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Conserved domains on  [gi|1993933988|ref|XP_039595199|]
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galactokinase [Polypterus senegalus]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-389 1.24e-175

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 494.29  E-value: 1.24e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEARAVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFAVIVTAakeaDEPHKIDF 91
Cdd:COG0153     1 RLERLIEAFEEAF-GEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSA----DFDEEVEF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  92 PIpegsSPLKPGEPK-WANYVKGVVQYYR-AG-PLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKA 168
Cdd:COG0153    76 DL----DDLEPGEEDgWANYVRGVAWALQeRGyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 169 LACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNKLIILVTNSNVRHTLSGSEYPTRRKQCEQAA 248
Cdd:COG0153   152 KIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 249 LALNKPSLREASIEDLEAARDKL-DEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPELD 327
Cdd:COG0153   232 AILGVKSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELD 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1993933988 328 QLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYS----GVPTFYITTPSEGAR 389
Cdd:COG0153   312 TLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGAR 377
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-389 1.24e-175

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 494.29  E-value: 1.24e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEARAVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFAVIVTAakeaDEPHKIDF 91
Cdd:COG0153     1 RLERLIEAFEEAF-GEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSA----DFDEEVEF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  92 PIpegsSPLKPGEPK-WANYVKGVVQYYR-AG-PLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKA 168
Cdd:COG0153    76 DL----DDLEPGEEDgWANYVRGVAWALQeRGyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 169 LACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNKLIILVTNSNVRHTLSGSEYPTRRKQCEQAA 248
Cdd:COG0153   152 KIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 249 LALNKPSLREASIEDLEAARDKL-DEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPELD 327
Cdd:COG0153   232 AILGVKSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELD 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1993933988 328 QLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYS----GVPTFYITTPSEGAR 389
Cdd:COG0153   312 TLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGAR 377
PRK05101 PRK05101
galactokinase; Provisional
 12-391 8.98e-140

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 403.15  E-value: 8.98e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEARAVFRKSFEdVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFaVIVTAA---KEADEphk 88
Cdd:PRK05101    3 LKQKTQSLFAQQFG-YPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRI-VRVIAAdydNQQDE--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  89 idFPIpegSSPLKP-GEPKWANYVKGVVQYY--RAGPLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLV 165
Cdd:PRK05101   78 --FSL---DAPIVPhPEQQWANYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 166 KKALACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNkLIILVTNSNVRHTLSGSEYPTRRKQCE 245
Cdd:PRK05101  153 EIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEG-VAVVIINSNVKRGLVDSEYNTRRQQCE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 246 QAALALNKPSLREASIEDLEAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPE 325
Cdd:PRK05101  232 TAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQ 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1993933988 326 LDQLVKLALEVDGVYGS-RMTGGGFGGCTVTLLNSSAVEKTTKHIQKHY---SGV-PTFYITTPSEGARSL 391
Cdd:PRK05101  312 IDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYeakTGLkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-391 1.52e-120

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 354.52  E-value: 1.52e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  15 EARAVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFaVIVTAA---KEADEpHKIDF 91
Cdd:TIGR00131   3 SIQKIFASAF-GAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKN-VRIYLAnadNKFAE-RSLDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  92 PIPegssplKPGEPKWANYVKGVV----QYYRAGPLpGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKK 167
Cdd:TIGR00131  80 PLD------GSEVSDWANYFKGVLhvaqERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 168 ALACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNKLIILVTNSNVRHTLSGSEYPTRRKQCEQA 247
Cdd:TIGR00131 153 LLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 248 ALALNKPS---LREASIEDL---EAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEV 321
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993933988 322 SCPELDQLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYSGVP----TFYITTPSEGARSL 391
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTglelTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 18-65 1.92e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 78.26  E-value: 1.92e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1993933988  18 AVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIV 65
Cdd:pfam10509   1 EAFEELF-GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVA 47
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-389 1.24e-175

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 494.29  E-value: 1.24e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEARAVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFAVIVTAakeaDEPHKIDF 91
Cdd:COG0153     1 RLERLIEAFEEAF-GEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSA----DFDEEVEF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  92 PIpegsSPLKPGEPK-WANYVKGVVQYYR-AG-PLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKA 168
Cdd:COG0153    76 DL----DDLEPGEEDgWANYVRGVAWALQeRGyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 169 LACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNKLIILVTNSNVRHTLSGSEYPTRRKQCEQAA 248
Cdd:COG0153   152 KIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 249 LALNKPSLREASIEDLEAARDKL-DEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPELD 327
Cdd:COG0153   232 AILGVKSLRDVTLEDLEAARARLgDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELD 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1993933988 328 QLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYS----GVPTFYITTPSEGAR 389
Cdd:COG0153   312 TLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAektgLEPDFYVVKPSDGAR 377
PRK05101 PRK05101
galactokinase; Provisional
 12-391 8.98e-140

