|
Name |
Accession |
Description |
Interval |
E-value |
| LysR |
COG0583 |
DNA-binding transcriptional regulator, LysR family [Transcription]; |
92-382 |
1.19e-42 |
|
DNA-binding transcriptional regulator, LysR family [Transcription];
Pssm-ID: 440348 [Multi-domain] Cd Length: 256 Bit Score: 149.63 E-value: 1.19e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFG 171
Cdd:COG0583 3 LRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAEL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 172 RQLASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDASRYDFEQMEICK 251
Cdd:COG0583 83 RALRGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGPPPDPGLVARPLGE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 252 VQLVPVVAPGflsfaptpetrhdalrsltqcvirdtarqpgtenHFLIEGAPQCSapDMAMKKELILNRLAWGHLPDFMV 331
Cdd:COG0583 163 ERLVLVASPD----------------------------------HPLARRAPLVN--SLEALLAAVAAGLGIALLPRFLA 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1995569479 332 EQEVRSGTLLNLQGRHLPGRREtLAVMRHRNKPHGPVAEALWRWIRDQLRS 382
Cdd:COG0583 207 ADELAAGRLVALPLPDPPPPRP-LYLVWRRRRHLSPAVRAFLDFLREALAE 256
|
|
| HTH_1 |
pfam00126 |
Bacterial regulatory helix-turn-helix protein, lysR family; |
92-151 |
6.72e-17 |
|
Bacterial regulatory helix-turn-helix protein, lysR family;
Pssm-ID: 459683 [Multi-domain] Cd Length: 60 Bit Score: 74.34 E-value: 6.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGR 151
Cdd:pfam00126 1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
|
|
| PRK10094 |
PRK10094 |
HTH-type transcriptional activator AllS; |
95-352 |
8.64e-14 |
|
HTH-type transcriptional activator AllS;
Pssm-ID: 182237 [Multi-domain] Cd Length: 308 Bit Score: 71.38 E-value: 8.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFGRQL 174
Cdd:PRK10094 7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQQV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 175 ASGEEAILRVVLGDLCPRPMILGA-LSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHrVDASRYDFEQMEIC--- 250
Cdd:PRK10094 87 NDGVERQVNIVINNLLYNPQAVAQlLAWLNERYPFTQFHISRQIYMGVWDSLLYEGFSLAIG-VTGTEALANTFSLDplg 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 251 KVQLVPVVAPGF-LSFAPTPETrHDALRSLTQCVIRDTARQPGTENHFLIEGAPQCSAPDMAMKKELILNRLAWGHLPDF 329
Cdd:PRK10094 166 SVQWRFVMAADHpLANVEEPLT-EAQLRRFPAVNIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFLPKS 244
|
250 260
....*....|....*....|...
gi 1995569479 330 MVEQEVRSGTLLnlqGRHLPGRR 352
Cdd:PRK10094 245 LCQSMIDNQQLV---SRVIPTMR 264
|
|
| PBP2_HupR |
cd08431 |
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which ... |
182-345 |
1.31e-08 |
|
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; HupR, a member of the LysR family, activates hupA transcription under low-iron conditions in the presence of hemin. The expression of many iron-uptake genes, such as hupA, is regulated at the transcriptional level by iron and an iron-binding repressor protein called Fur (ferric uptake regulation). Under iron-abundant conditions with heme, the active Fur repressor protein represses transcription of the iron-uptake gene hupA, and prevents transcriptional activation via HupR. Under low-iron conditions with heme, the Fur repressor is inactive and transcription of the hupA is allowed. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Pssm-ID: 176122 [Multi-domain] Cd Length: 195 Bit Score: 54.20 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 182 LRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLII-HRVDASRYDFEQMEICKVQLVPVVAP 260
Cdd:cd08431 2 LRIAIDTVLPLQPLYPLIAEFYQLNKATRIRLSEEVLGGTWDALASGRADLVIgATGELPPGGVKTRPLGEVEFVFAVAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 261 GF-LSFAPTPETRhDALRSLTQCVIRDTARQPGTENHFLIEGAPQCSAPDMAMKKELILNRLAWGHLPDFMVEQEVRSGT 339
Cdd:cd08431 82 NHpLAKLDGPLDA-SAIKQYPAIVVADTSRNLPPRSSGLLEGQDRIRVPTMQAKIDAQVLGLGVGYLPRHLAKPELASGE 160
|
....*.
gi 1995569479 340 LLNLQG 345
Cdd:cd08431 161 LVEKAL 166
|
|
| decaheme_TF |
NF041036 |
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, ... |
95-152 |
1.35e-06 |
|
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, including founding member GSU2202 from Geobacter sulfurreducens PCA, are LysR family transcriptional regulators found regularly in the vicinity of multiheme cytochromes such as GSU2203, a decaheme c-type cytochrome.
