIPMLQLLLH-----RKA 74
Cdd:cd17965 19 LKGSNKTDEEIKPSPIQTLAIKKLL--KTLMRKvtkqtsneepklevfllaAETGSGKTLAYLAPLLDYLKRqeqepFEE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 75 TGPVVEQA-----VRGLVLVPTKELARQAQSMIQQLATYCArdVRVANVSAA-EDSVSQRAVLMEKP-DVVVGTPSRILS 147
Cdd:cd17965 97 AEEEYESAkdtgrPRSVILVPTHELVEQVYSVLKKLSHTVK--LGIKTFSSGfGPSYQRLQLAFKGRiDILVTTPGKLAS 174
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 20139238 148 hLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSAT 199
Cdd:cd17965 175 -LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
273-380 |
7.01e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 72.63 E-value: 7.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 273 RLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAevlgapvkgkrrgrgpkgdkasdpeagVARGIDFH 352
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDV---------------------------AERGLDLP 54
|
90 100
....*....|....*....|....*...
gi 20139238 353 HVSAVLNFDLPPTPEAYIHRAGRTARAN 380
Cdd:smart00490 55 GVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
34-168 |
6.07e-12 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 64.53 E-value: 6.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQSMIQQLATYCARDV 113
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGS--------RALYLYPTKALAQDQLRSLRELLEQLGLGI 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 114 RVANVSAAEDSVSQRAVLMEKPDVVVGTPSR----ILSHLQQDSLKLRdSLELLVVDEA 168
Cdd:cd17923 77 RVATYDGDTPREERRAIIRNPPRILLTNPDMlhyaLLPHHDRWARFLR-NLRYVVLDEA 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
33-199 |
1.94e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 54.19 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 33 IQEKAI-PLALEGKDLLARARTGSGKT--AAYAIpmlqLLLHRKATGPVVeqavrglVLVPTKELARQ-AQSMIQQLATY 108
Cdd:cd17921 5 IQREALrALYLSGDSVLVSAPTSSGKTliAELAI----LRALATSGGKAV-------YIAPTRALVNQkEADLRERFGPL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 109 cardvrVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLfsfGFEEE---LKSLLC 185
Cdd:cd17921 74 ------GKNVGLLTGDPSVNKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLI---GDGERgvvLELLLS 144
|
170
....*....|....*..
gi 20139238 186 HLPRIYQAF---LMSAT 199
Cdd:cd17921 145 RLLRINKNArfvGLSAT 161
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
34-316 |
6.06e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 55.42 E-value: 6.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 34 QEKAI-----PLALEGKDLLARARTGSGKT--AAYAIpmLQLLLHRKAtgpvveqavrgLVLVPTKELARQAQSMIQQLa 106
Cdd:COG1061 85 QQEALeallaALERGGGRGLVVAPTGTGKTvlALALA--AELLRGKRV-----------LVLVPRRELLEQWAEELRRF- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 107 tycardVRVANVSAAEDSVSqravlmekPDVVVGTPSRILSHLQQDslKLRDSLELLVVDEADLLFSFGFEEelksLLCH 186
Cdd:COG1061 151 ------LGDPLAGGGKKDSD--------APITVATYQSLARRAHLD--ELGDRFGLVIIDEAHHAGAPSYRR----ILEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 187 LPRIYQaFLMSAT-FNEDVQALKELILHNPV---TLK-LQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRG-- 259
Cdd:COG1061 211 FPAAYR-LGLTATpFRSDGREILLFLFDGIVyeySLKeAIEDGYLAPPEYYGIRVDLTDERAEYDALSERLREALAADae 289
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20139238 260 -----------------KSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATD 316
Cdd:COG1061 290 rkdkilrellrehpddrKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVD 363
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
34-171 |
2.01e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 53.75 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 34 QEKAIPLAL-EGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveqavRGLVLVPTKELARQ-AQSMIQQLATYcar 111
Cdd:COG1204 27 QAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALLNGG----------KALYIVPLRALASEkYREFKRDFEEL--- 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 112 DVRVANVSAAEDSVSQRAvlmEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLL 171
Cdd:COG1204 94 GIKVGVSTGDYDSDDEWL---GRYDILVATPEKLDSLLRNGPSWLRD-VDLVVVDEAHLI 149
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
17-219 |
9.75e-07 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 49.46 E-value: 9.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 17 RLLQAVTDLGWSRPTliQEKAIPLALEGKDLLARARTGSGKTAAYAIPmlqLLLHRKATgpvveqavrgLVLVPTKELar 96
Cdd:cd17920 2 QILKEVFGYDEFRPG--QLEAINAVLAGRDVLVVMPTGGGKSLCYQLP---ALLLDGVT----------LVVSPLISL-- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 97 qAQSMIQQLAtycARDVRVANVSAAEDSVSQRAVLME----KPDVVVGTPSRILS-HLQQ--DSLKLRDSLELLVVDEAD 169