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 403.15  E-value: 8.98e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEARAVFRKSFEdVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFaVIVTAA---KEADEphk 88
Cdd:PRK05101    3 LKQKTQSLFAQQFG-YPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRI-VRVIAAdydNQQDE--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  89 idFPIpegSSPLKP-GEPKWANYVKGVVQYY--RAGPLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLV 165
Cdd:PRK05101   78 --FSL---DAPIVPhPEQQWANYVRGVVKHLqeRNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 166 KKALACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNkLIILVTNSNVRHTLSGSEYPTRRKQCE 245
Cdd:PRK05101  153 EIALNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEG-VAVVIINSNVKRGLVDSEYNTRRQQCE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 246 QAALALNKPSLREASIEDLEAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPE 325
Cdd:PRK05101  232 TAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQ 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1993933988 326 LDQLVKLALEVDGVYGS-RMTGGGFGGCTVTLLNSSAVEKTTKHIQKHY---SGV-PTFYITTPSEGARSL 391
Cdd:PRK05101  312 IDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYeakTGLkETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-391 1.52e-120

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 354.52  E-value: 1.52e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  15 EARAVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFaVIVTAA---KEADEpHKIDF 91
Cdd:TIGR00131   3 SIQKIFASAF-GAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKN-VRIYLAnadNKFAE-RSLDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  92 PIPegssplKPGEPKWANYVKGVV----QYYRAGPLpGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKK 167
Cdd:TIGR00131  80 PLD------GSEVSDWANYFKGVLhvaqERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 168 ALACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNKLIILVTNSNVRHTLSGSEYPTRRKQCEQA 247
Cdd:TIGR00131 153 LLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 248 ALALNKPS---LREASIEDL---EAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEV 321
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1993933988 322 SCPELDQLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYSGVP----TFYITTPSEGARSL 391
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTglelTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 21-391 4.41e-113

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 335.67  E-value: 4.41e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  21 RKSFEDV---RPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKfaVIVTAAKEADEPHKIDFPIPEgs 97
Cdd:PRK05322    7 KKKFAEVfgeEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDK--KVRLYSANFEDLGIIEFDLDD-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  98 spLKP-GEPKWANYVKGVVQYYRAGPLP---GFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKALACQR 173
Cdd:PRK05322   83 --LSFdKEDDWANYPKGVLKFLQEAGYKidhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 174 AEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEF--FPVPLTDNKLIIlvTNSNVRHTLSGSEYPTRRKQCEQAALAL 251
Cdd:PRK05322  161 TENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYeyVPLDLGDYVIVI--MNTNKRRELADSKYNERRAECEKALEEL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 252 NK----PSLREASIEDLEAARDKLDEET-FRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPEL 326
Cdd:PRK05322  239 QKkldiKSLGELTEEEFDEYSYLIKDETlLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLEL 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1993933988 327 DQLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYSGV----PTFYITTPSEGARSL 391
Cdd:PRK05322  319 DTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKigyaASFYVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 35-389 9.13e-104

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 310.39  E-value: 9.13e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  35 APGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPtSDKFAVIVTAAKEADEphkidFpipeGSSPLKPGEpKWANYVKGV 114
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEK-SEKFIFYSENFNEEKT-----F----ELDKLEKLN-SWADYIKGV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 115 V-----QYYRAGPlpgFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKALACQRAEHDFANMPCGIMDQF 189
Cdd:PRK03817   74 IwvlekRGYEVGG---VKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQF 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 190 ISVMAKEGHGLLIDCRSLEFFPVPLTDNkLIILVTNSNVRHTLSGSEYPTRRKQCEQAALALNKPSLREASIEDLEaard 269
Cdd:PRK03817  151 AVAFGKKDHAIFLDTMTLEYEYVPFPED-YEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLS---- 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 270 KLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPELDQLVKLALEVdGVYGSRMTGGGF 349
Cdd:PRK03817  226 KLPPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGAGF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1993933988 350 GGCTVTLLNSSAVEKTTKHI----QKHYSGVPTFYITTPSEGAR 389
Cdd:PRK03817  305 GGSAIALVDKGKFESIGEELleeyKKRFGIDPKYFVVESSDGVR 348
PRK00555 PRK00555
galactokinase; Provisional
 30-363 1.67e-85