Pssm-ID: 468965 [Multi-domain] Cd Length: 301 Bit Score: 49.74 E-value: 1.35e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRA 152
Cdd:NF041036 6 LKTLVIVAEEGSFSKAAEKLHLTQSAVSQRIKFLEECYGYQLFDRSGPSLEPTAAGEM 63
|
|
| HTH_MARR |
smart00347 |
helix_turn_helix multiple antibiotic resistance protein; |
94-157 |
9.36e-03 |
|
helix_turn_helix multiple antibiotic resistance protein;
Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 35.26 E-value: 9.36e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995569479 94 ELRCLDAVARFG--SFQSAADALHRSHPSVFASVARLEANlGL-----KLLDRSGYRVELTDAGRAFHARA 157
Cdd:smart00347 12 QFLVLRILYEEGplSVSELAKRLGVSPSTVTRVLDRLEKK-GLvrrepSPEDRRSVLVSLTEEGRELIEQL 81
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LysR |
COG0583 |
DNA-binding transcriptional regulator, LysR family [Transcription]; |
92-382 |
1.19e-42 |
|
DNA-binding transcriptional regulator, LysR family [Transcription];
Pssm-ID: 440348 [Multi-domain] Cd Length: 256 Bit Score: 149.63 E-value: 1.19e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFG 171
Cdd:COG0583 3 LRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAEL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 172 RQLASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDASRYDFEQMEICK 251
Cdd:COG0583 83 RALRGGPRGTLRIGAPPSLARYLLPPLLARFRARHPGVRLELREGNSDRLVDALLEGELDLAIRLGPPPDPGLVARPLGE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 252 VQLVPVVAPGflsfaptpetrhdalrsltqcvirdtarqpgtenHFLIEGAPQCSapDMAMKKELILNRLAWGHLPDFMV 331
Cdd:COG0583 163 ERLVLVASPD----------------------------------HPLARRAPLVN--SLEALLAAVAAGLGIALLPRFLA 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1995569479 332 EQEVRSGTLLNLQGRHLPGRREtLAVMRHRNKPHGPVAEALWRWIRDQLRS 382
Cdd:COG0583 207 ADELAAGRLVALPLPDPPPPRP-LYLVWRRRRHLSPAVRAFLDFLREALAE 256
|
|
| HTH_1 |
pfam00126 |
Bacterial regulatory helix-turn-helix protein, lysR family; |
92-151 |
6.72e-17 |
|
Bacterial regulatory helix-turn-helix protein, lysR family;
Pssm-ID: 459683 [Multi-domain] Cd Length: 60 Bit Score: 74.34 E-value: 6.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGR 151
Cdd:pfam00126 1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
|
|
| LysR_substrate |
pfam03466 |
LysR substrate binding domain; The structure of this domain is known and is similar to the ... |
182-381 |
1.97e-16 |
|
LysR substrate binding domain; The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460931 [Multi-domain] Cd Length: 205 Bit Score: 77.33 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 182 LRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDASRYDFEQMEICKVQLVPVVAPG 261
Cdd:pfam03466 4 LRIGAPPTLASYLLPPLLARFRERYPDVELELTEGNSEELLDLLLEGELDLAIRRGPPDDPGLEARPLGEEPLVLVAPPD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 262 FLSFAPTPET-----RHDALRSLTQCVIRDTARQPGTENHFLIEGAPQCSapDMAMKKELILNRLAWGHLPDFMVEQEVR 336
Cdd:pfam03466 84 HPLARGEPVSledlaDEPLILLPPGSGLRDLLDRALRAAGLRPRVVLEVN--SLEALLQLVAAGLGIALLPRSAVARELA 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1995569479 337 SGTLLNLQGRHLPGRREtLAVMRHRNKPHGPVAEALWRWIRDQLR 381
Cdd:pfam03466 162 DGRLVALPLPEPPLPRE-LYLVWRKGRPLSPAVRAFIEFLREALA 205
|
|
| PRK10094 |
PRK10094 |
HTH-type transcriptional activator AllS; |
95-352 |
8.64e-14 |
|
HTH-type transcriptional activator AllS;
Pssm-ID: 182237 [Multi-domain] Cd Length: 308 Bit Score: 71.38 E-value: 8.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFGRQL 174
Cdd:PRK10094 7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQQV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 175 ASGEEAILRVVLGDLCPRPMILGA-LSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHrVDASRYDFEQMEIC--- 250
Cdd:PRK10094 87 NDGVERQVNIVINNLLYNPQAVAQlLAWLNERYPFTQFHISRQIYMGVWDSLLYEGFSLAIG-VTGTEALANTFSLDplg 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 251 KVQLVPVVAPGF-LSFAPTPETrHDALRSLTQCVIRDTARQPGTENHFLIEGAPQCSAPDMAMKKELILNRLAWGHLPDF 329
Cdd:PRK10094 166 SVQWRFVMAADHpLANVEEPLT-EAQLRRFPAVNIEDSARTLTKRVAWRLPGQKEIIVPDMETKIAAHLAGVGIGFLPKS 244
|
250 260
....*....|....*....|...