Cdd:cd17920 65 -MQDQVDRLQ---QLGIRAAALNSTLSPEEKREVLLRikngQYKLLYVTPERLLSpDFLEllQRLPERKRLALIVVDEAH 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 20139238 170 LLFSFGFE-----EELKSLLCHLPRIyQAFLMSATFNEDVQA--LKELILHNPVTLK 219
Cdd:cd17920 141 CVSQWGHDfrpdyLRLGRLRRALPGV-PILALTATATPEVREdiLKRLGLRNPVIFR 196
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
34-167 |
2.24e-06 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 48.63 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvveQAVRGLVLVPTKELARQAQSmiqQLATYCARDV 113
Cdd:cd18036 7 QLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAG----EKGRVVVLVNKVPLVEQQLE---KFFKYFRKGY 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 114 RVANVSAAEDSVSQRAVLMEKPDVVVGTP----SRILSHLQQDSLKLRDsLELLVVDE 167
Cdd:cd18036 80 KVTGLSGDSSHKVSFGQIVKASDVIICTPqiliNNLLSGREEERVYLSD-FSLLIFDE 136
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
41-199 |
9.12e-06 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 48.66 E-value: 9.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 41 ALEGKDLLARARTGSGKTAAYAIPMLQLLLhrkatgpvvEQAVRGLVLVPTKELARQAqsmIQQLATYCARDVRVANVSA 120
Cdd:PRK00254 36 VLEGKNLVLAIPTASGKTLVAEIVMVNKLL---------REGGKAVYLVPLKALAEEK---YREFKDWEKLGLRVAMTTG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139238 121 AEDSVSQravLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSAT 199
Cdd:PRK00254 104 DYDSTDE---WLGKYDIIIATAEKFDSLLRHGSSWIKD-VKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSAT 178
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
53-200 |
2.76e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 44.22 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 53 TGSGKTaayaIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQaqsMIQQLATYCARDVRVANVSAAEDSVSQRavlm 132
Cdd:cd17926 27 TGSGKT----LTALALIAYLKEL--------RTLIVVPTDALLDQ---WKERFEDFLGDSSIGLIGGGKKKDFDDA---- 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 133 ekpDVVVGTPSrILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEELKSLLCHlpriYQAFLmSATF 200
Cdd:cd17926 88 ---NVVVATYQ-SLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTFSEILKELNAK----YRLGL-TATP 146
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
33-171 |
5.06e-05 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 44.65 E-value: 5.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 33 IQEKAIPLALEG-KDLLARARTGSGKTAAYAIPMLQLLlhrKATGPVVEQAVRGLVLVPTKELARqaqsmiQQLATYCAR 111
Cdd:cd18023 5 IQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAILRLL---KERNPLPWGNRKVVYIAPIKALCS------EKYDDWKEK 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20139238 112 DVRVaNVSAAE---DSVSQRAVLMEKPDVVVGTPSRI--LSHLQQDSLKLRDSLELLVVDEADLL 171
Cdd:cd18023 76 FGPL-GLSCAEltgDTEMDDTFEIQDADIILTTPEKWdsMTRRWRDNGNLVQLVALVLIDEVHII 139
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
42-199 |
6.28e-05 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 43.86 E-value: 6.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 42 LEGKDLLARARTGSGKTAAYAIPMLQLLLHRKatgpvveqavRGLVLVPTKELARQAqsmIQQLATYCARDVRVANVSAA 121
Cdd:cd18028 15 LKGENLLISIPTASGKTLIAEMAMVNTLLEGG----------KALYLVPLRALASEK---YEEFKKLEEIGLKVGISTGD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 122 EDSvsqRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDsLELLVVDEADLLFSFGFEEELKSLLCHLPRIY---QAFLMSA 198
Cdd:cd18028 82 YDE---DDEWLGDYDIIVATYEKFDSLLRHSPSWLRD-VGVVVVDEIHLISDEERGPTLESIVARLRRLNpntQIIGLSA 157
|
.
gi 20139238 199 T 199
Cdd:cd18028 158 T 158
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
45-168 |
6.68e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 44.18 E-value: 6.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 45 KDLLARARTGSGKT--AAYAI-PMLQLLLHRKATGPVVeqavrgLVLVPTKELARQaQSMiqQLATYCarDVRVANVSAA 121
Cdd:cd18034 17 RNTIVVLPTGSGKTliAVMLIkEMGELNRKEKNPKKRA------VFLVPTVPLVAQ-QAE--AIRSHT--DLKVGEYSGE 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 20139238 122 EDSVSQRAV----LMEKPDVVVGTPSRILSHLQQDSLKLrDSLELLVVDEA 168
Cdd:cd18034 86 MGVDKWTKErwkeELEKYDVLVMTAQILLDALRHGFLSL-SDINLLIFDEC 135
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
53-168 |
7.60e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 43.43 E-value: 7.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 53 TGSGKTAAYAIPMLQLLLHRKATgpvveqavRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRavlm 132
Cdd:pfam04851 32 TGSGKTLTAAKLIARLFKKGPIK--------KVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKDESVDDN---- 99
|
90 100 110
....*....|....*....|....*....|....*..