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 264.03  E-value: 1.67e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  30 TLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKfaVIVTAAKEADEPHKIdfPIPEGssplkPGEPK-WA 108
Cdd:PRK00555    2 TVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTD--AITASSDRADGSARI--PLDTT-----PGQVTgWA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 109 NYVKGVVQYYR-AG-PLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKALACQRAEHDFANMPCGIM 186
Cdd:PRK00555   73 AYAAGVIWALRgAGhPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 187 DQFISVMAKEGHGLLIDCRSLEFFPVPLTDNK--LIILVTNSNVRHTLSGSEYPTRRKQCEQAALALNKPSLREASIEDL 264
Cdd:PRK00555  153 DQLAALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 265 EAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDDYEVSCPELDQLVKLALEVdGVYGSRM 344
Cdd:PRK00555  233 AALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARM 311

                         330
                  ....*....|....*....
gi 1993933988 345 TGGGFGGCTVTLLNSSAVE 363
Cdd:PRK00555  312 TGGGFGGCVIALVPADRAE 330
PTZ00290 PTZ00290
galactokinase; Provisional
 9-373 1.54e-49

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 173.47  E-value: 1.54e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988   9 LSGLVDEARAVFRKSFE-----DVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMA-LPMCTVIVGIP---TSDKfaviVTA 79
Cdd:PTZ00290   11 LDSTLSTLKPIFLETFKvendaDVEWLLFTFAPGRVNFIGEHVDYMGGYVCPAAvLEGCHILVGRVkhfCDHK----LRF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  80 AKEADEPHKIDfpipegssplKPGEPK----WANYVKGVVQY--------YRAGPLPGFKAVIASNVPLGGGLSSSASLE 147
Cdd:PTZ00290   87 ATETDEHFVLD----------HLGGAKhnkaWTTFVRGAATLrlnrlgvaIDAPSLQGVCMVVHGTLPMGAGMSASASFG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 148 VAM----------------------YTFLQQlCPDDgDLVKKALACQRAEHDFANMPCGIMDQFISVMAKEGHGLLIDCR 205
Cdd:PTZ00290  157 VALlnaintvvtrrykgcptspgrrYSILPP-MSKE-ELIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 206 SLEFFPVPLT----DNKLIILVtNSNVRHTLSGSE---YPTRRKQCEQAALALNKPSLREASIEDLEAARDKLDEETFRR 278
Cdd:PTZ00290  235 SLTFESHDMTpllgDGACFLLI-DSMIKHDLLGGTagmYNTVRSDQEGAQKKIGKHRYRGKPFTFSDLVRNPKKYTFDGD 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 279 ARHVI---------GEIDR-TSQAAEELKLGNYREF----------------GKLMVESHNSLRDDYEVSCPELDQLVKL 332
Cdd:PTZ00290  314 VVAFMesckplmtpGEFERgTYNIMEQIRTLEFIKLndpelplsreerfrkaGEILNAGHQGMRDLMKITTPELDFIHEL 393

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1993933988 333 ALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHY 373
Cdd:PTZ00290  394 INEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKF 434
PLN02521 PLN02521
galactokinase
 12-393 8.83e-46

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 164.11  E-value: 8.83e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  12 LVDEAR---AVFRKSFEDV---RPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTvIVGIPTSDKFAVIVTAakeade 85
Cdd:PLN02521   24 LLEEARlryARLKAAFVEVygaKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDT-IVAIRRAEGSKKLRIA------ 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  86 phKIDFPIPEGSSPLKPGEP------KWANYV----KGVVQYYRA-----GPLPGFKAVIASNVPLGGGLSSSASLEVAm 150
Cdd:PLN02521   97 --NVNDKYTTCTFPADPDQEvdlanhKWGNYFicgyKGVFEFLKSkgvdvGPPVGLDVVVDGTVPTGSGLSSSAALVCS- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 151 yTFLQQLCPDDGDLVKKALA---CQRAEHdfANMPCGIMDQFISVMAKEGHGLLIDcrsleFFPVPLTD----------- 216
Cdd:PLN02521  174 -AAIAIMAALGLNFTKKEVAqftCKCERH--IGTQSGGMDQAISIMAQQGVAKLID-----FNPVRATDvqlpaggtfvi 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 217 -------NKLIILVTNSNVR--------------------------HTLSGSE-----YPTRRKQCEQAA----LALNKP 254
Cdd:PLN02521  246 anslaesNKAVTAATNYNNRvvecrlaaivlavklgmsaeeaiskvKTLSDVEglcvsFAGSHGSSDPAVavkeLLHEGP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 255 SLRE------------------ASIEDLEAARD-KLdeetFRRARHVIGEIDR--------TSQAAEELKLgnyREFGKL 307
Cdd:PLN02521  326 YTAEeieeilgesltsifknspTSLAVLKAAKHfKL----HQRAVHVYSEAKRvhafrdtvSSSLSEEEKL---KKLGDL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 308 MVESHNSLRDDYEVSCPELDQLVKLALEvDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHY------SGV----- 376
Cdd:PLN02521  399 MNESHYSCSVLYECSCPELEELVKVCRD-NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFyksrieKGVikeed 477