gi 1995569479 330 MVEQEVRSGTLLnlqGRHLPGRR 352
Cdd:PRK10094 245 LCQSMIDNQQLV---SRVIPTMR 264
|
|
| PRK11242 |
PRK11242 |
DNA-binding transcriptional regulator CynR; Provisional |
92-165 |
1.05e-13 |
|
DNA-binding transcriptional regulator CynR; Provisional
Pssm-ID: 183051 [Multi-domain] Cd Length: 296 Bit Score: 71.14 E-value: 1.05e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAF--HARAAvsLRDLD 165
Cdd:PRK11242 3 LRHIRYFLAVAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRTVRLTDAGEVYlrYARRA--LQDLE 76
|
|
| PRK11074 |
PRK11074 |
putative DNA-binding transcriptional regulator; Provisional |
93-247 |
1.46e-13 |
|
putative DNA-binding transcriptional regulator; Provisional
Pssm-ID: 182948 [Multi-domain] Cd Length: 300 Bit Score: 70.74 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 93 HELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFGR 172
Cdd:PRK11074 5 YSLEVVDAVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQETRRQCQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 173 QLASGEE-----AILRVVLGDLCpRPMILgalsKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDAS----RYD 243
Cdd:PRK11074 85 QVANGWRgqlsiAVDNIVRPDRT-RQLIV----DFYRHFDDVELIIRQEVFNGVWDALADGRVDIAIGATRAIpvggRFA 159
|
....
gi 1995569479 244 FEQM 247
Cdd:PRK11074 160 FRDM 163
|
|
| PRK09791 |
PRK09791 |
LysR family transcriptional regulator; |
87-245 |
8.19e-12 |
|
LysR family transcriptional regulator;
Pssm-ID: 182077 [Multi-domain] Cd Length: 302 Bit Score: 65.55 E-value: 8.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 87 PASFKLHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLD- 165
Cdd:PRK09791 2 AFQVKIHQIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRa 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 166 -HLDAFGRQ-LASGEeaiLRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDASRYD 243
Cdd:PRK09791 82 aQEDIRQRQgQLAGQ---INIGMGASIARSLMPAVISRFHQQHPQVKVRIMEGQLVSMINELRQGELDFTINTYYQGPYD 158
|
..
