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Conserved domains on  [gi|20137527|sp|Q9NRG9|]
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RecName: Full=Aladin; AltName: Full=Adracalin

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 1.88e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASS-TIVPSLKHRlQRNVASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 237 QVLshPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
Cdd:COG2319 198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190
                ....*....|....*....|....*....|
gi 20137527 316 AQMWTCERWPT-LSGRCQTGCWSPDGSRLL 344
Cdd:COG2319 275 LATGELLRTLTgHSGGVNSVAFSPDGKLLA 304
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 1.88e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASS-TIVPSLKHRlQRNVASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 237 QVLshPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
Cdd:COG2319 198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190
                ....*....|....*....|....*....|
gi 20137527 316 AQMWTCERWPT-LSGRCQTGCWSPDGSRLL 344
Cdd:COG2319 275 LATGELLRTLTgHSGGVNSVAFSPDGKLLA 304
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-343 4.61e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 4.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 133 SLRSEDLIAEFAQVTNWSSCClrvfAWHPHTNKFAVALLDDSVRVYN-ASSTIVPSLK-HrlQRNVASLAWKPlSASVLA 210
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSV----AFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRgH--TDWVNSVAFSP-DGTFVA 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 211 VACQ-SCILIWtlDPTSLStrpssgCAQVLShpGHT-PVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGG 288
Cdd:cd00200 152 SSSQdGTIKLW--DLRTGK------CVATLT--GHTgEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20137527 289 GVTNLLWSPDGSKILATTPSAVFRVWeaQMWTCERWPTLSG---RCQTGCWSPDGSRL 343
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGhtnSVTSLAWSPDGKRL 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 20137527    237 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 4.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20137527   237 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 1.88e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASS-TIVPSLKHRlQRNVASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 237 QVLshPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
Cdd:COG2319 198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190
                ....*....|....*....|....*....|
gi 20137527 316 AQMWTCERWPT-LSGRCQTGCWSPDGSRLL 344
Cdd:COG2319 275 LATGELLRTLTgHSGGVNSVAFSPDGKLLA 304
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-343 4.61e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 4.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 133 SLRSEDLIAEFAQVTNWSSCClrvfAWHPHTNKFAVALLDDSVRVYN-ASSTIVPSLK-HrlQRNVASLAWKPlSASVLA 210
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSV----AFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRgH--TDWVNSVAFSP-DGTFVA 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 211 VACQ-SCILIWtlDPTSLStrpssgCAQVLShpGHT-PVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGG 288
Cdd:cd00200 152 SSSQdGTIKLW--DLRTGK------CVATLT--GHTgEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLRGHEN 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20137527 289 GVTNLLWSPDGSKILATTPSAVFRVWeaQMWTCERWPTLSG---RCQTGCWSPDGSRL 343
Cdd:cd00200 221 GVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGhtnSVTSLAWSPDGKRL 276
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 1.49e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 1.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPlSASVLAVACQSC-ILIWTLDPTSlstrpssgCA 236
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE--------LL 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 237 QVLSHPGHtPVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
Cdd:COG2319 282 RTLTGHSG-GVNSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                       170       180       190
                ....*....|....*....|....*....|.
gi 20137527 317 QmwTCERWPTLSG---RCQTGCWSPDGSRLL 344
Cdd:COG2319 360 A--TGELLRTLTGhtgAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-346 2.54e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 155 RVFAWHPHTNKFAVALLDDSVRVYNASSTivpSLKHRLQ---RNVASLAWKPLSASVLAVACQSCILIWTLDptslstrp 231
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKghtGPVRDVAASADGTYLASGSSDKTIRLWDLE-------- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 232 SSGCAQVLShpGHT-PVTSLAWAPSGgRLLSASPVDAAIRVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKILATTPS 308
Cdd:cd00200  82 TGECVRTLT--GHTsYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQD 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 20137527 309 AVFRVWEAQMWTCERwpTLSG---RCQTGCWSPDGSRLLFT 346
Cdd:cd00200 157 GTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSS 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-315 2.90e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 2.90e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527  79 RCINIWrDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRWASSLHgsLFphlSLRSEDLIAEFAQVTNWSSCClrvfA 158
Cdd:cd00200  73 KTIRLW-DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK--VW---DVETGKCLTTLRGHTDWVNSV----A 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 159 WHPhTNKF-AVALLDDSVRVYNASStivPSLKHRL---QRNVASLAWKPLSASVLAVACQSCILIWTLDPTSlstrpssg 234
Cdd:cd00200 143 FSP-DGTFvASSSQDGTIKLWDLRT---GKCVATLtghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-------- 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 235 CAQVLShpGHT-PVTSLAWAPSGgRLLSASPVDAAIRVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKILATTPSAVF 311
Cdd:cd00200 211 CLGTLR--GHEnGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT--LSGhtNSVTSLAWSPDGKRLASGSADGTI 285


                ....
gi 20137527 312 RVWE 315
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
158-317 6.47e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPlSASVLAVACQSC-ILIWTLDPTSLstrpssgca 236
Cdd:COG2319 253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGtVRLWDLATGKL--------- 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 237 qVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
Cdd:COG2319 323 -LRTLTGHTgAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ..
gi 20137527 316 AQ 317
Cdd:COG2319 401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
167-343 9.98e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 9.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 167 AVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPssgcaqvlsHPGHTP 246
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---------LGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 247 VTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERwpT 326
Cdd:COG2319  81 VLSVAFSPDGRLLASASA-DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR--T 157

                       170       180
                ....*....|....*....|
gi 20137527 327 LSG---RCQTGCWSPDGSRL 343
Cdd:COG2319 158 LTGhsgAVTSVAFSPDGKLL 177
WD40 COG2319
WD40 repeat [General function prediction only];
158-276 4.63e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 4.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 158 AWHPHTNKFAVALLDDSVRVYNASS-TIVPSLKHRLQRnVASLAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319 295 AFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLA--------TGELL 365

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20137527 237 QVLShpGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWDVST 276
Cdd:COG2319 366 RTLT--GHTgAVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 243-346 2.13e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 2.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 243 GHT-PVTSLAWAPSGGRLLSASPvDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC 321
Cdd:cd00200   7 GHTgGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100
                ....*....|....*....|....*...
gi 20137527 322 ERwpTLSGRCQ---TGCWSPDGsRLLFT 346
Cdd:cd00200  86 VR--TLTGHTSyvsSVAFSPDG-RILSS 110
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 219-359 3.49e-07

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 50.06  E-value: 3.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20137527 219 IWTLDPTSLSTRpssgcaQVLSHPGHtpVTSLAWAPSGGRLL--SASPVDAAIRVWDVSTETCVPLpWFRGGGVTNLLWS 296
Cdd:COG0823  13 IYVVDLDGGEPR------RLTNSPGI--DTSPAWSPDGRRIAftSDRGGGPQIYVVDADGGEPRRL-TFGGGYNASPSWS 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20137527 297 PDGSKIL-ATTPSAVFRVW--------EAQMWTCERWPTlsgrcqtgcWSPDGSRLLFT--VLGEPLIYSLSFP 359
Cdd:COG0823  84 PDGKRLAfVSRSDGRFDIYvldldggaPRRLTDGPGSPS---------WSPDGRRIVFSsdRGGRPDLYVVDLD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.41e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.41e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 20137527    237 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 4.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 20137527   237 QVLSHPGHT-PVTSLAWAPSGGRLLSASpVDAAIRVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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