                         490
                  ....*....|....*....
gi 1993933988 377 --PTFYITTPSEGARSLTF 393
Cdd:PLN02521  478 lgLYVFASKPSSGAAILKF 496
PLN02865 PLN02865
galactokinase
 25-373 3.64e-43

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 155.73  E-value: 3.64e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  25 EDVRptlTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIVGIPTSDKFAVIVTAAKEADEPHKID---FPIPEGSSPLK 101
Cdd:PLN02865   28 GEVR---VVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEVRFRVDeiqHPIANVSSDSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 102 PgEPKWANYVKGVVQYYRAGPL---PGFKAVIASNVPL-GGGLSSSASLEVAMYTFLQqlcpDDGDLVKKALAC----QR 173
Cdd:PLN02865  105 E-ESNWGDYARGAVYALQSRGHalsQGITGYISGSEGLdSSGLSSSAAVGVAYLLALE----NANNLTVSPEDNieldRL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 174 AEHDFANMPCGIMDQFISVMAKEGHGLLIDCRSLEFFPVPLTDNK------LIILVTNSNVRHTL-SGSEYPTRRKQCEQ 246
Cdd:PLN02865  180 IENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALtNKPGYNLRVSECQE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 247 AALAL--------NKPSLREASIEDLEAARDKLDEETFRRARHVIGEIDRTSQAAEELKLGNYREFGKLMVESHNSLRDD 318
Cdd:PLN02865  260 AARFLleasgndeLEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIEN 339

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1993933988 319 YEVSCPELDQLVKLALEVDGVYGSRMTGGGFGGCTVTLLNSSAVEKTTKHIQKHY 373
Cdd:PLN02865  340 YECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEY 394
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 35-356 8.85e-22

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 93.75  E-value: 8.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  35 APGRVNLIGEHTD-YNQgfvlpMALPMctvivgiPTSDKFAVIVTAAkeADEPHKIDFPIPEGSSPLKPGEPKWANYVKG 113
Cdd:COG1577     1 APGKLILFGEHAVvYGQ-----PAIAV-------AVDRRATVTVEPS--DDDKLRIESPDLGGTLDLDPLADAALRYIKA 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 114 VVQY---YRAGPLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLC---PDDGDLVKKALACQRAEHDfanMPCGiMD 187
Cdd:COG1577    67 AIEAaleYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYgveLSKEELFKLALEAEKIVHG---NPSG-LD 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 188 QFISVMakeGHGLLIDC-RSLEFFPVPLtdnKLIILVTNSNVRHTlsgseypTRrkqceqaalalnkpslreASIEDLEA 266
Cdd:COG1577   143 TAASTY---GGPIYYQRgDRAEPLELPK---NLPLVVGDTGVPAS-------TK------------------ELVAKVRK 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 267 ARDKlDEETFRRARHVIGEIdrTSQAAEELKLGNYREFGKLMVESHNsLRDDYEVSCPELDQLVKLALEVdGVYGSRMTG 346
Cdd:COG1577   192 LKER-NPELYEAFLEEIGDL--VEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARKA-GALGAKLTG 266

                         330
                  ....*....|
gi 1993933988 347 GGFGGCTVTL 356
Cdd:COG1577   267 AGGGGCVIAL 276
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 35-356 3.19e-20