gi 1995569479 244 FE 245
Cdd:PRK09791 159 HE 160
|
|
| PRK11139 |
PRK11139 |
DNA-binding transcriptional activator GcvA; Provisional |
92-295 |
9.37e-11 |
|
DNA-binding transcriptional activator GcvA; Provisional
Pssm-ID: 182990 [Multi-domain] Cd Length: 297 Bit Score: 62.17 E-value: 9.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLdhLDAFG 171
Cdd:PRK11139 8 LNALRAFEAAARHLSFTRAAEELFVTQAAVSHQIKALEDFLGLKLFRRRNRSLLLTEEGQRYFLDIREIFDQL--AEATR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 172 RQLASGEEAILRVVLGD------LCPRpmilgaLSKFFAGHPRTRLHLdyEAVTGPFERLDEGttdliihrVD-ASRYDF 244
Cdd:PRK11139 86 KLRARSAKGALTVSLLPsfaiqwLVPR------LSSFNEAHPDIDVRL--KAVDRLEDFLRDD--------VDvAIRYGR 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995569479 245 EQMEICKVQ------LVPVVAPGFLSFAPTPET-----RHDALRSLTQCVIRDTARQPGTEN 295
Cdd:PRK11139 150 GNWPGLRVEklldeyLLPVCSPALLNGGKPLKTpedlaRHTLLHDDSREDWRAWFRAAGLDD 211
|
|
| rbcR |
CHL00180 |
LysR transcriptional regulator; Provisional |
89-153 |
1.16e-10 |
|
LysR transcriptional regulator; Provisional
Pssm-ID: 177082 [Multi-domain] Cd Length: 305 Bit Score: 61.96 E-value: 1.16e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995569479 89 SFKLHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAF 153
Cdd:CHL00180 4 PFTLDQLRILKAIATEGSFKKAAESLYISQPAVSLQIKNLEKQLNIPLFDRSKNKASLTEAGELL 68
|
|
| PRK09906 |
PRK09906 |
DNA-binding transcriptional regulator HcaR; Provisional |
91-236 |
3.85e-09 |
|
DNA-binding transcriptional regulator HcaR; Provisional
Pssm-ID: 182137 [Multi-domain] Cd Length: 296 Bit Score: 57.47 E-value: 3.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 91 KLHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAF 170
Cdd:PRK09906 2 ELRHLRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRKVALTAAGEVFLQDARAILEQAEKAKLR 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1995569479 171 GRQlASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHR 236
Cdd:PRK09906 82 ARK-IVQEDRQLTIGFVPSAEVNLLPKVLPMFRLRHPDTLIELVSLITTQQEEKLRRGELDVGFMR 146
|
|
| PRK12684 |
PRK12684 |
CysB family HTH-type transcriptional regulator; |
91-213 |
4.45e-09 |
|
CysB family HTH-type transcriptional regulator;
Pssm-ID: 237173 [Multi-domain] Cd Length: 313 Bit Score: 57.29 E-value: 4.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 91 KLHELRCLDAVARFG-SFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYR-VELTDAGRAFHARAAVSLRDLDHLD 168
Cdd:PRK12684 2 NLHQLRFVREAVRQNfNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRlRGLTEPGRIILASVERILQEVENLK 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1995569479 169 AFGRQLASGEEAIL---------RVVLgdlcPRpmilgALSKFFAGHPRTRLHL 213
Cdd:PRK12684 82 RVGKEFAAQDQGNLtiatthtqaRYAL----PA-----AIKEFKKRYPKVRLSI 126
|
|
| PBP2_HupR |
cd08431 |
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which ... |
182-345 |
1.31e-08 |
|
The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; HupR, a member of the LysR family, activates hupA transcription under low-iron conditions in the presence of hemin. The expression of many iron-uptake genes, such as hupA, is regulated at the transcriptional level by iron and an iron-binding repressor protein called Fur (ferric uptake regulation). Under iron-abundant conditions with heme, the active Fur repressor protein represses transcription of the iron-uptake gene hupA, and prevents transcriptional activation via HupR. Under low-iron conditions with heme, the Fur repressor is inactive and transcription of the hupA is allowed. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Pssm-ID: 176122 [Multi-domain] Cd Length: 195 Bit Score: 54.20 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 182 LRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLII-HRVDASRYDFEQMEICKVQLVPVVAP 260
Cdd:cd08431 2 LRIAIDTVLPLQPLYPLIAEFYQLNKATRIRLSEEVLGGTWDALASGRADLVIgATGELPPGGVKTRPLGEVEFVFAVAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 261 GF-LSFAPTPETRhDALRSLTQCVIRDTARQPGTENHFLIEGAPQCSAPDMAMKKELILNRLAWGHLPDFMVEQEVRSGT 339
Cdd:cd08431 82 NHpLAKLDGPLDA-SAIKQYPAIVVADTSRNLPPRSSGLLEGQDRIRVPTMQAKIDAQVLGLGVGYLPRHLAKPELASGE 160
|
....*.