gi 20139238 133 ekpDVVVGTPSRILSHLQQDSLKL-RDSLELLVVDEA 168
Cdd:pfam04851 100 ---KIVVTTIQSLYKALELASLELlPDFFDVIIIDEA 133
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
27-167 |
9.11e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 45.48 E-value: 9.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 27 WSRPTLIQEKAIPLALEGKDLLARARTGSGKT-AAYAIPMLQLLLHRKATGPvvEQAVRGLVLVPTKELA-------RQA 98
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAFLPALDELARRPRPGEL--PDGLRVLYISPLKALAndiernlRAP 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 99 QSMIQQLATYCARDVRVAnV-----SAAEdsvsqRAVLMEK-PDVVVGTP---SRILShlQQDSLKLRDSLELLVVDE 167
Cdd:COG1201 100 LEEIGEAAGLPLPEIRVG-VrtgdtPASE-----RQRQRRRpPHILITTPeslALLLT--SPDARELLRGVRTVIVDE 169
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
347-389 |
2.28e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.99 E-value: 2.28e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 20139238 347 RGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANN-PGIVLTFV 389
Cdd:cd18785 34 EGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKdEGEVILFV 77
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
44-167 |
2.87e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 41.80 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 44 GKDLLARARTGSGKTAAYAIPMLQLLLHRKATGpvveqaVRGLVLVPTKELARQAQSMIQQLATYCARDVRVAnVSAAED 123
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKG------VQVLYISPLKALINDQERRLEEPLDEIDLEIPVA-VRHGDT 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 20139238 124 SVSQRAVLMEK-PDVVVGTP---SRILSHLQQDSLkLRDsLELLVVDE 167
Cdd:cd17922 74 SQSEKAKQLKNpPGILITTPeslELLLVNKKLREL-FAG-LRYVVVDE 119
|
|
| DEXHc_TRCF |
cd17991 |
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
87-183 |
3.17e-04 |
|
DEXH/Q-box helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350749 [Multi-domain] Cd Length: 193 Bit Score: 41.79 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 87 VLVPTKELARQ-AQSMIQQLATYcarDVRVANVSAAEDSVSQRAVLME----KPDVVVGTpSRILShlqqDSLKLRDsLE 161
Cdd:cd17991 69 VLVPTTLLAQQhYETFKERFANF---PVNVELLSRFTTAAEQREILEGlkegKVDIVIGT-HRLLS----KDVEFKN-LG 139
|
90 100
....*....|....*....|....
gi 20139238 162 LLVVDEADLlfsFGFE--EELKSL 183
Cdd:cd17991 140 LLIIDEEQR---FGVKqkEKLKEL 160
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
29-167 |
5.42e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 41.25 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 29 RPTLIQEKAI---------PLALegkDLLARARTGSGKTAAYAIPMLQlllhrkatgpVVEQAVRGLVLVPTKELARQaq 99
Cdd:cd17918 15 SLTKDQAQAIkdiekdlhsPEPM---DRLLSGDVGSGKTLVALGAALL----------AYKNGKQVAILVPTEILAHQ-- 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139238 100 sMIQQLATYCArDVRVANVSAAedsvsQRAVLMEKPDVVVGTPSRIlshlQQDSLKLrdSLELLVVDE 167
Cdd:cd17918 80 -HYEEARKFLP-FINVELVTGG-----TKAQILSGISLLVGTHALL----HLDVKFK--NLDLVIVDE 134
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
34-168 |
5.56e-04 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 41.47 E-value: 5.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 34 QEKAIPLALEGKDLLARARTGSGKTAAYAIPmlQLLLHRKATGPvveqavrGLVLVPTKELAR-QAQSMIQQLATYCARd 112
Cdd:cd18018 17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLP--ALLLRRRGPGL-------TLVVSPLIALMKdQVDALPRAIKAAALN- 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 20139238 113 vrvANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEA 168
Cdd:cd18018 87 ---SSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLRQTPPISLLVVDEA 139
|
|
| DEXHc_RecG |
cd17992 |
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ... |
54-167 |
3.73e-03 |
|
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350750 [Multi-domain] Cd Length: 225 Bit Score: 39.05 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139238 54 GSGKTAAYAIPMLQlllhrkatgpVVEQAVRGLVLVPTKELARQ-AQSMIQQLATYcarDVRVA----NVSAAEdsvsQR 128
Cdd:cd17992 76 GSGKTVVAALAMLA----------AVENGYQVALMAPTEILAEQhYDSLKKLLEPL---GIRVAlltgSTKAKE----KR 138
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 20139238 129 AVLME----KPDVVVGTpsrilsH-LQQDSLKLRDsLELLVVDE 167
Cdd:cd17992 139 EILEKiasgEIDIVIGT------HaLIQEDVEFHN-LGLVIIDE 175
|
|
| |