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 89.66  E-value: 3.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  35 APGRVNLIGEHTD-YNQGfVLPMALPMCTVIVGIPTSDKFavivtaakeadephKIDFPIPEGSSPLKPGEPKWANYVKG 113
Cdd:TIGR00549   1 APGKIILFGEHAVvYGEP-AIAAPIPLRTTVTVIESSDGS--------------FIESDLGRGSLDDAPDELDGLKYVLA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 114 -VVQYYRAGPLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCPDDGDLVKKALACQRAEHDFANMPCGImDQFISV 192
Cdd:TIGR00549  66 eFLSRFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATST 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 193 MakeGHGLLIDCRSLEFfpVPLTDNKLIILVTNSNVRHTlsgseypTRRKQCEQAALALNKPSLREASIEdleaardkld 272
Cdd:TIGR00549 145 S---GGPVYFEKGEGEF--TKLISLDGYFVIADTGVSGS-------TKEAVARVRQLLERFPELIDSIMD---------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 273 eetfrrarhVIGEIdrTSQAAEELKLGNYREFGKLMVESHnSLRDDYEVSCPELDQLVKLALEVdGVYGSRMTGGGFGGC 352
Cdd:TIGR00549 203 ---------AIGEL--TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGGGC 269


                  ....
gi 1993933988 353 TVTL 356
Cdd:TIGR00549 270 MIAL 273
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 18-65 1.92e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 78.26  E-value: 1.92e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1993933988  18 AVFRKSFeDVRPTLTAVAPGRVNLIGEHTDYNQGFVLPMALPMCTVIV 65
Cdd:pfam10509   1 EAFEELF-GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVA 47
PRK03926 PRK03926
mevalonate kinase; Provisional
 32-389 1.05e-11

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 65.07  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988  32 TAVAPGRVNLIGEHTdynqgfVLPMALPMCTVI-----VGIPTSDKFAVIVTAAKEADEPHKidfpipegssplkpgepk 106
Cdd:PRK03926    3 LCSAPGKIYLFGEHA------VVYGKPAIACAIdlrtyVRAEFNDDSIYIESDYGKTGEKHP------------------ 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 107 wanYVKGVVQYYR-AGPLPGFKAVIASNVPLGGGLSSSASLEVAMYTFLQQLCpdDGDLVKKALA--CQRAEHDFANMPC 183
Cdd:PRK03926   59 ---YVSAAIEKMReEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLL--GLGLSLEEIAklGHKVELLVQGAAS 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 184 GImDQFISVMAkeGHGLLIDCRSLEFFPVPltdnkliILVTNSNVrhtlSGSeypTRRkqceqaaLALNKPSLREASIED 263
Cdd:PRK03926  134 PT-DTYVSTMG--GFVTIPDRKKLPFPECG-------IVVGYTGS----SGS---TKE-------LVANVRKLKEEYPEL 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 264 LEAARDkldeetfrrarhVIGEIdrtSQAAEELKL-GNYREFGKLMVESHnSLRDDYEVSCPELDQLVKLALEVdGVYGS 342
Cdd:PRK03926  190 IEPILS------------SIGKI---SEKGEELILsGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGA 252

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1993933988 343 RMTGGGFGGCTVTLLNSSAVEKTTKHIQKHYsGVPTfyITTPS-EGAR 389
Cdd:PRK03926  253 KITGAGGGGCMVALAAPEKQSEVATAIKIAG-GKPI--ITKITdEGLR 297
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 129-193 5.37e-11

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 57.56  E-value: 5.37e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1993933988 129 VIASNVPLGGGLSSSASLEVAMYTFLQQLCpdDGDLVKkalACQRAEHDFANMPCGIMDQFISVM 193
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELF--GLPLAK---LALEAEELAGGGRGGGMDVAASLY 62
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 292-374 1.33e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.48  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1993933988 292 AAEELKLGNYREFGKLMVESHNSL--RDDYEVSCPELDQLVKLALEVDgvYGSRMTGGGFGGCTVTLLNS-SAVEKTTKH 368
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG--LGAKLSGSGGGPTVFALFKDeDDAEEVARA 78


                  ....*.
gi 1993933988 369 IQKHYS 374
Cdd:pfam08544  79 LREAGK 84
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 290-361 1.18e-06

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 49.85  E-value: 1.18e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1993933988 290 SQAAEELKLGNYREFGKLMVESHNSLRdDYEVSCPELDQLVKLALEvDGVYGSRMTGGGFGGCTVTLLNSSA 361
Cdd:PTZ00298  228 SEAKEALQKGNLFRVGELMNANHDLCQ-KLTVSCRELDSIVQTCRT-YGALGAKMSGTGRGGLVVALAASED 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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