gi 1995569479 340 LLNLQG 345
Cdd:cd08431 161 LVEKAL 166
|
|
| PRK10086 |
PRK10086 |
DNA-binding transcriptional regulator DsdC; |
89-166 |
9.84e-08 |
|
DNA-binding transcriptional regulator DsdC;
Pssm-ID: 182231 [Multi-domain] Cd Length: 311 Bit Score: 53.08 E-value: 9.84e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1995569479 89 SFKLHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAG-RAFHARAAvSLRDLDH 166
Cdd:PRK10086 13 GWQLSKLHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGkRVFWALKS-SLDTLNQ 90
|
|
| PRK11151 |
PRK11151 |
DNA-binding transcriptional regulator OxyR; Provisional |
94-234 |
1.13e-07 |
|
DNA-binding transcriptional regulator OxyR; Provisional
Pssm-ID: 182999 [Multi-domain] Cd Length: 305 Bit Score: 52.72 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 94 ELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLdafgRQ 173
Cdd:PRK11151 5 DLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVL----KE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 174 LAS--GEEAILRVVLGdLCPR------PMILGALSKFFaghPRTRLHLdYEAVTGPF-ERLDEGTTDLII 234
Cdd:PRK11151 81 MASqqGETMSGPLHIG-LIPTvgpyllPHIIPMLHQTF---PKLEMYL-HEAQTHQLlAQLDSGKLDCAI 145
|
|
| PRK12682 |
PRK12682 |
transcriptional regulator CysB-like protein; Reviewed |
91-213 |
2.75e-07 |
|
transcriptional regulator CysB-like protein; Reviewed
Pssm-ID: 183679 [Multi-domain] Cd Length: 309 Bit Score: 51.92 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 91 KLHELRCLDAVARFG-SFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVE-LTDAGRAFHARAAVSLRDLDHLD 168
Cdd:PRK12682 2 NLQQLRFVREAVRRNlNLTEAAKALHTSQPGVSKAIIELEEELGIEIFIRHGKRLKgLTEPGKAVLDVIERILREVGNIK 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1995569479 169 AFGRQLASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHL 213
Cdd:PRK12682 82 RIGDDFSNQDSGTLTIATTHTQARYVLPRVVAAFRKRYPKVNLSL 126
|
|
| PRK10632 |
PRK10632 |
HTH-type transcriptional activator AaeR; |
101-154 |
7.41e-07 |
|
HTH-type transcriptional activator AaeR;
Pssm-ID: 182601 [Multi-domain] Cd Length: 309 Bit Score: 50.53 E-value: 7.41e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1995569479 101 VARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFH 154
Cdd:PRK10632 13 VVEFGSFTAAARQLQMSVSSISQTVSKLEDELQVKLLNRSTRSIGLTEAGRIYY 66
|
|
| decaheme_TF |
NF041036 |
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, ... |
95-152 |
1.35e-06 |
|
multiheme cytochrome-associated LysR family transcriptional regulator; Members of this family, including founding member GSU2202 from Geobacter sulfurreducens PCA, are LysR family transcriptional regulators found regularly in the vicinity of multiheme cytochromes such as GSU2203, a decaheme c-type cytochrome.
Pssm-ID: 468965 [Multi-domain] Cd Length: 301 Bit Score: 49.74 E-value: 1.35e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRA 152
Cdd:NF041036 6 LKTLVIVAEEGSFSKAAEKLHLTQSAVSQRIKFLEECYGYQLFDRSGPSLEPTAAGEM 63
|
|
| PRK09801 |
PRK09801 |
LysR family transcriptional regulator; |
94-276 |
1.49e-06 |
|
LysR family transcriptional regulator;
Pssm-ID: 182085 [Multi-domain] Cd Length: 310 Bit Score: 49.65 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 94 ELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFGRQ 173
Cdd:PRK09801 10 DLQVLVEIVHSGSFSAAAATLGQTPAFVTKRIQILENTLATTLLNRSARGVALTESGQRCYEHALEILTQYQRLVDDVTQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 174 LASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYeavtgpFER---LDEGTTDLIIHRVDASRYDFEQMEIC 250
Cdd:PRK09801 90 IKTRPEGMIRIGCSFGFGRSHIAPAITELMRNYPELQVHFEL------FDRqidLVQDNIDLDIRINDEIPDYYIAHLLT 163
|
170 180 190
....*....|....*....|....*....|.
gi 1995569479 251 KVQLVPVVAPGFLSFAPTPET-----RHDAL 276
Cdd:PRK09801 164 KNKRILCAAPEYLQKYPQPQSlqelsRHDCL 194
|
|
| PRK13348 |
PRK13348 |
HTH-type transcriptional regulator ArgP; |
94-187 |
1.10e-05 |
|
HTH-type transcriptional regulator ArgP;
Pssm-ID: 237357 [Multi-domain] Cd Length: 294 Bit Score: 46.89 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 94 ELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGyRVELTDAGRAF--HARaAVSLRDLDHLdafg 171
Cdd:PRK13348 6 QLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVRGR-PCRPTPAGQRLlrHLR-QVALLEADLL---- 79
|
90
....*....|....*.
gi 1995569479 172 RQLASGEEAILRVVLG 187
Cdd:PRK13348 80 STLPAERGSPPTLAIA 95
|
|
| PBP2_LTTR_substrate |
cd05466 |
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the ... |
195-376 |
3.01e-05 |
|
The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.
Pssm-ID: 176102 [Multi-domain] Cd Length: 197 Bit Score: 44.51 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 195 ILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLIIHRVDASRYDFEQMEICKVQLVPVVAPGFlsfaptPETRHD 274
Cdd:cd05466 15 LPPLLAAFRQRYPGVELSLVEGGSSELLEALLEGELDLAIVALPVDDPGLESEPLFEEPLVLVVPPDH------PLAKRK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 275 ALRsltqcvIRDTARQP------GTENHFLIEGA---------PQCSAPDMAMKKELILNRLAWGHLPDFMVEQEVRSGt 339
Cdd:cd05466 89 SVT------LADLADEPlilferGSGLRRLLDRAfaeagftpnIALEVDSLEAIKALVAAGLGIALLPESAVEELADGG- 161
|
170 180 190
....*....|....*....|....*....|....*....
gi 1995569479 340 llnLQGRHL--PGRRETLAVMRHRNKPHGPVAEALWRWI 376
Cdd:cd05466 162 ---LVVLPLedPPLSRTIGLVWRKGRYLSPAARAFLELL 197
|
|
| PRK10837 |
PRK10837 |
putative DNA-binding transcriptional regulator; Provisional |
92-213 |
1.74e-04 |
|
putative DNA-binding transcriptional regulator; Provisional
Pssm-ID: 182768 [Multi-domain] Cd Length: 290 Bit Score: 43.14 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARaAVSLrdldhLDAFG 171
Cdd:PRK10837 5 LRQLEVFAEVLKSGSTTQASVMLALSQSAVSAALTDLEGQLGVQLFDRVGKRLVVNEHGRLLYPR-ALAL-----LEQAV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1995569479 172 --RQLASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHL 213
Cdd:PRK10837 79 eiEQLFREDNGALRIYASSTIGNYILPAMIARYRRDYPQLPLEL 122
|
|
| PRK10341 |
PRK10341 |
transcriptional regulator TdcA; |
91-164 |
1.92e-04 |
|
transcriptional regulator TdcA;
Pssm-ID: 182391 [Multi-domain] Cd Length: 312 Bit Score: 42.93 E-value: 1.92e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995569479 91 KLHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDL 164
Cdd:PRK10341 8 KTQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELIVRKNTGVTLTPAGQVLLSRSESITREM 81
|
|
| PRK11233 |
PRK11233 |
nitrogen assimilation transcriptional regulator; Provisional |
105-162 |
7.02e-04 |
|
nitrogen assimilation transcriptional regulator; Provisional
Pssm-ID: 183045 [Multi-domain] Cd Length: 305 Bit Score: 41.21 E-value: 7.02e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995569479 105 GSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLR 162
Cdd:PRK11233 16 GSLTQAAEVLHIAQPALSQQVATLEGELNQQLLIRTKRGVTPTEAGKILYTHARAILR 73
|
|
| PRK12683 |
PRK12683 |
transcriptional regulator CysB-like protein; Reviewed |
91-184 |
8.70e-04 |
|
transcriptional regulator CysB-like protein; Reviewed
Pssm-ID: 237172 [Multi-domain] Cd Length: 309 Bit Score: 40.80 E-value: 8.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 91 KLHELRCLDAVARFG-SFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVE-LTDAGRAFHARAAVSLRDLDHLD 168
Cdd:PRK12683 2 NFQQLRIIREAVRQNfNLTEVANALYTSQSGVSKQIKDLEDELGVEIFIRRGKRLTgLTEPGKELLQIVERMLLDAENLR 81
|
90
....*....|....*.
gi 1995569479 169 AFGRQLASGEEAILRV 184
Cdd:PRK12683 82 RLAEQFADRDSGHLTV 97
|
|
| PRK12680 |
PRK12680 |
LysR family transcriptional regulator; |
92-234 |
1.07e-03 |
|
LysR family transcriptional regulator;
Pssm-ID: 183677 [Multi-domain] Cd Length: 327 Bit Score: 40.76 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFG-SFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVE-LTDAGRAFHARAAVSLRDLDHLDA 169
Cdd:PRK12680 3 LTQLRYLVAIADAElNITLAAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLEsVTPAGVEVIERARAVLSEANNIRT 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995569479 170 FGRQLASGEEAILRVVLGDLCPRPMILGALSKFFAGHPRTRLHLDYEAVTGPFERLDEGTTDLII 234
Cdd:PRK12680 83 YAANQRRESQGQLTLTTTHTQARFVLPPAVAQIKQAYPQVSVHLQQAAESAALDLLGQGDADIAI 147
|
|
| PRK11013 |
PRK11013 |
DNA-binding transcriptional regulator LysR; Provisional |
100-212 |
2.04e-03 |
|
DNA-binding transcriptional regulator LysR; Provisional
Pssm-ID: 236819 [Multi-domain] Cd Length: 309 Bit Score: 39.59 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 100 AVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAG-RAFH--ARAAVSLRDLDHLDAFGRQLAS 176
Cdd:PRK11013 14 AVMTAGSLTEAARLLHTSQPTVSRELARFEKVIGLKLFERVRGRLHPTVQGlRLFEevQRSYYGLDRIVSAAESLREFRQ 93
|
90 100 110
....*....|....*....|....*....|....*...
gi 1995569479 177 GEEAI--LRVVLGDLCPrpmilGALSKFFAGHPRTRLH 212
Cdd:PRK11013 94 GQLSIacLPVFSQSLLP-----GLCQPFLARYPDVSLN 126
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
111-152 |
3.13e-03 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 37.49 E-value: 3.13e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1995569479 111 ADALHRSHPSVFASVARLEANlglKLLDRSGYR-VELTDAGRA 152
Cdd:COG1321 31 AERLGVSPPSVTEMLKKLEEK---GLVEYEPYGgITLTEEGRE 70
|
|
| PBP2_CrgA_like |
cd08422 |
The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its ... |
192-340 |
3.67e-03 |
|
The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.
Pssm-ID: 176114 [Multi-domain] Cd Length: 197 Bit Score: 38.19 E-value: 3.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 192 RPMILGALSKFFAGHPRTRLHLDyeavtgpferLDEGTTDLIIHRVDAS-RYDFEQME------ICKVQLVPVVAPGFLS 264
Cdd:cd08422 13 RLHLAPLLAEFLARYPDVRLELV----------LSDRLVDLVEEGFDLAiRIGELPDSslvarrLGPVRRVLVASPAYLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 265 FAPTPET-----RHDALR-SLTQCVIRDTARQPGTENHFLIEGAPQCSAPDMAmkKELILNRLAWGHLPDFMVEQEVRSG 338
Cdd:cd08422 83 RHGTPQTpedlaRHRCLGyRLPGRPLRWRFRRGGGEVEVRVRGRLVVNDGEAL--RAAALAGLGIALLPDFLVAEDLASG 160
|
..
gi 1995569479 339 TL 340
Cdd:cd08422 161 RL 162
|
|
| PRK09986 |
PRK09986 |
LysR family transcriptional regulator; |
92-187 |
3.75e-03 |
|
LysR family transcriptional regulator;
Pssm-ID: 182183 [Multi-domain] Cd Length: 294 Bit Score: 38.94 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 92 LHELRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHARAAVSLRDLDHLDAFG 171
Cdd:PRK09986 9 LKLLRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRLLDNAEQSLARV 88
|
90
....*....|....*.
gi 1995569479 172 RQLASGEEAilRVVLG 187
Cdd:PRK09986 89 EQIGRGEAG--RIEIG 102
|
|
| PRK03635 |
PRK03635 |
ArgP/LysG family DNA-binding transcriptional regulator; |
95-378 |
6.12e-03 |
|
ArgP/LysG family DNA-binding transcriptional regulator;
Pssm-ID: 235144 [Multi-domain] Cd Length: 294 Bit Score: 38.22 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRsGYRVELTDAGRAFharaavsLRDLDHLdafgRQL 174
Cdd:PRK03635 7 LEALAAVVREGSFERAAQKLHITQSAVSQRIKALEERVGQVLLVR-TQPCRPTEAGQRL-------LRHARQV----RLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 175 asgeEAILRVVLGDLCPRPMIL--------------GALSKFFAGHP-RTRLHLDYEAVTGpfERLDEGTtdlIIHRVDA 239
Cdd:PRK03635 75 ----EAELLGELPALDGTPLTLsiavnadslatwflPALAPVLARSGvLLDLVVEDQDHTA--ELLRRGE---VVGAVTT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 240 SRydfEQMEICKVQL------VPVVAPGF----LSFAPTPET----------RHDAL--RSLTQCVIRDTARQPgteNHF 297
Cdd:PRK03635 146 EP---QPVQGCRVDPlgamryLAVASPAFaaryFPDGVTAEAlakapavvfnRKDDLqdRFLRQAFGLPPGSVP---CHY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 298 LiegapqcsaPDMAMKKELILNRLAWGHLPDFMVEQEVRSGTLLNLqgrhLPGRRETLAVMRHRNKPHGPVAEALWRWIR 377
Cdd:PRK03635 220 V---------PSSEAFVRAALAGLGWGMIPELQIEPELASGELVDL----TPGRPLDVPLYWQHWRLESRLLDRLTDALL 286
|
.
gi 1995569479 378 D 378
Cdd:PRK03635 287 A 287
|
|
| PRK15092 |
PRK15092 |
DNA-binding transcriptional repressor LrhA; Provisional |
95-234 |
7.36e-03 |
|
DNA-binding transcriptional repressor LrhA; Provisional
Pssm-ID: 237907 [Multi-domain] Cd Length: 310 Bit Score: 38.09 E-value: 7.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 95 LRCLDAVARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAF--HAR--------AAVSLR-- 162
Cdd:PRK15092 16 LRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLlgYARkilrfndeACSSLMys 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1995569479 163 DLDHLDAFGrqlASGEEA--ILrvvlgdlcprPMILGALSKFFAghprtRLHLDYEAVTGPF--ERLDEGTTDLII 234
Cdd:PRK15092 96 NLQGVLTIG---ASDDTAdtIL----------PFLLNRVSSVYP-----KLALDVRVKRNAFmmEMLESQEVDLAV 153
|
|
| PRK14997 |
PRK14997 |
LysR family transcriptional regulator; Provisional |
101-214 |
7.79e-03 |
|
LysR family transcriptional regulator; Provisional
Pssm-ID: 184959 [Multi-domain] Cd Length: 301 Bit Score: 38.05 E-value: 7.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995569479 101 VARFGSFQSAADALHRSHPSVFASVARLEANLGLKLLDRSGYRVELTDAGRAFHaraavslrdlDHLDAFGRQLASGEEA 180
Cdd:PRK14997 13 VVEEGGFAAAGRALDEPKSKLSRRIAQLEERLGVRLIQRTTRQFNVTEVGQTFY----------EHCKAMLVEAQAAQDA 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1995569479 181 IL------RVVLGDLCPRPM----ILGALSKFFAGHPRTRLHLD 214
Cdd:PRK14997 83 IAalqvepRGIVKLTCPVTLlhvhIGPMLAKFMARYPDVSLQLE 126
|
|
| HTH_MARR |
smart00347 |
helix_turn_helix multiple antibiotic resistance protein; |
94-157 |
9.36e-03 |
|
helix_turn_helix multiple antibiotic resistance protein;
Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 35.26 E-value: 9.36e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995569479 94 ELRCLDAVARFG--SFQSAADALHRSHPSVFASVARLEANlGL-----KLLDRSGYRVELTDAGRAFHARA 157
Cdd:smart00347 12 QFLVLRILYEEGplSVSELAKRLGVSPSTVTRVLDRLEKK-GLvrrepSPEDRRSVLVSLTEEGRELIEQL 81
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